Publications by authors named "Charles L Hoppel"

100Publications

Identification of Unusual Phospholipids from Bovine Heart Mitochondria by HPLC-MS/MS.

J Lipid Res 2020 Sep 30. Epub 2020 Sep 30.

Pharmacology, Case Western Reserve University, United States

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http://dx.doi.org/10.1194/jlr.RA120001044DOI Listing
September 2020

Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki).

Front Physiol 2020 16;11:677. Epub 2020 Jun 16.

Center for Mitochondrial Disease, Case Western Reserve University, Cleveland, OH, United States.

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http://dx.doi.org/10.3389/fphys.2020.00677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308651PMC
June 2020

Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy.

Free Radic Biol Med 2019 12 28;145:284-299. Epub 2019 Sep 28.

The Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; The Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910229PMC
December 2019

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene () causing pyruvate dehydrogenase complex deficiency.

JIMD Rep 2019 Jul 17;48(1):26-35. Epub 2019 Jun 17.

Division of Genetics and Genomics, The Manton Center for Orphan Disease Research Boston Children's Hospital, Harvard Medical School Boston Massachusetts.

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http://dx.doi.org/10.1002/jmd2.12054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606986PMC
July 2019

Cardiac mitochondrial structure and function in tafazzin-knockdown mice.

Mitochondrion 2018 11 30;43:53-62. Epub 2018 Oct 30.

Center for Mitochondrial Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Departments of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15677249183007
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http://dx.doi.org/10.1016/j.mito.2018.10.005DOI Listing
November 2018

Isolation of mitochondrial subpopulations from skeletal muscle: Optimizing recovery and preserving integrity.

Acta Physiol (Oxf) 2019 02 17;225(2):e13182. Epub 2018 Sep 17.

Center for Mitochondrial Diseases, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1111/apha.13182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335164PMC
February 2019

Morphological Pathways of Mitochondrial Division.

Antioxidants (Basel) 2018 Feb 15;7(2). Epub 2018 Feb 15.

Center for Mitochondrial Disease, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.3390/antiox7020030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836020PMC
February 2018

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.

Nat Commun 2017 11 24;8(1):1769. Epub 2017 Nov 24.

Department of Radiation Oncology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

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http://www.nature.com/articles/s41467-017-01965-8
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http://dx.doi.org/10.1038/s41467-017-01965-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701259PMC
November 2017

Selective and accurate C5 acylcarnitine quantitation by UHPLC-MS/MS: Distinguishing true isovaleric acidemia from pivalate derived interference.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Sep 12;1061-1062:128-133. Epub 2017 Jul 12.

Center for Mitochondrial Diseases, Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2017.07.018DOI Listing
September 2017

Mitochondrial Dysfunction in Cardiovascular Aging.

Adv Exp Med Biol 2017 ;982:451-464

Department of Biological Sciences, CWRU School of Dental Medicine, Cleveland, OH, 44106, USA.

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http://dx.doi.org/10.1007/978-3-319-55330-6_24DOI Listing
September 2017

Lethal neonatal case and review of primary short-chain enoyl-CoA hydratase (SCEH) deficiency associated with secondary lymphocyte pyruvate dehydrogenase complex (PDC) deficiency.

Mol Genet Metab 2017 04 2;120(4):342-349. Epub 2017 Feb 2.

Departments of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ymgme.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382105PMC
April 2017

Correcting false positive medium-chain acyl-CoA dehydrogenase deficiency results from newborn screening; synthesis, purification, and standardization of branched-chain C8 acylcarnitines for use in their selective and accurate absolute quantitation by UHPLC-MS/MS.

Mol Genet Metab 2017 04 8;120(4):363-369. Epub 2017 Feb 8.

Center for Mitochondrial Diseases, Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2017.02.006DOI Listing
April 2017

Succinyl-CoA synthetase (SUCLA2) deficiency in two siblings with impaired activity of other mitochondrial oxidative enzymes in skeletal muscle without mitochondrial DNA depletion.

Mol Genet Metab 2017 03 12;120(3):213-222. Epub 2016 Nov 12.

Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346465PMC
March 2017

Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies.

Annu Rev Pharmacol Toxicol 2017 01;57:535-565

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; email:

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http://www.annualreviews.org/doi/10.1146/annurev-pharmtox-01
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http://dx.doi.org/10.1146/annurev-pharmtox-010715-103335DOI Listing
January 2017

The M405V allele of the glutaryl-CoA dehydrogenase gene is an important marker for glutaric aciduria type I (GA-I) low excretors.

Mol Genet Metab 2016 09 1;119(1-2):50-6. Epub 2016 Jul 1.

Center for Human Genetics, University Hospitals Case Medical Center, Cleveland, OH, United States; Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, United States; Center for Inherited Disorders of Energy Metabolism (CIDEM), University Hospitals Case Medical Center, Cleveland, OH, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2016.06.012DOI Listing
September 2016

Mitochondrial Metabolism in Aging Heart.

Circ Res 2016 05;118(10):1593-611

From the Division of Cardiology, Department of Medicine, Pauley Heart Center (E.J.L, Q.C.), Departments of Biochemistry and Molecular Biology and Physiology and Biophsyics (E.J.L.), Virginia Commonwealth University, Richmond, VA (E.J.L., Q.C.); Medical Service, McGuire Veterans Affairs Medical Center, Richmond, VA (E.J.L.); and Departments of Pharmacology (C.L.H.) and Medicine (E.J.L., C.L.H.), Center for Mitochondrial Disease (C.L.H.), Case Western Reserve University, School of Medicine, Cleveland, OH.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.307505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009371PMC
May 2016

The Failing Heart Relies on Ketone Bodies as a Fuel.

Circulation 2016 Feb 27;133(8):698-705. Epub 2016 Jan 27.

From Cardiovascular Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (G.A., O.J.M., J.L.H., L.L., R.B.V., T.C.L., S.J.G., P.A.C., D.P.K.); Departments of Medicine, Pharmacology, and Cancer Biology, Duke University, Durham, NC (T.K., D.M.M.); CECAD Research Center, Institute for Genetics, University of Cologne, Cologne, Germany (M.K.); Departments of Pharmacology and Medicine, Case Western Reserve University, Cleveland, OH (C.L.H.); College of Medicine, University of Illinois at Chicago, Chicago, IL (E.D.L.); and Department of Medicine, Washington University School of Medicine, St. Louis, MO (P.A.C.).

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http://circ.ahajournals.org/content/early/2016/01/27/CIRCULA
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http://circ.ahajournals.org/content/early/2016/01/27/CIRCULA
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http://circ.ahajournals.org/content/133/8/698.full.pdf
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http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAH
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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.017355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766035PMC
February 2016

Quantitative acylcarnitine determination by UHPLC-MS/MS--Going beyond tandem MS acylcarnitine "profiles".

Mol Genet Metab 2015 Dec 8;116(4):231-41. Epub 2015 Oct 8.

Center for Mitochondrial Diseases, Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192153006
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http://dx.doi.org/10.1016/j.ymgme.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009370PMC
December 2015

Validated method for the quantification of free and total carnitine, butyrobetaine, and acylcarnitines in biological samples.

Anal Chem 2015 Sep 13;87(17):8994-9001. Epub 2015 Aug 13.

Center for Mitochondrial Diseases, †Department of Pharmacology and ‡Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio 44106, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b02198DOI Listing
September 2015

Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) Mouse.

Ultrastruct Pathol 2015 25;39(5):336-9. Epub 2015 Jun 25.

e Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University , Cleveland , OH , USA , and.

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http://dx.doi.org/10.3109/01913123.2015.1042610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827860PMC
July 2016

Aging effects on oxidative phosphorylation in rat adrenocortical mitochondria.

Mech Ageing Dev 2014 Jun 31;138:10-4. Epub 2014 Jan 31.

Departments of Pharmacology and of Medicine and Center for Mitochondrial Disease, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2014.01.009DOI Listing
June 2014

Multiple muscle cell alterations in a case of encephalomyopathy.

Ultrastruct Pathol 2014 Feb 17;38(1):13-25. Epub 2013 Oct 17.

Electron Microscopy Facility and Center for Mitochondrial Disease, School of Medicine .

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http://dx.doi.org/10.3109/01913123.2013.831158DOI Listing
February 2014

Leucine and protein metabolism in obese Zucker rats.

PLoS One 2013 20;8(3):e59443. Epub 2013 Mar 20.

Department of Cellular and Molecular Physiology, the Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059443PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603883PMC
September 2013

Measuring oxidative phosphorylation in human skin fibroblasts.

Anal Biochem 2013 Jun 24;437(1):52-8. Epub 2013 Feb 24.

Center for Mitochondrial Disease, Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.ab.2013.02.010DOI Listing
June 2013

Aging-dependent changes in rat heart mitochondrial glutaredoxins--Implications for redox regulation.

Redox Biol 2013 12;1:586-98. Epub 2013 Nov 12.

Department of Pharmacology, Division of Cardiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA ; Louis Stokes Cleveland Veterans Affairs Medical Research Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.redox.2013.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127417PMC
April 2015

Comprehensive approach to the quantitative analysis of mitochondrial phospholipids by HPLC-MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Jan 5;912:105-14. Epub 2012 Nov 5.

Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, United States.

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http://dx.doi.org/10.1016/j.jchromb.2012.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135309PMC
January 2013

String mitochondria in mouse soleus muscle.

Microsc Res Tech 2013 Mar 23;76(3):237-41. Epub 2012 Nov 23.

Electron Microscopy Facility, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1002/jemt.22158DOI Listing
March 2013

Isolation of rat adrenocortical mitochondria.

Biochem Biophys Res Commun 2012 Oct 12;427(1):96-9. Epub 2012 Sep 12.

Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.bbrc.2012.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120703PMC
October 2012

Mitochondria in cardiac hypertrophy and heart failure.

J Mol Cell Cardiol 2013 Feb 13;55:31-41. Epub 2012 Sep 13.

Center for Mitochondrial Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106‐4981, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00222828120033
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http://dx.doi.org/10.1016/j.yjmcc.2012.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805050PMC
February 2013

Mitochondrial dysfunction in heart failure.

Heart Fail Rev 2013 Sep;18(5):607-22

Departments of Medicine and Pharmacology and Center for Mitochondrial Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106-4981, USA.

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http://dx.doi.org/10.1007/s10741-012-9340-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855291PMC
September 2013

Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids.

FASEB J 2012 Oct 10;26(10):4316-26. Epub 2012 Jul 10.

Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases (F0-222), Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1096/fj.12-206326DOI Listing
October 2012

Mitochondrial division in rat cardiomyocytes: an electron microscope study.

Anat Rec (Hoboken) 2012 Sep 2;295(9):1455-61. Epub 2012 Jul 2.

Electron Microscopy Facility and Center for Mitochondrial Disease, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1002/ar.22523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744323PMC
September 2012

Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes.

Diabetes 2012 Aug 14;61(8):2074-83. Epub 2012 May 14.

Center of Mitochondrial Diseases, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.2337/db11-1437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402323PMC
August 2012

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.

Proc Natl Acad Sci U S A 2012 Apr 9;109(17):6739-44. Epub 2012 Apr 9.

Harrington Heart and Vascular Institute and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1073/pnas.1121060109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340075PMC
April 2012

Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia.

Future Oncol 2012 Feb;8(2):145-50

Department of Epidemiology & Biostatistics, University Hospitals Case Medical Center & Case Western Reserve School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.2217/fon.11.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292053PMC
February 2012

Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite.

Metabolism 2012 Jul 29;61(7):966-73. Epub 2011 Dec 29.

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.metabol.2011.11.009DOI Listing
July 2012

VDAC proteomics: post-translation modifications.

Biochim Biophys Acta 2012 Jun 19;1818(6):1520-5. Epub 2011 Nov 19.

Center for Mitochondrial Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.bbamem.2011.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120668PMC
June 2012

Decreased cytochrome c oxidase subunit VIIa in aged rat heart mitochondria: immunocytochemistry.

Anat Rec (Hoboken) 2011 Nov 4;294(11):1825-33. Epub 2011 Oct 4.

Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1002/ar.21486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744322PMC
November 2011

Urinary acylcarnitines are altered in human kidney cancer.

Int J Cancer 2012 Jun 14;130(12):2791-800. Epub 2011 Sep 14.

Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1002/ijc.26274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258465PMC
June 2012

Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex.

J Biol Chem 2011 Jul 26;286(29):25655-62. Epub 2011 May 26.

Center for Mitochondrial Diseases, Cleveland, Ohio 44106-4981, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.228692
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http://dx.doi.org/10.1074/jbc.M111.228692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138250PMC
July 2011

Cardiac mitochondria in heart failure: normal cardiolipin profile and increased threonine phosphorylation of complex IV.

Biochim Biophys Acta 2011 Nov 12;1807(11):1373-82. Epub 2011 Feb 12.

Center for Mitochondrial Diseases; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00052728110003
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http://dx.doi.org/10.1016/j.bbabio.2011.02.003DOI Listing
November 2011

A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.

FASEB J 2011 Mar 24;25(3):948-59. Epub 2010 Nov 24.

Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44160, USA.

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http://dx.doi.org/10.1096/fj.10-173906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042841PMC
March 2011

Monolysocardiolipin: improved preparation with high yield.

J Lipid Res 2011 Feb 19;52(2):389-92. Epub 2010 Oct 19.

Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1194/jlr.D010587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023560PMC
February 2011

Post-translational modifications of mitochondrial outer membrane proteins.

Free Radic Res 2011 Jan 13;45(1):16-28. Epub 2010 Oct 13.

Department of Pharmacology, Center for Mitochondrial Diseases, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.

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http://www.tandfonline.com/doi/full/10.3109/10715762.2010.51
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http://dx.doi.org/10.3109/10715762.2010.515218DOI Listing
January 2011

Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance.

Obesity (Silver Spring) 2011 May 30;19(5):917-24. Epub 2010 Sep 30.

Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/oby.2010.214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749733PMC
May 2011

Cardiolipin: characterization of distinct oxidized molecular species.

J Lipid Res 2011 Jan 20;52(1):125-35. Epub 2010 Sep 20.

Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://www.jlr.org/content/52/1/125.full.pdf
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http://www.jlr.org/cgi/doi/10.1194/jlr.M010520
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http://dx.doi.org/10.1194/jlr.M010520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999925PMC
January 2011

Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype.

J Gerontol A Biol Sci Med Sci 2010 Nov 26;65(11):1157-64. Epub 2010 Aug 26.

Center for Mitochondrial Disease, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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https://academic.oup.com/biomedgerontology/article-lookup/do
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http://dx.doi.org/10.1093/gerona/glq141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981518PMC
November 2010

Mitochondria in heart failure.

Cardiovasc Res 2010 Oct 28;88(1):40-50. Epub 2010 Jul 28.

Center for Mitochondrial Diseases, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1093/cvr/cvq240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025720PMC
October 2010

Synthesis and characterization of cis-4-decenoyl-CoA, 3-phenylpropionyl-CoA, and 2,6-dimethylheptanoyl-CoA.

Anal Biochem 2010 Jun 23;401(1):114-24. Epub 2010 Feb 23.

Center for Mitochondrial Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.ab.2010.02.026DOI Listing
June 2010

Decreased cytochrome c mediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria.

Biochem J 2010 Mar 15;427(1):105-12. Epub 2010 Mar 15.

Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1042/BJ20091373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759985PMC
March 2010

Mitochondria of human Leydig cells as seen by high resolution scanning electron microscopy.

Arch Histol Cytol 2010 ;73(1):37-44

Department of Cytomorphology, School of Medicine, University of Cagliari, Italy.

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http://dx.doi.org/10.1679/aohc.73.37DOI Listing
August 2011

Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry.

J Lipid Res 2010 Apr 30;51(4):856-65. Epub 2009 Oct 30.

Center for Mitochondrial Diseases, Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1194/jlr.D002857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842139PMC
April 2010

Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging.

Antioxid Redox Signal 2010 Jun;12(12):1339-53

Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106-4965, USA.

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http://dx.doi.org/10.1089/ars.2009.2791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864653PMC
June 2010

Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?

Adv Drug Deliv Rev 2009 Nov 29;61(14):1332-1342. Epub 2009 Aug 29.

Center for Mitochondrial Diseases and Departments of Medicine and Pharmacology, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.addr.2009.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120470PMC
November 2009

Mitochondrial long chain fatty acid beta-oxidation in man and mouse.

Biochim Biophys Acta 2009 Aug 22;1791(8):806-15. Epub 2009 May 22.

Department of Clinical Chemistry, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbalip.2009.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763615PMC
August 2009

Dynamic organization of mitochondria in human heart and in myocardial disease.

Int J Biochem Cell Biol 2009 Oct 14;41(10):1949-56. Epub 2009 May 14.

Department of Pharmacology and Medicine and Center for Mitochondrial Disease, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.biocel.2009.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221317PMC
October 2009

Post-translational modifications of mitochondrial outer membrane proteins.

Methods Enzymol 2009 ;457:97-115

Department of Pharmacology, and Center for Mitochondrial Disease, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1016/S0076-6879(09)05006-XDOI Listing
July 2009

Phase II and pharmacokinetic trial of rebeccamycin analog in advanced biliary cancers.

Cancer Chemother Pharmacol 2009 Dec 28;65(1):73-8. Epub 2009 Apr 28.

University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1007/s00280-009-1005-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220168PMC
December 2009

New aspects of impaired mitochondrial function in heart failure.

J Bioenerg Biomembr 2009 Apr;41(2):107-12

Center for Mitochondrial Diseases and Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/s10863-009-9215-9DOI Listing
April 2009

Involvement of all-trans-retinal in acute light-induced retinopathy of mice.

J Biol Chem 2009 May 20;284(22):15173-83. Epub 2009 Mar 20.

Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1074/jbc.M900322200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685698PMC
May 2009

Enhanced modification of cardiolipin during ischemia in the aged heart.

J Mol Cell Cardiol 2009 Jun 19;46(6):1008-15. Epub 2009 Mar 19.

Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2009.03.007DOI Listing
June 2009

Prolonged exposure to high dietary lipids is not associated with lipotoxicity in heart failure.

J Mol Cell Cardiol 2009 Jun 3;46(6):883-90. Epub 2009 Mar 3.

Department of Physiology and Biophysics, School of Medicine E558, Case Western Reserve University, Cleveland, OH 44106-4970, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2009.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683194PMC
June 2009

Altered expression of the adenine nucleotide translocase isoforms and decreased ATP synthase activity in skeletal muscle mitochondria in heart failure.

J Mol Cell Cardiol 2009 Jun 20;46(6):927-35. Epub 2009 Feb 20.

Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4981, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2009.02.009DOI Listing
June 2009

Mass spectrometric demonstration of the presence of liver carnitine palmitoyltransferase-I (CPT-I) in heart mitochondria of adult rats.

Biochim Biophys Acta 2009 Mar 3;1794(3):431-7. Epub 2008 Dec 3.

Department Pharmacology, Case Western Reserve University, Cleveland OH 44106, USA.

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http://dx.doi.org/10.1016/j.bbapap.2008.11.009DOI Listing
March 2009

Proteomics of mitochondrial inner and outer membranes.

Proteomics 2008 Oct;8(19):4066-82

Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1002/pmic.200800102DOI Listing
October 2008

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation.

Cardiovasc Res 2008 Oct 18;80(1):30-9. Epub 2008 Aug 18.

Department of Medicine, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland 44106-4981, OH, USA.

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http://dx.doi.org/10.1093/cvr/cvn184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533423PMC
October 2008

Quantification of carnitine and acylcarnitines in biological matrices by HPLC electrospray ionization-mass spectrometry.

Clin Chem 2008 Sep 4;54(9):1451-62. Epub 2008 Aug 4.

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1373/clinchem.2007.099226DOI Listing
September 2008

Rat liver mitochondrial carnitine palmitoyltransferase-I, hepatic carnitine, and malonyl-CoA: effect of starvation.

Arch Physiol Biochem 2008 Jul;114(3):161-70

Department of Nutrition, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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July 2008

Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat.

Biochim Biophys Acta 2008 Jul-Aug;1777(7-8):1020-7. Epub 2008 Jun 2.

Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1016/j.bbabio.2008.05.444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527751PMC
August 2008

Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue.

Anal Biochem 2008 May 29;376(2):275-6. Epub 2008 Feb 29.

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.ab.2008.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444051PMC
May 2008

Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure.

Cardiovasc Res 2008 Jul 13;79(2):331-40. Epub 2008 Mar 13.

Department of Physiology and Biophysics, School of Medicine E553, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA.

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http://dx.doi.org/10.1093/cvr/cvn066DOI Listing
July 2008

Quinol type compound in cytochrome c preparations leads to non-enzymatic reduction of cytochrome c during the measurement of complex III activity.

Mitochondrion 2008 Mar 23;8(2):155-63. Epub 2007 Dec 23.

Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.mito.2007.12.001DOI Listing
March 2008

Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria.

Am J Physiol Cell Physiol 2008 Feb 12;294(2):C460-6. Epub 2007 Dec 12.

Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00211.2007
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February 2008

Fatty acid oxidation in cardiac and skeletal muscle mitochondria is unaffected by deletion of CD36.

Arch Biochem Biophys 2007 Nov 29;467(2):234-8. Epub 2007 Aug 29.

Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, USA.

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http://dx.doi.org/10.1016/j.abb.2007.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702466PMC
November 2007

What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria?

Antioxid Redox Signal 2007 Nov;9(11):2027-33

Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1089/ars.2007.1642DOI Listing
November 2007

Fatty acid chain-elongation in perfused rat heart: synthesis of stearoylcarnitine from perfused palmitate.

FEBS Lett 2007 Sep 22;581(23):4491-4. Epub 2007 Aug 22.

Case Western Reserve University, School of Medicine, Department of Nutrition, Cleveland, OH 44106, United States.

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http://doi.wiley.com/10.1016/j.febslet.2007.08.026
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http://dx.doi.org/10.1016/j.febslet.2007.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743553PMC
September 2007

Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry.

Biochim Biophys Acta 2007 May 28;1774(5):628-36. Epub 2007 Mar 28.

Department of Medicine, Case Western Reserve University, Cleveland OH, 44106, USA.

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http://dx.doi.org/10.1016/j.bbapap.2007.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950290PMC
May 2007

Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.

J Lipid Res 2007 Jul 16;48(7):1511-7. Epub 2007 Apr 16.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M600364-JLR200
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July 2007