Publications by authors named "Charles G Drake"

100Publications

Differential Immune Modulation With Carbon-Ion Versus Photon Therapy.

Int J Radiat Oncol Biol Phys 2020 Nov 13. Epub 2020 Nov 13.

Department of Radiation Oncology, Columbia University Irving Medical Center, New York, New York; Department of Urology, Columbia University Medical Center, New York, New York; Department of Hematology Oncology, Columbia University Medical Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2020.09.053DOI Listing
November 2020

PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice.

Gastroenterology 2020 Oct 28. Epub 2020 Oct 28.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA;. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.10.036DOI Listing
October 2020

Kidney Cancer: An Overview of Current Therapeutic Approaches.

Urol Clin North Am 2020 Nov;47(4):419-431

Columbia Center for Translational Immunology, Columbia University Medical Center, 177 Fort Washington Avenue, Suite 6GN-435, New York, NY 10032, USA; Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 177 Fort Washington Avenue, Suite 6GN-435, New York, NY 10032, USA; Division of Hematology and Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 177 Fort Washington Avenue, Suite 6GN-435, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ucl.2020.07.009DOI Listing
November 2020

Impact of baseline serum IL-8 on metastatic hormone-sensitive prostate cancer outcomes in the Phase 3 CHAARTED trial (E3805).

Prostate 2020 Dec 19;80(16):1429-1437. Epub 2020 Sep 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, Lank Center for Genitourinary Oncology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/pros.24074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606809PMC
December 2020

Prostate carcinogenesis: inflammatory storms.

Nat Rev Cancer 2020 08 16;20(8):455-469. Epub 2020 Jun 16.

Institute of Oncology Research, Bellinzona, Switzerland.

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http://dx.doi.org/10.1038/s41568-020-0267-9DOI Listing
August 2020

Transcriptional profiling of tumor associated macrophages in human renal cell carcinoma reveals significant heterogeneity and opportunity for immunomodulation.

Am J Clin Exp Urol 2020 25;8(1):48-58. Epub 2020 Feb 25.

Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine and The Sidney Kimmel Comprehensive Cancer Center Baltimore, MD 21231, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076295PMC
February 2020

Putting the Pieces Together: Completing the Mechanism of Action Jigsaw for Sipuleucel-T.

J Natl Cancer Inst 2020 Jun;112(6):562-573

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/jnci/djaa021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301097PMC
June 2020

Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019.

Eur Urol 2020 04 27;77(4):508-547. Epub 2020 Jan 27.

University of Bern, Bern, Switzerland; Department of Medical Oncology and Haematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

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http://dx.doi.org/10.1016/j.eururo.2020.01.012DOI Listing
April 2020

Targeting PD-1 or PD-L1 in Metastatic Kidney Cancer: Combination Therapy in the First-Line Setting.

Clin Cancer Res 2020 May 16;26(9):2087-2095. Epub 2020 Jan 16.

Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3323DOI Listing
May 2020

A novel approach to assess real-world efficacy of cancer therapy in metastatic prostate cancer. Analysis of national data on Veterans treated with abiraterone and enzalutamide.

Semin Oncol 2019 Aug - Oct;46(4-5):351-361. Epub 2019 Nov 16.

James J. Peters Bronx Veterans Affairs Medical Center, Bronx, NY; Columbia University Herbert Irving Comprehensive Cancer Center, New York, NY. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2019.11.004DOI Listing
January 2020

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition.

J Immunother Cancer 2019 10 25;7(1):277. Epub 2019 Oct 25.

Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s40425-019-0758-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814994PMC
October 2019

A pilot trial of pembrolizumab plus prostatic cryotherapy for men with newly diagnosed oligometastatic hormone-sensitive prostate cancer.

Prostate Cancer Prostatic Dis 2020 03 14;23(1):184-193. Epub 2019 Oct 14.

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41391-019-0176-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031012PMC
March 2020

Combined Next-generation Sequencing and Flow Cytometry Analysis for an Anti-PD-L1 Partial Responder over Time: An Exploration of Mechanisms of PD-L1 Activity and Resistance in Bladder Cancer.

Eur Urol Oncol 2019 Feb 26. Epub 2019 Feb 26.

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Greenberg Bladder Cancer Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.euo.2019.01.017DOI Listing
February 2019

Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients?

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:147-164. Epub 2019 May 17.

5 Division of Hematology and Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.

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http://dx.doi.org/10.1200/EDBK_240837DOI Listing
January 2019

Combined local and systemic attacks.

Nat Biomed Eng 2018 08;2(8):564-565

Department of Medicine, Division of Hematology / Oncology, Columbia University Medical Center, New York, NY, USA.

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http://www.nature.com/articles/s41551-018-0277-z
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http://dx.doi.org/10.1038/s41551-018-0277-zDOI Listing
August 2018

A Subset of TREM2 Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth.

Cell Stem Cell 2019 04 28;24(4):654-669.e6. Epub 2019 Mar 28.

Department of Dermatology, Columbia University, New York, NY, USA; Department of Genetics & Development, Columbia University, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193001
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http://dx.doi.org/10.1016/j.stem.2019.01.011DOI Listing
April 2019

The Immunobiology of Kidney Cancer.

J Clin Oncol 2018 Oct 29:JCO2018792648. Epub 2018 Oct 29.

Charles G. Drake and Mark N. Stein, Columbia University Medical Center; and Charles G. Drake, Columbia University, New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2018.79.2648
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http://dx.doi.org/10.1200/JCO.2018.79.2648DOI Listing
October 2018

A role for paracrine interleukin-6 signaling in the tumor microenvironment in prostate tumor growth.

Prostate 2019 02 21;79(2):215-222. Epub 2018 Oct 21.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23726DOI Listing
February 2019

Cooperation of loss of and inflammation in prostate cancer initiation.

Dis Model Mech 2018 11 16;11(11). Epub 2018 Nov 16.

Departments of Urology, Medicine, Pathology & Cell Biology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA

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http://dx.doi.org/10.1242/dmm.035139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262819PMC
November 2018

Immunotherapy for Prostate Cancer.

Cold Spring Harb Perspect Med 2019 05 1;9(5). Epub 2019 May 1.

Division of Hematology and Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a030627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496329PMC
May 2019

Immunotherapy in Prostate Cancer: Teaching an Old Dog New Tricks.

Curr Oncol Rep 2018 08 18;20(9):75. Epub 2018 Aug 18.

Division of Hematology/Oncology, NewYork-Presbyterian/Columbia University Medical Center, 177 Fort Washington Avenue, 6GN-435, New York, NY, 10032, USA.

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http://link.springer.com/10.1007/s11912-018-0712-z
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http://dx.doi.org/10.1007/s11912-018-0712-zDOI Listing
August 2018

Absence of host NF-κB p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization.

Cancer Immunol Immunother 2018 Oct 21;67(10):1491-1503. Epub 2018 Jul 21.

Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University, CRB I, Rm 253, 1650 Orleans St., Baltimore, MD, 21231, USA.

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http://dx.doi.org/10.1007/s00262-018-2184-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168375PMC
October 2018

IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy.

Cell Syst 2018 07 27;7(1):92-103.e4. Epub 2018 Jun 27.

Department of Dermatology, Columbia University Medical Center, New York, NY, USA; Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.05.020DOI Listing
July 2018

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer.

Am J Pathol 2018 06 22;188(6):1478-1485. Epub 2018 Mar 22.

Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland; Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173117
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http://dx.doi.org/10.1016/j.ajpath.2018.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971230PMC
June 2018

Blocking PD-1/PD-L1 in Genitourinary Malignancies: To Immunity and Beyond.

Cancer J 2018 Jan/Feb;24(1):20-30

From the Hematology/Oncology, NewYork-Presbyterian/Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1097/PPO.0000000000000302DOI Listing
March 2019

Inhibitors of the PD-1 Pathway in Tumor Therapy.

J Immunol 2018 01;200(2):375-383

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1701044
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http://dx.doi.org/10.4049/jimmunol.1701044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924692PMC
January 2018

Combining intratumoral Treg depletion with androgen deprivation therapy (ADT): preclinical activity in the Myc-CaP model.

Prostate Cancer Prostatic Dis 2018 04 4;21(1):113-125. Epub 2017 Dec 4.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41391-017-0013-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897134PMC
April 2018

Biomarkers for immunotherapy in bladder cancer: a moving target.

J Immunother Cancer 2017 11 21;5(1):94. Epub 2017 Nov 21.

New York-Presbyterian/Columbia University Medical Center, Hematology/Oncology, 177 Fort Washington Avenue, 6GN-435, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s40425-017-0299-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697433PMC
November 2017

Cutaneous Eruptions in Patients Receiving Immune Checkpoint Blockade: Clinicopathologic Analysis of the Nonlichenoid Histologic Pattern.

Am J Surg Pathol 2017 Oct;41(10):1381-1389

Departments of *Dermatology ‡Pathology §Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center ∥The Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD Departments of †Medicine, Thoracic Oncology Service ¶Pathology #Dermatology, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/PAS.0000000000000900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657299PMC
October 2017

The Landscape of Whole-genome Alterations and Pathologic Features in Genitourinary Malignancies: An Analysis of the Cancer Genome Atlas.

Eur Urol Focus 2017 12 8;3(6):584-589. Epub 2017 Feb 8.

The James Buchanan Brady Urological Institute & Department of Urology, Johns Hopkins University School of Medicine.

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http://dx.doi.org/10.1016/j.euf.2017.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548653PMC
December 2017

Intravesical BCG Induces CD4 T-Cell Expansion in an Immune Competent Model of Bladder Cancer.

Cancer Immunol Res 2017 07 6;5(7):594-603. Epub 2017 Jun 6.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536898PMC
July 2017

Myeloid-derived cells in prostate cancer progression: phenotype and prospective therapies.

J Leukoc Biol 2017 08 26;102(2):393-406. Epub 2017 May 26.

Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA

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http://dx.doi.org/10.1189/jlb.5VMR1116-491RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608078PMC
August 2017

Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment.

J Natl Cancer Inst 2017 04;109(4)

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center and The Brady Urological Institute, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/jnci/djw261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441294PMC
April 2017

Phase I clinical trial of sipuleucel-T combined with escalating doses of ipilimumab in progressive metastatic castrate-resistant prostate cancer.

Immunotargets Ther 2017 20;6:11-16. Epub 2017 Mar 20.

The Sidney Kimmel Cancer Center; The James Buchanan Brady Urological Institute, John Hopkins Medical Institutions, Baltimore, MD, USA.

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http://dx.doi.org/10.2147/ITT.S122497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365325PMC
March 2017

LAG3 (CD223) as a cancer immunotherapy target.

Immunol Rev 2017 03;276(1):80-96

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/imr.12519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338468PMC
March 2017

Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic Chemotherapy-Naive Castration-Resistant Prostate Cancer.

J Clin Oncol 2017 Jan 31;35(1):40-47. Epub 2016 Oct 31.

Tomasz M. Beer, Oregon Health and Science University, Portland, OR; Eugene D. Kwon, Mayo Clinic, Rochester, MN; Charles G. Drake, Johns Hopkins University, Baltimore, MD; Karim Fizazi, University of Paris-Sud, Villejuif; Gwenaelle Gravis, Institut Paoli-Calmettes, Marseille, France; Christopher Logothetis, University of Texas MD Anderson Cancer Center, Houston, TX; Vinod Ganju, Monash University, Melbourne, Victoria; Siobhan S. Ng, St John of God Hospital, Subiaco, Western Australia; Francis X. Parnis, Adelaide Cancer Centre, Adelaide, South Australia, Australia; Jonathan Polikoff, Southern California Permanente Medical Group, San Marcos, CA; Fred Saad, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada; Piotr Humanski, Niepubliczny Zaklad Opieki Zdrowotnej Specjalista, Kutno, Poland; Josep M. Piulats, Institut Català d'Oncologia, Barcelona; Javier Puente, Hospital Clínico San Carlos, Madrid, Spain; Pablo Gonzalez Mella, Instituto Oncologico, Viña del Mar; Pablo Gonzalez Mella, Fundación Arturo Lopez Pérez, Santiago, Chile; Dirk Jaeger, University Hospital, Heidelberg, Germany; Fabio A. Franke, Hospital de Caridade de Ijuí, Ijuí, Brazil; Roman Carvajal, Hospital Regional Valentin Gomez Farias, Zapopan, Mexico; Lisa Sengeløv, Herlev Hospital, Herlev, Denmark; M. Brent McHenry, Bristol-Myers Squibb, Wallingford, CT; Arvind Varma, DOCS Inc, New York, NY; Alfonsus J. van den Eertwegh, VU University Medical Center, Amsterdam; and Winald Gerritsen, Radboud University, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2016.69.1584DOI Listing
January 2017

Risk Associated With High-Dose Bicalutamide.

Authors:
Charles G Drake

J Clin Oncol 2017 02 21;35(4):471. Epub 2016 Nov 21.

Charles G. Drake, Columbia University, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.69.4299DOI Listing
February 2017

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors.

Proc Natl Acad Sci U S A 2016 11 11;113(48):E7769-E7777. Epub 2016 Nov 11.

Department of Oncology, The Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287;

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http://dx.doi.org/10.1073/pnas.1607836113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137776PMC
November 2016

Programmed Cell Death Ligand-1 Blockade in Urothelial Bladder Cancer: To Select or Not to Select.

J Clin Oncol 2016 09 25;34(26):3115-6. Epub 2016 Jul 25.

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center and The James Buchanan Brady Urological Institute, Baltimore, MD.

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http://dx.doi.org/10.1200/JCO.2016.68.4696DOI Listing
September 2016

A phased strategy to differentiate human CD14+monocytes into classically and alternatively activated macrophages and dendritic cells.

Biotechniques 2016 1;61(1):33-41. Epub 2016 Jul 1.

The James Buchanan Brady Urological Institute at the Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.2144/000114435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504907PMC
October 2017

Recent advances in immunotherapy for kidney cancer.

Discov Med 2016 04;21(116):305-13

The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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April 2016

Personalized Immune Therapy: A Slippery Fish?

Oncology (Williston Park) 2016 Apr;30(4):308-9

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April 2016

Combination immunotherapy in renal cell carcinoma.

Authors:
Charles G Drake

Clin Adv Hematol Oncol 2016 Feb;14(2):99-100

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February 2016

Blocking immune checkpoints in prostate, kidney, and urothelial cancer: An overview.

Urol Oncol 2016 Apr 28;34(4):171-81. Epub 2016 Feb 28.

Department of Oncology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2016.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834698PMC
April 2016

Circulating Beta-2 Microglobulin and Risk of Cancer: The Atherosclerosis Risk in Communities Study (ARIC).

Cancer Epidemiol Biomarkers Prev 2016 04 5;25(4):657-64. Epub 2016 Feb 5.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-0849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873421PMC
April 2016