Charles Duyckaerts

Charles Duyckaerts

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Charles Duyckaerts

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Increased prevalence of granulovacuolar degeneration in C9orf72 mutation.

Acta Neuropathol 2019 Nov 29;138(5):783-793. Epub 2019 May 29.

Raymond Escourolle Neuropathology Department, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, AP-HP, 75651 Cedex 13, Paris, France.

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http://dx.doi.org/10.1007/s00401-019-02028-6DOI Listing
November 2019

Loss of paraplegin drives spasticity rather than ataxia in a cohort of 241 patients with .

Neurology 2019 Jun 8;92(23):e2679-e2690. Epub 2019 May 8.

From Sorbonne Université (G.C., C.E., B.F., M.-L.M., F.M., M.P., C.-S.D., G.S., A.D.), Institut du Cerveau et de la Moelle épinière (ICM), AP-HP, INSERM, CNRS, University Hospital Pitié-Salpêtrière; Department of Genetics (G.C., C.E., M.-L.M., P.C., F.M., G.B., G.S., A.D.), Pitié-Salpêtrière Charles-Foix University Hospital, Assistance publique-Hôpitaux de Paris, Sorbonne Université, Paris, France; Center for Neurology and Hertie Institute for Clinical Brain Research (R.S., M.S., L.S.), University of Tübingen, German Center for Neurodegenerative Diseases; German Center for Neurodegenerative Diseases (R.S., M.S., L.S.), Tübingen; Department of Neurology (B.P.C.v.d.W., E.G.H.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Neurogenetics Group (P.D.J., J.B., T.D., P.M., J.D.B., M.D.), University of Antwerp; Laboratories of Neurogenetics and Neuromuscular Pathology (P.D.J., J.B., T.D., P.M., J.D.B., M.D.), Institute Born-Bunge, University of Antwerp; Department of Neurology (P.D.J., J.B., T.D., P.M., J.D.B., M.D.), Antwerp University Hospital, Belgium; Scientific Institute IRCCS "E. Medea" (A.M.), Conegliano, Italy; Department of Neurology (M.A.), Hôpital de Hautepierre, Strasbourg; Institut de Génétique et de Biologie Moléculaire et Cellulaire (M.A.), INSERM-U964/CNRS-UMR7104/Université de Strasbourg, Illkirch; Fédération de Médecine Translationnelle de Strasbourg (M.A.), Université de Strasbourg; Department of Neurology (B.F.), Pitié-Salpêtrière Charles-Foix University Hospital, Assistance publique-Hôpitaux de Paris, Sorbonne Université, France; Department of Neurology (T. Klockgether, D.K.), University of Bonn; German Center for Neurodegenerative Diseases (T. Klockgether, D.K.), Bonn; Scientific Institute IRCCS E. Medea Neurorehabilitation Unit (M.G.D.), Bosisio Parini, Lecco, Italy; ULB Center of Human Genetics (I.M.), Brussels, Belgium; Scientific Institute IRCCS E. Medea Laboratory of Molecular Biology (M.T.B.), Bosisio Parini, Lecco, Italy; Department of Neurology With Friedrich-Baur Institute (T. Klopstock), University Hospital of the Ludwig-Maximilians-Universität München; German Center for Neurodegenerative Diseases (T. Klopstock); Munich Cluster for Systems Neurology (T. Klopstock), Germany; Department of Genetics (E.O.-R.), Croix-Rousse University Hospital, Lyon, France; Department of Neurology (C.K.), University of Rostock, Germany; Ecole Pratique des Hautes Etudes (M.P., G.S.), PSL Research University; Sorbonne Université (S.T.d.M.), INSERM, Institut Pierre Louis de Santé Publique, Medical Information Unit, Pitié-Salpêtrière Charles-Foix University Hospital, Assistance publique-Hôpitaux de Paris; and Raymond Escourolle Neuropathology Department (D.S., C.D.), Pitié-Salpêtrière University Hospital, Assistance publique-Hôpitaux de Paris, Sorbonne Université, France.

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http://dx.doi.org/10.1212/WNL.0000000000007606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556095PMC
June 2019

The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease.

Curr Opin Neurol 2019 04;32(2):266-271

Equipe Alzheimer-Prion, Institut du Cerveau et de la Moelle (ICM), Paris, France.

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http://dx.doi.org/10.1097/WCO.0000000000000672DOI Listing
April 2019

Amyloid Angiopathy in Brain Hemorrhage: A Postmortem Neuropathological-Magnetic Resonance Imaging Study.

Cerebrovasc Dis 2018 20;45(3-4):124-131. Epub 2018 Mar 20.

INSERM LVTS (Laboratory for Vascular Translational Science) 1148 and Paris-Diderot University, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1159/000486554DOI Listing
March 2019

Spastic paraplegia due to SPAST mutations is modified by the underlying mutation and sex.

Brain 2018 12;141(12):3331-3342

Institut du Cerveau et de la Moelle épinière (ICM), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne Université, Pitié-Salpêtrière University Hospital, Paris, France.

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
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http://dx.doi.org/10.1093/brain/awy285DOI Listing
December 2018

3D imaging in the postmortem human brain with CLARITY and CUBIC.

Handb Clin Neurol 2018 ;150:303-317

Laboratoire de Neuropathologie Escourolle, Hôpital de la Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/B978-0-444-63639-3.00021-9DOI Listing
August 2018

Is Lewy pathology in the human nervous system chiefly an indicator of neuronal protection or of toxicity?

Cell Tissue Res 2018 07 5;373(1):149-160. Epub 2018 Jun 5.

Escourolle Neuropathology Department, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, 47 Boulevard de l'Hopital, 75651, Paris Cedex 13, France.

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http://dx.doi.org/10.1007/s00441-018-2854-6DOI Listing
July 2018

Evidence for altered dendritic spine compartmentalization in Alzheimer's disease and functional effects in a mouse model.

Acta Neuropathol 2018 06 25;135(6):839-854. Epub 2018 Apr 25.

Institut du Cerveau et de la Moelle épinière, INSERM U1127, CNRS UMR7225, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.

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http://dx.doi.org/10.1007/s00401-018-1847-6DOI Listing
June 2018

Fatal Aβ cerebral amyloid angiopathy 4 decades after a dural graft at the age of 2 years.

Acta Neuropathol 2018 05 5;135(5):801-803. Epub 2018 Mar 5.

Département de Neuropathologie Raymond Escourolle, GH Pitié-Salpêtrière, Faculté de médecine Sorbonne Université, Paris, France.

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http://dx.doi.org/10.1007/s00401-018-1828-9DOI Listing
May 2018

Necrosis in anti-SRP and anti-HMGCRmyopathies: Role of autoantibodies and complement.

Neurology 2018 02 12;90(6):e507-e517. Epub 2018 Jan 12.

From the Departments of Neuropathology (Y.A., C.P., H.R., H.-H.G., W.S.) and Pathology (P.H., N.Z.), Charité-Universitätsmedizin, Berlin, Germany; Internal Medicine Department (Y.A., N.C., K.M., A.R., O. Benveniste), Reference for Neuro-muscular Diseases, Paris Est, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris; Myology Research Center (Y.A., L.A.-D., G.B.-B., D.A., O. Benveniste), Sorbonne Universités UPMC Univ Paris 06, INSERM UMRS974, Pitié-Salpêtrière University Hospital; Department of Neuropathology (T.M., S.L.-L., C.D.) and Institut de Myologie (B.E.), Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris; and Department of Immunology (C.B., L.D., O. Boyer), UNIROUEN, INSERM, U1234, Normandie University, Rouen University Hospital, France.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000004923DOI Listing
February 2018

Alzheimer disease.

Handb Clin Neurol 2017 ;145:325-337

Raymond Escourolle Neuropathology Department. Groupe Hospitalier Pitié-Salpêtrière, Paris, France; Alzheimer-Prion Research Team, Institut du Cerveau et de la Moelle (ICM), Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/B97801280239520
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http://dx.doi.org/10.1016/B978-0-12-802395-2.00023-7DOI Listing
January 2018

Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas.

Brain Pathol 2017 Sep 28;27(5):567-579. Epub 2016 Oct 28.

POLA Network investigators: Amiens: Christine Desenclos, Henri Sevestre; Angers: Philippe Menei, Audrey Rousseau; Besançon: Joel Godard, Gabriel Viennet; Bobigny: Antoine Carpentier; Bordeaux: Sandrine Eimer, Hugues Loiseau; Brest: Phong Dam-Hieu, Isabelle Quintin-Roué; Caen: Jean-Sebastien Guillamo, Emmanuelle Lechapt-Zalcman; Clermont-Ferrand:Jean-Louis Kemeny, Toufik Khallil; Clichy: Dominique Cazals-Hatem, Thierry Faillot; Cornebarrieu: Ioana Carpiuc, Pomone Richard; Créteil: Caroline Le Guerinel; Colmar: Claude Gaultier, Marie-Christine Tortel; Dijon: Marie-Hélène Aubriot-Lorton, François Ghiringhelli; Kremlin-Bicêtre: Clovis Adam, Fabrice Parker; Lille: Claude-Alain Maurage, Carole Ramirez; Limoges: Edouard Marcel Gueye, François Labrousse; Lyon: Anne Jouvet; Marseille: Olivier Chinot; Montpellier: Luc Bauchet, Valérie Rigau; Nancy: Patrick Beauchesne, Dr Guillaume Gauchotte; Nantes: Mario Campone, Delphine Loussouarn; Nice: Denys Fontaine, Fanny Vandenbos; Orléans: Claire Blechet, Mélanie Fesneau; Paris: Jean Yves Delattre (national coordinator of the network), Selma Elouadhani-Hamdi, Damien Ricard; Poitiers: Delphine Larrieu-Ciron, Pierre-Marie Levillain; Reims: Philippe Colin, Marie-Danièle Diebold; Rennes: Danchristian Chiforeanu, Elodie Vauléon; Rouen: Olivier Langlois, Annie Laquerrière; Saint-Etienne: Marie Janette Motsuo Fotso, Michel Peoc'h; Saint-Pierre de la réunion: Marie Andraud, Gwenaelle Runavot; Strasbourg: Marie-Pierre Chenard, Georges Noel; Suresnes: Dr Stéphane Gaillard, Dr Chiara Villa; Toulon: Nicolas Desse; Toulouse: Elisabeth Cohen-Moyal, Emmanuelle Uro-Coste; Villejuif: Frédéric Dhermain.

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http://dx.doi.org/10.1111/bpa.12434DOI Listing
September 2017

Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease.

J Neuropathol Exp Neurol 2017 Sep;76(9):800-812

Service de Neuropathologie, Laboratoire Raymond Escourolle, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Hôpital de la Pitié-Salpêtrière, Paris, France; Institut du Cerveau et de la Moelle Épinière (ICM), INSERM U1127, CNRS UMR 7225, Sorbonne Universités, Université Pierre et Marie Curie, Univ Paris 06, UPMC-P6 UMR S 1127, Hôpital de la Pitié-Salpêtrière, Paris, France; Département de Neurologie, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Paris, France; Centre de Référence des Démences Rares, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Paris, France; Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan; and Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1093/jnen/nlx063DOI Listing
September 2017

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

J Neuropathol Exp Neurol 2017 Jul;76(7):605-619

Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlx041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251511PMC
July 2017

Alzheimer's senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures.

J Neural Transm (Vienna) 2017 06 6;124(6):685-694. Epub 2017 Apr 6.

Alzheimer's and Prion Diseases Team, Institut du Cerveau et de la Moelle Epinière, CNRS UMR 7225, INSERM 1127, UPMC UM75, Paris, France.

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http://dx.doi.org/10.1007/s00702-017-1718-7DOI Listing
June 2017

The MAPT gene is differentially methylated in the progressive supranuclear palsy brain.

Mov Disord 2016 12 6;31(12):1883-1890. Epub 2016 Oct 6.

Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.

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http://dx.doi.org/10.1002/mds.26820DOI Listing
December 2016

Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.

Neurobiol Dis 2016 Oct 31;94:32-43. Epub 2016 May 31.

Laboratory of Histology, Neuroanatomy and Neuropathology, UNI (ULB Neuroscience Institute), Université Libre de Bruxelles, B-1070 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.05.017DOI Listing
October 2016

Caspase-cleaved Tau-D(421) is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons.

Neurobiol Aging 2016 10 5;46:124-37. Epub 2016 Jul 5.

INSERM, Unité mixte de recherche 1195, Université Paris-Saclay, Le Kremlin Bicêtre, France. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.06.017DOI Listing
October 2016

Progressive Supranuclear Palsy Syndrome and Semantic Dementia in Neuropathologically Proven Lewy Body Disease: A Report of Two Cases.

J Alzheimers Dis 2015 ;47(1):95-101

Neurology of Memory and Language Unit, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-150203DOI Listing
June 2016

Coronary and Basilar Artery Ectasia Are Associated: Results From an Autopsy Case-Control Study.

Stroke 2016 Jan 29;47(1):224-7. Epub 2015 Oct 29.

From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.).

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http://dx.doi.org/10.1161/STROKEAHA.115.010797DOI Listing
January 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.

Acta Neuropathol 2016 Jan 29;131(1):5-25. Epub 2015 Dec 29.

Laboratoire de Neuropathologie Raymond-Escourolle, Hopital de la Pitie-Salpetriere, 47, boulevard de l'Hopital, 75651, Paris Cedex 13, France.

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http://dx.doi.org/10.1007/s00401-015-1516-yDOI Listing
January 2016

Extensive brain demyelinating lesions under natalizumab: The role of anti-natalizumab antibodies.

Neurology 2015 Nov 9;85(18):1630-2. Epub 2015 Oct 9.

From the Department of Neurology (R.D., E.M., R.F., C.P., C.L.), Department of Neuroradiology (D.G.), Department of Neuropathology (C.D.), Salpêtrière Hospital, Paris AP HP, France; and Institute of Neuropathology (C.S.), University Medical Center Göttingen, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000002084DOI Listing
November 2015

A Recurrent Mutation in CACNA1G Alters Cav3.1 T-Type Calcium-Channel Conduction and Causes Autosomal-Dominant Cerebellar Ataxia.

Am J Hum Genet 2015 Nov 8;97(5):726-37. Epub 2015 Oct 8.

INSERM U 1127, 75013 Paris, France; Centre National de la Recherche Scientifique UMR 7225, 75013 Paris, France; UMRS 1127, Université Pierre et Marie Curie (Paris 06), Sorbonne Universités, 75013 Paris, France; Institut du Cerveau et de la Moelle Épinière, 75013 Paris, France; Ecole Pratique des Hautes Etudes, 75014 Paris, France; Centre de Référence de Neurogénétique, Hôpital de la Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667105PMC
November 2015

Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion.

J Neurol Neurosurg Psychiatry 2015 Sep 4;86(9):986-95. Epub 2014 Dec 4.

Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S1127, Paris, France Inserm, U1127, Paris, France Cnrs, UMR 7225, Paris, France AP-HP, Groupe Hospitalier Pitié-Salpêtriére, Departement of Genetics and Cytogenetics, Paris, France.

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http://dx.doi.org/10.1136/jnnp-2014-309153DOI Listing
September 2015

Chordoid gliomas of the third ventricle share TTF-1 expression with organum vasculosum of the lamina terminalis.

Am J Surg Pathol 2015 Jul;39(7):948-56

*Neuropathology Department Raymond-Escourolle ***AP-HP, Neurology 2 Mazarin Department, Pitié-Salpêtrière Hospital §§§Onconeurotek, Pitié-Salpêtrière Hospital ††Pathology Department, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris †Sorbonne Universités, UPMC Univ Paris 06, UM 75 ‡Institut National de la Santé et de la Recherche Médicale, U 1127 §Centre National de la Recherche Scientifique, UMR 7225, ICM ∥Brain and Spine Institute #Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Université Paris Descartes, Paris ¶Department of Anatomical and Cytological Pathology, Hôpital Foch, Suresnes **Pathology Department, Hôpital Bretonneau, CHRU Tours, Tours ‡‡Pathology and Neuropathology Department, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron §§Pathology Department, Plateau technique de Biologie, CHU, Dijon ∥∥Department of Pathology, Caen University Hospital ¶¶Centre National de la Recherche Scientifique, UMR 6301 ISTCT CERVOxy Group, Caen ##Pathology Department, CHU Besançon, Besançon †††Pathology and Neuropathology Department, Assistance Publique-Hôpitaux de Marseille, AP-HM CHU, Timone ‡‡‡Aix-Marseille university, INSERM U911, Marseille, France.

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http://dx.doi.org/10.1097/PAS.0000000000000421DOI Listing
July 2015

Acute amnestic encephalopathy in amyloid-β oligomer-injected mice is due to their widespread diffusion in vivo.

Neurobiol Aging 2015 Jun 16;36(6):2043-52. Epub 2015 Mar 16.

Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Inserm, U 1127, CNRS UMR 7225, ICM, Paris, France.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.005DOI Listing
June 2015

TDP-43 Pathology Progression Along the Olfactory Pathway as a Possible Substrate for Olfactory Impairment in Amyotrophic Lateral Sclerosis.

J Neuropathol Exp Neurol 2015 Jun;74(6):547-56

From the Department of Neurology, Tokyo Women's Medical University (TT, MI, SU); Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute of Medical Science (TT, TU); Department of Neurology, Tokyo Women's Medical University Yachiyo Medical Center, Tokyo, Japan (TO); and Raymond Escourolle Laboratory of Neuropathology, Université Pierre et Marie Curie, Assistance Publique-Hôpitaux de Paris, La Salpêtrière Hospital, Paris, France (TT, DS, CD).

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http://dx.doi.org/10.1097/NEN.0000000000000198DOI Listing
June 2015

PART is part of Alzheimer disease.

Acta Neuropathol 2015 May 28;129(5):749-56. Epub 2015 Jan 28.

Laboratoire de Neuropathologie Escourolle, AP-HP, Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75651, Paris Cedex 13, France,

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http://dx.doi.org/10.1007/s00401-015-1390-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405349PMC
May 2015

Th1 response and systemic treg deficiency in inclusion body myositis.

PLoS One 2014 4;9(3):e88788. Epub 2014 Mar 4.

Inflammation-Immunopathology-Biotherapy (i2B), Hôpital Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris, Paris, France; Internal Medicine Department 1, Centre de référence Maladie Neuromusculaire, Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière Paris, France; U974, Sorbonne Universités, Pierre and Marie Curie University, Paris 06, Paris, France; U974, Institut National de la Santé et de la Recherche Médicale, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088788PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942319PMC
February 2015

Ultra performance liquid chromatography - mass spectrometry studies of formalin-induced alterations of human brain lipidome.

J Mass Spectrom 2014 Oct;49(10):1035-42

Chimie-Toxicologie Analytique et Cellulaire, UMR CNRS 8638 COMETE, Faculté des Sciences Pharmaceutiques et Biologiques de Paris, Université Paris Descartes, Sorbonne Paris Cité, 75006, Paris, France; Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198, Gif-sur-Yvette, France; Technologie Servier, 45000, Orléans, France.

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http://dx.doi.org/10.1002/jms.3424DOI Listing
October 2014

Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D.

Acta Neuropathol 2014 Sep 29;128(3):457-9. Epub 2014 Jul 29.

Laboratoire de Neuropathologie Escourolle, AP-HP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France.

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http://dx.doi.org/10.1007/s00401-014-1322-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131133PMC
September 2014

Multifunctional nanoliposomes with curcumin-lipid derivative and brain targeting functionality with potential applications for Alzheimer disease.

Eur J Med Chem 2014 Jun 18;80:175-83. Epub 2014 Apr 18.

Laboratory of Pharmaceutical Technology, Dept. of Pharmacy, School of Health Sciences, University of Patras, Rio 26510, Greece; Institute of Chemical Engineering Sciences, FORTH/ICES, Rio, 26504 Patras, Greece. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234140037
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http://dx.doi.org/10.1016/j.ejmech.2014.04.050DOI Listing
June 2014

Ceramides and sphingomyelinases in senile plaques.

Neurobiol Dis 2014 May 28;65:193-201. Epub 2014 Jan 28.

Laboratoire de Neuropathologie Escourolle, Hôpital de la Salpêtrière, AP-HP, Paris, France; Centre de recherche de l'ICM, UPMC, INSERM UMR S 975, CNRS UMR 7225, France; Equipe de Statistique Appliquée, ESPCI Paris Tech, Paris, France.

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http://dx.doi.org/10.1016/j.nbd.2014.01.010DOI Listing
May 2014

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020.

Biochem Pharmacol 2014 Apr 22;88(4):426-49. Epub 2013 Nov 22.

Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié Salpêtrière, Paris, France; Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1016/j.bcp.2013.11.009DOI Listing
April 2014

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.

Brain 2014 Feb 8;137(Pt 2):537-52. Epub 2014 Jan 8.

1 Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, 6041-Gosselies, Belgium.

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http://dx.doi.org/10.1093/brain/awt344DOI Listing
February 2014

Dendritic retraction, but not atrophy, is consistent in amyotrophic lateral sclerosis-comparison between Onuf's neurons and other sacral motor neurons.

Acta Neuropathol Commun 2014 Jan 27;2:11. Epub 2014 Jan 27.

Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1186/2051-5960-2-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922781PMC
January 2014

An elderly woman with difficulty reading and abnormal eye movements.

J Neuroophthalmol 2013 Sep;33(3):296-301

Hospices Civils de Lyon, Service d'Anatomo-pathologie, Groupement Hospitalier Est, Bron, France.

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http://dx.doi.org/10.1097/WNO.0b013e318292bf35DOI Listing
September 2013

Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: possible applications to Alzheimer disease.

Nanomedicine 2013 Jul 7;9(5):712-21. Epub 2012 Dec 7.

Laboratoire de Neuropathologie Escourolle, Hôpital de la Salpêtrière, AP-HP, 47 Bd de l'Hôpital, Paris, France.

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http://dx.doi.org/10.1016/j.nano.2012.11.004DOI Listing
July 2013

[Progress in neuropathology changes the understanding of neurodegenerative diseases].

Rev Prat 2013 May;63(5):655-61

Laboratoire de neuropathologie Raymond-Escourolle, groupe hospitalier Pitié-Salpêtrière, AP-HP, 75013 Paris, France.

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May 2013

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients.

Acta Neuropathol 2013 Jan 7;125(1):133-44. Epub 2012 Sep 7.

Laboratoire de Neuropathologie Escourolle, Hôpital de la Salpêtrière, AP-HP, 47 Bd de l'Hôpital, 75013 Paris, France.

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http://dx.doi.org/10.1007/s00401-012-1041-1DOI Listing
January 2013

[New insights into intracellular inclusions and intracellular proteolysis].

Bull Acad Natl Med 2012 Nov;196(8):1575-85; discussion 1585-6

L'Académie nationale de médecine.

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November 2012

Choline-containing phospholipids in microdissected human Alzheimer's disease brain senile plaque versus neuropil.

Bioanalysis 2012 Sep;4(17):2153-5159

Chimie-Toxicologie Analytique et Cellulaire, EA 4463, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, France.

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http://dx.doi.org/10.4155/bio.12.189DOI Listing
September 2012

Association between a Primitive Brain Tumor and Cerebral Aspergillosis.

Case Rep Med 2012 20;2012:748202. Epub 2012 Feb 20.

Laboratoire de Neuropathologie Escourolle, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47-83 boulevard de l'Hôpital, 75651 Paris cedex 13, France.

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http://dx.doi.org/10.1155/2012/748202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295534PMC
August 2012

Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.

J Alzheimers Dis 2012 ;29(2):471-83

Institut National de la Santé et de la Recherche Médicale U788, Stéroïdes et Systèmes Nerveux, Le Kremlin-Bicêtre Cedex, France.

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http://dx.doi.org/10.3233/JAD-2011-111895DOI Listing
July 2012

Combining immunofluorescence and electron microscopy with quantum dots.

Am J Pathol 2012 Apr 25;180(4):1356-7. Epub 2012 Feb 25.

Raymond Escourolle Neuropathology Laboratory, GHU Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/j.ajpath.2012.02.001DOI Listing
April 2012

Abnormal TDP-43 and FUS proteins in muscles of sporadic IBM: similarities in a TARDBP-linked ALS patient.

J Neurol Neurosurg Psychiatry 2011 Dec 18;82(12):1414-6. Epub 2010 Jun 18.

Fédération des Maladies du Système Nerveux, Bât Paul Castaigne, Hôpital Pitié-Salpêtrière, 83 bd de l'Hôpital, 75013 Paris, France;

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http://dx.doi.org/10.1136/jnnp.2010.208868DOI Listing
December 2011

Disentangling Alzheimer's disease.

Lancet Neurol 2011 Sep 27;10(9):774-5. Epub 2011 Jul 27.

Laboratoire de Neuropathologie Escourolle, Assistance Publique-Hôpitaux de Paris, Université Pierre and Marie Curie, and Institut du Cerveau et de la Moelle, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/S1474-4422(11)70171-5DOI Listing
September 2011

Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia.

Mol Cell Neurosci 2011 Jul 27;47(3):191-202. Epub 2011 Apr 27.

INSERM, U975, Université Pierre et Marie Curie-Paris 6, UMR_S975, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CR-icm), GHU Pitié-Salpêtrière, CNRS, Paris, France.

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http://dx.doi.org/10.1016/j.mcn.2011.04.004DOI Listing
July 2011

Fronto-temporal lobar degeneration: neuropathology in 60 cases.

J Neural Transm (Vienna) 2011 May 4;118(5):753-64. Epub 2011 May 4.

Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, INSERM UMR_S975, CNRS UMR7225, Groupe Hospitalier Pitié-Salpêtrière, AP-HP and UPMC-Sorbonne Universités, Paris, France.

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http://dx.doi.org/10.1007/s00702-011-0649-yDOI Listing
May 2011

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

FASEB J 2011 Apr 21;25(4):1295-305. Epub 2011 Jan 21.

Centre de Recherche de l'Institut du Cerveau et de la Moelle, UPMC, INSERM UMR-S975, Centre National de la Recherche Scientifique (CNRS) UMR7225, Hôpital de la Pitié-Salpêtrière, Paris, France.

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http://www.fasebj.org/doi/10.1096/fj.10-168633
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http://dx.doi.org/10.1096/fj.10-168633DOI Listing
April 2011

Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear inclusions and cytotoxicity in spinocerebellar ataxia-7 (SCA7).

Neurobiol Dis 2011 Jan 20;41(1):33-42. Epub 2010 Aug 20.

Jikei University School of Medicine, Division of Neuropathology, 3-25-8 Nishi-Shinbashi, Minato-ku, 105-8461, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.nbd.2010.08.016DOI Listing
January 2011

[Update on the pathophysiology of Parkinson' disease].

Bull Acad Natl Med 2010 Oct;194(7):1287-303; discussion 1303-4

Laboratoire de neuropathologie Escourolle - Hôpital de la Pitié Salpêtrière - 47 bld de l'Hôpital, 75651 Paris cedex 13.

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October 2010

Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease.

J Neuropathol Exp Neurol 2010 Sep;69(9):959-72

Laboratory of Molecular Basis, Physiopathology and Treatment of Neurodegenerative Diseases, Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France.

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http://dx.doi.org/10.1097/NEN.0b013e3181efc01cDOI Listing
September 2010

Cholesterol changes in Alzheimer's disease: methods of analysis and impact on the formation of enlarged endosomes.

Biochim Biophys Acta 2010 Aug 27;1801(8):839-45. Epub 2010 Mar 27.

Centre de Recherche de l'Institut du Cerveau et de la Moelle, CNRS UMR7225, INSERM UMR975 and UPMC, Hôpital de la Pitié-Salpêtrière, 75013 Paris, France.

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http://dx.doi.org/10.1016/j.bbalip.2010.03.010DOI Listing
August 2010

Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol.

Biochim Biophys Acta 2010 Aug 24;1801(8):846-52. Epub 2010 May 24.

Centre de Recherche de l'Institut du Cerveau et de la Moelle, CNRS UMRS7225 INSERM UMRS975 UPMC, Hôpital de La Salpêtrière, 75651, Paris Cedex 13, France.

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http://dx.doi.org/10.1016/j.bbalip.2010.05.010DOI Listing
August 2010