Publications by authors named "Charles Swanton"

100Publications

Consequences of COVID-19 for cancer care - a CRUK perspective.

Nat Rev Clin Oncol 2020 Oct 23. Epub 2020 Oct 23.

Cancer Research UK, Redman Place, London, UK.

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http://dx.doi.org/10.1038/s41571-020-00446-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582444PMC
October 2020

Cancer Screening, Surrogates of Survival, and the Soma.

Cancer Cell 2020 Oct 17;38(4):433-437. Epub 2020 Sep 17.

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.09.003DOI Listing
October 2020

Effect of delays in the 2-week-wait cancer referral pathway during the COVID-19 pandemic on cancer survival in the UK: a modelling study.

Lancet Oncol 2020 08 20;21(8):1035-1044. Epub 2020 Jul 20.

Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK; National Cancer Registration and Analysis Service, Public Health England, London, UK; Department of Clinical Genetics, Royal Marsden NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(20)30392-2DOI Listing
August 2020

Cancer Research: The Lessons to Learn from COVID-19.

Cancer Discov 2020 09 15;10(9):1263-1266. Epub 2020 Jul 15.

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-20-0823DOI Listing
September 2020

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers.

Lancet 2020 07 9;396(10246):e6-e7. Epub 2020 Jul 9.

Department of Clinical Virology, University College London Hospitals, London W1T 4EU, UK; Advanced Pathogen Diagnostics Unit, University College London Hospitals, London W1T 4EU, UK; Great Ormond Street Institute of Child Health, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(20)31484-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347344PMC
July 2020

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver.

Cell 2020 Jun;181(6):1395-1405.e11

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298618PMC
June 2020

Protecting "covid protected" cancer hubs.

BMJ 2020 05 28;369:m2062. Epub 2020 May 28.

The BMJ.

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http://dx.doi.org/10.1136/bmj.m2062DOI Listing
May 2020

Take lessons from cancer evolution to the clinic.

Authors:
Charles Swanton

Nature 2020 05;581(7809):382-383

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http://dx.doi.org/10.1038/d41586-020-01347-zDOI Listing
May 2020

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.

NPJ Breast Cancer 2020 12;6:17. Epub 2020 May 12.

21Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC Australia.

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http://dx.doi.org/10.1038/s41523-020-0156-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217863PMC
May 2020

COVID-19: the case for health-care worker screening to prevent hospital transmission.

Lancet 2020 05 16;395(10234):1418-1420. Epub 2020 Apr 16.

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; University College London Hospitals NHS Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(20)30917-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162624PMC
May 2020

Author Correction: Resolving genetic heterogeneity in cancer.

Nat Rev Genet 2020 Jan;21(1):65

Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London, UK.

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http://dx.doi.org/10.1038/s41576-019-0188-1DOI Listing
January 2020

Neoantigen quality, not quantity.

Sci Transl Med 2019 08;11(506)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aax7918DOI Listing
August 2019

Resolving genetic heterogeneity in cancer.

Nat Rev Genet 2019 07;20(7):404-416

Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London, UK.

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http://dx.doi.org/10.1038/s41576-019-0114-6DOI Listing
July 2019

Artificial intelligence in cancer imaging: Clinical challenges and applications.

CA Cancer J Clin 2019 03 5;69(2):127-157. Epub 2019 Feb 5.

Associate Professor, Departments of Radiation Oncology and Radiology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.3322/caac.21552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403009PMC
March 2019

Kidney cancer: The next decade.

J Exp Med 2018 10 14;215(10):2477-2479. Epub 2018 Sep 14.

Pfizer Inc., New York, NY

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http://dx.doi.org/10.1084/jem.20181617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170181PMC
October 2018

Lung cancer in the UK: addressing geographical inequality and late diagnosis.

Lancet Oncol 2018 08;19(8):1015-1017

Cancer Research UK, London, EC1V 4AD, UK; University of Leicester, Leicester, UK; Centre for Cancer Outcomes, University College London Hospitals, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183049
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http://dx.doi.org/10.1016/S1470-2045(18)30496-0DOI Listing
August 2018

Early stage NSCLC - challenges to implementing ctDNA-based screening and MRD detection.

Nat Rev Clin Oncol 2018 09;15(9):577-586

Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, London, UK.

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http://www.nature.com/articles/s41571-018-0058-3
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http://dx.doi.org/10.1038/s41571-018-0058-3DOI Listing
September 2018

Reply to J.J. Tao et al.

J Clin Oncol 2018 08 1;36(23):2451. Epub 2018 Jun 1.

John D. Hainsworth, Sarah Cannon Research Institute; Tennessee Oncology, PLLC, Nashville, TN; Funda Meric-Bernstam, The University of Texas MD Anderson Cancer Center, Houston, TX; Charles Swanton, Francis Crick Institute, London, United Kingdom; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Genentech, South San Francisco, CA; David R. Spigel, Sarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, TN; Christopher Sweeney, Dana-Farber Cancer Institute; Harvard Medical School, Boston, MA; Howard Burris, Sarah Cannon Research Institute; Tennessee Oncology, PLLC, Nashville, TN; Ron Bose, Washington University School of Medicine, St Louis, MO; Bongin Yoo, Alisha Stein, and Mary Beattie, Genentech, South San Francisco, CA; and Razelle Kurzrock, Moores Cancer Center, University of California, San Diego, San Diego, CA.

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http://dx.doi.org/10.1200/JCO.2018.78.6392DOI Listing
August 2018

The function and dysfunction of memory CD8 T cells in tumor immunity.

Immunol Rev 2018 05;283(1):194-212

Cancer Immunology Unit, University College London Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1111/imr.12657DOI Listing
May 2018

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.

Cancer Cell 2018 05 12;33(5):843-852.e4. Epub 2018 Apr 12.

Department of Medicine, Memorial Sloan Kettering Cancer Center, 885 2(nd) Avenue, New York, NY 10017, USA; Weill Cornell School of Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183012
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http://dx.doi.org/10.1016/j.ccell.2018.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953836PMC
May 2018

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal.

Cell 2018 04 12;173(3):595-610.e11. Epub 2018 Apr 12.

Translational Cancer Therapeutics Laboratory, the Francis Crick Institute, London NW1 1AT, UK; Cancer Research UK Lung Cancer Centre of Excellence London, University College London Cancer Institute, London WC1E 6DD, UK; Department of Medical Oncology, University College London Hospitals, London NW1 2BU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938372PMC
April 2018

Cancer therapeutics through an evolutionary lens.

Authors:
Charles Swanton

J R Soc Med 2018 Jan;111(1):8-14

Francis Crick Institute, UCL Hospitals and UCL Cancer Institute, Midland Road, London NW1 1AT, UK.

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http://dx.doi.org/10.1177/0141076817742096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784489PMC
January 2018

Targeted Therapy for Advanced Solid Tumors on the Basis of Molecular Profiles: Results From MyPathway, an Open-Label, Phase IIa Multiple Basket Study.

J Clin Oncol 2018 02 10;36(6):536-542. Epub 2018 Jan 10.

John D. Hainsworth, David R. Spigel, and Howard Burris, Sarah Cannon Research Institute; Tennessee Oncology, Nashville, TN; Funda Meric-Bernstam, University of Texas MD Anderson Cancer Center, Houston, TX; Charles Swanton, Francis Crick Institute, London, United Kingdom; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Christopher Sweeney, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Ron Bose, Washington University School of Medicine, St Louis, MO; Bongin Yoo, Alisha Stein, and Mary Beattie, Genentech, South San Francisco; and Razelle Kurzrock, Moores Cancer Center, University of California San Diego, San Diego, CA.

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http://dx.doi.org/10.1200/JCO.2017.75.3780DOI Listing
February 2018

Determinants and clinical implications of chromosomal instability in cancer.

Nat Rev Clin Oncol 2018 03 3;15(3):139-150. Epub 2018 Jan 3.

The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, UK.

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http://dx.doi.org/10.1038/nrclinonc.2017.198DOI Listing
March 2018

Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Authors:
Christopher Abbosh Nicolai J Birkbak Gareth A Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari John Le Quesne David A Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kirkizlar Thomas B K Watkins Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin Hiley Siow Ming Lee Martin D Forster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Martin Hayward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M Janes Ricky Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Joseph Anne Marie Quinn Phil A Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter Marianne Nicolson Hardy Remmen Keith Kerr Mahendran Chetty Lesley Gomersall Dean A Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash Jason F Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U Akarca John A Hartley Helen L Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltan Szallasi Roland F Schwarz Javier Herrero Aengus Stewart Sergio A Quezada Karl S Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J W L Aerts Allan Hackshaw Jacqui A Shaw Bernhard G Zimmermann Charles Swanton

Nature 2018 02 20;554(7691):264. Epub 2017 Dec 20.

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http://dx.doi.org/10.1038/nature25161DOI Listing
February 2018

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.

Cell 2017 Nov 26;171(6):1259-1271.e11. Epub 2017 Oct 26.

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720478PMC
November 2017

Cancer Evolution Constrained by the Immune Microenvironment.

Cell 2017 08;170(5):825-827

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.08.012DOI Listing
August 2017

Evolution and cancer medicine - transformative insights.

Nat Rev Clin Oncol 2017 12 22;14(12):709-710. Epub 2017 Aug 22.

Translational Cancer Therapeutics Laboratory, Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

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http://dx.doi.org/10.1038/nrclinonc.2017.121DOI Listing
December 2017

The GENIE Is Out of the Bottle: Landmark Cancer Genomics Dataset Released.

Cancer Discov 2017 08;7(8):796-798

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0604DOI Listing
August 2017

Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection.

BMC Bioinformatics 2017 Jul 25;18(1):354. Epub 2017 Jul 25.

UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1186/s12859-017-1753-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526259PMC
July 2017

Tumor Evolution as a Therapeutic Target.

Cancer Discov 2017 Jul 20. Epub 2017 Jul 20.

Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO), IRCCS, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0343DOI Listing
July 2017

The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome.

BMC Med 2017 07 18;15(1):133. Epub 2017 Jul 18.

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.

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http://dx.doi.org/10.1186/s12916-017-0900-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514532PMC
July 2017

Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.

Lancet Oncol 2017 08 7;18(8):1009-1021. Epub 2017 Jul 7.

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK; Department of Medical Oncology, University College London Hospitals, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045173051
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http://dx.doi.org/10.1016/S1470-2045(17)30516-8DOI Listing
August 2017

Origins of lymphatic and distant metastases in human colorectal cancer.

Science 2017 Jul;357(6346):55-60

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/science.aai8515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536201PMC
July 2017

Evolving adoptive cellular therapies in urological malignancies.

Lancet Oncol 2017 06;18(6):e341-e353

Department of Oncology, University College London Cancer Institute, London, UK; Department of Oncology, University College London Hospitals, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30327-3DOI Listing
June 2017

Implications of cancer evolution for drug development.

Nat Rev Drug Discov 2017 Jul 28;16(7):441-442. Epub 2017 Apr 28.

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, UK.

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http://dx.doi.org/10.1038/nrd.2017.78DOI Listing
July 2017

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Authors:
Christopher Abbosh Nicolai J Birkbak Gareth A Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari John Le Quesne David A Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kirkizlar Thomas B K Watkins Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin Hiley Siow Ming Lee Martin D Forster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Martin Hayward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M Janes Ricky Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Joseph Anne Marie Quinn Phil A Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter Marianne Nicolson Hardy Remmen Keith Kerr Mahendran Chetty Lesley Gomersall Dean A Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash Jason F Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U Akarca John A Hartley Helen L Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltan Szallasi Roland F Schwarz Javier Herrero Aengus Stewart Sergio A Quezada Karl S Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J W L Aerts Allan Hackshaw Jacqui A Shaw Bernhard G Zimmermann Charles Swanton

Nature 2017 04;545(7655):446-451

Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.

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http://dx.doi.org/10.1038/nature22364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812436PMC
April 2017

Tracking the Evolution of Non-Small-Cell Lung Cancer.

N Engl J Med 2017 06 26;376(22):2109-2121. Epub 2017 Apr 26.

From the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., G.A.W., N. McGranahan, N.J.B., S.V., S.S., D.H.J., R.R., S.-M.L., M.D.F., C.A., S.M.J., C.D., C.S.), London and Manchester, Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., J.A.H.), Bill Lyons Informatics Centre (J.H.), and Cancer Immunology Unit (S.A.Q.), UCL Cancer Institute, the Translational Cancer Therapeutics Laboratory (G.A.W., N. McGranahan, N.J.B., T.B.K.W., A.R., T.C., S. Turajlic, H.X., C.T.H., C.S.), Department of Bioinformatics and Biostatistics (R.M., M.S., S.H., M.E., A.S.), Advanced Sequencing Facility (N. Matthews), and Cancer Genomics Laboratory (S.D., P.V.L.), Francis Crick Institute, the Renal and Skin Units, Royal Marsden Hospital (S. Turajlic), the Departments of Medical Oncology (M.J.-H., S.-M.L., M.D.F., T.A., C.A., C.S.), Pathology (M.F., E.B., T.M.), Cardiothoracic Surgery (D.L., M.H., S. Kolvekar, N.P.), Respiratory Medicine (S.M.J., R.T.), and Radiology (A.A.), UCL Hospitals, Lungs for Living, UCL Respiratory, UCL (S.M.J.), the Department of Radiotherapy, North Middlesex University Hospital (G.A.), the Department of Respiratory Medicine, Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., H.B., Y.N., A.H.), London, Cancer Studies, University of Leicester (D.A.M., D.A.F., J.A.S., J.L.Q.), the Department of Thoracic Surgery, Glenfield Hospital (A.N., S.R.), and the Medical Research Center Toxicology Unit (J.L.Q.), Leicester, the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., Y.S.), the Departments of Cardiothoracic Surgery (R.S.) and Pathology (L.J., A.M.Q.) and the North West Lung Centre (P.A.C.), University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Manchester, the Departments of Thoracic Surgery (B.N.) and Cellular Pathology (G.L., S. Trotter), Birmingham Heartlands Hospital, Molecular Pathology Diagnostic Services, Queen Elizabeth Hospital (P.T., B.O.), and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Birmingham, the Departments of Medical Oncology (M.N.), Cardiothoracic Surgery (H.R.), Pathology (K.K.), Respiratory Medicine (M.C.), and Radiology (L.G.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen, the Department of Respiratory Medicine, Barnet and Chase Farm Hospitals, Barnet (S. Khan), the Department of Respiratory Medicine, Princess Alexandra Hospital, Harlow (P.R.), the Department of Clinical Oncology, St. Luke's Cancer Centre, Guildford (V.E.), the Departments of Pathology (B.I.), Respiratory Medicine (M.I.-S.), and Radiology (V.P.), Ashford and St. Peters' Hospitals, Surrey, the Department of Clinical Oncology, Velindre Hospital (J.F.L.), the Departments of Radiology (H.A.) and Respiratory Medicine (H.D.), University Hospital Llandough, the Departments of Pathology (R.A.) and Cardiothoracic Surgery (M.K.), University Hospital of Wales, and Cardiff University (R.A.), Cardiff, and Wellcome Trust Sanger Institute, Hinxton, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom; the Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby (Z.S.); the Computational Health Informatics Program, Boston Children's Hospital and Harvard Medical School, Boston (Z.S.); MTA-SE-NAP, Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary (Z.S.); Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin (R.F.S.); and the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.).

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http://dx.doi.org/10.1056/NEJMoa1616288DOI Listing
June 2017

Evolutionary dynamics in pre-invasive neoplasia.

Curr Opin Syst Biol 2017 Apr;2:1-8

UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O'Gorman Building, Huntley St., London WC1E 6DD, UK.

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http://dx.doi.org/10.1016/j.coisb.2017.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312179PMC
April 2017

Treatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution.

Cold Spring Harb Perspect Med 2017 Aug 1;7(8). Epub 2017 Aug 1.

Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158.

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http://dx.doi.org/10.1101/cshperspect.a026617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538404PMC
August 2017

Renal cell carcinoma.

Nat Rev Dis Primers 2017 Mar 9;3:17009. Epub 2017 Mar 9.

Department of Experimental and Clinical Medical Sciences - Urologic Clinic, University of Udine, Udine, Italy.

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http://dx.doi.org/10.1038/nrdp.2017.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936048PMC
March 2017

Constraints in cancer evolution.

Biochem Soc Trans 2017 02;45(1):1-13

UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O'Gorman Building, Huntley St., London WC1E 6DD, U.K.

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http://dx.doi.org/10.1042/BST20160229DOI Listing
February 2017

Evaluating the significance of density, localization, and PD-1/PD-L1 immunopositivity of mononuclear cells in the clinical course of lung adenocarcinoma patients with brain metastasis.

Neuro Oncol 2017 Aug;19(8):1058-1067

First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary; MTA-SE NAP, Brain Metastasis Research Group, Hungarian Academy of Sciences, Second Department of Pathology, Semmelweis University, Budapest, Hungary; Department of Pulmonology, Semmelweis University, Budapest, Hungary; Department of Physics of Complex Systems, Eötvös Loránd University, Budapest, Hungary; Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary; Department of Neurooncology, National Institute of Clinical Neurosciences, Budapest, Hungary; Department of Radiology, National Institute of Clinical Neurosciences, Budapest, Hungary; Sixth Department of Pulmonology, National Korányi Institute of Pulmonology, Budapest, Hungary; Hungarian Academy of Sciences-Semmelweis University, Molecular Oncology Research Unit, Budapest, Hungary; Department of Tumor Biology, National Korányi Institute of Pulmonology-Semmelweis University, Budapest, Hungary; Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Budapest, Hungary; Division of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Children's Hospital Informatics Program at the Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, London, UK; Francis Crick Institute, London, UK.

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http://dx.doi.org/10.1093/neuonc/now309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570158PMC
August 2017

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.

Cell 2017 02;168(4):613-628

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, UK; Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London NW1 2BU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.018DOI Listing
February 2017

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

Cancer Cell 2017 01;31(1):79-93

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Translational Cancer Therapeutics Laboratory, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC2E 6DD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225404PMC
January 2017

The Role of Aneuploidy in Cancer Evolution.

Cold Spring Harb Perspect Med 2017 Jan 3;7(1). Epub 2017 Jan 3.

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratories, London WC2A 3LY, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a028373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204330PMC
January 2017

Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease.

Lancet 2016 Sep 1;388(10048):1002-11. Epub 2016 Sep 1.

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, UK; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)31340-XDOI Listing
September 2016

The Emergence of Precision Urologic Oncology: A Collaborative Review on Biomarker-driven Therapeutics.

Eur Urol 2017 02 25;71(2):237-246. Epub 2016 Aug 25.

Department of Urology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, New York, NY, USA; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1016/j.eururo.2016.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195855PMC
February 2017