Dr. Charles GUENANCIA, MD, PhD - Cardiology Department, University Hospital, Dijon, France

Dr. Charles GUENANCIA

MD, PhD

Cardiology Department, University Hospital, Dijon, France

Dijon | France

Main Specialties: Cardiovascular Disease, Clinical Cardiac Electrophysiology

Additional Specialties: Electrophysiology

ORCID logohttps://orcid.org/0000-0002-3554-7714

Dr. Charles GUENANCIA, MD, PhD - Cardiology Department, University Hospital, Dijon, France

Dr. Charles GUENANCIA

MD, PhD

Introduction

Primary Affiliation: Cardiology Department, University Hospital, Dijon, France - Dijon , France

Specialties:

Additional Specialties:

Experience

Nov 2013 - Sep 2017
Centre Hospitalier Universitaire de Dijon
Assistant Chef de Clinique
Sep 2017
Centre Hospitalier Universitaire de Dijon
MCU-PH
Cardiologie - Physiologie

Publications

42Publications

723Reads

-Profile Views

120PubMed Central Citations

Should we predict post-operative atrial fibrillation with atrial cardiomyopathy biomarkers?

Int J Cardiol 2020 May 20;307:71-72. Epub 2020 Feb 20.

Dijon Bourgogne University Hospital, Department of Cardiology, Dijon, France; PEC2, EA 7460 Dijon, France.

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http://dx.doi.org/10.1016/j.ijcard.2020.02.049DOI Listing
May 2020
4.036 Impact Factor

Silent atrial fibrillation: clinical management and perspectives.

Future Cardiol 2020 Mar 3;16(2):133-142. Epub 2020 Mar 3.

Department of Cardiology, University Hospital, 21000 Dijon, France.

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http://dx.doi.org/10.2217/fca-2019-0066DOI Listing
March 2020

Contractibility sensor signal evolution predicts cardiovascular events in patients with cardiac resynchronization therapy.

Arch Cardiovasc Dis 2019 Jan 24;112(1):22-30. Epub 2018 Dec 24.

Service de cardiologie, CHU de Poitiers, 86021 Poitiers, France.

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http://dx.doi.org/10.1016/j.acvd.2018.07.003DOI Listing
January 2019
3 Reads

High rate of recurrence at long-term follow-up after new-onset atrial fibrillation during acute myocardial infarction.

Europace 2018 12;20(12):e179-e188

Department of Cardiology, University Hospital, 14 rue Paul Gaffarel, Dijon, France.

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http://dx.doi.org/10.1093/europace/euy168DOI Listing
December 2018
24 Reads
3.050 Impact Factor

New-onset atrial fibrillation in ICU: A FROG in the throat.

Int J Cardiol 2018 11;270:189

University Hospital, Intensive Care Unit, Dijon, France; INSERM, CIE 1, Dijon, France.

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183388
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http://dx.doi.org/10.1016/j.ijcard.2018.06.101DOI Listing
November 2018
8 Reads
4.040 Impact Factor

[Is it possible to practice sports with an implantable cardioverter-defibrillator?]

Presse Med 2018 Sep 13;47(9):792-797. Epub 2018 Jun 13.

University Hospital, department of cardiology, 86000 Poitiers, France.

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http://dx.doi.org/10.1016/j.lpm.2018.05.001DOI Listing
September 2018
3 Reads
1.173 Impact Factor

Incidence, Predictive Factors, and Prognostic Impact of Silent Atrial Fibrillation After Transcatheter Aortic Valve Implantation.

Am J Cardiol 2018 08 1;122(3):446-454. Epub 2018 May 1.

Department of Cardiology, University Hospital, Dijon, France; Laboratory of Cerebro-Vascular Pathophysiology and epidemiology (PEC2) EA 7460, University of Burgundy, Dijon, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183102
Publisher Site
http://dx.doi.org/10.1016/j.amjcard.2018.04.029DOI Listing
August 2018
30 Reads
3.280 Impact Factor

Could vagal tone increase explain the excess of bradycardia episodes during the last day of the long interdialytic interval?

Kidney Int 2018 08;94(2):430

Nephrology Department, University Hospital, Dijon, France.

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http://dx.doi.org/10.1016/j.kint.2018.05.011DOI Listing
August 2018
3 Reads
8.563 Impact Factor

Blood Transfusion in Elderly Patients with Acute Myocardial Infarction: Data from the RICO Survey.

Am J Med 2018 04 10;131(4):422-429.e4. Epub 2017 Oct 10.

Laboratoire Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Université de Bourgogne Franche-Comté, Dijon, France; Service de Cardiologie, Centre Hospitalier Universitaire, Dijon, France.

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http://dx.doi.org/10.1016/j.amjmed.2017.09.027DOI Listing
April 2018
19 Reads
5.003 Impact Factor

Obesity As a Risk Factor for Anthracyclines and Trastuzumab Cardiotoxicity in Breast Cancer: A Systematic Review and Meta-Analysis.

J Clin Oncol 2016 09 25;34(26):3157-65. Epub 2016 Jul 25.

Charles Guenancia, Annick Lefebvre, and Yves Cottin, University Hospital; Charles Guenancia, Marianne Zeller, Luc Rochette, Yves Cottin, and Catherine Vergely, Institut National de la Santé et de la Recherche Médicale, U866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques; Sylvain Ladoire and François Ghiringhelli, Georges François Leclerc Cancer Center; Sylvain Ladoire and François Ghiringhelli, Institut National de la Santé et de la Recherche Médicale, CRI-866, University of Burgundy, Dijon; Annick Lefebvre, University Hospital, Reims, France; Daniela Cardinale, European Institute of Oncology, Milan, Italy; and Anthony F. Yu, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.67.4846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569689PMC
September 2016
46 Reads
7 Citations
18.430 Impact Factor

Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice.

Sci Rep 2016 07 28;6:30817. Epub 2016 Jul 28.

Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne Franche-Comté, Dijon, France.

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http://dx.doi.org/10.1038/srep30817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964358PMC
July 2016
7 Reads
2 Citations
5.080 Impact Factor

New-Onset Atrial Fibrillation in Sepsis: So Common, but So Different.

Crit Care Med 2016 May;44(5):e306-7

Department of Cardiology, University Hospital, Dijon, France, and INSERM, U866, Dijon, France Department of Cardiology, University Hospital, Dijon, France, and CNRS, UMR 5158, Le2I, Dijon, France Intensive Care Unit, University Hospital, Dijon, France INSERM, U866, Dijon, France, INSERM, CIE 1, Dijon, France, and Intensive Care Unit, University Hospital, Dijon, France.

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http://dx.doi.org/10.1097/CCM.0000000000001541DOI Listing
May 2016
1 Read
1 Citation
6.312 Impact Factor

Letter to the editor: "Doxorubicin and ErbB2 overexpression: another piece in the mitochondrial jigsaw".

Am J Physiol Heart Circ Physiol 2016 05;310(9):H1275-6

Institut national de la santé et de la recherche médicale UMR866, University of Bourgogne-Franche Comté, Laboratoire de Physiopathologie et Pharmacologie Cardio-métaboliques, Faculties of Health Sciences, Dijon, France; and

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http://dx.doi.org/10.1152/ajpheart.00179.2016DOI Listing
May 2016
2 Reads
3.840 Impact Factor

Incidence and Predictors of New-Onset Silent Atrial Fibrillation after Coronary Artery Bypass Graft Surgery.

Biomed Res Int 2015 28;2015:703685. Epub 2015 Jul 28.

University Hospital, Department of Cardiothoracic Surgery, 21000 Dijon, France ; CNRS, UMR 5158, Le2I, 21000 Dijon, France.

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http://dx.doi.org/10.1155/2015/703685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531157PMC
April 2016
8 Reads
2 Citations

Overweight in mice, induced by perinatal programming, exacerbates doxorubicin and trastuzumab cardiotoxicity.

Cancer Chemother Pharmacol 2016 Apr 25;77(4):777-85. Epub 2016 Feb 25.

Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Inserm UMR866, Faculties of Health Sciences, University of Bourgogne-Franche-Comte, 7 Bd Jeanne d'Arc, 21000, Dijon, France.

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http://dx.doi.org/10.1007/s00280-016-2995-9DOI Listing
April 2016
41 Reads
2 Citations
2.770 Impact Factor

Atrial Fibrillation Is Associated with a Marker of Endothelial Function and Oxidative Stress in Patients with Acute Myocardial Infarction.

PLoS One 2015 9;10(7):e0131439. Epub 2015 Jul 9.

Laboratory of Cardiometabolic Physiopathology and Pharmacology, UMR INSERM U866, University of Burgundy, Dijon, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131439PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497674PMC
April 2016
86 Reads
5 Citations
3.234 Impact Factor

Incidence and Predictors of New-Onset Atrial Fibrillation in Septic Shock Patients in a Medical ICU: Data from 7-Day Holter ECG Monitoring.

PLoS One 2015 12;10(5):e0127168. Epub 2015 May 12.

INSERM, UMR866, LPPCM, Dijon, France; INSERM, CIC1432, Clinical epidemiology unit, Dijon, France; University Hospital, Intensive Care Unit, Dijon, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127168PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428753PMC
February 2016
8 Reads
7 Citations
3.234 Impact Factor

Pre-operative growth differentiation factor 15 as a novel biomarker of acute kidney injury after cardiac bypass surgery.

Int J Cardiol 2015 Oct 17;197:66-71. Epub 2015 Jun 17.

University Hospital, Department of Cardiothoracic Surgery, Dijon, France.

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http://dx.doi.org/10.1016/j.ijcard.2015.06.012DOI Listing
October 2015
27 Reads
6 Citations
4.040 Impact Factor

Low Circulating Levels of Growth Differentiation Factor-15 Before Coronary Artery Bypass Surgery May Predict Postoperative Atrial Fibrillation.

J Cardiothorac Vasc Anesth 2015 Oct 9;29(5):1131-9. Epub 2015 Jan 9.

Department of Cardiology, University Hospital, Dijon, France; CNRS, UMR 5158, Le2I, Dijon, France.

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http://dx.doi.org/10.1053/j.jvca.2015.01.023DOI Listing
October 2015
26 Reads
2 Citations
1.482 Impact Factor

N-Terminal Fragment of Pro B-type Natriuretic Peptide as a Marker of Contrast-Induced Nephropathy After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction.

Am J Cardiol 2015 Sep 25;116(6):865-71. Epub 2015 Jun 25.

Laboratoire de Physiopathologie et Pharmacologie Cardiométaboliques, INSERM UMR866, Université de Bourgogne-Franche Comté, Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2015.06.007DOI Listing
September 2015
24 Reads
3 Citations
3.280 Impact Factor

Prognosis of silent atrial fibrillation after acute myocardial infarction at 1-year follow-up.

Heart 2015 Jun 22;101(11):864-9. Epub 2015 Apr 22.

Cardiology Department, University Hospital, Dijon, France.

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http://dx.doi.org/10.1136/heartjnl-2014-307253DOI Listing
June 2015
8 Reads
4 Citations
5.595 Impact Factor

Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.

PLoS One 2014 29;9(8):e105759. Epub 2014 Aug 29.

Institut National de la Santé et de la Recherche Médicale (Inserm) U866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne, Facultés des Sciences de la Santé, Dijon, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105759PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149498PMC
June 2015
12 Reads
10 Citations
3.234 Impact Factor

Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms.

Trends Pharmacol Sci 2015 Jun 17;36(6):326-48. Epub 2015 Apr 17.

Laboratoire de Physiopathologie et Pharmacologie Cardio-métaboliques (LPPCM), Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche 866, Facultés de Médecine et de Pharmacie - Université de Bourgogne, 7 Boulevard Jeanne d'Arc, 21033 Dijon, France.

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http://dx.doi.org/10.1016/j.tips.2015.03.005DOI Listing
June 2015
68 Reads
24 Citations
11.540 Impact Factor

Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice.

Toxicol Appl Pharmacol 2015 Apr 21;284(2):152-62. Epub 2015 Feb 21.

INSERM UMR866, University of Burgundy, LPPCM, Faculties of Medicine and Pharmacy, Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.02.015DOI Listing
April 2015
6 Reads
5 Citations
3.705 Impact Factor

The iron-regulatory hormone hepcidin: a possible therapeutic target?

Pharmacol Ther 2015 Feb 7;146:35-52. Epub 2014 Sep 7.

Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM) Inserm UMR866, Facultés de Médecine et de Pharmacie, Université de Bourgogne, 7 Bld Jeanne d'Arc, 21033 DIJON, France.

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http://dx.doi.org/10.1016/j.pharmthera.2014.09.004DOI Listing
February 2015
3 Reads
9 Citations
9.723 Impact Factor

Smokeless tobacco, sport and the heart.

Arch Cardiovasc Dis 2015 Jan 12;108(1):75-83. Epub 2014 Nov 12.

Laboratory of Cardiometabolic Physiopathology and Pharmacology, INSERM U866, University of Burgundy, Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.acvd.2014.10.003DOI Listing
January 2015
10 Reads
3 Citations

Frequency and predictors of stroke after acute myocardial infarction: specific aspects of in-hospital and postdischarge events.

Stroke 2014 Dec 4;45(12):3514-20. Epub 2014 Nov 4.

From the Department of Cardiology, University Hospital, Dijon, France (H.O., G.C., S.K., R.C., Y.V., G.A., C.Y., L.L.); LPPCM, INSERM U866, University of Burgundy, Dijon, France (H.O., G.C., S.K., R.C., G.A., C.Y., L.L.); and The Dijon Stroke Registry (EA 4184), University of Burgundy, University Hospital and Faculty of Medicine of Dijon, Dijon, France (D.B., B.Y., G.M.).

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http://dx.doi.org/10.1161/STROKEAHA.114.006707DOI Listing
December 2014
21 Reads
4 Citations
5.723 Impact Factor

Obesity and new-onset atrial fibrillation in acute myocardial infarction: a gender specific risk factor.

Int J Cardiol 2014 Oct 12;176(3):1039-41. Epub 2014 Aug 12.

Laboratory of Cardiometabolic Physiopathology and Pharmacology, UMR INSERM U866, University of Burgundy, Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2014.07.291DOI Listing
October 2014
12 Reads
3 Citations
4.040 Impact Factor

Iron, oxidative stress, and redox signaling in the cardiovascular system.

Mol Nutr Food Res 2014 Aug 30;58(8):1721-38. Epub 2014 May 30.

Laboratoire de Physiopathologie et Pharmacologie Cardio-métaboliques (LPPCM) Inserm UMR866, Facultés de Médecine et de Pharmacie, Université de Bourgogne, Dijon, France; Service de Cardiologie CHU Bocage, Dijon, France.

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http://dx.doi.org/10.1002/mnfr.201400036DOI Listing
August 2014
21 Reads
3 Citations
4.603 Impact Factor

Incidence and prognostic significance of silent atrial fibrillation in acute myocardial infarction.

Int J Cardiol 2014 Jul 22;174(3):611-7. Epub 2014 Apr 22.

Cardiology Department, University Hospital, Dijon, France.

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http://dx.doi.org/10.1016/j.ijcard.2014.04.158DOI Listing
July 2014
21 Reads
4 Citations
4.040 Impact Factor

Prognostic value of fragmented QRS on a 12-lead ECG in patients with acute myocardial infarction.

Heart Lung 2013 Sep-Oct;42(5):326-31. Epub 2013 Jul 11.

Department of Cardiology, University Hospital, Dijon, France.

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http://dx.doi.org/10.1016/j.hrtlng.2013.05.005DOI Listing
February 2014
52 Reads
7 Citations
1.320 Impact Factor

Postnatal overfeeding causes early shifts in gene expression in the heart and long-term alterations in cardiometabolic and oxidative parameters.

PLoS One 2013 26;8(2):e56981. Epub 2013 Feb 26.

Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Faculties of Medicine and Pharmacy, University of Burgundy, Dijon, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056981PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582632PMC
August 2013
18 Reads
6 Citations
3.234 Impact Factor

Predictors of post-stress LVEF drop 6 months after reperfused myocardial infarction: a gated myocardial perfusion SPECT study.

Ann Nucl Med. 2013 Feb;27(2):112-22

Ann Nucl Med.

OBJECTIVE: To identify the predictive factors of myocardial stunning as assessed by the drop in post-stress Left Ventricular Ejection Fraction (LVEF) in patients with a recent history of myocardial infarction (MI). METHODS: We prospectively included 215 consecutive patients admitted for acute MI who underwent percutaneous coronary intervention with a greater than or equal to grade-3 TIMI flow in the culprit vessel. Six months after discharge, a post-stress/rest 99mTc-sestamibi gated SPECT was performed. The perfusion score was evaluated visually using a 17-segment model. The LVEF drop was considered significant if the post-stress LVEF was ≥ 5% below the rest LVEF (QGS® software). RESULTS: A post-stress LVEF drop was observed in 51 (24%) patients. Patients with an LVEF drop were more likely than patients with a stable post-stress LVEF to have diabetes (22% vs. 10%, p = 0.048), significant ischemia (SDS > 2) (51% vs. 28% p = 0.003) and higher rest LVEF [62% (56-69) vs. 56% (49-63) p < 0.001]. In contrast, summed rest score, related to infarct size, did not differ between the groups. Multivariate logistic regression analysis identified SDS > 2 (OR 3.78, 95% CI 1.8-7.92, p < 0.001), diabetes (OR 3.35, 95% CI 1.33-8.49; p = 0.011) and rest LVEF (OR 1.08, 95% CI 1.04-1.12, p < 0.001) as independent explanatory variables of an LVEF drop. CONCLUSION: In patients with recent MI and post-procedural grade-3 TIMI flow, ischemia and diabetes were independent predictive factors of myocardial stunning. The higher incidence of reversible perfusion abnormalities validates the model of myocardial stunning in the post-MI period, and excludes the potential involvement of myocardial necrosis.

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February 2013
3 Reads

Top co-authors

Yves Cottin
Yves Cottin

University Hospital

23
Marianne Zeller
Marianne Zeller

University of Burgundy

16
Catherine Vergely
Catherine Vergely

Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM)

13
Luc Lorgis
Luc Lorgis

University Hospital

12
Karim Stamboul
Karim Stamboul

University Hospital

11
Luc Rochette
Luc Rochette

Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques

11
Olivier Hachet
Olivier Hachet

University of Lausanne

9
Aurelie Gudjoncik
Aurelie Gudjoncik

University Hospital

8
Fabien Garnier
Fabien Garnier

Laboratoire de Bactériologie-Virologie-Hygiène

7
Gabriel Laurent
Gabriel Laurent

Keenan Research Center

6