Publications by authors named "Charles E Chalfant"

96Publications

Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo.

Pathog Dis 2020 Nov 21. Epub 2020 Nov 21.

Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA.

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http://dx.doi.org/10.1093/femspd/ftaa072DOI Listing
November 2020

Plasma ceramide is increased and associated with proteinuria in women with pre-eclampsia and HELLP syndrome.

Pregnancy Hypertens 2020 Jan 17;19:100-105. Epub 2019 Dec 17.

Reproductive Biology Laboratory, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.preghy.2019.12.006DOI Listing
January 2020

The Role of Ceramide 1-Phosphate in Inflammation, Cellular Proliferation, and Wound Healing.

Adv Exp Med Biol 2019 ;1159:65-77

Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1007/978-3-030-21162-2_5DOI Listing
September 2019

Serine/Arginine-Rich Splicing Factor 3 Modulates the Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2.

Mol Cancer Res 2019 09 28;17(9):1920-1930. Epub 2019 May 28.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), Richmond Virginia.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726571PMC
September 2019

Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 02 22;1864(2):158-167. Epub 2018 Nov 22.

Hormel Institute, University of Minnesota, Austin, MN 55912, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448591PMC
February 2019

Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase.

Am J Physiol Lung Cell Mol Physiol 2018 01 12;314(1):L206-L214. Epub 2017 Oct 12.

Division of Pediatric Pulmonary Medicine, Children's Hospital of Richmond at Virginia Commonwealth University , Richmond, Virginia.

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http://dx.doi.org/10.1152/ajplung.00322.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866429PMC
January 2018

Lipidomics in translational research and the clinical significance of lipid-based biomarkers.

Transl Res 2017 11 15;189:13-29. Epub 2017 Jun 15.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), Richmond, Va; Research Service, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, Va; VCU Massey Cancer Center, Cancer Cell Signaling Program, Virginia Commonwealth University, Richmond, Va; VCU Institute of Molecular Medicine, Richmond, Va; VCU Johnson Center for Critical Care and Pulmonary Research, Richmond, Va. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659874PMC
November 2017

Impact of high dose vitamin C on platelet function.

World J Crit Care Med 2017 Feb 4;6(1):37-47. Epub 2017 Feb 4.

Bassem M Mohammed, Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

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http://dx.doi.org/10.5492/wjccm.v6.i1.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295168PMC
February 2017

Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients.

J Lipid Res 2017 04 10;58(4):636-648. Epub 2017 Feb 10.

Departments of Ophthalmology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK 73104

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http://dx.doi.org/10.1194/jlr.M067264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392739PMC
April 2017

PRMT2 interacts with splicing factors and regulates the alternative splicing of BCL-X.

J Biochem 2017 Jul;162(1):17-25

Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1093/jb/mvw102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892402PMC
July 2017

Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis.

Cancer Res 2016 05 29;76(10):2977-89. Epub 2016 Mar 29.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia. Research and Development, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, Virginia. The VCU Institute of Molecular Medicine, The VCU Massey Cancer Center, and The VCU Johnson Center, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874651PMC
May 2016

Role of integrin α7β1 signaling in myoblast differentiation on aligned polydioxanone scaffolds.

Acta Biomater 2016 07 30;39:44-54. Epub 2016 Apr 30.

Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, United States; Department of Periodontics, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, United States.

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http://dx.doi.org/10.1016/j.actbio.2016.04.046DOI Listing
July 2016

Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration.

J Lipid Res 2016 05 5;57(5):818-31. Epub 2016 Mar 5.

Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 Dean McGee Eye Institute, Oklahoma City, OK 73104 Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104

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http://dx.doi.org/10.1194/jlr.M063719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847629PMC
May 2016

The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer.

J Biol Chem 2015 Oct 24;290(42):25717-27. Epub 2015 Aug 24.

From the Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond Virginia 23298, Virginia Commonwealth University Massey Cancer Center Massey Cancer Center, Richmond, Virginia 23298,

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http://dx.doi.org/10.1074/jbc.M115.671206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646214PMC
October 2015

Anaplasma phagocytophilum Rab10-dependent parasitism of the trans-Golgi network is critical for completion of the infection cycle.

Cell Microbiol 2016 Feb 7;18(2):260-81. Epub 2015 Oct 7.

Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

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http://dx.doi.org/10.1111/cmi.12500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891814PMC
February 2016

Arachidonic acid-derived signaling lipids and functions in impaired healing.

Wound Repair Regen 2015 Sep 14;23(5):644-56. Epub 2015 Sep 14.

Department of Cell Biology and Neuroscience, University of California, Riverside, California.

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http://dx.doi.org/10.1111/wrr.12337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837701PMC
September 2015

Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension.

PLoS One 2015 18;10(3):e0120157. Epub 2015 Mar 18.

Pulmonary and Critical care Medicine Division, Victoria Johnson Center for Lung Research, Richmond, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364907PMC
February 2016

Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.

J Biol Chem 2015 Apr 11;290(17):11021-31. Epub 2015 Mar 11.

the Department of Cell, Developmental, and Integrative Biology and Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, Alabama 35294,

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http://dx.doi.org/10.1074/jbc.M115.648956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409262PMC
April 2015

A novel model of chronic wounds: importance of redox imbalance and biofilm-forming bacteria for establishment of chronicity.

PLoS One 2014 14;9(10):e109848. Epub 2014 Oct 14.

Departments of Cell Biology and Neuroscience, University of California Riverside, Riverside, California, United States of America; Bioengineering Interdepartmental Graduate Program, University of California Riverside, Riverside, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109848PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196950PMC
June 2015

Resolution of sterile inflammation: role for vitamin C.

Mediators Inflamm 2014 9;2014:173403. Epub 2014 Sep 9.

Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980050, Richmond, VA 23298-0050, USA.

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http://dx.doi.org/10.1155/2014/173403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175383PMC
June 2015

Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts.

J Lipid Res 2014 07 13;55(7):1298-309. Epub 2014 May 13.

Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, VA 23249 Department of Biochemistry and Molecular Biology, Virginia Commonwealth University-School of Medicine, Richmond, VA 23298 The Massey Cancer Center, Richmond, VA 23298.

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http://dx.doi.org/10.1194/jlr.M048207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076082PMC
July 2014

Challenges in the Treatment of Triple Negative and HER2-Overexpressing Breast Cancer.

J Surg Sci 2013 Dec;1(1):3-7

Hunter Holmes McGuire VAMC, Dept. of Research and Development, Richmond VA, 23224 ( ), Virginia Commonwealth University Reanimation Engineering Science Center (VCURES), Richmond, Virginia 23298 ( ), Massey Cancer Center, Virginia Commonwealth University, Richmond VA, 23298 ( and Virginia Commonwealth University, Dept. of Biochemistry and Molecular Biology, Richmond VA, 23298 ( ).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012677PMC
December 2013

Structural Stereochemistry of Androstene Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoid Receptors.

Int J Med Chem 2013 Mar;2013:203606

Virginia Commonwealth University Reanimation Engineering Science Center (VCURES), Virginia Commonwealth University, Richmond, VA 23298, USA ; Department of Microbiology, Immunology, Pathology and Emergency Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1155/2013/203606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981456PMC
March 2013

Dietary fish oil improves endothelial function and lowers blood pressure via suppression of sphingolipid-mediated contractions in spontaneously hypertensive rats.

J Hypertens 2014 May;32(5):1050-8; discussion 1058

aDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht bDivision of Pharmacology & Pharmacotherapy, Academic Medical Center, Amsterdam cNutricia Research, Centre for Specialised Nutrition, Utrecht, The Netherlands dHunter Holmes McGuire Veterans Administration Medical Center eDepartment of Biochemistry & Molecular Biology, Virginia Commonwealth University fVirginia Commonwealth University Reanimation Engineering Science Center (VCURES) gThe Massey Cancer Center, Richmond, Virginia, USA.

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http://dx.doi.org/10.1097/HJH.0000000000000131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312004PMC
May 2014

Systems-Level Lipid Analysis Methodologies for Qualitative and Quantitative Investigation of Lipid Signaling Events During Wound Healing.

Adv Wound Care (New Rochelle) 2013 Nov;2(9):538-548

Research and Development, Hunter Holmes McGuire Veterans' Affairs Medical Center , Richmond, Virginia. ; Department of Biochemistry and Molecular Biology, School of Medicine, Virginia Commonwealth University , Richmond, Virginia. ; Virginia Commonwealth University Reanimation Engineering Science Center (VCURES); Virginia Commonwealth University , Richmond, Virginia. ; The Massey Cancer Center , Richmond, Virginia.

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http://dx.doi.org/10.1089/wound.2012.0402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816989PMC
November 2013

OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2.

BMC Cancer 2013 May 24;13:256. Epub 2013 May 24.

University of Richmond, 28 Westhampton Way, Richmond, VA 23173, USA.

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http://dx.doi.org/10.1186/1471-2407-13-256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674920PMC
May 2013

Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size.

J Cereb Blood Flow Metab 2013 Aug 1;33(8):1197-206. Epub 2013 May 1.

Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/jcbfm.2013.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734770PMC
August 2013

The role of ceramide-1-phosphate in biological functions.

Handb Exp Pharmacol 2013 (215):153-66

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, 1101 East Marshall Street, P.O Box 980614, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1007/978-3-7091-1368-4_8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598467PMC
July 2013

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase.

J Lipid Res 2013 Jul 10;54(7):1834-47. Epub 2013 Apr 10.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1194/jlr.M035683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679386PMC
July 2013

hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.

J Biol Chem 2013 Mar 8;288(12):8575-84. Epub 2013 Feb 8.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.443333
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http://dx.doi.org/10.1074/jbc.M112.443333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605676PMC
March 2013

The molecular basis of ceramide-1-phosphate recognition by C2 domains.

J Lipid Res 2013 Mar 31;54(3):636-48. Epub 2012 Dec 31.

Department of Chemistry and Biochemistry and the Mike and Josie Harper Center for Cancer Research, University of Notre Dame, Notre Dame, IN, USA.

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http://dx.doi.org/10.1194/jlr.M031088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617939PMC
March 2013

Metallofullerene-nanoplatform-delivered interstitial brachytherapy improved survival in a murine model of glioblastoma multiforme.

Bioconjug Chem 2012 Sep 21;23(9):1873-80. Epub 2012 Aug 21.

Departments of Radiology, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1021/bc300206qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448337PMC
September 2012

The Proto-oncogene PKCι regulates the alternative splicing of Bcl-x pre-mRNA.

Mol Cancer Res 2012 May 20;10(5):660-9. Epub 2012 Apr 20.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University-School of Medicine, Room 2-016, Sanger Hall, 1101 East Marshall Street, P.O. Box 980614, Richmond, VA 23298, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-11
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http://dx.doi.org/10.1158/1541-7786.MCR-11-0363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356487PMC
May 2012

The flip-flop HuR: part of the problem or the solution in fighting cancer?

J Clin Invest 2012 Jan 27;122(1):16-9. Epub 2011 Dec 27.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298-0614, USA.

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http://dx.doi.org/10.1172/JCI61677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248312PMC
January 2012

Characterization of lysophosphatidic acid subspecies produced by autotaxin using a modified HPLC ESI-MS/MS method.

Anal Methods 2011 Nov;3(12):2822-2828

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, 1101 East Marshall Street, P.O. Box 980614, Richmond, Virginia, 23298-0614 ; Research and Development, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, Virginia, 23249 ; The Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, 23298.

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http://dx.doi.org/10.1039/C1AY05459GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956132PMC
November 2011

Caspase 9b: a new target for therapy in non-small-cell lung cancer.

Expert Rev Anticancer Ther 2011 Apr;11(4):499-502

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http://dx.doi.org/10.1586/era.11.23DOI Listing
April 2011

Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a.

Cancer Res 2010 Nov 2;70(22):9185-96. Epub 2010 Nov 2.

Department of Biochemistry, Virginia Commonwealth University, VAMC, and Massey Cancer Center, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059118PMC
November 2010

A ceramide analog inhibits cPLA(2) activity and consequent PGE(2) formation in LPS-stimulated macrophages.

Immunol Lett 2011 Mar 30;135(1-2):136-43. Epub 2010 Oct 30.

Department of Biochemistry and Molecular Biology, Life Sciences Institute, Tel-Aviv University, Tel-Aviv 69978, Israel.

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http://dx.doi.org/10.1016/j.imlet.2010.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026855PMC
March 2011

hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing.

J Clin Invest 2010 Nov 25;120(11):3923-39. Epub 2010 Oct 25.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

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http://dx.doi.org/10.1172/JCI43552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964989PMC
November 2010

Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.

Cardiovasc Res 2010 Apr 14;86(1):55-62. Epub 2009 Dec 14.

Department of Physiology and Biophysics, Medical College of Virginia, Virginia Commonwealth University, 1101 East Marshall Street, PO Box 980551, Richmond, VA 23298-0551, USA.

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http://dx.doi.org/10.1093/cvr/cvp399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836262PMC
April 2010

JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2.

J Biol Chem 2009 Nov 24;284(47):32359-69. Epub 2009 Sep 24.

Institut de Neurociències i Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, E-08193 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M109.061515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781651PMC
November 2009

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels.

J Lipid Res 2010 Mar 4;51(3):641-51. Epub 2009 Aug 4.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.D000430
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http://dx.doi.org/10.1194/jlr.D000430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817594PMC
March 2010

Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis.

J Biol Chem 2009 Sep 23;284(39):26897-907. Epub 2009 Jul 23.

Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0614, USA.

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http://dx.doi.org/10.1074/jbc.M109.001677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785377PMC
September 2009

Ceramide kinase and the ceramide-1-phosphate/cPLA2alpha interaction as a therapeutic target.

Curr Drug Targets 2008 Aug;9(8):674-82

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University-School of Medicine, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.2174/138945008785132349DOI Listing
August 2008

Emetine and the alternative splicing of Bcl-X: where to next?

Chem Biol 2007 Dec;14(12):1313-4

Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1016/j.chembiol.2007.12.002DOI Listing
December 2007

Ceramide kinase and ceramide-1-phosphate.

Methods Enzymol 2007 ;434:265-92

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)34015-9DOI Listing
December 2007

Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms.

J Lipid Res 2007 Dec 21;48(12):2701-8. Epub 2007 Sep 21.

Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1194/jlr.M700356-JLR200DOI Listing
December 2007

Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain.

J Biol Chem 2007 Jul 30;282(28):20467-74. Epub 2007 Apr 30.

Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1074/jbc.M701396200DOI Listing
July 2007

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.

J Cell Biol 2007 Mar 19;176(7):929-39. Epub 2007 Mar 19.

Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200701005
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http://dx.doi.org/10.1083/jcb.200701005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064079PMC
March 2007

Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.

FEBS Lett 2007 Feb 25;581(4):735-40. Epub 2007 Jan 25.

Department of Biochemistry and Massey Cancer Center, Virginia Commonwealth University School of Medicine, 2-011 Sanger Hall, 1101 E. Marshall Street, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1016/j.febslet.2007.01.041DOI Listing
February 2007

SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA.

FASEB J 2006 Aug 21;20(10):1680-2. Epub 2006 Jun 21.

Department of Biochemistry, Rm. 2-016, Sanger Hall, Virginia Commonwealth University, 1101 East Marshall St., P.O. Box 980614, Richmond, Virginia 23298-0614, USA.

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http://dx.doi.org/10.1096/fj.05-5021fjeDOI Listing
August 2006

Fine tuning therapeutic targeting of the sphingolipid biosynthetic pathway to treat atherosclerosis.

Curr Vasc Pharmacol 2006 Apr;4(2):151-4

Prince of Wales Medical Research Institute, Randwick, NSW, Australia.

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http://dx.doi.org/10.2174/157016106776359844DOI Listing
April 2006

SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness.

J Lipid Res 2006 May 27;47(5):892-7. Epub 2006 Feb 27.

Department of Biochemistry, Virginia Commonwealth University, Richmond, 23298, USA.

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http://dx.doi.org/10.1194/jlr.C600003-JLR200DOI Listing
May 2006

Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation.

Mol Interv 2005 Dec;5(6):358-67

Department of Biochemistry, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1124/mi.5.6.8DOI Listing
December 2005

Ceramide regulates SR protein phosphorylation during adenoviral infection.

Virology 2006 Feb 3;345(1):280-9. Epub 2005 Nov 3.

Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.

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February 2006

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.

J Cell Sci 2005 Oct;118(Pt 20):4605-12

Department of Biochemistry, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, VA 23298, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.02637
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October 2005

Substrate specificity of human ceramide kinase.

J Lipid Res 2005 Dec 18;46(12):2706-16. Epub 2005 Sep 18.

Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1194/jlr.M500313-JLR200DOI Listing
December 2005

The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate.

Mol Pharmacol 2005 Aug 17;68(2):330-5. Epub 2005 May 17.

Department of Biochemistry and Molecular Biology, Room 501, Basic Science Building, Medical University of South Carolina, 173 Ashley Avenue, P.O. Box 250509, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1124/mol.104.008722DOI Listing
August 2005

Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.

J Biol Chem 2005 May 1;280(18):17601-7. Epub 2005 Mar 1.

Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M414173200
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May 2005

Insulin regulates protein kinase CbetaII alternative splicing in multiple target tissues: development of a hormonally responsive heterologous minigene.

Mol Endocrinol 2004 Apr 29;18(4):899-911. Epub 2004 Jan 29.

Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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April 2004

Identification of two RNA cis-elements that function to regulate the 5' splice site selection of Bcl-x pre-mRNA in response to ceramide.

J Biol Chem 2004 Apr 20;279(16):15799-804. Epub 2004 Jan 20.

Department of Biochemistry, Virginia Commonwealth University, Richmond, Virgina 23298, USA.

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April 2004

Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2.

J Biol Chem 2004 Mar 15;279(12):11320-6. Epub 2003 Dec 15.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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March 2004

The structural requirements for ceramide activation of serine-threonine protein phosphatases.

J Lipid Res 2004 Mar 1;45(3):496-506. Epub 2003 Dec 1.

Department of Biochemistry & Molecular Biology, Medical University of South Carolina, and Ralph H Johnson Veterans Administration Mecial Center, Charleston, SC, USA.

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March 2004

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.

FASEB J 2003 Aug;17(11):1411-21

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://www.fasebj.org/doi/10.1096/fj.02-1038com
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August 2003

Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.

J Biol Chem 2003 Oct 10;278(40):38206-13. Epub 2003 Jul 10.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M304816200DOI Listing
October 2003

Ceramide in apoptosis: an overview and current perspectives.

Biochim Biophys Acta 2002 Dec;1585(2-3):114-25

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/s1388-1981(02)00331-1DOI Listing
December 2002

The protein kinase C beta II exon confers mRNA instability in the presence of high glucose concentrations.

J Biol Chem 2003 Jan 28;278(2):1149-57. Epub 2002 Oct 28.

Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa 33612, USA.

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January 2003

Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins.

J Biol Chem 2002 Nov 27;277(45):42572-8. Epub 2002 Aug 27.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M207346200DOI Listing
November 2002

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

J Biol Chem 2002 Apr 18;277(15):12587-95. Epub 2002 Jan 18.

Department of Biochemistry & Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

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April 2002