Publications by authors named "Charles M Perou"

100Publications

Receiver operating characteristic curves and confidence bands for support vector machines.

Biometrics 2020 Aug 31. Epub 2020 Aug 31.

Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1111/biom.13365DOI Listing
August 2020

A pan-cancer analysis of the frequency of DNA alterations across cell cycle activity levels.

Oncogene 2020 Aug 24;39(32):5430-5440. Epub 2020 Jun 24.

Department of Oncology and Pathology, Karolinska Institutet and University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41388-020-1367-4DOI Listing
August 2020

Combined associations of a polygenic risk score and classical risk factors with breast cancer risk.

Authors:
Pooja Middha Kapoor Nasim Mavaddat Parichoy Pal Choudhury Amber N Wilcox Sara Lindström Sabine Behrens Kyriaki Michailidou Joe Dennis Manjeet K Bolla Qin Wang Audrey Jung Zomoroda Abu-Ful Thomas Ahearn Irene L Andrulis Hoda Anton-Culver Volker Arndt Kristan J Aronson Paul L Auer Laura E Beane Freeman Heiko Becher Matthias W Beckmann Alicia Beeghly-Fadiel Javier Benitez Leslie Bernstein Stig E Bojesen Hiltrud Brauch Hermann Brenner Thomas Brüning Qiuyin Cai Daniele Campa Federico Canzian Angel Carracedo Brian D Carter Jose E Castelao Stephen J Chanock Nilanjan Chatterjee Georgia Chenevix-Trench Christine L Clarke Fergus J Couch Angela Cox Simon S Cross Kamila Czene James Y Dai H Shelton Earp Arif B Ekici A Heather Eliassen Mikael Eriksson D Gareth Evans Peter A Fasching Jonine Figueroa Lin Fritschi Marike Gabrielson Manuela Gago-Dominguez Chi Gao Susan M Gapstur Mia M Gaudet Graham G Giles Anna González-Neira Pascal Guénel Lothar Haeberle Christopher A Haiman Niclas Håkansson Per Hall Ute Hamann Sigrid Hatse Jane Heyworth Bernd Holleczek Robert N Hoover John L Hopper Anthony Howell David J Hunter Esther M John Michael E Jones Rudolf Kaaks Renske Keeman Cari M Kitahara Yon-Dschun Ko Stella Koutros Allison W Kurian Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Martha Linet Jolanta Lissowska Ana Llaneza Robert J MacInnis Maria Elena Martinez Tabea Maurer Catriona McLean Susan L Neuhausen William G Newman Aaron Norman Katie M O'Brien Andrew F Olshan Janet E Olson Håkan Olsson Nick Orr Charles M Perou Guillermo Pita Eric C Polley Ross L Prentice Gad Rennert Hedy S Rennert Kathryn J Ruddy Dale P Sandler Christobel Saunders Minouk J Schoemaker Ben Schöttker Fredrick Schumacher Christopher Scott Rodney J Scott Xiao-Ou Shu Ann Smeets Melissa C Southey John J Spinelli Jennifer Stone Anthony J Swerdlow Rulla M Tamimi Jack A Taylor Melissa A Troester Celine M Vachon Elke M van Veen Xiaoliang Wang Clarice R Weinberg Caroline Weltens Walter Willett Stacey J Winham Alicja Wolk Xiaohong R Yang Wei Zheng Argyrios Ziogas Alison M Dunning Paul D P Pharoah Marjanka K Schmidt Peter Kraft Douglas F Easton Roger L Milne Montserrat García-Closas Jenny Chang-Claude

J Natl Cancer Inst 2020 May 2. Epub 2020 May 2.

Division of Cancer Epidemiology. German Cancer Research Center (DKFZ). Heidelberg: Germany.

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http://dx.doi.org/10.1093/jnci/djaa056DOI Listing
May 2020

A framework for transcriptome-wide association studies in breast cancer in diverse study populations.

Genome Biol 2020 02 20;21(1):42. Epub 2020 Feb 20.

Department of Biostatistics, University of North Carolina-Chapel Hill, Chapel Hill, USA.

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http://dx.doi.org/10.1186/s13059-020-1942-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033948PMC
February 2020

Virus expression detection reveals RNA-sequencing contamination in TCGA.

BMC Genomics 2020 Jan 28;21(1):79. Epub 2020 Jan 28.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.

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http://dx.doi.org/10.1186/s12864-020-6483-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986043PMC
January 2020

Genetic determinants of the molecular portraits of epithelial cancers.

Nat Commun 2019 12 11;10(1):5666. Epub 2019 Dec 11.

Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41467-019-13588-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906458PMC
December 2019

The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.

Dis Model Mech 2019 07 5;12(7). Epub 2019 Jul 5.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

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http://dx.doi.org/10.1242/dmm.037192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679375PMC
July 2019

I-Boost: an integrative boosting approach for predicting survival time with multiple genomics platforms.

Genome Biol 2019 03 7;20(1):52. Epub 2019 Mar 7.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, NC, USA.

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http://dx.doi.org/10.1186/s13059-019-1640-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404283PMC
March 2019

Improved indel detection in DNA and RNA via realignment with ABRA2.

Bioinformatics 2019 09;35(17):2966-2973

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735753PMC
September 2019

Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas.

Cancer Causes Control 2019 Jan 8;30(1):31-39. Epub 2019 Jan 8.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Dr, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10552-018-1121-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396692PMC
January 2019

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.

Breast Cancer Res Treat 2019 Feb 27;174(1):143-155. Epub 2018 Nov 27.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, CB#7264, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10549-018-5061-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418066PMC
February 2019

Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.

Cell Rep 2018 10;25(3):702-714.e6

Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276789PMC
October 2018

Intrinsic molecular subtypes of breast cancers categorized as HER2-positive using an alternative chromosome 17 probe assay.

Breast Cancer Res 2018 07 11;20(1):75. Epub 2018 Jul 11.

Department of Hematology-Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Shapiro 9, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s13058-018-1005-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042281PMC
July 2018

TP53 protein levels, RNA-based pathway assessment, and race among invasive breast cancer cases.

NPJ Breast Cancer 2018 25;4:13. Epub 2018 Jun 25.

1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA.

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http://www.nature.com/articles/s41523-018-0067-5
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http://dx.doi.org/10.1038/s41523-018-0067-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018637PMC
June 2018

Clinical implications of the non-luminal intrinsic subtypes in hormone receptor-positive breast cancer.

Cancer Treat Rev 2018 Jun 7;67:63-70. Epub 2018 May 7.

Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Department of Medical Oncology, Hospital Clínic de Barcelona, Spain; SOLTI Breast Cancer Cooperative Group, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2018.04.015DOI Listing
June 2018

Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening-Reply.

JAMA Oncol 2018 06;4(6):883-884

Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaoncol.2017.5909DOI Listing
June 2018

GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network.

Nat Commun 2018 03 13;9(1):1059. Epub 2018 Mar 13.

Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA.

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http://www.nature.com/articles/s41467-018-03478-4
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http://dx.doi.org/10.1038/s41467-018-03478-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849768PMC
March 2018

Race-associated biological differences among luminal A and basal-like breast cancers in the Carolina Breast Cancer Study.

Breast Cancer Res 2017 Dec 11;19(1):131. Epub 2017 Dec 11.

Department of Epidemiology, University of North Carolina at Chapel Hill, Campus Box 7435, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1186/s13058-017-0914-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725885PMC
December 2017

Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study.

Cancer Causes Control 2018 01 9;29(1):25-32. Epub 2017 Nov 9.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10552-017-0977-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903274PMC
January 2018

Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts.

Clin Cancer Res 2017 Dec 29;23(24):7512-7520. Epub 2017 Sep 29.

Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822691PMC
December 2017

Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.

J Natl Cancer Inst 2018 02;110(2)

Department of Epidemiology, Lineberger Comprehensive Cancer Center; Department of Pathology and Lab Medicine, Department of Nutrition (EHA), and Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC; Dana Farber Cancer Institute, Harvard University, Boston, MA; Center for Clinical Cancer Genetics, Global Health Department of Medicine, The University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1093/jnci/djx135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059138PMC
February 2018

SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling.

Genome Biol 2017 04 8;18(1):66. Epub 2017 Apr 8.

Section of Genetic Medicine, Department of Medicine, The University of Chicago, 900 East 57th Street, KCBD 3220A, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1186/s13059-017-1193-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385048PMC
April 2017

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness.

J Natl Cancer Inst 2017 07;109(7)

Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

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http://dx.doi.org/10.1093/jnci/djw317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059180PMC
July 2017

Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer.

Breast Cancer Res Treat 2017 04 7;162(3):439-450. Epub 2017 Feb 7.

Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, CINJ 4558, New Brunswick, NJ, 08903, USA.

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http://dx.doi.org/10.1007/s10549-017-4139-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334195PMC
April 2017

MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays.

Radiology 2016 Nov 5;281(2):382-391. Epub 2016 May 5.

From the Depts of Radiology (H.L., K.D., M.L.G.) and Public Health Sciences (Y.J.), The Univ of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; Program of Computational Genomics & Medicine, NorthShore Univ HealthSystem, Evanston, Ill (Y.Z., Y.J.); Dept of Radiology, Univ of Wisconsin-Madison, Madison, Wis (E.S.B.); Lineberger Comprehensive Cancer Ctr, Univ of North Carolina, Chapel Hill, NC (K.A.H., C.F., C.M.P.); Dept of Medicine, Section of Hematology & Oncology, The Univ of Chicago, Chicago, Ill (S.D.C.); Dept of Diagnostic Radiology, The Univ of Texas MD Anderson Cancer Ctr, Houston, Tex (G.J.W.); Dept of Radiology, Memorial Sloan-Kettering Cancer Ctr, New York, NY (E.J.S., E.A.M.); Dept of Radiology, Univ of Miami Sylvester Comprehensive Cancer Ctr, Miami, Fla (J.M.N.); Dept of Radiology, Univ of Pittsburgh Medical Ctr, Pittsburgh, Pa (M.G.); and Div of Cancer Treatment and Diagnosis, National Cancer Inst, Biometric Research Branch, Bethesda, Md (E.H.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069147PMC
http://dx.doi.org/10.1148/radiol.2016152110DOI Listing
November 2016

Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types.

J Natl Cancer Inst 2016 11 22;108(11). Epub 2016 Jun 22.

Affiliations of authors: Lineberger Comprehensive Cancer Center (MDI, JSP, KAH, JSS, CMP, BGV), Curriculum in Genetics and Molecular Biology (MDI, JSP), Department of Medicine (JSS, BGV), Department of Genetics (KAH, CMP), Department of Microbiology and Immunology (JSS), and Department of Pathology & Laboratory Medicine (CMP), University of North Carolina, Chapel Hill, Chapel Hill, NC.

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http://jnci.oxfordjournals.org/content/108/11/djw144.full.pd
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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djw144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241901PMC
November 2016

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity.

Biomaterials 2016 09 4;101:296-309. Epub 2016 Jun 4.

Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, USA; Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119992, Russia. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S014296121630256
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http://dx.doi.org/10.1016/j.biomaterials.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035646PMC
September 2016

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.

Cancer Res 2016 07 23;76(13):3826-37. Epub 2016 May 23.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930678PMC
July 2016

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.

Dis Model Mech 2016 07 5;9(7):749-57. Epub 2016 May 5.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA

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http://dx.doi.org/10.1242/dmm.025239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958311PMC
July 2016

Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes.

Curr Protoc Pharmacol 2016 Mar 18;72:14.38.1-14.38.11. Epub 2016 Mar 18.

Deptartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.

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http://dx.doi.org/10.1002/0471141755.ph1438s72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826719PMC
March 2016

Identification of mRNA isoform switching in breast cancer.

BMC Genomics 2016 Mar 3;17:181. Epub 2016 Mar 3.

Department of Genetics, University of North Carolina, 27599, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1186/s12864-016-2521-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778320PMC
March 2016

Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium.

Cancer Epidemiol Biomarkers Prev 2016 Mar 28;25(3):470-8. Epub 2015 Dec 28.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-0874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779705PMC
March 2016