Charles G Mullighan

Charles G Mullighan

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Charles G Mullighan

Publications by authors named "Charles G Mullighan"

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Immunophenotyping of Murine Precursor B-Cell Leukemia/Lymphoma: A Comparison of Immunohistochemistry and Flow Cytometry.

Vet Pathol 2019 11 6;56(6):950-958. Epub 2019 Jun 6.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1177/0300985819852138DOI Listing
November 2019

The Biology of B-Progenitor Acute Lymphoblastic Leukemia.

Cold Spring Harb Perspect Med 2019 Oct 25. Epub 2019 Oct 25.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1101/cshperspect.a034835DOI Listing
October 2019

Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia.

Cancer Res 2019 May 12;79(9):2339-2351. Epub 2019 Mar 12.

Department of Pediatrics, Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497548PMC
May 2019

Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability.

Leukemia 2019 02 25;33(2):457-468. Epub 2018 Jul 25.

Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1038/s41375-018-0206-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365384PMC
February 2019

ShinyCNV: a Shiny/R application to view and annotate DNA copy number variations.

Bioinformatics 2019 01;35(1):126-129

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298054PMC
January 2019

IGF1 Brings Growing Pains for T-ALL LSCs.

Cell Stem Cell 2018 11;23(5):632-633

Department of Pathology and the Hematological Malignancy Program, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.022DOI Listing
November 2018

Drugging DNA repair to target T-ALL cells.

Leuk Lymphoma 2018 07 8;59(7):1746-1749. Epub 2017 Nov 8.

a Department of Microbiology and Immunology, Fels Institute for Cancer Research & Molecular Biology , Temple University Lewis Katz School of Medicine , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/10428194.2017.1397662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940588PMC
July 2018

TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

J Clin Oncol 2018 02 4;36(6):591-599. Epub 2018 Jan 4.

Maoxiang Qian, Xueyuan Cao, Wenjian Yang, Cheng Cheng, Hui Zhang, Takaya Moriyama, Gerard Zambetti, Kim E. Nichols, Ching-Hon Pui, Charles G. Mullighan, William E. Evans, Mary V. Relling, and Jun J. Yang, St Jude Children's Research Hospital, Memphis, TN; Meenakshi Devidas and Yunfeng Dai, University of Florida, Gainesville, FL; Andrew Carroll, University of Alabama at Birmingham, Birmingham, AL; Nyla A. Heerema and Julie M. Gastier-Foster, The Ohio State University and Wexner Medical Center; Julie M. Gastier-Foster and Elaine R. Mardis, Nationwide Children's Hospital, Columbus, OH; Hui Zhang, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong; Heng Xu, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China; Elizabeth Raetz, University of Utah, Salt Lake City, UT; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; W. Paul Bowman, Cook Children's Medical Center, Fort Worth, TX; Paul L. Martin, Duke University, Durham, NC; Robert Fulton, Washington University School of Medicine, St Louis, MO; Michael Borowitz, Johns Hopkins Medical Institute, Baltimore, MD; Brent Wood, University of Washington, Seattle, WA; William L. Carroll, New York University, New York, NY; Stephen P. Hunger, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; and Mignon L. Loh, Benioff Children's Hospital and University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1200/JCO.2017.75.5215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815403PMC
February 2018

Integration of Next-Generation Sequencing to Treat Acute Lymphoblastic Leukemia with Targetable Lesions: The St. Jude Children's Research Hospital Approach.

Front Pediatr 2017 4;5:258. Epub 2017 Dec 4.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States.

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http://dx.doi.org/10.3389/fped.2017.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722984PMC
December 2017

The genomic landscape of pediatric myelodysplastic syndromes.

Nat Commun 2017 11 16;8(1):1557. Epub 2017 Nov 16.

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41467-017-01590-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691144PMC
November 2017

Philadelphia Chromosome-like Acute Lymphoblastic Leukemia.

Clin Lymphoma Myeloma Leuk 2017 08;17(8):464-470

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN.

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https://linkinghub.elsevier.com/retrieve/pii/S21522650173058
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http://dx.doi.org/10.1016/j.clml.2017.03.299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638138PMC
August 2017

Mutations in Hypodiploid Acute Lymphoblastic Leukemia.

Cold Spring Harb Perspect Med 2017 Mar 1;7(3). Epub 2017 Mar 1.

Departments of Pathology and the Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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http://dx.doi.org/10.1101/cshperspect.a026286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334249PMC
March 2017

Genetic Basis of Acute Lymphoblastic Leukemia.

J Clin Oncol 2017 Mar 13;35(9):975-983. Epub 2017 Feb 13.

All authors: St Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2016.70.7836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455679PMC
March 2017

Ikaros: Exploiting and targeting the hematopoietic stem cell niche in B-progenitor acute lymphoblastic leukemia.

Exp Hematol 2017 Feb 16;46:1-8. Epub 2016 Nov 16.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241204PMC
February 2017

High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.

J Clin Oncol 2017 Feb 21;35(4):394-401. Epub 2016 Nov 21.

Kathryn G. Roberts, Zhaohui Gu, Debbie Payne-Turner, Kelly McCastlain, Deqing Pei, Ilaria Iacobucci, Marcus Valentine, Stanley B. Pounds, Lei Shi, Yongjin Li, Jinghui Zhang, Cheng Cheng, and Charles G. Mullighan, St Jude Children's Research Hospital, Memphis, TN; Richard C. Harvey, I-Ming Chen, and Cheryl L. Willman, University of New Mexico Cancer Center, Albuquerque, NM; Alessandro Rambaldi, Manuela Tosi, and Orietta Spinelli, Ospedale Papa Giovanni XXIII, Bergamo, Italy; Jerald P. Radich, Fred Hutchinson Cancer Research Center, Seattle, WA; Mark D. Minden, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Jacob M. Rowe, Shaare Zedek Medical Center, Jerusalem, Israel; Selina Luger, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mark R. Litzow, Mayo Clinic, Rochester, MN; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York; Peter H. Wiernik, Cancer Research Foundation of New York; Elisabeth Paietta, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; Ravi Bhatia, The University of Alabama at Birmingham, Birmingham, AL; Ibrahim Aldoss and Guido Marcucci, City of Hope, Duarte, CA; Jessica Kohlschmidt, Krzysztof Mrózek, and Clara D. Bloomfield, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; Wendy Stock, University of Chicago Medical Center, Chicago, IL; and Stephen Kornblau, Hagop M. Kantarjian, and Marina Konopleva, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.69.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455698PMC
February 2017

Advances in the Genetics and Therapy of Acute Lymphoblastic Leukemia.

Am Soc Clin Oncol Educ Book 2016 ;35:e314-22

From the Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy; Chao Family Comprehensive Cancer Center, School of Medicine, University of California, Irvine, CA; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1200/EDBK_156628DOI Listing
January 2017

Acute Leukemias in Children.

Arch Med Res 2016 11;47(8):583-584

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1016/j.arcmed.2017.01.005DOI Listing
November 2016

Welcoming a new age for gene therapy in hematology.

Blood 2016 05 6;127(21):2523-4. Epub 2016 Apr 6.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/blood-2016-03-678714DOI Listing
May 2016

Acute Lymphoblastic Leukemia in Children.

N Engl J Med 2015 Oct;373(16):1541-52

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http://www.nejm.org/doi/10.1056/NEJMra1400972
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http://dx.doi.org/10.1056/NEJMra1400972DOI Listing
October 2015

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):2938-48. Epub 2015 Aug 24.

Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel; Gabriele Escherich, Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Andrea Biondi, Clinica Pediatrica and Centro Ricerca Tettamanti, Università di Milano-Bicocca, Monza, Italy; Ajay Vora, Children's Cancer Group, School of Cancer, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; André Baruchel, Hôpital Robert Debré and University of Paris Diderot, Paris, France; Lewis B. Silverman, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA; Kjeld Schmiegelow, Institute of Clinical Medicine, University of Copenhagen and Juliane Marie Centre, the University Hospital Rigshospitalet, Copenhagen, Denmark; Keizo Horibe, Nagoya Medical Center, Clinical Research Center, Nagoya, Japan; Yves C.M. Benoit, Universiteit Gent, Gent, Belgium; Shai Izraeli, Chaim Sheba Medical Center and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Allen Eng Juh Yeoh, Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore; and Der-Cherng Liang, Mackay Memorial Hospital, Taipei, Taiwan.

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http://jco.ascopubs.org/content/early/2015/08/21/JCO.2014.59
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http://200.40.135.66:90/toc/0873/2015/0873-20150920-27-01.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.1636
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http://dx.doi.org/10.1200/JCO.2014.59.1636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567699PMC
September 2015

Genomics in acute lymphoblastic leukaemia: insights and treatment implications.

Nat Rev Clin Oncol 2015 Jun 17;12(6):344-57. Epub 2015 Mar 17.

Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/nrclinonc.2015.38DOI Listing
June 2015

CONSERTING: integrating copy-number analysis with structural-variation detection.

Nat Methods 2015 Jun 4;12(6):527-30. Epub 2015 May 4.

1] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. [2] Pediatric Cancer Genome Project, St. Jude Children's Research Hospital and Washington University School of Medicine, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nmeth.3394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591043PMC
June 2015

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine.

Blood 2015 Jun 21;125(26):3977-87. Epub 2015 May 21.

Department of Pathology and the Hematological Malignancies Program, St. Jude Children's Research Hospital Memphis, TN.

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http://dx.doi.org/10.1182/blood-2015-02-580043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481590PMC
June 2015

Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia.

Nat Med 2015 Jun;21(6):553-4

Department of Pathology and the Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nm.3876DOI Listing
June 2015

Generation of human acute lymphoblastic leukemia xenografts for use in oncology drug discovery.

Curr Protoc Pharmacol 2015 Mar 2;68:14.32.1-19. Epub 2015 Mar 2.

Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee; The Beijer Laboratory for Gene and Neurosciences, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1002/0471141755.ph1432s68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369388PMC
March 2015

The genomic landscape of acute lymphoblastic leukemia in children and young adults.

Hematology Am Soc Hematol Educ Program 2014 Dec 18;2014(1):174-80. Epub 2014 Nov 18.

Department of Pathology and Hematological Malignancies Program, St Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/asheducation-2014.1.174DOI Listing
December 2014

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

Nature 2014 Oct 17;514(7523):513-7. Epub 2014 Aug 17.

1] Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York 10016, USA [2] NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nature13605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209203PMC
October 2014

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.

Genes Dev 2014 Jun;28(12):1337-50

Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia;

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http://dx.doi.org/10.1101/gad.240416.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066403PMC
June 2014

Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.

J Exp Med 2014 Apr 31;211(4):701-13. Epub 2014 Mar 31.

Department of Hematology and 2 Department of Pathology, Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105.

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http://www.jem.org/lookup/doi/10.1084/jem.20122727
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http://dx.doi.org/10.1084/jem.20122727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978278PMC
April 2014

Genomic characterization of childhood acute lymphoblastic leukemia.

Semin Hematol 2013 Oct 4;50(4):314-24. Epub 2013 Oct 4.

Department of Pathology and the Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2013.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848419PMC
October 2013