Charles G Irvin

Charles G Irvin

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Charles G Irvin

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BMI but not central obesity predisposes to airway closure during bronchoconstriction.

Respirology 2019 Jun 29;24(6):543-550. Epub 2019 Jan 29.

Division of Pulmonary and Critical Care Medicine, Vermont Lung Center, University of Vermont Larner College of Medicine, Burlington, VT, USA.

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http://dx.doi.org/10.1111/resp.13478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525043PMC
June 2019

Advancing Professional Development Through a Community of Practice: the New England Network for Faculty Affairs.

J Contin Educ Health Prof 2018 ;38(1):73-78

Ms. Power: Director, Office for Faculty Development, Dana-Farber Cancer Institute, Boston, MA. Dr. Thorndyke: Vice Provost for Faculty Affairs and Professor of Medicine, University of Massachusetts Medical School, Worcester, MA. Dr. Milner: Associate Vice Provost for Professional Development and Professor of Neurology, University of Massachusetts Medical School, Worcester, MA. Ms. Lowney: Assistant Dean for Faculty Affairs, Tufts University School of Medicine, Boston, MA. Dr. Irvin: Associate Dean for Faculty, College of Medicine, and Professor of Medicine, University of Vermont, Burlington, VT. Dr. Fonseca-Kelly: Assistant Dean for Science, Faculty of Arts and Sciences, Harvard University, Cambridge, MA. Dr. Benjamin: Assistant Provost for Faculty Development, Boston University Medical Campus, Vice Chair, Faculty Development and Diversity, Department of Medicine, Professor of Medicine and Epidemiology. Boston University Schools of Medicine and Public Health, Boston, MA.Ms. Bhasin: Director of Faculty Development, Boston University Medical Campus, Boston, MA. Dr. Connelly: Dean for Faculty Affairs, Assistant Professor, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA.

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http://Insights.ovid.com/crossref?an=00005141-201803810-0001
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http://dx.doi.org/10.1097/CEH.0000000000000186DOI Listing
May 2019

The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma.

Pharmacogenomics J 2018 09 3;18(5):665-677. Epub 2018 Jan 3.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41397-017-0006-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150906PMC
September 2018

Classifying the Severity of COPD: Are We There Yet? Editorial for "Coton, S. et al. Severity of Airflow Obstruction in Chronic Obstructive Pulmonary Disease (COPD): Proposal for a New Classification".

Authors:
Charles G Irvin

COPD 2017 10;14(5):463-464

a Department of Medicine, Vermont Lung Center, Robert Learner MD College of Medicine , University of Vermont , Burlington , VT , USA.

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http://dx.doi.org/10.1080/15412555.2017.1359244DOI Listing
October 2017

Chronic Rhinosinusitis and Structural Remodeling.

Authors:
Charles G Irvin

Am J Respir Cell Mol Biol 2017 09;57(3):265-266

1 Vermont Lung Center and Department of Medicine University of Vermont Burlington, Vermont.

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http://dx.doi.org/10.1165/rcmb.2017-0152EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625230PMC
September 2017

Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.

Am J Respir Crit Care Med 2017 05;195(10):1321-1332

3 Division of Hematology/Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona.

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http://dx.doi.org/10.1164/rccm.201606-1129OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443899PMC
May 2017

Fluctuation Analysis of Peak Expiratory Flow and Its Association with Treatment Failure in Asthma.

Am J Respir Crit Care Med 2017 Apr;195(8):993-999

1 Pulmonary and Critical Care, University of Vermont College of Medicine, Burlington, Vermont.

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http://dx.doi.org/10.1164/rccm.201601-0076OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803646PMC
April 2017

Interleukin-6 as a biomarker for asthma: hype or is there something else?

Eur Respir J 2016 10;48(4):979-981

Vermont Lung Center, Dept of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA

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http://dx.doi.org/10.1183/13993003.01597-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518110PMC
October 2016

Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma.

PLoS One 2015 17;10(6):e0129385. Epub 2015 Jun 17.

Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, United States of America; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129385PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470685PMC
April 2016

An epilogue to lung function and lung disease: state-of-the-art 2015.

Respirology 2015 Oct 3;20(7):1008-9. Epub 2015 Aug 3.

Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1111/resp.12601DOI Listing
October 2015

Reply: To PMID 25174863.

J Allergy Clin Immunol 2015 Jul 8;136(1):212-3. Epub 2015 May 8.

Department of Medicine, Johns Hopkins University, Baltimore, Md.

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http://dx.doi.org/10.1016/j.jaci.2015.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606190PMC
July 2015

What long-term changes in lung function can tell us about asthma control.

Curr Allergy Asthma Rep 2015 Mar;15(3):505

Pulmonary and Critical Care Medicine, College of Medicine, University of Vermont, Given D213, 89 Beaumont Avenue, Burlington, VT, 05405, USA,

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http://dx.doi.org/10.1007/s11882-014-0505-xDOI Listing
March 2015

Animal models of allergic airways disease: where are we and where to next?

J Cell Biochem 2014 Dec;115(12):2055-64

Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont; Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/jcb.24881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199895PMC
December 2014

Influence of distinct asthma phenotypes on lung function following weight loss in the obese.

Respirology 2014 Nov 19;19(8):1170-7. Epub 2014 Aug 19.

Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.

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http://dx.doi.org/10.1111/resp.12368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194162PMC
November 2014

Using lung function measurements to greater advantage in patients with lung disease: which test and when?

Respirology 2014 Aug 25;19(6):780-1. Epub 2014 Jun 25.

Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1111/resp.12331DOI Listing
August 2014

Assessing maximal exercise capacity: peak work or peak oxygen consumption?

Respir Care 2014 Jan 18;59(1):90-6. Epub 2013 Jun 18.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont.

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http://dx.doi.org/10.4187/respcare.02253DOI Listing
January 2014

Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation.

Am J Respir Cell Mol Biol 2013 Dec;49(6):1074-84

1 Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona.

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http://dx.doi.org/10.1165/rcmb.2013-0009OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931112PMC
December 2013

Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis.

Respir Res 2013 Dec 24;14:141. Epub 2013 Dec 24.

Department of Pathology, Vermont Lung Center University of Vermont College of Medicine, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1186/1465-9921-14-141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877992PMC
December 2013

Obesity in children with poorly controlled asthma: Sex differences.

Pediatr Pulmonol 2013 Sep 9;48(9):847-56. Epub 2012 Nov 9.

Division of Pulmonology, Allergy & Immunology, Nemours Children's Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1002/ppul.22707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578966PMC
September 2013

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.

Pharmacogenet Genomics 2013 Jun;23(6):324-8

Department of Medicine, Channing Division of Network Medicine, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283607acfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767309PMC
June 2013

Role of IL-6 in asthma and other inflammatory pulmonary diseases.

Int J Biol Sci 2012 25;8(9):1281-90. Epub 2012 Oct 25.

Department of Medicine, Immunobiology Division, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.7150/ijbs.4874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491451PMC
April 2013

Neutrophils, airway hyperresponsiveness and COPD: true, true and related?

Authors:
Charles G Irvin

Eur Respir J 2012 Nov;40(5):1067-9

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http://dx.doi.org/10.1183/09031936.00129912DOI Listing
November 2012

Obesity and asthma: an inflammatory disease of adipose tissue not the airway.

Am J Respir Crit Care Med 2012 Oct 26;186(7):598-605. Epub 2012 Jul 26.

Division of Pulmonary and Critical Care Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1164/rccm.201203-0573OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480522PMC
October 2012

Methacholine challenge test: diagnostic characteristics in asthmatic patients receiving controller medications.

J Allergy Clin Immunol 2012 Jul 1;130(1):69-75.e6. Epub 2012 Apr 1.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749120035
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http://dx.doi.org/10.1016/j.jaci.2012.02.025DOI Listing
July 2012

A role for sensory nerves in the late asthmatic response.

Thorax 2012 Jan 13;67(1):19-25. Epub 2011 Aug 13.

Respiratory Pharmacology Group, Pharmacology and Toxicology, National Heart and Lung Institute, Faculty of Medicine, London, UK.

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http://www.ariopharma.com/Raemdonck-et-al_Thorax-2011_Role-T
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http://thorax.bmj.com/content/67/1/19.full.pdf
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http://thorax.bmj.com/cgi/doi/10.1136/thoraxjnl-2011-200365
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http://dx.doi.org/10.1136/thoraxjnl-2011-200365DOI Listing
January 2012

Risk factors for montelukast treatment failure in step-down therapy for controlled asthma.

J Asthma 2011 Dec 27;48(10):1051-7. Epub 2011 Oct 27.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.3109/02770903.2011.627488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277696PMC
December 2011

Will the small airways rise again?

Authors:
Charles G Irvin

Am J Respir Crit Care Med 2011 Sep;184(5):499-501

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http://dx.doi.org/10.1164/rccm.201107-1188EDDOI Listing
September 2011

Oscillation mechanics of the respiratory system.

Compr Physiol 2011 Jul;1(3):1233-72

Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, USA.

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http://dx.doi.org/10.1002/cphy.c100058DOI Listing
July 2011

Complex systems in pulmonary medicine: a systems biology approach to lung disease.

J Appl Physiol (1985) 2011 Jun 23;110(6):1716-22. Epub 2010 Dec 23.

Pulmonary and Critical Care Medicine, Given D-213, 89 Beaumont Ave., Burlington, VT 05405, USA.

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http://dx.doi.org/10.1152/japplphysiol.01310.2010DOI Listing
June 2011

Asthma treatment through the beta receptor: lessons from animal models.

Front Biosci (Elite Ed) 2011 Jun 1;3:1201-8. Epub 2011 Jun 1.

Vermont Lung Center, College of Medicine, University of Vermont, Burlington, VT 05405-0075, USA.

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June 2011

Airway resistance: synonyms, surrogates, and precision.

Am J Physiol Lung Cell Mol Physiol 2011 Mar;300(3):L506; author reply L507

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http://dx.doi.org/10.1152/ajplung.00410.2010DOI Listing
March 2011

It's not all smooth muscle: non-smooth-muscle elements in control of resistance to airflow.

Annu Rev Physiol 2010 ;72:437-62

The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Providence Health Care/St. Paul's Hospital, Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC.

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http://dx.doi.org/10.1146/annurev-physiol-021909-135851DOI Listing
May 2010

It's much more than just pretty pictures.

Am J Respir Cell Mol Biol 2010 May;42(5):515-6

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http://dx.doi.org/10.1165/rcmb.2010-0085EDDOI Listing
May 2010

Airways hyperresponsiveness: a perspective from 15,000 ft.

Authors:
Charles G Irvin

J Appl Physiol (1985) 2010 Apr 4;108(4):765-6. Epub 2010 Feb 4.

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http://dx.doi.org/10.1152/japplphysiol.00103.2010DOI Listing
April 2010

Development of a Pharmacogenetic Predictive Test in asthma: proof of concept.

Pharmacogenet Genomics 2010 Feb;20(2):86-93

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215-5301, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32833428d0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654515PMC
February 2010

Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation.

Am J Physiol Lung Cell Mol Physiol 2010 Jan 6;298(1):L57-66. Epub 2009 Nov 6.

Department of Pathology, Univ. of Vermont, HSRF Bldg., Rm. 216A, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1152/ajplung.00037.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806198PMC
January 2010

Acid aspiration-induced airways hyperresponsiveness in mice.

J Appl Physiol (1985) 2009 Dec 1;107(6):1763-70. Epub 2009 Oct 1.

Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, Vermont, USA.

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http://dx.doi.org/10.1152/japplphysiol.00572.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793199PMC
December 2009

Anatomy, pathology, and physiology of the tracheobronchial tree: emphasis on the distal airways.

J Allergy Clin Immunol 2009 Dec;124(6 Suppl):S72-7

California National Primate Research Center, University of California, Davis, CA, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.08.048DOI Listing
December 2009

Animal models of asthma.

Am J Physiol Lung Cell Mol Physiol 2009 Sep 26;297(3):L401-10. Epub 2009 Jun 26.

Vermont Lung Center and Center for Immunology and Infectious Disease, University of Vermont College of Medicine, HSRF 228, 149 Beaumont Ave., Burlington, VT 05405-0075, USA.

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http://dx.doi.org/10.1152/ajplung.00027.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739768PMC
September 2009

Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers.

J Allergy Clin Immunol 2009 Sep 25;124(3):436-44, 444e1-8. Epub 2009 Jul 25.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, Md 21224, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948850PMC
September 2009

Physiologic dysfunction of the asthmatic lung: what's going on down there, anyway?

Proc Am Thorac Soc 2009 May;6(3):306-11

Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, VT 05405-0075, USA.

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http://dx.doi.org/10.1513/pats.200808-091RMDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677406PMC
May 2009

c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis.

Am J Respir Cell Mol Biol 2009 Apr 3;40(4):422-32. Epub 2008 Oct 3.

Department of Pathology, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0174OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660560PMC
April 2009

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response.

Pharmacogenet Genomics 2009 Feb;19(2):129-38

Nemours Children's Clinic, Pharmacogenetics Center, Nemours Biomedical Research, Jacksonville, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32831bd98cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641037PMC
February 2009

Lower airway disease in asthmatics with and without rhinitis.

Lung 2008 Nov-Dec;186(6):361-8. Epub 2008 Oct 9.

Department of Medicine, University of Vermont College of Medicine, Vermont Lung Center, HSRF 226, 149 Beaumont Avenue, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1007/s00408-008-9119-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826710PMC
January 2009

TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.

J Immunol 2008 Sep;181(6):4089-97

Department of Pediatrics, Lung Immunology and Host Defense Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638757PMC
http://dx.doi.org/10.4049/jimmunol.181.6.4089DOI Listing
September 2008

Dividing the FEV1 into its component parts.

J Appl Physiol (1985) 2008 Jul;105(1):392; author reply 393

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http://www.physiology.org/doi/10.1152/japplphysiol.90489.200
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http://dx.doi.org/10.1152/japplphysiol.90489.2008DOI Listing
July 2008

Computational assessment of airway wall stiffness in vivo in allergically inflamed mouse models of asthma.

J Appl Physiol (1985) 2008 Jun 17;104(6):1601-10. Epub 2008 Apr 17.

Vermont Lung center, University of Vermont College of Medicine, Burlington, VT, USA.

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http://dx.doi.org/10.1152/japplphysiol.01207.2007DOI Listing
June 2008

Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation.

Proc Natl Acad Sci U S A 2008 May 24;105(18):6690-5. Epub 2008 Apr 24.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1073/pnas.0708809105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373348PMC
May 2008

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1.

J Cell Sci 2008 Apr 11;121(Pt 7):1036-45. Epub 2008 Mar 11.

Department of Pathology, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1242/jcs.019455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876720PMC
April 2008

The synergistic interactions of allergic lung inflammation and intratracheal cationic protein.

Am J Respir Crit Care Med 2008 Feb 25;177(3):261-8. Epub 2007 Oct 25.

Vermont Lung Center, Burlington, Vermont, USA.

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http://dx.doi.org/10.1164/rccm.200706-832OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2218848PMC
February 2008

Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine.

J Appl Physiol (1985) 2008 Jan 18;104(1):10-9. Epub 2007 Oct 18.

Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1152/japplphysiol.00519.2007DOI Listing
January 2008

Unrestrained video-assisted plethysmography: a noninvasive method for assessment of lung mechanical function in small animals.

J Appl Physiol (1985) 2008 Jan 25;104(1):253-61. Epub 2007 Oct 25.

Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, USA.

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http://dx.doi.org/10.1152/japplphysiol.00737.2007DOI Listing
January 2008

Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease.

Am J Respir Crit Care Med 2007 Nov 29;176(10):974-82. Epub 2007 Aug 29.

Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1164/rccm.200702-334OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2078678PMC
November 2007

The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics.

Chest 2007 Sep 23;132(3):868-74. Epub 2007 Jul 23.

Department of Preventive Medicine, USC Keck School of Medicine, 2250 Alcazar St, IGM 206, Los Angeles, CA 90033, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001236921536652
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http://dx.doi.org/10.1378/chest.07-0831DOI Listing
September 2007