Charles R Allerson

Charles R Allerson

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Charles R Allerson

Charles R Allerson

Publications by authors named "Charles R Allerson"

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Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.

Chem Commun (Camb) 2012 Aug 22;48(66):8195-7. Epub 2012 May 22.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1039/c2cc32286bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404228PMC
August 2012

Structural requirements for hybridization at the 5'-position are different in α-l-LNA as compared to β-D-LNA.

Bioorg Med Chem Lett 2012 Jan 11;22(1):296-9. Epub 2011 Nov 11.

Department of Medicinal Chemistry, Isis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.11.012DOI Listing
January 2012

Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid.

Biochemistry 2012 Jan 29;51(1):7-9. Epub 2011 Dec 29.

Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States.

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http://dx.doi.org/10.1021/bi201810rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257178PMC
January 2012

Synthesis and biophysical characterization of R-6'-Me-α-L-LNA modified oligonucleotides.

Bioorg Med Chem Lett 2011 Feb 31;21(4):1122-5. Epub 2010 Dec 31.

Department of Medicinal Chemistry, Isis Pharmaceuticals, 1891 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.12.119DOI Listing
February 2011

Replacing the 2'-oxygen with an exocyclic methylene group reverses the stabilization effects of α-L-LNA.

Bioorg Med Chem Lett 2011 Jan 14;21(1):588-91. Epub 2010 Oct 14.

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc, 1891 Rutherford Road, Carlsbad, CA 92008, United States.

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http://dx.doi.org/10.1016/j.bmcl.2010.10.025DOI Listing
January 2011

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

Nucleic Acids Symp Ser (Oxf) 2008 (52):553-4

Medicinal Chemistry, Isis Pharmaceuticals, Inc., 1891 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1093/nass/nrn280DOI Listing
November 2010

Solution-state structure of a fully alternately 2'-F/2'-OMe modified 42-nt dimeric siRNA construct.

Nucleic Acids Res 2010 Nov 12;38(20):7298-307. Epub 2010 Jul 12.

Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.

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http://dx.doi.org/10.1093/nar/gkq621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978378PMC
November 2010

An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.

J Am Chem Soc 2010 Oct;132(42):14942-50

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc., 1891 Rutherford Road, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/ja105875eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993159PMC
October 2010

Competition for RISC binding predicts in vitro potency of siRNA.

Nucleic Acids Res 2006 31;34(16):4467-76. Epub 2006 Aug 31.

ISIS Pharmaceuticals, Carlsbad Research Center, 1896 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1093/nar/gkl589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636362PMC
October 2006

Regioselective syntheses of 7-nitro-7-deazapurine nucleosides and nucleotides for efficient PCR incorporation.

Org Lett 2005 Sep;7(18):3865-8

Variagenics Inc., Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1021/ol051144rDOI Listing
September 2005

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

J Med Chem 2005 Feb;48(4):901-4

Department of Medicinal Chemistry, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/jm049167jDOI Listing
February 2005

A high-capacity RNA affinity column for the purification of human IRP1 and IRP2 overexpressed in Pichia pastoris.

RNA 2003 Mar;9(3):364-74

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370403PMC
http://dx.doi.org/10.1261/rna.2143303DOI Listing
March 2003