Charles D Smith

Charles D Smith

UNVERIFIED PROFILE

Are you Charles D Smith?   Register this Author

Register author
Charles D Smith

Charles D Smith

Publications by authors named "Charles D Smith"

Are you Charles D Smith?   Register this Author

100Publications

2783Reads

5Profile Views

Post-acquisition processing confounds in brain volumetric quantification of white matter hyperintensities.

J Neurosci Methods 2019 Nov 10;327:108391. Epub 2019 Aug 10.

Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY, 40506, United States; Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, 40506, United States; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, KY, 40506, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2019.108391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746343PMC
November 2019

Targeting Sphingosine Kinases for the Treatment of Cancer.

Adv Cancer Res 2018 9;140:295-325. Epub 2018 Jun 9.

Apogee Biotechnology Corporation, Hummelstown, PA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.acr.2018.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447312PMC
September 2019

Distinct patterns of default mode and executive control network circuitry contribute to present and future executive function in older adults.

Neuroimage 2019 07 4;195:320-332. Epub 2019 Apr 4.

Department of Neuroscience, University of Kentucky, Lexington, KY, 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, 40536, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2019.03.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536351PMC
July 2019

Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.

J Clin Exp Neuropsychol 2018 10 20;40(8):761-776. Epub 2018 Feb 20.

a Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13803395.2018.1430230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397625PMC
October 2018

Age and Alzheimer's pathology disrupt default mode network functioning via alterations in white matter microstructure but not hyperintensities.

Cortex 2018 07 19;104:58-74. Epub 2018 Apr 19.

Department of Neuroscience, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cortex.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008234PMC
July 2018

The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.

Int J Cancer 2018 05 4;142(10):2153-2162. Epub 2018 Jan 4.

Department of Genetics, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, 1700 Tulane Ave., New Orleans, LA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.31234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867242PMC
May 2018

ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus-Infected Cell Autophagic Death and Represses Tumor Growth.

Mol Cancer Ther 2017 Dec 22;16(12):2724-2734. Epub 2017 Sep 22.

Department of Pediatrics, Research Center for Translational Medicine and Key Laboratory of Arrhythmias, East Hospital, Tongji University School of Medicine, Shanghai, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-17-0485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716930PMC
December 2017

Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease.

Neuroimage Clin 2017 25;13:106-115. Epub 2016 Nov 25.

Department of Neuroscience, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2016.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137184PMC
November 2017

Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults.

Neurobiol Aging 2017 10 24;58:102-111. Epub 2017 Jun 24.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581730PMC
October 2017

Deconstructing normal pressure hydrocephalus: Ventriculomegaly as early sign of neurodegeneration.

Ann Neurol 2017 Oct 4;82(4):503-513. Epub 2017 Oct 4.

Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, University Health Network, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25046DOI Listing
October 2017

Bilateral Radiation Optic Neuropathy Following Concurrent Chemotherapy and Radiation in Glioblastoma.

Neuroophthalmology 2017 Oct 30;41(5):287-290. Epub 2017 May 30.

Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01658107.2017.1322989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762177PMC
October 2017

Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells.

PLoS One 2017 14;12(3):e0173246. Epub 2017 Mar 14.

Medical University of South Carolina, Department of Biochemistry & Molecular Biology, 173 Ashley Avenue, Charleston, SC, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173246PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349447PMC
September 2017

Clinical Reasoning: Two see or not two see-Is it really double vision?

Neurology 2017 08;89(6):e56-e60

From the Department of Neurology, University of Kentucky, Lexington.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004196DOI Listing
August 2017

Tolyporphin Macrocycles from the Cyanobacterium Tolypothrix nodosa Selectively Bind Copper and Silver and Reverse Multidrug Resistance.

Inorg Chem 2017 May 27;56(10):5577-5585. Epub 2017 Feb 27.

Institute for Molecular Bioscience, University of Queensland , Brisbane 4072, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.6b03000DOI Listing
May 2017

White Matter Hyperintensity Associations with Cerebral Blood Flow in Elderly Subjects Stratified by Cerebrovascular Risk.

J Stroke Cerebrovasc Dis 2017 Apr 4;26(4):779-786. Epub 2017 Jan 4.

Department of Biomedical Engineering, School of Engineering, University of Kentucky, Lexington, Kentucky; Magnetic Resonance Imaging and Spectroscopy Center (MRISC), University of Kentucky, Lexington, Kentucky; Department of Neurology, University of Kentucky Medical College, Lexington, Kentucky. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473621PMC
April 2017

A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging.

Alzheimers Res Ther 2017 Jan 19;9(1). Epub 2017 Jan 19.

Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13195-016-0229-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244569PMC
January 2017

Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow.

Bioanalysis 2015 27;7(20):2611-9. Epub 2015 Oct 27.

Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.15.174DOI Listing
August 2016

"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).

J Neuropathol Exp Neurol 2016 06 21;75(6):482-98. Epub 2016 May 21.

From the Department of Pathology, Division of Neuropathology (PTN, JHN), Department of Neurology (GAJ, FAS, CDS), Department of Statistics (DWF, RJK), Department of Anatomy and Neurobiology (PTN, JHN, LJVE, ETI), Department of Epidemiology (ELA), and Sanders-Brown Center on Aging (PTN, ELA, OMA-J, GAJ, FAS, CDS, DWF, WXW, RJK, LJVE, ETI), University of Kentucky, Lexington, Kentucky; Department of Pathology & Laboratory Medicine and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, Pennsylvannia (JQT); Department of Epidemiology, University of Washington, Seattle, Washington (WAK); and Department of Pathology, Houston Methodist Hospital, Houston, Texas (MDC).

View Article

Download full-text PDF

Source
https://academic.oup.com/jnen/article-lookup/doi/10.1093/jne
Publisher Site
http://dx.doi.org/10.1093/jnen/nlw033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366658PMC
June 2016

Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression.

Parkinsons Dis 2015 17;2015:513452. Epub 2015 Dec 17.

Department of Neurology, University of Kentucky, Lexington, KY 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA; Department of Behavioral Science, University of Kentucky, Lexington, KY 40536, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2015/513452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697088PMC
January 2016

Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells.

PLoS One 2014 10;9(7):e102314. Epub 2014 Jul 10.

Department of Medicine, Louisiana State University Health Sciences Center, HIV Malignancies Program, Louisiana Cancer Research Center, New Orleans, Louisiana, United States of America; Department of Microbiology/Immunology/Parasitology, Louisiana State University Health Sciences Center, HIV Malignancies Program, Louisiana Cancer Research Center, New Orleans, Louisiana, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102314PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092155PMC
November 2015

Sugihara causality analysis of scalp EEG for detection of early Alzheimer's disease.

Neuroimage Clin 2015 13;7:258-65. Epub 2014 Dec 13.

Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY, USA ; Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, KY 40356, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2014.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300018PMC
September 2015

Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression.

Oncotarget 2015 Sep;6(27):24246-60

Department of Microbiology/Immunology/Parasitology, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, New Orleans, LA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.4759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695183PMC
September 2015

Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature.

J Neuropathol Exp Neurol 2015 Jul;74(7):642-52

From Department of Pathology, Division of Neuropathology (JHN, PTN), Department of Neurology (GAJ, FAS, CDS), Department of Statistics (RJK), Department of Epidemiology (ELA), Sanders-Brown Center on Aging (GAJ, FAS, ELA, RJK, CDS, TD, SA, EL, AB, LVE, PTN), and Department of Anatomy and Neurobiology (ETI, LVE, PTN), University of Kentucky, Lexington, Kentucky.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NEN.0000000000000204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539239PMC
July 2015

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.

Sci Signal 2015 Jun 16;8(381):ra58. Epub 2015 Jun 16.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aaa4998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492107PMC
June 2015

Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort.

Dement Geriatr Cogn Disord 2014 31;37(5-6):294-306. Epub 2013 Dec 31.

University of Kentucky Alzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Ky., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000355478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057973PMC
February 2015

Reversible cognitive, motor, and driving impairments in severe hypothyroidism.

Thyroid 2015 Jan;25(1):28-36

1 Department of Neurology, University of Kentucky College of Medicine , Lexington Kentucky.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/thy.2014.0371DOI Listing
January 2015

White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.

Neurobiol Aging 2014 Oct 2;35(10):2263-71. Epub 2014 May 2.

Department of Neurology, University of Kentucky, Lexington, KY, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2014.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087077PMC
October 2014

Self-reported memory complaints: implications from a longitudinal cohort with autopsies.

Neurology 2014 Oct 24;83(15):1359-65. Epub 2014 Sep 24.

From the Sanders-Brown Center on Aging (R.J.K., E.L.A., G.E.C., G.A.J., P.T.N., C.D.S., L.J.V.E., L.W., F.A.S.), Alzheimer's Disease Center (R.J.K., E.L.A., G.E.C., D.W.F., G.A.J., P.T.N., C.D.S., L.J.V.E., F.A.S.), Departments of Biostatistics (R.J.K., D.W.F.), Statistics (R.J.K., L.W.), Epidemiology (E.L.A.), and Pathology (P.T.N.), Department of Anatomy and Neurobiology, College of Medicine (L.J.V.E.), and Department of Neurology, College of Medicine (G.A.J., C.D.S., F.A.S.), University of Kentucky, Lexington; and Baptist Neurology Center (G.E.C.), Lexington, KY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189103PMC
October 2014

Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl1 axis.

PLoS One 2013 26;8(9):e75414. Epub 2013 Sep 26.

Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075414PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784419PMC
July 2014

Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment.

J Clin Exp Neuropsychol 2013 30;35(9):946-59. Epub 2013 Sep 30.

a Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.1080/13803395.2013.838
Publisher Site
http://dx.doi.org/10.1080/13803395.2013.838942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884808PMC
June 2014

Spectral and complexity analysis of scalp EEG characteristics for mild cognitive impairment and early Alzheimer's disease.

Comput Methods Programs Biomed 2014 Apr 8;114(2):153-63. Epub 2014 Feb 8.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40356, United States; Department of Behavioral Science, University of Kentucky, Lexington, KY 40356, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmpb.2014.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021716PMC
April 2014

Dopaminergic modulation of memory and affective processing in Parkinson depression.

Psychiatry Res 2013 Nov 6;210(1):146-9. Epub 2013 Jul 6.

Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St., Lexington, KY, USA; Department of Behavioral Science, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2013.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805794PMC
November 2013

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

Rheumatol Int 2013 Oct 3;33(10):2677-81. Epub 2012 Aug 3.

Departments of Microbiology and Immunology, 173 Ashley Avenue MSC 504 Room 203, Charleston, SC, 29425, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00296-012-2493-2
Publisher Site
http://dx.doi.org/10.1007/s00296-012-2493-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784643PMC
October 2013

Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation.

J Cereb Blood Flow Metab 2013 May 30;33(5):708-15. Epub 2013 Jan 30.

Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1038/jcbfm.2013.1
Publisher Site
http://dx.doi.org/10.1038/jcbfm.2013.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652696PMC
May 2013

Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.

PLoS One 2012 25;7(7):e41834. Epub 2012 Jul 25.

Department of Pharmaceutical & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041834PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405047PMC
April 2013

Characterization of isoenzyme-selective inhibitors of human sphingosine kinases.

PLoS One 2012 10;7(9):e44543. Epub 2012 Sep 10.

Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044543PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438171PMC
March 2013

Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors.

Bioorg Med Chem 2013 Mar 3;21(5):1180-9. Epub 2013 Jan 3.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09680896120100
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2012.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582361PMC
March 2013

Multimodal imaging evidence for axonal and myelin deterioration in amnestic mild cognitive impairment.

J Alzheimers Dis 2012 ;31 Suppl 3:S19-31

Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, KY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-2012-112165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448019PMC
February 2013

Structural brain alterations before mild cognitive impairment in ADNI: validation of volume loss in a predefined antero-temporal region.

J Alzheimers Dis 2012 ;31 Suppl 3:S49-58

Department of Neurology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536-0098, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-2012-120157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652624PMC
February 2013

Lifelong bilingualism maintains neural efficiency for cognitive control in aging.

J Neurosci 2013 Jan;33(2):387-96

Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3837-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710134PMC
January 2013

Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction.

Biochem J 2012 Sep;446(3):455-67

Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20111961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767384PMC
September 2012

Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Authors:
Mariet Allen Fanggeng Zou High Seng Chai Curtis S Younkin Julia Crook V Shane Pankratz Minerva M Carrasquillo Christopher N Rowley Asha A Nair Sumit Middha Sooraj Maharjan Thuy Nguyen Li Ma Kimberly G Malphrus Ryan Palusak Sarah Lincoln Gina Bisceglio Constantin Georgescu Debra Schultz Fariborz Rakhshan Christopher P Kolbert Jin Jen Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg Ronald C Petersen Neill R Graff-Radford Dennis W Dickson Steven G Younkin Nilüfer Ertekin-Taner Liana G Apostolova Steven E Arnold Clinton T Baldwin Robert Barber Michael M Barmada Thomas Beach Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Jacqueline Buros Joseph D Buxbaum Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Paul K Crane Carlos Cruchaga Jeffrey L Cummings Philip L De Jager Charles DeCarli Steven T DeKosky F Yesim Demirci Ramon Diaz-Arrastia Malcolm Dick Beth A Dombroski Ranjan Duara William D Ellis Denis Evans Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Tatiana M Foroud Matthew Frosch Douglas R Galasko Paul J Gallins Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass Alison M Goate Robert C Green John H Growdon Hakon Hakonarson Ronald L Hamilton John Hardy Lindy E Harrell Elizabeth Head Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun M Ilyas Kamboh Jason Karlawish Anna Karydas John S K Kauwe Jeffrey A Kaye Nancy Kennedy Ronald Kim Edward H Koo Neil W Kowall Patricia Kramer Walter A Kukull James J Lah Eric B Larson Allan I Levey Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Amanda J Myers Adam C Naj Petra Nowotny Joseph E Parisi Daniel P Perl Elaine Peskind Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Ruchita A Rajbhandary Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Peter St George-Hyslop Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Badri Narayan Vardarajan Harry V Vinters Jean Paul Vonsattel Li-San Wang Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer

Neurology 2012 Jul 20;79(3):221-8. Epub 2012 Jun 20.

Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0b013e3182605801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398432PMC
July 2012

Partial least squares for discrimination in fMRI data.

Magn Reson Imaging 2012 Apr 5;30(3):446-52. Epub 2012 Jan 5.

Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536-0098, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mri.2011.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288364PMC
April 2012

Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.

Am J Pathol 2012 Apr 7;180(4):1740-50. Epub 2012 Feb 7.

Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2011.12.024DOI Listing
April 2012

Structural imaging in early pre-states of dementia.

Authors:
Charles D Smith

Biochim Biophys Acta 2012 Mar 14;1822(3):317-24. Epub 2011 Jul 14.

Alzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2011.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223541PMC
March 2012

White matter integrity and vulnerability to Alzheimer's disease: preliminary findings and future directions.

Biochim Biophys Acta 2012 Mar 23;1822(3):416-22. Epub 2011 Jul 23.

Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2011.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213315PMC
March 2012

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Authors:
Trygve E Bakken J Cooper Roddey Srdjan Djurovic Natacha Akshoomoff David G Amaral Cinnamon S Bloss B J Casey Linda Chang Thomas M Ernst Jeffrey R Gruen Terry L Jernigan Walter E Kaufmann Tal Kenet David N Kennedy Joshua M Kuperman Sarah S Murray Elizabeth R Sowell Lars M Rimol Morten Mattingsdal Ingrid Melle Ingrid Agartz Ole A Andreassen Nicholas J Schork Anders M Dale Michael Weiner Paul Aisen Ronald Petersen Clifford R Jack William Jagust John Q Trojanowki Arthur W Toga Laurel Beckett Robert C Green Andrew J Saykin John Morris Enchi Liu Tom Montine Anthony Gamst Ronald G Thomas Michael Donohue Sarah Walter Devon Gessert Tamie Sather Danielle Harvey John Kornak Anders Dale Matthew Bernstein Joel Felmlee Nick Fox Paul Thompson Norbert Schuff Gene Alexander Charles DeCarli Dan Bandy Robert A Koeppe Norm Foster Eric M Reiman Kewei Chen Chet Mathis Nigel J Cairns Lisa Taylor-Reinwald J Q Trojanowki Les Shaw Virginia M Y Lee Magdalena Korecka Karen Crawford Scott Neu Tatiana M Foroud Steven Potkin Li Shen Zaven Kachaturian Richard Frank Peter J Snyder Susan Molchan Jeffrey Kaye Joseph Quinn Betty Lind Sara Dolen Lon S Schneider Sonia Pawluczyk Bryan M Spann James Brewer Helen Vanderswag Judith L Heidebrink Joanne L Lord Kris Johnson Rachelle S Doody Javier Villanueva-Meyer Munir Chowdhury Yaakov Stern Lawrence S Honig Karen L Bell John C Morris Beau Ances Maria Carroll Sue Leon Mark A Mintun Stacy Schneider Daniel Marson Randall Griffith David Clark Hillel Grossman Effie Mitsis Aliza Romirowsky Leyla deToledo-Morrell Raj C Shah Ranjan Duara Daniel Varon Peggy Roberts Marilyn Albert Chiadi Onyike Stephanie Kielb Henry Rusinek Mony J de Leon Lidia Glodzik Susan De Santi P Murali Doraiswamy Jeffrey R Petrella R Edward Coleman Steven E Arnold Jason H Karlawish David Wolk Charles D Smith Greg Jicha Peter Hardy Oscar L Lopez MaryAnn Oakley Donna M Simpson Anton P Porsteinsson Bonnie S Goldstein Kim Martin Kelly M Makino M Saleem Ismail Connie Brand Ruth A Mulnard Gaby Thai Catherine Mc-Adams-Ortiz Kyle Womack Dana Mathews Mary Quiceno Ramon Diaz-Arrastia Richard King Myron Weiner Kristen Martin-Cook Michael DeVous Allan I Levey James J Lah Janet S Cellar Jeffrey M Burns Heather S Anderson Russell H Swerdlow Liana Apostolova Po H Lu George Bartzokis Daniel H S Silverman Neill R Graff-Radford Francine Parfitt Heather Johnson Martin R Farlow Ann Marie Hake Brandy R Matthews Scott Herring Christopher H van Dyck Richard E Carson Martha G MacAvoy Howard Chertkow Howard Bergman Chris Hosein Sandra Black Bojana Stefanovic Curtis Caldwell Ging-Yuek Robin Hsiung Howard Feldman Benita Mudge Michele Assaly Andrew Kertesz John Rogers Dick Trost Charles Bernick Donna Munic Diana Kerwin Marek-Marsel Mesulam Kristina Lipowski Chuang-Kuo Wu Nancy Johnson Carl Sadowsky Walter Martinez Teresa Villena Raymond Scott Turner Kathleen Johnson Brigid Reynolds Reisa A Sperling Keith A Johnson Gad Marshall Meghan Frey Jerome Yesavage Joy L Taylor Barton Lane Allyson Rosen Jared Tinklenberg Marwan Sabbagh Christine Belden Sandra Jacobson Neil Kowall Ronald Killiany Andrew E Budson Alexander Norbash Patricia Lynn Johnson Thomas O Obisesan Saba Wolday Salome K Bwayo Alan Lerner Leon Hudson Paula Ogrocki Evan Fletcher Owen Carmichael John Olichney Smita Kittur Michael Borrie T-Y Lee Rob Bartha Sterling Johnson Sanjay Asthana Cynthia M Carlsson Steven G Potkin Adrian Preda Dana Nguyen Pierre Tariot Adam Fleisher Stephanie Reeder Vernice Bates Horacio Capote Michelle Rainka Douglas W Scharre Maria Kataki Earl A Zimmerman Dzintra Celmins Alice D Brown Godfrey D Pearlson Karen Blank Karen Anderson Robert B Santulli Eben S Schwartz Kaycee M Sink Jeff D Williamson Pradeep Garg Franklin Watkins Brian R Ott Henry Querfurth Geoffrey Tremont Stephen Salloway Paul Malloy Stephen Correia Howard J Rosen Bruce L Miller Jacobo Mintzer Crystal Flynn Longmire Kenneth Spicer Elizabether Finger Irina Rachinsky Dick Drost Terry Jernigan Connor McCabe Ellen Grant Thomas Ernst Josh Kuperman Yoon Chung Sarah Murray Cinnamon Bloss Burcu Darst Lexi Pritchett Ashley Saito David Amaral Mishaela DiNino Bella Eyngorina Elizabeth Sowell Suzanne Houston Lindsay Soderberg Walter Kaufmann Peter van Zijl Hilda Rizzo-Busack Mohsin Javid Natasha Mehta Erika Ruberry Alisa Powers Bruce Rosen Nitzah Gebhard Holly Manigan Jean Frazier David Kennedy Lauren Yakutis Michael Hill Jeffrey Gruen Joan Bosson-Heenan Heatherly Carlson

Proc Natl Acad Sci U S A 2012 Mar 16;109(10):3985-90. Epub 2012 Feb 16.

Medical Scientist Training Program, University of California at San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1105829109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309762PMC
March 2012

Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion.

J Hepatol 2012 Jan 12;56(1):137-45. Epub 2011 Jul 12.

Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2011.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220779PMC
January 2012

Sphingosine kinase 2 mediates cerebral preconditioning and protects the mouse brain against ischemic injury.

Stroke 2012 Jan 6;43(1):199-204. Epub 2011 Oct 6.

Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.111.626911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246529PMC
January 2012

Combined anticancer effects of sphingosine kinase inhibitors and sorafenib.

Invest New Drugs 2011 Dec 18;29(6):1132-42. Epub 2010 May 18.

Drug Discovery Core, Hollings Cancer Center and Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-010-9452-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089696PMC
December 2011

Discovery and evaluation of inhibitors of human ceramidase.

Mol Cancer Ther 2011 Nov 1;10(11):2052-61. Epub 2011 Sep 1.

Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-11-0365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213284PMC
November 2011

Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.

Mol Cancer Res 2011 Nov 6;9(11):1509-19. Epub 2011 Sep 6.

Department of Pharmaceutical & Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article

Download full-text PDF

Source
http://mcr.aacrjournals.org/content/9/11/1509.full.pdf
Web Search
http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-11
Publisher Site
http://dx.doi.org/10.1158/1541-7786.MCR-11-0336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219805PMC
November 2011

Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2.

Pharmacology 2011 22;87(3-4):135-43. Epub 2011 Feb 22.

Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17036, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000323911DOI Listing
August 2011

Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents.

Cancer Biol Ther 2011 Aug 1;12(3):229-38. Epub 2011 Aug 1.

Penn State Hershey Cancer Institute, Penn State Hershey Medical Center, Hershey, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cbt.12.3.17033DOI Listing
August 2011

Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer.

Cancer Biol Ther 2011 Aug 1;12(3):239-51. Epub 2011 Aug 1.

Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Hematology/Oncology Division, Penn State Hershey Cancer Institute, Penn State Hershey Medical Center, Hershey, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cbt.12.3.17034DOI Listing
August 2011

FLT-PET may not be a reliable indicator of therapeutic response in p53-null malignancy.

Int J Oncol 2011 Jul 29;39(1):91-100. Epub 2011 Apr 29.

Department of Radiology, University of Pennsylvania School of Medicine, 1 Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijo.2011.1019DOI Listing
July 2011

2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance.

Bioorg Med Chem 2011 Jul 23;19(14):4355-65. Epub 2011 May 23.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2011.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138178PMC
July 2011

Your idea and your university: issues in academic technology transfer.

Authors:
Charles D Smith

J Investig Med 2011 Jun;59(5):752-7

Apogee Biotechnology Corporation, Hummelstown, PA 17036, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2310/JIM.0b013e31820d0fdfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660085PMC
June 2011

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:
Adam C Naj Gyungah Jun Gary W Beecham Li-San Wang Badri Narayan Vardarajan Jacqueline Buros Paul J Gallins Joseph D Buxbaum Gail P Jarvik Paul K Crane Eric B Larson Thomas D Bird Bradley F Boeve Neill R Graff-Radford Philip L De Jager Denis Evans Julie A Schneider Minerva M Carrasquillo Nilufer Ertekin-Taner Steven G Younkin Carlos Cruchaga John S K Kauwe Petra Nowotny Patricia Kramer John Hardy Matthew J Huentelman Amanda J Myers Michael M Barmada F Yesim Demirci Clinton T Baldwin Robert C Green Ekaterina Rogaeva Peter St George-Hyslop Steven E Arnold Robert Barber Thomas Beach Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Jeffrey L Cummings Charles DeCarli Steven T DeKosky Ramon Diaz-Arrastia Malcolm Dick Dennis W Dickson William G Ellis Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Nancy Johnson Jason Karlawish Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall James J Lah Allan I Levey Andrew P Lieberman Oscar L Lopez Wendy J Mack Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Joseph E Parisi Daniel P Perl Elaine Peskind Ronald C Petersen Wayne W Poon Joseph F Quinn Ruchita A Rajbhandary Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Roger N Rosenberg Mary Sano Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer Laura B Cantwell Beth A Dombroski Duane Beekly Kathryn L Lunetta Eden R Martin M Ilyas Kamboh Andrew J Saykin Eric M Reiman David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg

Nat Genet 2011 May 3;43(5):436-41. Epub 2011 Apr 3.

The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090745PMC
May 2011

Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.

Inflammopharmacology 2011 Apr 11;19(2):75-87. Epub 2010 Oct 11.

Department of Pharmacology, Penn State College of Medicine, Hershey, Hummelstown, PA 17036, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10787-010-0060-6DOI Listing
April 2011

Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.

Cancer Biol Ther 2011 Apr 1;11(7):678-89. Epub 2011 Apr 1.

Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Tulane University School of Medicine, New Orleans, LA, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084971PMC
http://dx.doi.org/10.4161/cbt.11.7.14903DOI Listing
April 2011

Giant fibrous hamartoma of infancy: a report of two cases and review of the literature.

J Am Acad Dermatol 2011 Mar 2;64(3):579-86. Epub 2010 Jul 2.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2009.09.012DOI Listing
March 2011

Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.

Cancer Biol Ther 2011 Mar 1;11(5):524-34. Epub 2011 Mar 1.

Drug Discovery Core; Hollings Cancer Center, Medical University of South Carolina, Charleston, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087901PMC
http://dx.doi.org/10.4161/cbt.11.5.14677DOI Listing
March 2011

The Pim protein kinases regulate energy metabolism and cell growth.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):528-33. Epub 2010 Dec 27.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1013214108
Publisher Site
http://dx.doi.org/10.1073/pnas.1013214108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021022PMC
January 2011

Association between male gender and cortical Lewy body pathology in large autopsy series.

J Neurol 2010 Nov 20;257(11):1875-81. Epub 2010 Jun 20.

Division of Neuropathology, Department of Pathology, Sanders-Brown Center on Aging, University of Kentucky, Rm 311, Sanders-Brown Building, 800 S. Limestone, Lexington, KY 40536-0230, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-010-5630-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040648PMC
November 2010

Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.

Endocrinology 2010 Nov 22;151(11):5124-35. Epub 2010 Sep 22.

Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2010-0420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954724PMC
November 2010

Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease.

Neuroimage 2010 Oct 21;52(4):1487-94. Epub 2010 May 21.

Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2010.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910213PMC
October 2010

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.

Carcinogenesis 2010 Oct 5;31(10):1787-93. Epub 2010 Aug 5.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina and Medical University of South Carolina, Columbia, SC 29208, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgq158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981458PMC
October 2010

A novel sphingosine kinase inhibitor induces autophagy in tumor cells.

J Pharmacol Exp Ther 2010 May 23;333(2):454-64. Epub 2010 Feb 23.

Drug Discovery Core, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article

Download full-text PDF

Source
http://jpet.aspetjournals.org/content/333/2/454.full.pdf
Web Search
http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.109.16333
Publisher Site
http://dx.doi.org/10.1124/jpet.109.163337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872961PMC
May 2010

Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease.

Inflammopharmacology 2010 Apr 12;18(2):73-85. Epub 2010 Feb 12.

Apogee Biotechnology Corporation, Hershey Center for Applied Research, 1214 Research Blvd, Suite 1016, Hummelstown, PA 17036, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10787-010-0032-xDOI Listing
April 2010

DHHC20: a human palmitoyl acyltransferase that causes cellular transformation.

Mol Membr Biol 2010 Apr;27(2-3):123-36

Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.3109/0968768100361685
Publisher Site
http://dx.doi.org/10.3109/09687681003616854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893407PMC
April 2010

Improved synthesis of a fluorogenic ceramidase substrate.

Bioorg Med Chem 2010 Feb 6;18(3):1003-9. Epub 2010 Jan 6.

Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, MSC 140, Charleston, SC 29425, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2009.12.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841511PMC
February 2010