Publications by authors named "Charles G Mullighan"

100Publications

Pediatric acute lymphoblastic leukemia.

Haematologica 2020 Sep 10;Online ahead of print. Epub 2020 Sep 10.

Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.3324/haematol.2020.247031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604619PMC
September 2020

Molecular markers in ALL: Clinical implications.

Best Pract Res Clin Haematol 2020 Sep 7;33(3):101193. Epub 2020 Jun 7.

Department of Pathology, Hematological Malignancies Program, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, 38105, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2020.101193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548398PMC
September 2020

Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies.

Blood 2020 Nov;136(20):2275-2289

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/blood.2020007093DOI Listing
November 2020

Integrative genomic analysis of B-lymphoblastic lymphoma with intrachromosomal amplification of chromosome 21.

Pediatr Blood Cancer 2020 09 29;67(9):e28357. Epub 2020 May 29.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.28357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674224PMC
September 2020

How advanced are we in targeting novel subtypes of ALL?

Best Pract Res Clin Haematol 2019 12 18;32(4):101095. Epub 2019 Oct 18.

Department of Pathology, Hematological Malignancies Program, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, 38105, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2019.101095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927537PMC
December 2019

The Biology of B-Progenitor Acute Lymphoblastic Leukemia.

Cold Spring Harb Perspect Med 2020 07 1;10(7). Epub 2020 Jul 1.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1101/cshperspect.a034835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328455PMC
July 2020

Immunophenotyping of Murine Precursor B-Cell Leukemia/Lymphoma: A Comparison of Immunohistochemistry and Flow Cytometry.

Vet Pathol 2019 11 6;56(6):950-958. Epub 2019 Jun 6.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1177/0300985819852138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140381PMC
November 2019

Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia.

Cancer Res 2019 05 12;79(9):2339-2351. Epub 2019 Mar 12.

Department of Pediatrics, Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497548PMC
May 2019

ShinyCNV: a Shiny/R application to view and annotate DNA copy number variations.

Bioinformatics 2019 01;35(1):126-129

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298054PMC
January 2019

IGF1 Brings Growing Pains for T-ALL LSCs.

Cell Stem Cell 2018 11;23(5):632-633

Department of Pathology and the Hematological Malignancy Program, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.022DOI Listing
November 2018

Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability.

Leukemia 2019 02 25;33(2):457-468. Epub 2018 Jul 25.

Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1038/s41375-018-0206-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365384PMC
February 2019

TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

J Clin Oncol 2018 02 4;36(6):591-599. Epub 2018 Jan 4.

Maoxiang Qian, Xueyuan Cao, Wenjian Yang, Cheng Cheng, Hui Zhang, Takaya Moriyama, Gerard Zambetti, Kim E. Nichols, Ching-Hon Pui, Charles G. Mullighan, William E. Evans, Mary V. Relling, and Jun J. Yang, St Jude Children's Research Hospital, Memphis, TN; Meenakshi Devidas and Yunfeng Dai, University of Florida, Gainesville, FL; Andrew Carroll, University of Alabama at Birmingham, Birmingham, AL; Nyla A. Heerema and Julie M. Gastier-Foster, The Ohio State University and Wexner Medical Center; Julie M. Gastier-Foster and Elaine R. Mardis, Nationwide Children's Hospital, Columbus, OH; Hui Zhang, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong; Heng Xu, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China; Elizabeth Raetz, University of Utah, Salt Lake City, UT; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; W. Paul Bowman, Cook Children's Medical Center, Fort Worth, TX; Paul L. Martin, Duke University, Durham, NC; Robert Fulton, Washington University School of Medicine, St Louis, MO; Michael Borowitz, Johns Hopkins Medical Institute, Baltimore, MD; Brent Wood, University of Washington, Seattle, WA; William L. Carroll, New York University, New York, NY; Stephen P. Hunger, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; and Mignon L. Loh, Benioff Children's Hospital and University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1200/JCO.2017.75.5215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815403PMC
February 2018

Integration of Next-Generation Sequencing to Treat Acute Lymphoblastic Leukemia with Targetable Lesions: The St. Jude Children's Research Hospital Approach.

Front Pediatr 2017 4;5:258. Epub 2017 Dec 4.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States.

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http://dx.doi.org/10.3389/fped.2017.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722984PMC
December 2017

The genomic landscape of pediatric myelodysplastic syndromes.

Nat Commun 2017 11 16;8(1):1557. Epub 2017 Nov 16.

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41467-017-01590-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691144PMC
November 2017

Drugging DNA repair to target T-ALL cells.

Leuk Lymphoma 2018 07 8;59(7):1746-1749. Epub 2017 Nov 8.

a Department of Microbiology and Immunology, Fels Institute for Cancer Research & Molecular Biology , Temple University Lewis Katz School of Medicine , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/10428194.2017.1397662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940588PMC
July 2018

Philadelphia Chromosome-like Acute Lymphoblastic Leukemia.

Clin Lymphoma Myeloma Leuk 2017 08;17(8):464-470

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN.

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https://linkinghub.elsevier.com/retrieve/pii/S21522650173058
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http://dx.doi.org/10.1016/j.clml.2017.03.299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638138PMC
August 2017

Acute Leukemias in Children.

Arch Med Res 2016 11;47(8):583-584

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1016/j.arcmed.2017.01.005DOI Listing
November 2016

Genetic Basis of Acute Lymphoblastic Leukemia.

J Clin Oncol 2017 Mar 13;35(9):975-983. Epub 2017 Feb 13.

All authors: St Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2016.70.7836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455679PMC
March 2017

Mutations in Hypodiploid Acute Lymphoblastic Leukemia.

Cold Spring Harb Perspect Med 2017 Mar 1;7(3). Epub 2017 Mar 1.

Departments of Pathology and the Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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http://dx.doi.org/10.1101/cshperspect.a026286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334249PMC
March 2017

High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.

J Clin Oncol 2017 Feb 21;35(4):394-401. Epub 2016 Nov 21.

Kathryn G. Roberts, Zhaohui Gu, Debbie Payne-Turner, Kelly McCastlain, Deqing Pei, Ilaria Iacobucci, Marcus Valentine, Stanley B. Pounds, Lei Shi, Yongjin Li, Jinghui Zhang, Cheng Cheng, and Charles G. Mullighan, St Jude Children's Research Hospital, Memphis, TN; Richard C. Harvey, I-Ming Chen, and Cheryl L. Willman, University of New Mexico Cancer Center, Albuquerque, NM; Alessandro Rambaldi, Manuela Tosi, and Orietta Spinelli, Ospedale Papa Giovanni XXIII, Bergamo, Italy; Jerald P. Radich, Fred Hutchinson Cancer Research Center, Seattle, WA; Mark D. Minden, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Jacob M. Rowe, Shaare Zedek Medical Center, Jerusalem, Israel; Selina Luger, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mark R. Litzow, Mayo Clinic, Rochester, MN; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York; Peter H. Wiernik, Cancer Research Foundation of New York; Elisabeth Paietta, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; Ravi Bhatia, The University of Alabama at Birmingham, Birmingham, AL; Ibrahim Aldoss and Guido Marcucci, City of Hope, Duarte, CA; Jessica Kohlschmidt, Krzysztof Mrózek, and Clara D. Bloomfield, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; Wendy Stock, University of Chicago Medical Center, Chicago, IL; and Stephen Kornblau, Hagop M. Kantarjian, and Marina Konopleva, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.69.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455698PMC
February 2017

Ikaros: Exploiting and targeting the hematopoietic stem cell niche in B-progenitor acute lymphoblastic leukemia.

Exp Hematol 2017 Feb 16;46:1-8. Epub 2016 Nov 16.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241204PMC
February 2017

Advances in the Genetics and Therapy of Acute Lymphoblastic Leukemia.

Am Soc Clin Oncol Educ Book 2016 ;35:e314-22

From the Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy; Chao Family Comprehensive Cancer Center, School of Medicine, University of California, Irvine, CA; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1200/EDBK_156628DOI Listing
January 2017

Welcoming a new age for gene therapy in hematology.

Blood 2016 05 6;127(21):2523-4. Epub 2016 Apr 6.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/blood-2016-03-678714DOI Listing
May 2016

Acute Lymphoblastic Leukemia in Children.

N Engl J Med 2015 Oct;373(16):1541-52

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http://www.nejm.org/doi/10.1056/NEJMra1400972
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http://dx.doi.org/10.1056/NEJMra1400972DOI Listing
October 2015

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):2938-48. Epub 2015 Aug 24.

Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel; Gabriele Escherich, Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Andrea Biondi, Clinica Pediatrica and Centro Ricerca Tettamanti, Università di Milano-Bicocca, Monza, Italy; Ajay Vora, Children's Cancer Group, School of Cancer, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; André Baruchel, Hôpital Robert Debré and University of Paris Diderot, Paris, France; Lewis B. Silverman, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA; Kjeld Schmiegelow, Institute of Clinical Medicine, University of Copenhagen and Juliane Marie Centre, the University Hospital Rigshospitalet, Copenhagen, Denmark; Keizo Horibe, Nagoya Medical Center, Clinical Research Center, Nagoya, Japan; Yves C.M. Benoit, Universiteit Gent, Gent, Belgium; Shai Izraeli, Chaim Sheba Medical Center and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Allen Eng Juh Yeoh, Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore; and Der-Cherng Liang, Mackay Memorial Hospital, Taipei, Taiwan.

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http://jco.ascopubs.org/content/early/2015/08/21/JCO.2014.59
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http://200.40.135.66:90/toc/0873/2015/0873-20150920-27-01.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.1636
Publisher Site
http://dx.doi.org/10.1200/JCO.2014.59.1636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567699PMC
September 2015

Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia.

Nat Med 2015 Jun;21(6):553-4

Department of Pathology and the Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nm.3876DOI Listing
June 2015

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine.

Blood 2015 Jun 21;125(26):3977-87. Epub 2015 May 21.

Department of Pathology and the Hematological Malignancies Program, St. Jude Children's Research Hospital Memphis, TN.

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http://dx.doi.org/10.1182/blood-2015-02-580043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481590PMC
June 2015

CONSERTING: integrating copy-number analysis with structural-variation detection.

Nat Methods 2015 Jun 4;12(6):527-30. Epub 2015 May 4.

1] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. [2] Pediatric Cancer Genome Project, St. Jude Children's Research Hospital and Washington University School of Medicine, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nmeth.3394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591043PMC
June 2015