Charles E McCall

Charles E McCall

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Charles E McCall

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S100A9 maintains myeloid-derived suppressor cells in chronic sepsis by inducing miR-21 and miR-181b.

Mol Immunol 2019 Aug 9;112:72-81. Epub 2019 May 9.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2019.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646085PMC
August 2019

SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis.

Shock 2019 Aug 6. Epub 2019 Aug 6.

Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195.

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http://dx.doi.org/10.1097/SHK.0000000000001429DOI Listing
August 2019

Epigenetic and metabolic programming of innate immunity in sepsis.

Innate Immun 2019 Jul 18;25(5):267-279. Epub 2019 Apr 18.

2 Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1177/1753425919842320DOI Listing
July 2019

Mitochondrial Sirtuin 4 Resolves Immune Tolerance in Monocytes by Rebalancing Glycolysis and Glucose Oxidation Homeostasis.

Front Immunol 2018 9;9:419. Epub 2018 Mar 9.

Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

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http://dx.doi.org/10.3389/fimmu.2018.00419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854658PMC
June 2019

Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.

Inflammation 2019 Feb;42(1):156-169

Department of Anesthesiology, Section on Critical Care, Department of Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.

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http://dx.doi.org/10.1007/s10753-018-0881-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380915PMC
February 2019

Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response.

J Leukoc Biol 2019 02 11;105(2):215-228. Epub 2019 Jan 11.

Department of Internal Medicine/Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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http://doi.wiley.com/10.1002/JLB.3HI0918-373R
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http://dx.doi.org/10.1002/JLB.3HI0918-373RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466628PMC
February 2019

Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.

J Immunol Res 2018 4;2018:2402593. Epub 2018 Jul 4.

Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1155/2018/2402593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057336PMC
November 2018

IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development.

Cell Immunol 2018 10 11;332:32-38. Epub 2018 Jul 11.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183005
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http://dx.doi.org/10.1016/j.cellimm.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129403PMC
October 2018

Sirtuins and Immuno-Metabolism of Sepsis.

Int J Mol Sci 2018 Sep 13;19(9). Epub 2018 Sep 13.

Departments of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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http://www.mdpi.com/1422-0067/19/9/2738
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http://dx.doi.org/10.3390/ijms19092738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164482PMC
September 2018

Antioxidant treatment after injury suppresses second hit immune priming.

J Trauma Acute Care Surg 2018 08;85(2):367-374

From the Departments of General Surgery (J.J.H., J.D.W., B.K.Y.), Internal Medicine, Section on Molecular Medicine (C.M.F., C.E.M.), and Emergency Medicine (L.M.S), Wake Forest School of Medicine, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1097/TA.0000000000001951DOI Listing
August 2018

Correction for McPeak et al., "Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival".

Infect Immun 2018 03 20;86(3). Epub 2018 Feb 20.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tennessee, USA.

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http://dx.doi.org/10.1128/IAI.00820-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820970PMC
March 2018

Sirtuin 2 Regulates Microvascular Inflammation during Sepsis.

J Immunol Res 2017 19;2017:2648946. Epub 2017 Apr 19.

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1155/2017/2648946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414591PMC
February 2018

Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis.

Innate Immun 2018 01 27;24(1):54-65. Epub 2017 Nov 27.

1 Department of Internal Medicine, 12324 East Tennessee State University College of Medicine , Johnson City, TN, USA.

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http://dx.doi.org/10.1177/1753425917742956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240914PMC
January 2018

Expression of C/EBPβ in myeloid progenitors during sepsis promotes immunosuppression.

Mol Immunol 2017 11 19;91:165-172. Epub 2017 Sep 19.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653439PMC
November 2017

Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis.

Front Immunol 2017 17;8:1565. Epub 2017 Nov 17.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, United States.

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http://dx.doi.org/10.3389/fimmu.2017.01565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698275PMC
November 2017

The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.

Sci Rep 2017 09 8;7(1):11005. Epub 2017 Sep 8.

Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.

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http://dx.doi.org/10.1038/s41598-017-11388-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591240PMC
September 2017

Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice.

PLoS One 2016 8;11(8):e0160431. Epub 2016 Aug 8.

Departments of Anesthesiology Wake Forest School of Medicine, Winston-Salem, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160431PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976857PMC
August 2017

Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice.

J Leukoc Biol 2017 08 5;102(2):191-200. Epub 2017 May 5.

Department of Internal Medicine, College of Medicine, East Tennessee State University Johnson City, Tennessee, USA;

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http://dx.doi.org/10.1189/jlb.4HI1216-537RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505744PMC
August 2017

Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival.

Infect Immun 2017 04 23;85(4). Epub 2017 Mar 23.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tennessee, USA

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http://dx.doi.org/10.1128/IAI.00066-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364314PMC
April 2017

Stat3 and C/EBPβ synergize to induce miR-21 and miR-181b expression during sepsis.

Immunol Cell Biol 2017 01 19;95(1):42-55. Epub 2016 Jul 19.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, USA.

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http://dx.doi.org/10.1038/icb.2016.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209283PMC
January 2017

Sirtuins Link Inflammation and Metabolism.

J Immunol Res 2016 20;2016:8167273. Epub 2016 Jan 20.

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1155/2016/8167273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745579PMC
November 2016

Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice.

J Inflamm Res 2016 5;9:167-174. Epub 2016 Oct 5.

Department of Anesthesiology, Medicine and Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.2147/JIR.S119021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063563PMC
October 2016

Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages.

J Innate Immun 2015 19;7(6):572-83. Epub 2015 May 19.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tenn., USA.

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https://www.karger.com/Article/FullText/381915
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http://dx.doi.org/10.1159/000381915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618041PMC
August 2016

GAPDH Binding to TNF-α mRNA Contributes to Posttranscriptional Repression in Monocytes: A Novel Mechanism of Communication between Inflammation and Metabolism.

J Immunol 2016 Mar 3;196(6):2541-51. Epub 2016 Feb 3.

Department of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157;

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http://dx.doi.org/10.4049/jimmunol.1501345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779706PMC
March 2016

NFI-A disrupts myeloid cell differentiation and maturation in septic mice.

J Leukoc Biol 2016 Jan 10;99(1):201-11. Epub 2015 Aug 10.

*Departments of Internal Medicine and Center for Inflammation, Infectious Diseases and Immunity, East Tennessee State University College of Medicine, Johnson City, Tennessee, USA; and Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

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http://dx.doi.org/10.1189/jlb.4A0415-171RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673479PMC
January 2016

Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice.

Obesity (Silver Spring) 2015 Jun 9;23(6):1209-17. Epub 2015 May 9.

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1002/oby.21086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446191PMC
June 2015

SIRT1 mediates a primed response to immune challenge after traumatic lung injury.

J Trauma Acute Care Surg 2015 May;78(5):1034-8

From the Departments of Emergency Medicine (L.M.S.), General Surgery (J.J.H., J.D.W., B.K.Y.), and Anesthesiology/Critical Care (V.T.V.), and Section on Molecular Medicine (C.E.M.), Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1097/TA.0000000000000598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410426PMC
May 2015

Age-related variations in the methylome associated with gene expression in human monocytes and T cells.

Nat Commun 2014 Nov 18;5:5366. Epub 2014 Nov 18.

Departments of Epidemiology & Prevention, and Biostatistics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1038/ncomms6366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280798PMC
November 2014

MicroRNA 21 (miR-21) and miR-181b couple with NFI-A to generate myeloid-derived suppressor cells and promote immunosuppression in late sepsis.

Infect Immun 2014 Sep 30;82(9):3816-25. Epub 2014 Jun 30.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tennessee, USA

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http://dx.doi.org/10.1128/IAI.01495-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187818PMC
September 2014

Epigenetic coordination of acute systemic inflammation: potential therapeutic targets.

Expert Rev Clin Immunol 2014 Sep 4;10(9):1141-50. Epub 2014 Aug 4.

Department of Anesthesiology, Section on Critical Care, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1586/1744666X.2014.943192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634938PMC
September 2014

Complement mediates a primed inflammatory response after traumatic lung injury.

J Trauma Acute Care Surg 2014 Mar;76(3):601-8; discussion 608-9

From the Department of General Surgery (J.J.H., J.D.W., B.K.Y.), and Section on Molecular Medicine (C.E.M.), Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1097/TA.0000000000000129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426490PMC
March 2014

Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes.

Clin Vaccine Immunol 2013 Sep 3;20(9):1396-404. Epub 2013 Jul 3.

Departments of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tennessee, USA.

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http://dx.doi.org/10.1128/CVI.00264-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889586PMC
September 2013

MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes.

Immunol Cell Biol 2013 Sep 30;91(8):532-40. Epub 2013 Jul 30.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, USA.

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http://dx.doi.org/10.1038/icb.2013.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770753PMC
September 2013

Deacetylation by SIRT1 Reprograms Inflammation and Cancer.

Genes Cancer 2013 Mar;4(3-4):135-47

Molecular Medicine Section, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1177/1947601913476948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764465PMC
March 2013

Adoptive transfer of CD34(+) cells during murine sepsis rebalances macrophage lipopolysaccharide responses.

Immunol Cell Biol 2012 Nov 26;90(10):925-34. Epub 2012 Jun 26.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, USA.

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http://dx.doi.org/10.1038/icb.2012.32DOI Listing
November 2012

Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance.

J Gerontol A Biol Sci Med Sci 2012 Oct 8;67(10):1014-21. Epub 2012 Mar 8.

Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1093/gerona/gls008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437965PMC
October 2012

Fueling the flame: bioenergy couples metabolism and inflammation.

J Leukoc Biol 2012 Sep 9;92(3):499-507. Epub 2012 May 9.

Section of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://www.jleukbio.org/content/early/2012/05/08/jlb.0212078
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http://www.jleukbio.org/cgi/doi/10.1189/jlb.0212078
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http://dx.doi.org/10.1189/jlb.0212078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427613PMC
September 2012

MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators.

Immunol Cell Biol 2012 Jul 13;90(6):587-93. Epub 2011 Sep 13.

Department of Internal Medicine, East Tennessee University College of Medicine, Johnson City, TN 37614, USA.

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http://dx.doi.org/10.1038/icb.2011.74DOI Listing
July 2012

NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.

J Biol Chem 2012 Jul 14;287(31):25758-69. Epub 2012 Jun 14.

Section of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157.

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http://dx.doi.org/10.1074/jbc.M112.362343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406663PMC
July 2012

Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response.

Infect Immun 2012 Jun 26;80(6):2026-34. Epub 2012 Mar 26.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tennessee, USA.

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http://dx.doi.org/10.1128/IAI.00239-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370575PMC
June 2012

Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses.

Shock 2012 Apr;37(4):385-91

Department of General Surgery, Section on Molecular Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1097/SHK.0b013e3182478478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307129PMC
April 2012

Hematopoietic stem-progenitor cells restore immunoreactivity and improve survival in late sepsis.

Infect Immun 2012 Feb 5;80(2):602-11. Epub 2011 Dec 5.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tennessee, USA.

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http://dx.doi.org/10.1128/IAI.05480-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264285PMC
February 2012

MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-α during TLR4-induced gene reprogramming.

J Leukoc Biol 2011 Sep 11;90(3):509-19. Epub 2011 May 11.

Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, USA.

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http://dx.doi.org/10.1189/jlb.0211074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157899PMC
September 2011

Mechanism of neutrophil recruitment to the lung after pulmonary contusion.

Shock 2011 Jun;35(6):604-9

Department of General Surgery, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1097/SHK.0b013e3182144a50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108153PMC
June 2011

NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance.

J Biol Chem 2011 Mar 18;286(11):9856-64. Epub 2011 Jan 18.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.196790
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http://dx.doi.org/10.1074/jbc.M110.196790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058977PMC
March 2011

Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis.

Cytokine 2011 Feb;53(2):145-52

Department of Surgery, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.cyto.2010.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021647PMC
February 2011

Gene-specific epigenetic regulation in serious infections with systemic inflammation.

J Innate Immun 2010 27;2(5):395-405. Epub 2010 Apr 27.

Translational Science Institute, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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https://www.karger.com/Article/FullText/314077
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http://dx.doi.org/10.1159/000314077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968760PMC
January 2011

MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance.

J Biol Chem 2010 Jul 30;285(27):20940-51. Epub 2010 Apr 30.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1074/jbc.M110.115063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898346PMC
July 2010

Dynamic and selective nucleosome repositioning during endotoxin tolerance.

J Biol Chem 2010 Jan 9;285(2):1259-71. Epub 2009 Nov 9.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1074/jbc.M109.067330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801254PMC
January 2010

The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance.

J Biol Chem 2009 Oct 18;284(41):27857-65. Epub 2009 Aug 18.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1074/jbc.M109.000950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788836PMC
October 2009

Pulmonary contusion primes systemic innate immunity responses.

J Trauma 2009 Jul;67(1):14-21; discussion 21-2

Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1097/TA.0b013e31819ea600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819072PMC
July 2009

Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion.

Shock 2009 Apr;31(4):376-81

Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1097/SHK.0b013e3181862279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918369PMC
April 2009

Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance.

Mol Cell Biol 2009 Apr 21;29(7):1959-71. Epub 2009 Jan 21.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1128/MCB.01862-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655606PMC
April 2009

RelB sustains IkappaBalpha expression during endotoxin tolerance.

Clin Vaccine Immunol 2009 Jan 19;16(1):104-10. Epub 2008 Nov 19.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1128/CVI.00320-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2620660PMC
January 2009

G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance.

J Biol Chem 2008 Nov 22;283(47):32198-208. Epub 2008 Sep 22.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1074/jbc.M803446200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583293PMC
November 2008

Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion.

Shock 2007 Oct;28(4):447-52

Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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October 2007

Assembly of inflammation-related genes for pathway-focused genetic analysis.

PLoS One 2007 Oct 17;2(10):e1035. Epub 2007 Oct 17.

Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001184PMC
October 2007

Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance.

J Biol Chem 2007 Sep 23;282(37):26857-64. Epub 2007 Jul 23.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1074/jbc.M704584200DOI Listing
September 2007

Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin.

Immunol Lett 2007 Jul 25;111(1):36-44. Epub 2007 May 25.

Department of Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.imlet.2007.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034364PMC
July 2007

Gene silencing in severe systemic inflammation.

Am J Respir Crit Care Med 2007 Apr 25;175(8):763-7. Epub 2007 Jan 25.

Section of Molecular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1042, USA.

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http://dx.doi.org/10.1164/rccm.200610-1436CPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176094PMC
April 2007

Induction of RelB participates in endotoxin tolerance.

J Immunol 2006 Sep;177(6):4080-5

Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.4049/jimmunol.177.6.4080DOI Listing
September 2006

The pathogenesis of pulmonary contusion: an open chest model in the rat.

J Trauma 2006 Jul;61(1):32-44; discussion 44-5

Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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July 2006

Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter.

J Immunol 2005 Jul;175(1):461-8

Molecular Genetics Program and Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.4049/jimmunol.175.1.461DOI Listing
July 2005

Distinct post-receptor alterations generate gene- and signal-selective adaptation and cross-adaptation of TLR4 and TLR2 in human leukocytes.

J Endotoxin Res 2003 ;9(1):39-44

Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27104, USA.

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http://dx.doi.org/10.1179/096805103125001324DOI Listing
August 2003

Association of an IL-1A 3'UTR polymorphism with end-stage renal disease and IL-1 alpha expression.

Kidney Int 2003 Apr;63(4):1211-9

The Center for Human Genomics and Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1046/j.1523-1755.2003.00856.xDOI Listing
April 2003

Inhibition of histone deacetylation enhances endotoxin-stimulated transcription but does not reverse endotoxin tolerance.

J Endotoxin Res 2002 ;8(2):109-14

Department of Medicine, Section on Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1179/096805102125000245DOI Listing
September 2002