Charles P Lin

Charles P Lin

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Fluorescence monitoring of rare circulating tumor cell and cluster dissemination in a multiple myeloma xenograft model in vivo.

J Biomed Opt 2019 Aug;24(8):1-11

Northeastern University, Department of Bioengineering, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1117/1.JBO.24.8.085004DOI Listing
August 2019

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress.

Cell Stem Cell 2019 Jun 18;24(6):944-957.e5. Epub 2019 Apr 18.

The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193011
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http://dx.doi.org/10.1016/j.stem.2019.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597014PMC
June 2019

Prx1 Expressing Cells Are Required for Periodontal Regeneration of the Mouse Incisor.

Front Physiol 2019 22;10:591. Epub 2019 May 22.

Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, United States.

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http://dx.doi.org/10.3389/fphys.2019.00591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558369PMC
May 2019

In Vivo Flow Cytometry of Extremely Rare Circulating Cells.

Sci Rep 2019 Mar 4;9(1):3366. Epub 2019 Mar 4.

Northeastern University, Department of Electrical and Computer Engineering, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-019-40143-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399281PMC
March 2019

Intravital Imaging of Mouse Bone Marrow: Hemodynamics and Vascular Permeability.

Methods Mol Biol 2018 ;1763:11-22

Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7762-8_2DOI Listing
February 2019

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.

Nat Commun 2018 06 18;9(1):2377. Epub 2018 Jun 18.

Office of the Dean and the Cancer Center, Long School of Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA.

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http://dx.doi.org/10.1038/s41467-018-04716-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006146PMC
June 2018

Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy.

Biomed Opt Express 2018 May 23;9(5):2304-2311. Epub 2018 Apr 23.

School of Applied Physics and Engineering, Cornell University, Ithaca, NY 14850, USA.

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http://dx.doi.org/10.1364/BOE.9.002304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946790PMC
May 2018

In Vivo 3D Histomorphometry Quantifies Bone Apposition and Skeletal Progenitor Cell Differentiation.

Sci Rep 2018 04 3;8(1):5580. Epub 2018 Apr 3.

Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-018-23785-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882859PMC
April 2018

Fluorescence detection, enumeration and characterization of single circulating cells in vivo: technology, applications and future prospects.

Phys Med Biol 2017 Dec 14;63(1):01TR01. Epub 2017 Dec 14.

Department of Bioengineering, Northeastern University, Boston, MA 02115, United States of America. Institute of Hydrochemistry, Technical University of Munich, Munich, Germany.

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http://stacks.iop.org/0031-9155/63/i=1/a=01TR01?key=crossref
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http://dx.doi.org/10.1088/1361-6560/aa98f9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753400PMC
December 2017

Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy.

PLoS One 2017 24;12(10):e0186846. Epub 2017 Oct 24.

Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186846PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655444PMC
November 2017

Fluorescence detection, enumeration and characterization of single circulating cells in vivo: technology, applications and future prospects.

Phys Med Biol 2017 Nov 8. Epub 2017 Nov 8.

Bioengineering, Northeastern University, 360 Huntington Ave, 217 ISEC, Boston, Massachusetts, 02115, UNITED STATES.

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http://dx.doi.org/10.1088/1361-6560/aa98f9DOI Listing
November 2017

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.

J Clin Invest 2017 Jun 8;127(6):2433-2437. Epub 2017 May 8.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI92030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451245PMC
June 2017

Image-guided transplantation of single cells in the bone marrow of live animals.

Sci Rep 2017 06 20;7(1):3875. Epub 2017 Jun 20.

Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-02896-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478633PMC
June 2017

Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration.

Stem Cell Reports 2017 04 30;8(4):933-946. Epub 2017 Mar 30.

Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390237PMC
April 2017

Diffuse fluorescence fiber probe for in vivo detection of circulating cells.

J Biomed Opt 2017 03;22(3):37004

Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.

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http://biomedicaloptics.spiedigitallibrary.org/article.aspx?
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http://dx.doi.org/10.1117/1.JBO.22.3.037004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348644PMC
March 2017

Intravital multiphoton photoconversion with a cell membrane dye.

J Biophotonics 2017 02 19;10(2):206-210. Epub 2016 Jul 19.

Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/jbio.201600077DOI Listing
February 2017

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.

Science 2016 12 13;354(6316):1156-1160. Epub 2016 Oct 13.

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1126/science.aaf5530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164878PMC
December 2016

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

Cell 2016 11;167(5):1310-1322.e17

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)31466-0.pdf
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http://www.cell.com/cms/attachment/2072756198/2068594890/mmc
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http://dx.doi.org/10.1016/j.cell.2016.10.045DOI Listing
November 2016

Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells.

Stem Cells 2016 10 17;34(10):2501-2511. Epub 2016 Jul 17.

Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Harvard University, Cambridge, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064874PMC
http://dx.doi.org/10.1002/stem.2435DOI Listing
October 2016

Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study.

Theranostics 2015 13;5(12):1317-27. Epub 2015 Sep 13.

1. Cardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School ; 3. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School.

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http://dx.doi.org/10.7150/thno.12494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615735PMC
August 2016

Defining Clonal Color in Fluorescent Multi-Clonal Tracking.

Sci Rep 2016 Apr 13;6:24303. Epub 2016 Apr 13.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/srep24303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829845PMC
April 2016

Molecular Order of Arterial Collagen Using Circular Polarization Second-Harmonic Generation Imaging.

Biophys J 2016 Feb 21;110(3):530-533. Epub 2016 Jan 21.

Wellman Center for Photomedicine and Center for System Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744203PMC
February 2016

Statins improve the resolution of established murine venous thrombosis: reductions in thrombus burden and vein wall scarring.

PLoS One 2015 13;10(2):e0116621. Epub 2015 Feb 13.

Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116621PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334538PMC
January 2016

Analyzing Structure and Function of Vascularization in Engineered Bone Tissue by Video-Rate Intravital Microscopy and 3D Image Processing.

Tissue Eng Part C Methods 2015 Oct 24;21(10):1025-31. Epub 2015 Jul 24.

1 Department of Orthopaedic Surgery, Massachusetts General Hospital , Harvard Medical School, Boston, Massachusetts.

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https://www.liebertpub.com/doi/10.1089/ten.tec.2015.0091
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http://dx.doi.org/10.1089/ten.TEC.2015.0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593976PMC
October 2015

Rapid Functional Decline of Activated and Memory Graft-versus-Host-Reactive T Cells Encountering Host Antigens in the Absence of Inflammation.

J Immunol 2015 Aug 17;195(3):1282-92. Epub 2015 Jun 17.

Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032; Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1401511
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http://dx.doi.org/10.4049/jimmunol.1401511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506852PMC
August 2015

Continuous volumetric imaging via an optical phase-locked ultrasound lens.

Nat Methods 2015 Aug 13;12(8):759-62. Epub 2015 Jul 13.

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.

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http://dx.doi.org/10.1038/nmeth.3476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551496PMC
August 2015

Intravital imaging of hematopoietic stem cells in the mouse skull.

Methods Mol Biol 2014 ;1185:247-65

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-1133-2_17DOI Listing
March 2015

Intravital imaging of mesenchymal stem cell trafficking and association with platelets and neutrophils.

Stem Cells 2015 Jan;33(1):265-77

Harvard-MIT Health Sciences and Technology, Cambridge, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Center for Vascular Biology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Brigham and Women's Hospital, Department of Biomedical Engineering, Harvard Stem Cell Institute, Cambridge, Massachusetts, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/stem.1848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270897PMC
January 2015

Femtosecond laser bone ablation with a high repetition rate fiber laser source.

Biomed Opt Express 2015 Jan 5;6(1):32-42. Epub 2014 Dec 5.

Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA ; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA ; Co-corresponding authors.

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http://dx.doi.org/10.1364/BOE.6.000032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317121PMC
January 2015

An authentic imaging probe to track cell fate from beginning to end.

Nat Commun 2014 Oct 17;5:5216. Epub 2014 Oct 17.

Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medical College, 413 East 69th Street, Box 290, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ncomms6216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852472PMC
October 2014

Characterization of multiphoton microscopy in the bone marrow following intravital laser osteotomy.

Biomed Opt Express 2014 Oct 12;5(10):3578-88. Epub 2014 Sep 12.

Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1364/BOE.5.003578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206326PMC
October 2014

Quantification of Mesenchymal Stem Cell (MSC) delivery to a target site using in vivo confocal microscopy.

PLoS One 2013 29;8(10):e78145. Epub 2013 Oct 29.

Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078145PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812161PMC
September 2014

Chronic variable stress activates hematopoietic stem cells.

Nat Med 2014 Jul 22;20(7):754-758. Epub 2014 Jun 22.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge St., Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/nm.3589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087061PMC
July 2014

ABCB5 is a limbal stem cell gene required for corneal development and repair.

Nature 2014 Jul 2;511(7509):353-7. Epub 2014 Jul 2.

1] Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts 02130, USA [2] Transplant Research Program, Division of Nephrology, Boston Children's Hospital, Boston, Massachusetts 02115, USA [3] Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02138, USA [4] Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [5].

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http://dx.doi.org/10.1038/nature13426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246512PMC
July 2014

In vivo imaging of microglia turnover in the mouse retina after ionizing radiation and dexamethasone treatment.

Invest Ophthalmol Vis Sci 2014 Jul 31;55(8):5314-9. Epub 2014 Jul 31.

Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1167/iovs.14-14254DOI Listing
July 2014

Two-photon antenna-core oxygen probe with enhanced performance.

Anal Chem 2014 Jun 3;86(12):5937-45. Epub 2014 Jun 3.

Department of Biochemistry and Biophysics, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.

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http://pubs.acs.org/doi/10.1021/ac501028m
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http://dx.doi.org/10.1021/ac501028mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066907PMC
June 2014

Arterial extracellular matrix: a mechanobiological study of the contributions and interactions of elastin and collagen.

Biophys J 2014 Jun;106(12):2684-92

Department of Mechanical Engineering, Boston University, Boston, Massachusetts; Department of Biomedical Engineering, Boston University, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495140051
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http://dx.doi.org/10.1016/j.bpj.2014.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070071PMC
June 2014

Sequential in vivo imaging of osteogenic stem/progenitor cells during fracture repair.

J Vis Exp 2014 May 23(87). Epub 2014 May 23.

Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute;

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http://dx.doi.org/10.3791/51289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206246PMC
May 2014

Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label.

PLoS One 2013 26;8(8):e69257. Epub 2013 Aug 26.

Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069257PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753322PMC
April 2014

Direct measurement of local oxygen concentration in the bone marrow of live animals.

Nature 2014 Apr 2;508(7495):269-73. Epub 2014 Mar 2.

1] Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA [2] Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA [3] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature13034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984353PMC
April 2014

A new image of the hematopoietic stem cell vascular niche.

Cell Stem Cell 2013 Nov;13(5):514-6

Division of Transfusion Medicine, Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.stem.2013.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148778PMC
November 2013

mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation.

Blood 2013 Oct 26;122(14):e23-32. Epub 2013 Aug 26.

Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA;

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http://dx.doi.org/10.1182/blood-2013-04-495119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790516PMC
October 2013

Improved diffuse fluorescence flow cytometer prototype for high sensitivity detection of rare circulating cells in vivo.

J Biomed Opt 2013 Jul;18(7):077002

Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1117/1.JBO.18.7.077002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702234PMC
July 2013

High-resolution optical mapping of inflammatory macrophages following endovascular arterial injury.

Mol Imaging Biol 2013 Jun;15(3):282-9

Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Room 3206, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s11307-012-0599-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650124PMC
June 2013

Inflammation modulates murine venous thrombosis resolution in vivo: assessment by multimodal fluorescence molecular imaging.

Arterioscler Thromb Vasc Biol 2012 Nov 20;32(11):2616-24. Epub 2012 Sep 20.

Harvard Medical School, Massachusetts General Hospital, Cardiovascular Research Center, 185 Cambridge St, Suite 3206, Boston, MA 02114, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.251983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516622PMC
November 2012

Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy.

Biomed Opt Express 2012 Sep 31;3(9):1972-7. Epub 2012 Jul 31.

School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA ; Each author contributed equally to this work.

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http://dx.doi.org/10.1364/BOE.3.001972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447541PMC
September 2012

Tracking mesenchymal stem cells with iron oxide nanoparticle loaded poly(lactide-co-glycolide) microparticles.

Nano Lett 2012 Aug 12;12(8):4131-9. Epub 2012 Jul 12.

Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Harvard-MIT, Division of Health Sciences and Technology, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA.

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http://pubs.acs.org/doi/10.1021/nl301658q
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http://dx.doi.org/10.1021/nl301658qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552518PMC
August 2012

Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy.

Nanomedicine (Lond) 2012 Jul 21;7(7):1017-28. Epub 2012 Feb 21.

Center for Systems Biology, Harvard Medical School & Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.2217/nnm.11.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360120PMC
July 2012

Tomographic sensing and localization of fluorescently labeled circulating cells in mice in vivo.

Phys Med Biol 2012 Jul 2;57(14):4627-41. Epub 2012 Jul 2.

Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1088/0031-9155/57/14/4627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555500PMC
July 2012

Validation of a device for fluorescence sensing of rare circulating cells with diffusive light in an optical flow phantom model.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:486-9

Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1109/IEMBS.2011.6090071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555486PMC
June 2012

Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.

JACC Cardiovasc Imaging 2012 Jun;5(6):607-15

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.jcmg.2012.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376390PMC
June 2012

Instrument for fluorescence sensing of circulating cells with diffuse light in mice in vivo.

J Biomed Opt 2012 Mar;17(3):037001

Northeastern University, Department of Electrical and Computer Engineering, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1117/1.JBO.17.3.037001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380949PMC
March 2012

An optical platform for cell tracking in adult zebrafish.

Cytometry A 2012 Feb 7;81(2):176-82. Epub 2011 Dec 7.

Advanced microscopy program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://doi.wiley.com/10.1002/cyto.a.21167
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http://dx.doi.org/10.1002/cyto.a.21167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383206PMC
February 2012

Engineered cell homing.

Blood 2011 Dec 27;118(25):e184-91. Epub 2011 Oct 27.

Center for Regenerative Therapeutics and Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, 65 Landsdowne St., Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1182/blood-2010-10-311464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242725PMC
December 2011

Cell labeling approaches for fluorescence-based in vivo flow cytometry.

Cytometry A 2011 Oct 8;79(10):758-65. Epub 2011 Sep 8.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cyto.a.21125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686107PMC
October 2011

FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.

J Immunol 2011 Sep 25;187(5):2244-51. Epub 2011 Jul 25.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.4049/jimmunol.1100670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167479PMC
September 2011

Cell-surface sensors for real-time probing of cellular environments.

Nat Nanotechnol 2011 Jul 17;6(8):524-31. Epub 2011 Jul 17.

Center for Regenerative Therapeutics & Department of Medicine, Brigham & Women's Hospital, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nnano.2011.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163485PMC
July 2011

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.

Nature 2011 Jun 8;474(7350):216-9. Epub 2011 Jun 8.

Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature10160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725645PMC
June 2011

Optical techniques for tracking multiple myeloma engraftment, growth, and response to therapy.

J Biomed Opt 2011 Jan-Feb;16(1):011006

Massachusetts General Hospital, Wellman Center for Photomedicine, Advanced Microscopy Program, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1117/1.3520571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033873PMC
May 2011

Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice.

J Biomed Opt 2011 Feb;16(2):021109

Brigham and Women's Hospital, Center for Neurologic Diseases, Partner Multiple Sclerosis Center, Harvard Medical School, Department of Neurology, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1117/1.3533312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061329PMC
February 2011

In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow.

Nat Protoc 2011 Jan 9;6(1):1-14. Epub 2010 Dec 9.

Center for Regenerative Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2010.168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382040PMC
January 2011

In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response.

Nat Med 2010 Jun 23;16(6):718-22. Epub 2010 May 23.

Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.2155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894571PMC
June 2010

In vivo observations of cell trafficking in allotransplanted vascularized skin flaps and conventional skin grafts.

J Plast Reconstr Aesthet Surg 2010 Apr 26;63(4):711-9. Epub 2009 Mar 26.

Plastic Surgery Research Laboratory, Department of Surgery, WAC 435, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.bjps.2009.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835845PMC
April 2010

Persistence of donor-derived protein in host myeloid cells after induced rejection of engrafted allogeneic bone marrow cells.

Exp Hematol 2010 Apr 16;38(4):333-9. Epub 2010 Feb 16.

Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/j.exphem.2010.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965294PMC
April 2010

Engineered vascularized bone grafts.

Proc Natl Acad Sci U S A 2010 Feb 2;107(8):3311-6. Epub 2010 Feb 2.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.0905445107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840421PMC
February 2010

Imaging leukocyte trafficking in vivo with two-photon-excited endogenous tryptophan fluorescence.

Opt Express 2010 Jan;18(2):988-99

Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369551PMC
http://dx.doi.org/10.1364/OE.18.000988DOI Listing
January 2010

In vivo imaging of hematopoietic stem cells and their microenvironment.

J Biophotonics 2009 Nov;2(11):619-31

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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http://doi.wiley.com/10.1002/jbio.200910072
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http://dx.doi.org/10.1002/jbio.200910072DOI Listing
November 2009

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.

Nature 2009 May 25;459(7243):103-7. Epub 2009 Mar 25.

Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature07859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761017PMC
May 2009

Real-time in vivo assessment of the nerve microenvironment with coherent anti-Stokes Raman scattering microscopy.

Plast Reconstr Surg 2009 Feb;123(2 Suppl):123S-30S

Plastic Surgery Research Laboratory, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1097/PRS.0b013e318191c5b8DOI Listing
February 2009

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.

Nature 2009 Jan 3;457(7225):92-6. Epub 2008 Dec 3.

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA.

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http://www.nature.com/articles/nature07434
Publisher Site
http://dx.doi.org/10.1038/nature07434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820276PMC
January 2009

In vivo confocal and multiphoton microendoscopy.

J Biomed Opt 2008 Jan-Feb;13(1):010501

Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 50 Blossom St., BAR 818, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1117/1.2839043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752311PMC
June 2008