Charles M Perou

Charles M Perou

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Charles M Perou

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Improved indel detection in DNA and RNA via realignment with ABRA2.

Bioinformatics 2019 Sep;35(17):2966-2973

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735753PMC
September 2019

The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.

Dis Model Mech 2019 Jul 5;12(7). Epub 2019 Jul 5.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

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http://dx.doi.org/10.1242/dmm.037192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679375PMC
July 2019

I-Boost: an integrative boosting approach for predicting survival time with multiple genomics platforms.

Genome Biol 2019 03 7;20(1):52. Epub 2019 Mar 7.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, NC, USA.

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http://dx.doi.org/10.1186/s13059-019-1640-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404283PMC
March 2019

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.

Breast Cancer Res Treat 2019 Feb 27;174(1):143-155. Epub 2018 Nov 27.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, CB#7264, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10549-018-5061-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418066PMC
February 2019

Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas.

Cancer Causes Control 2019 Jan 8;30(1):31-39. Epub 2019 Jan 8.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Dr, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10552-018-1121-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396692PMC
January 2019

Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.

Cell Rep 2018 10;25(3):702-714.e6

Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276789PMC
October 2018

Intrinsic molecular subtypes of breast cancers categorized as HER2-positive using an alternative chromosome 17 probe assay.

Breast Cancer Res 2018 07 11;20(1):75. Epub 2018 Jul 11.

Department of Hematology-Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Shapiro 9, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s13058-018-1005-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042281PMC
July 2018

Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening-Reply.

JAMA Oncol 2018 06;4(6):883-884

Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaoncol.2017.5909DOI Listing
June 2018

Clinical implications of the non-luminal intrinsic subtypes in hormone receptor-positive breast cancer.

Cancer Treat Rev 2018 Jun 7;67:63-70. Epub 2018 May 7.

Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Department of Medical Oncology, Hospital Clínic de Barcelona, Spain; SOLTI Breast Cancer Cooperative Group, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2018.04.015DOI Listing
June 2018

TP53 protein levels, RNA-based pathway assessment, and race among invasive breast cancer cases.

NPJ Breast Cancer 2018 25;4:13. Epub 2018 Jun 25.

1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA.

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http://www.nature.com/articles/s41523-018-0067-5
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http://dx.doi.org/10.1038/s41523-018-0067-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018637PMC
June 2018

GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network.

Nat Commun 2018 03 13;9(1):1059. Epub 2018 Mar 13.

Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA.

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http://www.nature.com/articles/s41467-018-03478-4
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http://dx.doi.org/10.1038/s41467-018-03478-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849768PMC
March 2018

Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.

J Natl Cancer Inst 2018 02;110(2)

Department of Epidemiology, Lineberger Comprehensive Cancer Center; Department of Pathology and Lab Medicine, Department of Nutrition (EHA), and Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC; Dana Farber Cancer Institute, Harvard University, Boston, MA; Center for Clinical Cancer Genetics, Global Health Department of Medicine, The University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1093/jnci/djx135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059138PMC
February 2018

Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study.

Cancer Causes Control 2018 01 9;29(1):25-32. Epub 2017 Nov 9.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10552-017-0977-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903274PMC
January 2018

Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts.

Clin Cancer Res 2017 Dec 29;23(24):7512-7520. Epub 2017 Sep 29.

Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822691PMC
December 2017

Race-associated biological differences among luminal A and basal-like breast cancers in the Carolina Breast Cancer Study.

Breast Cancer Res 2017 Dec 11;19(1):131. Epub 2017 Dec 11.

Department of Epidemiology, University of North Carolina at Chapel Hill, Campus Box 7435, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1186/s13058-017-0914-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725885PMC
December 2017

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness.

J Natl Cancer Inst 2017 07;109(7)

Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

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http://dx.doi.org/10.1093/jnci/djw317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059180PMC
July 2017

Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer.

Breast Cancer Res Treat 2017 04 7;162(3):439-450. Epub 2017 Feb 7.

Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, CINJ 4558, New Brunswick, NJ, 08903, USA.

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http://dx.doi.org/10.1007/s10549-017-4139-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334195PMC
April 2017

SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling.

Genome Biol 2017 04 8;18(1):66. Epub 2017 Apr 8.

Section of Genetic Medicine, Department of Medicine, The University of Chicago, 900 East 57th Street, KCBD 3220A, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1186/s13059-017-1193-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385048PMC
April 2017

Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types.

J Natl Cancer Inst 2016 11 22;108(11). Epub 2016 Jun 22.

Affiliations of authors: Lineberger Comprehensive Cancer Center (MDI, JSP, KAH, JSS, CMP, BGV), Curriculum in Genetics and Molecular Biology (MDI, JSP), Department of Medicine (JSS, BGV), Department of Genetics (KAH, CMP), Department of Microbiology and Immunology (JSS), and Department of Pathology & Laboratory Medicine (CMP), University of North Carolina, Chapel Hill, Chapel Hill, NC.

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http://jnci.oxfordjournals.org/content/108/11/djw144.full.pd
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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djw144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241901PMC
November 2016

MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays.

Radiology 2016 Nov 5;281(2):382-391. Epub 2016 May 5.

From the Depts of Radiology (H.L., K.D., M.L.G.) and Public Health Sciences (Y.J.), The Univ of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; Program of Computational Genomics & Medicine, NorthShore Univ HealthSystem, Evanston, Ill (Y.Z., Y.J.); Dept of Radiology, Univ of Wisconsin-Madison, Madison, Wis (E.S.B.); Lineberger Comprehensive Cancer Ctr, Univ of North Carolina, Chapel Hill, NC (K.A.H., C.F., C.M.P.); Dept of Medicine, Section of Hematology & Oncology, The Univ of Chicago, Chicago, Ill (S.D.C.); Dept of Diagnostic Radiology, The Univ of Texas MD Anderson Cancer Ctr, Houston, Tex (G.J.W.); Dept of Radiology, Memorial Sloan-Kettering Cancer Ctr, New York, NY (E.J.S., E.A.M.); Dept of Radiology, Univ of Miami Sylvester Comprehensive Cancer Ctr, Miami, Fla (J.M.N.); Dept of Radiology, Univ of Pittsburgh Medical Ctr, Pittsburgh, Pa (M.G.); and Div of Cancer Treatment and Diagnosis, National Cancer Inst, Biometric Research Branch, Bethesda, Md (E.H.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069147PMC
http://dx.doi.org/10.1148/radiol.2016152110DOI Listing
November 2016

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity.

Biomaterials 2016 09 4;101:296-309. Epub 2016 Jun 4.

Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, USA; Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119992, Russia. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S014296121630256
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http://dx.doi.org/10.1016/j.biomaterials.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035646PMC
September 2016

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.

Dis Model Mech 2016 07 5;9(7):749-57. Epub 2016 May 5.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA

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http://dx.doi.org/10.1242/dmm.025239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958311PMC
July 2016

Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.

Cancer Res 2016 07 23;76(13):3826-37. Epub 2016 May 23.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930678PMC
July 2016

Validation of the Lung Subtyping Panel in Multiple Fresh-Frozen and Formalin-Fixed, Paraffin-Embedded Lung Tumor Gene Expression Data Sets.

Arch Pathol Lab Med 2016 Jun 2;140(6):536-42. Epub 2015 Oct 2.

From the Clinical Development Department, GeneCentric Diagnostics, Durham, North Carolina (Drs Faruki, Mayhew, and Lai-Goldman); the Lineberger Comprehensive Cancer Center (Mr Fan and Drs Hayes and Perou) and the Department of Genetics (Drs Wilkerson and Perou), University of North Carolina, Chapel Hill; and the Center for Molecular Biology and Pathology, Laboratory Corporation of America Holdings, Research Triangle Park, North Carolina (Mr Parker and Drs Kam-Morgan, Eisenberg, and Horten).

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http://dx.doi.org/10.5858/arpa.2015-0113-OADOI Listing
June 2016

Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium.

Cancer Epidemiol Biomarkers Prev 2016 Mar 28;25(3):470-8. Epub 2015 Dec 28.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-0874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779705PMC
March 2016

Identification of mRNA isoform switching in breast cancer.

BMC Genomics 2016 Mar 3;17:181. Epub 2016 Mar 3.

Department of Genetics, University of North Carolina, 27599, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1186/s12864-016-2521-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778320PMC
March 2016

Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes.

Curr Protoc Pharmacol 2016 Mar 18;72:14.38.1-11. Epub 2016 Mar 18.

Deptartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.

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http://dx.doi.org/10.1002/0471141755.ph1438s72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826719PMC
March 2016

Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal Growth Factor Receptor 2 Targeting in CALGB 40601, a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib.

J Clin Oncol 2016 Feb 2;34(6):542-9. Epub 2015 Nov 2.

Lisa A. Carey, David W. Ollila, Carey K. Anders, Katherine A. Hoadley, Michael Iglesia, and Charles M. Perou, University of North Carolina Chapel Hill, Chapel Hill; Constance T. Cirrincione and Brandelyn N. Pitcher, Alliance Statistics and Data Center, Duke University, Durham, NC; Donald A. Berry, Alliance Statistics and Data Center, MD Anderson, Houston, TX; William T. Barry, Alliance Statistics and Data Center, Dana-Farber Cancer Institute; Ian E. Krop and Eric P. Winer, Dana-Farber Cancer Institute, Boston, MA; Lyndsay N. Harris, University Hospitals of Cleveland, Cleveland, OH; Norah Lynn Henry, University of Michigan, Ann Arbor, MI; Douglas J. Weckstein, New Hampshire Hematology-Oncology, Hooksett, NH; Baljit Singh, New York University; Clifford A. Hudis, Memorial Sloan-Kettering Cancer Center, New York, NY; and Maggie Chon U. Cheang, Clinical Trials and Statistics Unit, Institute of Cancer Research, Belmont, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2015.62.1268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980567PMC
February 2016

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

Authors:
W Marston Linehan Paul T Spellman Christopher J Ricketts Chad J Creighton Suzanne S Fei Caleb Davis David A Wheeler Bradley A Murray Laura Schmidt Cathy D Vocke Myron Peto Abu Amar M Al Mamun Eve Shinbrot Anurag Sethi Samira Brooks W Kimryn Rathmell Angela N Brooks Katherine A Hoadley A Gordon Robertson Denise Brooks Reanne Bowlby Sara Sadeghi Hui Shen Daniel J Weisenberger Moiz Bootwalla Stephen B Baylin Peter W Laird Andrew D Cherniack Gordon Saksena Scott Haake Jun Li Han Liang Yiling Lu Gordon B Mills Rehan Akbani Mark D M Leiserson Benjamin J Raphael Pavana Anur Donald Bottaro Laurence Albiges Nandita Barnabas Toni K Choueiri Bogdan Czerniak Andrew K Godwin A Ari Hakimi Thai H Ho James Hsieh Michael Ittmann William Y Kim Bhavani Krishnan Maria J Merino Kenna R Mills Shaw Victor E Reuter Ed Reznik Carl S Shelley Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Satish Tickoo Kenneth Burnett Daniel Crain Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph D Paulauskis Robert J Penny Candace Shelton W Troy Shelton Mark Sherman Eric Thompson Peggy Yena Melissa T Avedon Jay Bowen Julie M Gastier-Foster Mark Gerken Kristen M Leraas Tara M Lichtenberg Nilsa C Ramirez Tracie Santos Lisa Wise Erik Zmuda John A Demchok Ina Felau Carolyn M Hutter Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C Zenklusen Jiashan Zhang Brenda Ayala Julien Baboud Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Adrian Ally Miruna Balasundaram Saianand Balu Rameen Beroukhim Tom Bodenheimer Christian Buhay Yaron S N Butterfield Rebecca Carlsen Scott L Carter Hsu Chao Eric Chuah Amanda Clarke Kyle R Covington Mahmoud Dahdouli Ninad Dewal Noreen Dhalla Harsha V Doddapaneni Jennifer A Drummond Stacey B Gabriel Richard A Gibbs Ranabir Guin Walker Hale Alicia Hawes D Neil Hayes Robert A Holt Alan P Hoyle Stuart R Jefferys Steven J M Jones Corbin D Jones Divya Kalra Christie Kovar Lora Lewis Jie Li Yussanne Ma Marco A Marra Michael Mayo Shaowu Meng Matthew Meyerson Piotr A Mieczkowski Richard A Moore Donna Morton Lisle E Mose Andrew J Mungall Donna Muzny Joel S Parker Charles M Perou Jeffrey Roach Jacqueline E Schein Steven E Schumacher Yan Shi Janae V Simons Payal Sipahimalani Tara Skelly Matthew G Soloway Carrie Sougnez Angela Tam Donghui Tan Nina Thiessen Umadevi Veluvolu Min Wang Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Jane Zhou Jason Bedford Fengju Chen Yao Fu Mark Gerstein David Haussler Katayoon Kasaian Phillip Lai Shiyun Ling Amie Radenbaugh David Van Den Berg John N Weinstein Jingchun Zhu Monique Albert Iakovina Alexopoulou Jeremiah J Andersen J Todd Auman John Bartlett Sheldon Bastacky Julie Bergsten Michael L Blute Lori Boice Roni J Bollag Jeff Boyd Erik Castle Ying-Bei Chen John C Cheville Erin Curley Benjamin Davies April DeVolk Rajiv Dhir Laura Dike John Eckman Jay Engel Jodi Harr Ronald Hrebinko Mei Huang Lori Huelsenbeck-Dill Mary Iacocca Bruce Jacobs Michael Lobis Jodi K Maranchie Scott McMeekin Jerome Myers Joel Nelson Jeremy Parfitt Anil Parwani Nicholas Petrelli Brenda Rabeno Somak Roy Andrew L Salner Joel Slaton Melissa Stanton R Houston Thompson Leigh Thorne Kelinda Tucker Paul M Weinberger Cynthia Winemiller Leigh Anne Zach Rosemary Zuna

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.

Cell Rep 2015 Dec 10;13(11):2353-2361. Epub 2015 Dec 10.

Molecular and Cell Biology Lab of Key Laboratory of Molecular Medicine of Ministry of Education and Institutes of Biomedical Sciences, Shanghai Medical College, College of Life Science, Fudan University, Shanghai 200032, China; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01329-7.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501329
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http://dx.doi.org/10.1016/j.celrep.2015.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694633PMC
December 2015

Proper Use of Allele-Specific Expression Improves Statistical Power for -eQTL Mapping with RNA-Seq Data.

J Am Stat Assoc 2015;110(511):962-974. Epub 2015 Nov 7.

Department of Genetics, University of North Carolina, Chapel Hill, NC 27599.

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http://dx.doi.org/10.1080/01621459.2015.1038449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642818PMC
November 2015

Body Mass Index, PAM50 Subtype, and Outcomes in Node-Positive Breast Cancer: CALGB 9741 (Alliance).

J Natl Cancer Inst 2015 Sep 25;107(9). Epub 2015 Jun 25.

Dana-Farber Cancer Institute, Boston, MA (JAL, EW); Alliance Statistics and Data Center, Durham, NC (CTC); Mayo Clinic, Rochester, MN (ML, JNI); Hofstra North Shore - LIJ School of Medicine, ProHEALTH Care Associates, Lake Success, NY (MC); Northwestern University Feinberg School of Medicine, Chicago, IL (WG); The Angeles Clinic and Research Institute, Santa Monica, CA (SM); Rhode Island Hospital, Providence, RI (WS); St. Barnabas Medical Center, Livingston, NJ (RM); The Genome Institute, Washington University in St. Louis, St. Louis, MO (EM); Department of Genetics, Lineberger Cancer Center, University of North Carolina, Chapel Hill, NC (CMP); Breast Cancer Program, Siteman Cancer Center and Washington University School of Medicine, St. Louis, MO (ME); Memorial Sloan Kettering Cancer Center, New York, NY (CAH); Alliance Statistics and Data Center, MD Anderson Cancer Center, Houston, TX (DB); Alliance Statistics and Data Center, Dana-Farber Cancer Institute, Boston, MA (WTB).

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http://jnci.oxfordjournals.org/content/107/9/djv179.full.pdf
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http://dx.doi.org/10.1093/jnci/djv179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651106PMC
September 2015

Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells.

Cell Rep 2015 Sep 10;12(12):2035-48. Epub 2015 Sep 10.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591253PMC
September 2015

Tumor Heterogeneity: Focus on the Leaves, the Trees, or the Forest?

Cancer Cell 2015 Aug;28(2):149-50

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.07.011DOI Listing
August 2015

Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.

Cell Rep 2015 Jul 9;12(3):511-24. Epub 2015 Jul 9.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512851PMC
July 2015

Palbociclib--Taking Breast-Cancer Cells Out of Gear.

N Engl J Med 2015 Jul;373(3):273-4

From the Departments of Medicine (L.A.C.) and Genetics (C.M.P.), University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill.

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http://dx.doi.org/10.1056/NEJMe1506680DOI Listing
July 2015