Publications by authors named "Charles N Serhan"

100Publications

D-series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution.

FASEB J 2020 Dec 12;34(12):15888-15906. Epub 2020 Oct 12.

Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH, USA.

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http://dx.doi.org/10.1096/fj.201903025RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686130PMC
December 2020

Acute injection of a DHA triglyceride emulsion after hypoxic-ischemic brain injury in mice increases both DHA and EPA levels in blood and brain.

Prostaglandins Leukot Essent Fatty Acids 2020 Nov 25;162:102176. Epub 2020 Sep 25.

Institute of Human Nutrition, Columbia University Irving Medical Center, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.plefa.2020.102176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685398PMC
November 2020

NPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury.

Exp Neurol 2020 Oct 8;335:113495. Epub 2020 Oct 8.

Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, 10032, NY, United States of America; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, 10032, NY, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2020.113495DOI Listing
October 2020

Dexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19.

Allergy 2020 Sep 21. Epub 2020 Sep 21.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1111/all.14595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537007PMC
September 2020

The Atlas of Inflammation Resolution (AIR).

Mol Aspects Med 2020 08 3;74:100894. Epub 2020 Sep 3.

Department of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany; Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2020.100894DOI Listing
August 2020

Carcinogenesis: Failure of resolution of inflammation?

Pharmacol Ther 2020 Sep 3:107670. Epub 2020 Sep 3.

Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2020.107670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470770PMC
September 2020

Specialized pro-resolving mediator network: an update on production and actions.

Essays Biochem 2020 09;64(3):443-462

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, U.S.A.

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http://dx.doi.org/10.1042/EBC20200018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682745PMC
September 2020

WITHDRAWN: The Atlas of Inflammation Resolution (AIR).

Mol Aspects Med 2020 Aug 29:100893. Epub 2020 Aug 29.

Department of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany; Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2020.100893DOI Listing
August 2020

Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells.

Am J Pathol 2020 09 16;190(9):1823-1832. Epub 2020 Jun 16.

Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450248PMC
September 2020

Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.

FASEB J 2020 Aug 16;34(8):10560-10573. Epub 2020 Jun 16.

Division of Cardiovascular Sciences, Department of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1096/fj.202000495RRDOI Listing
August 2020

Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca ] and secretion in conjunctival goblet cells.

J Cell Physiol 2020 Jun 8. Epub 2020 Jun 8.

Schepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jcp.29846DOI Listing
June 2020

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

Cancer Metastasis Rev 2020 06;39(2):337-340

Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California, Davis, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1007/s10555-020-09889-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207990PMC
June 2020

RvE1 uses the LTB receptor BLT1 to increase [Ca] and stimulate mucin secretion in cultured rat and human conjunctival goblet cells.

Ocul Surf 2020 07 30;18(3):470-482. Epub 2020 Apr 30.

Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jtos.2020.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301495PMC
July 2020

Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice.

J Am Heart Assoc 2020 Apr 16;9(8):e015672. Epub 2020 Apr 16.

Division of Cardiovascular Sciences Department of Medicine University of South Florida Tampa FL.

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http://dx.doi.org/10.1161/JAHA.119.015672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428548PMC
April 2020

Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure.

Mol Metab 2020 01 16;31:138-149. Epub 2019 Nov 16.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Alabama, 35294, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920298PMC
January 2020

Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5.

Sci Adv 2019 11 13;5(11):eaax0629. Epub 2019 Nov 13.

Clinical Medicine Research Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

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http://dx.doi.org/10.1126/sciadv.aax0629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853772PMC
November 2019

Resolution metabolomes activated by hypoxic environment.

Sci Adv 2019 10 23;5(10):eaax4895. Epub 2019 Oct 23.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/sciadv.aax4895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810174PMC
October 2019

Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes.

J Allergy Clin Immunol 2020 01 14;145(1):335-344. Epub 2019 Oct 14.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308163PMC
January 2020

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents.

FASEB J 2019 12 5;33(12):13794-13807. Epub 2019 Oct 5.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.201902003RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894058PMC
December 2019

A tribute to Gerald Weissmann (1930-2019).

J Clin Invest 2019 11;129(11):4553-4555

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI133490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819099PMC
November 2019

Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface.

Adv Exp Med Biol 2019 ;1161:13-25

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-3-030-21735-8_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859005PMC
October 2019

Endogenous Specialized Proresolving Mediator Profiles in a Novel Experimental Model of Lymphatic Obstruction and Intestinal Inflammation in African Green Monkeys.

Am J Pathol 2019 10;189(10):1953-1972

Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana; Department of Life Sciences, Brunel University London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880773PMC
October 2019

Adipocytes promote ovarian cancer chemoresistance.

Sci Rep 2019 09 16;9(1):13316. Epub 2019 Sep 16.

Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-019-49649-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746782PMC
September 2019

Resolvin D4 attenuates the severity of pathological thrombosis in mice.

Blood 2019 10;134(17):1458-1468

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and.

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http://dx.doi.org/10.1182/blood.2018886317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839959PMC
October 2019

Resolvin D2 elevates cAMP to increase intracellular [Ca] and stimulate secretion from conjunctival goblet cells.

FASEB J 2019 07 23;33(7):8468-8478. Epub 2019 Apr 23.

Schepens Eye Research Institute, Massachusetts Eye and Ear-Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.201802467RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593886PMC
July 2019

Aspirin-triggered proresolving mediators stimulate resolution in cancer.

Proc Natl Acad Sci U S A 2019 03 12;116(13):6292-6297. Epub 2019 Mar 12.

Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1804000116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442621PMC
March 2019

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.

FASEB J 2019 05 8;33(5):6140-6153. Epub 2019 Feb 8.

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena, Germany.

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http://dx.doi.org/10.1096/fj.201802509RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988863PMC
May 2019

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes.

Front Pharmacol 2018 17;9:1582. Epub 2019 Jan 17.

Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, United States.

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http://dx.doi.org/10.3389/fphar.2018.01582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344435PMC
January 2019

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.

Neuron 2018 12;100(6):1292-1311

Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312407PMC
December 2018

Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions.

Cell Chem Biol 2019 02 13;26(2):244-254.e4. Epub 2018 Dec 13.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road BTM 3-016, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405215PMC
February 2019

Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids.

J Immunol 2018 12 24;201(11):3161-3165. Epub 2018 Oct 24.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1800806
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http://dx.doi.org/10.4049/jimmunol.1800806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246799PMC
December 2018

Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model.

Mucosal Immunol 2019 01 2;12(1):145-153. Epub 2018 Oct 2.

Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41385-018-0089-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301119PMC
January 2019

Correction for Diaz et al., "Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection".

Infect Immun 2018 10 21;86(10). Epub 2018 Sep 21.

Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1128/IAI.00363-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204740PMC
October 2018

Targeting lipid mediators in cancer biology.

Cancer Metastasis Rev 2018 09;37(2-3):557-572

Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10555-018-9754-9DOI Listing
September 2018

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.

Front Pharmacol 2018 1;9:412. Epub 2018 May 1.

Department of Anesthesiology, Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, United States.

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http://dx.doi.org/10.3389/fphar.2018.00412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938385PMC
May 2018

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators.

J Clin Invest 2018 07 14;128(7):2657-2669. Epub 2018 May 14.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI97943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025982PMC
July 2018

Identification of proresolving and inflammatory lipid mediators in human psoriasis.

J Clin Lipidol 2018 Jul - Aug;12(4):1047-1060. Epub 2018 Apr 6.

Section of Inflammation and Cardiometabolic Diseases, Cardio-Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19332874183019
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http://dx.doi.org/10.1016/j.jacl.2018.03.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112609PMC
October 2019

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca in cultured rat conjunctival goblet cells.

Exp Eye Res 2018 08 25;173:64-72. Epub 2018 Apr 25.

Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Department of Plastic and Reconstructive Surgery, University of Oslo, Oslo, Norway. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183000
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http://dx.doi.org/10.1016/j.exer.2018.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488018PMC
August 2018

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology.

Br J Pharmacol 2019 04 3;176(8):1024-1037. Epub 2018 Jun 3.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anaesthesia, Perioperative and Pain Medicine, Building for Transformative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bph.14336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451074PMC
April 2019

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration.

Am J Pathol 2018 04;188(4):950-966

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Building for Transformative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866152PMC
April 2018

Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.

JCI Insight 2018 03 22;3(6). Epub 2018 Mar 22.

Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.94463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926908PMC
March 2018

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair.

J Invest Dermatol 2018 09 17;138(9):2051-2060. Epub 2018 Mar 17.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.03.1498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109422PMC
September 2018

Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.

Biochem Biophys Res Commun 2018 10 15;504(3):553-561. Epub 2018 Mar 15.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road, BTM 3016, Boston, MA, 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139088PMC
October 2018

Splenic leukocytes define the resolution of inflammation in heart failure.

Sci Signal 2018 03 6;11(520). Epub 2018 Mar 6.

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1126/scisignal.aao1818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145858PMC
March 2018

Author Correction: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.

Sci Rep 2018 Mar 2;8(1):4143. Epub 2018 Mar 2.

Center for Clinical and Translational Research, The Forsyth Institute, 245 First Street, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1038/s41598-018-22520-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834529PMC
March 2018

New maresin conjugates in tissue regeneration pathway counters leukotriene D-stimulated vascular responses.

FASEB J 2018 07 28;32(7):4043-4052. Epub 2018 Feb 28.

Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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https://www.fasebj.org/doi/10.1096/fj.201701493R
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http://dx.doi.org/10.1096/fj.201701493RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998978PMC
July 2018

Immune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure.

FASEB J 2018 07 13;32(7):3717-3729. Epub 2018 Feb 13.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.201701173RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998972PMC
July 2018

Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation.

J Leukoc Biol 2018 Jan 29. Epub 2018 Jan 29.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Building for Transformative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://doi.wiley.com/10.1002/JLB.3MI0617-254R
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http://dx.doi.org/10.1002/JLB.3MI0617-254RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136982PMC
January 2018

Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis.

Methods Mol Biol 2018 ;1730:59-72

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7592-1_4DOI Listing
December 2018

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity.

Nat Commun 2018 01 4;9(1):59. Epub 2018 Jan 4.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road, BTM 3016, Boston, MA, 02115, USA.

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http://www.nature.com/articles/s41467-017-02538-5
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http://dx.doi.org/10.1038/s41467-017-02538-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754355PMC
January 2018

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function.

Front Immunol 2017 1;8:1400. Epub 2017 Nov 1.

Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2017.01400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671941PMC
November 2017

Immunoresolvents signaling molecules at intersection between the brain and immune system.

Curr Opin Immunol 2018 02 16;50:48-54. Epub 2017 Nov 16.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Building for Transformative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.coi.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869050PMC
February 2018

Atherosclerosis, Periodontal Disease, and Treatment with Resolvins.

Curr Atheroscler Rep 2017 Nov 6;19(12):57. Epub 2017 Nov 6.

Department of Applied Oral Sciences, The Forsyth Institute, 245 First Street, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1007/s11883-017-0696-4DOI Listing
November 2017

ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.

Sci Rep 2017 10 9;7(1):12848. Epub 2017 Oct 9.

Center for Clinical and Translational Research, The Forsyth Institute, 245 First Street, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1038/s41598-017-13185-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634420PMC
October 2017

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

J Lipid Res 2017 12 6;58(12):2275-2288. Epub 2017 Oct 6.

Lipidomics Core Facility and Department of Pathology, Wayne State University, Detroit, MI.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M079012
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http://dx.doi.org/10.1194/jlr.M079012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711491PMC
December 2017

Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways.

Invest Ophthalmol Vis Sci 2017 09;58(11):4530-4544

Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1167/iovs.17-21914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595227PMC
September 2017

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration.

Mol Aspects Med 2018 12 1;64:1-17. Epub 2017 Sep 1.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.mam.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832503PMC
December 2018

A cluster of immunoresolvents links coagulation to innate host defense in human blood.

Sci Signal 2017 Aug 1;10(490). Epub 2017 Aug 1.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aan1471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683850PMC
August 2017

Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection.

Infect Immun 2017 10 20;85(10). Epub 2017 Sep 20.

Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA

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http://dx.doi.org/10.1128/IAI.00464-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607424PMC
October 2017

The novel lipid mediator PD1: An overview of the structural elucidation, synthesis, biosynthesis and bioactions.

Prostaglandins Other Lipid Mediat 2017 Nov 7;133:103-110. Epub 2017 Jun 7.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, United States.

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http://dx.doi.org/10.1016/j.prostaglandins.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720935PMC
November 2017

Protectin D1 and resolvin D5 are effectors of intestinal protection.

Proc Natl Acad Sci U S A 2017 04 29;114(15):3963-3968. Epub 2017 Mar 29.

The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1617290114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393238PMC
April 2017

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors.

Mol Aspects Med 2017 Dec 31;58:114-129. Epub 2017 Mar 31.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623601PMC
December 2017

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology.

Authors:
Charles N Serhan

Mol Aspects Med 2017 Dec 3;58:1-11. Epub 2017 Mar 3.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582020PMC
December 2017

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics.

Prostaglandins Leukot Essent Fatty Acids 2017 02 19;117:17-27. Epub 2017 Jan 19.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. Electronic address:

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http://dx.doi.org/10.1016/j.plefa.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329889PMC
February 2017

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms.

Authors:
Charles N Serhan

FASEB J 2017 04 13;31(4):1273-1288. Epub 2017 Jan 13.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

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http://dx.doi.org/10.1096/fj.201601222RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349794PMC
April 2017

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution.

Immunity 2017 01 5;46(1):92-105. Epub 2017 Jan 5.

Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283610PMC
January 2017

Fish Oil Supplementation in Pregnancy.

N Engl J Med 2016 12;375(26):2599-2601

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http://dx.doi.org/10.1056/NEJMclde1614333DOI Listing
December 2016

Novel Resolvin D2 Receptor Axis in Infectious Inflammation.

J Immunol 2017 01 19;198(2):842-851. Epub 2016 Dec 19.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.1601650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225078PMC
January 2017

Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes.

J Immunol 2017 01 19;198(2):718-728. Epub 2016 Dec 19.

Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA 02142;

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http://dx.doi.org/10.4049/jimmunol.1601543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224973PMC
January 2017

Lipoxin A Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells.

Sci Rep 2016 11 8;6:36124. Epub 2016 Nov 8.

Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/srep36124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099697PMC
November 2016

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation.

J Immunol 2016 12 31;197(11):4444-4452. Epub 2016 Oct 31.

Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.4049/jimmunol.1600837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127279PMC
December 2016

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.

Proc Natl Acad Sci U S A 2016 10 6;113(43):12232-12237. Epub 2016 Oct 6.

Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1607003113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087052PMC
October 2016

Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins.

J Nat Prod 2016 10 5;79(10):2693-2702. Epub 2016 Oct 5.

School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo , P.O. Box 1068 Blindern, N-0316 Oslo, Norway.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149404PMC
October 2016

Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue.

J Immunol 2016 10 19;197(8):3360-3370. Epub 2016 Sep 19.

Department of Biochemistry and Molecular Genetics, Hospital Clínic, August Pi i Sunyer Biomedical Research Institute, Barcelona 08036, Spain;

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http://dx.doi.org/10.4049/jimmunol.1502522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101161PMC
October 2016

Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.

Crit Care Med 2017 Jan;45(1):58-68

1Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 3Center for Clinical Investigation, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/CCM.0000000000002014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549882PMC
January 2017

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.

Sci Transl Med 2016 08;8(353):353ra111

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf7483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149396PMC
August 2016

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation.

J Immunol 2016 09 17;197(6):2362-8. Epub 2016 Aug 17.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and

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http://dx.doi.org/10.4049/jimmunol.1502268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011006PMC
September 2016

Selective identification of specialized pro-resolving lipid mediators from their biosynthetic double di-oxygenation isomers.

RSC Adv 2016;6(34):28820-28829. Epub 2016 Mar 4.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115.

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http://dx.doi.org/10.1039/C6RA00414HDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981487PMC
March 2016

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.

Crit Care Med 2016 Dec;44(12):e1236-e1245

1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.2Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.3Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.4Department of Medicine, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, NY.

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http://dx.doi.org/10.1097/CCM.0000000000001999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113254PMC
December 2016

Addition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice.

J Nutr Biochem 2016 09 19;35:58-65. Epub 2016 Jun 19.

Lipoprotein Metabolism Section, Cardio-Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2016.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201429PMC
September 2016

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.

Am J Pathol 2016 07 10;186(7):1801-1813. Epub 2016 May 10.

Pulmonary and Critical Care Medicine Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929400PMC
July 2016