Charles Boone

Charles Boone

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Integrating yeast chemical genomics and mammalian cell pathway analysis.

Acta Pharmacol Sin 2019 May 28. Epub 2019 May 28.

The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, 201203, China.

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http://www.nature.com/articles/s41401-019-0231-y
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http://dx.doi.org/10.1038/s41401-019-0231-yDOI Listing
May 2019

Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase.

Microb Cell 2019 May 20;6(6):286-294. Epub 2019 May 20.

School of Medical Sciences, North West Cancer Research Institute, Bangor University, Deniol Road, Bangor, LL57 2UW, United Kingdom.

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http://dx.doi.org/10.15698/mic2019.06.680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545439PMC
May 2019

Genetic interaction networks in cancer cells.

Curr Opin Genet Dev 2019 Apr 8;54:64-72. Epub 2019 Apr 8.

Donnelly Centre, University of Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.03.002DOI Listing
April 2019

Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.

J Mol Biol 2019 Mar 11;431(6):1160-1171. Epub 2019 Feb 11.

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, M5S3E1, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.02.007DOI Listing
March 2019

Complex modifier landscape underlying genetic background effects.

Proc Natl Acad Sci U S A 2019 03 25;116(11):5045-5054. Epub 2019 Feb 25.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada;

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http://dx.doi.org/10.1073/pnas.1820915116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421401PMC
March 2019

Global Genetic Networks and the Genotype-to-Phenotype Relationship.

Cell 2019 Mar;177(1):85-100

The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada; Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.01.033DOI Listing
March 2019

Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.

Nat Protoc 2019 02;14(2):415-440

Bioinformatics and Computational Biology Graduate Program, University of Minnesota Twin Cities, Minneapolis, MN, USA.

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http://dx.doi.org/10.1038/s41596-018-0099-1DOI Listing
February 2019

Integrating genetic and protein-protein interaction networks maps a functional wiring diagram of a cell.

Curr Opin Microbiol 2018 10 28;45:170-179. Epub 2018 Jul 28.

The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.

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http://dx.doi.org/10.1016/j.mib.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295359PMC
October 2018

Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression.

Trends Genet 2018 08 11;34(8):578-586. Epub 2018 Jun 11.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085889PMC
August 2018

Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis.

Dev Cell 2018 08;46(4):495-503.e2

North West Cancer Research Institute, School of Medical Sciences, Bangor University, Deniol Road, Bangor LL57 2UW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.07.011DOI Listing
August 2018

Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.

Mol Biol Cell 2018 04 30;29(8):923-936. Epub 2018 Mar 30.

Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.

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http://www.molbiolcell.org/doi/10.1091/mbc.E17-10-0592
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http://dx.doi.org/10.1091/mbc.E17-10-0592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896931PMC
April 2018

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.

Cell 2018 03 8;173(1):62-73.e9. Epub 2018 Mar 8.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Cambridge, MA 02139, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183017
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http://dx.doi.org/10.1016/j.cell.2018.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945206PMC
March 2018

Mapping a diversity of genetic interactions in yeast.

Curr Opin Syst Biol 2017 Dec 12;6:14-21. Epub 2017 Aug 12.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St., Toronto ON, Canada M5S 3E1.

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http://dx.doi.org/10.1016/j.coisb.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269142PMC
December 2017

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.

Cell Rep 2017 Sep;20(11):2735-2748

Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.074DOI Listing
September 2017

Pathway-based discovery of genetic interactions in breast cancer.

PLoS Genet 2017 Sep 28;13(9):e1006973. Epub 2017 Sep 28.

Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619706PMC
September 2017

Mechanisms of suppression: The wiring of genetic resilience.

Bioessays 2017 07 5;39(7). Epub 2017 Jun 5.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/bies.201700042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681848PMC
July 2017

Automated analysis of high-content microscopy data with deep learning.

Mol Syst Biol 2017 04 18;13(4):924. Epub 2017 Apr 18.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408780PMC
http://dx.doi.org/10.15252/msb.20177551DOI Listing
April 2017

Machine learning and computer vision approaches for phenotypic profiling.

J Cell Biol 2017 Jan 9;216(1):65-71. Epub 2016 Dec 9.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada

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http://dx.doi.org/10.1083/jcb.201610026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223612PMC
January 2017

High-Content Screening for Quantitative Cell Biology.

Trends Cell Biol 2016 08 22;26(8):598-611. Epub 2016 Apr 22.

The Donnelly Centre, University of Toronto, Toronto, ON M5S3E1, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09628924163000
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http://dx.doi.org/10.1016/j.tcb.2016.03.008DOI Listing
August 2016

An extended set of yeast-based functional assays accurately identifies human disease mutations.

Genome Res 2016 05 14;26(5):670-80. Epub 2016 Mar 14.

Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; Canadian Institute for Advanced Research, Toronto, Ontario, M5G 1Z8, Canada.

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http://dx.doi.org/10.1101/gr.192526.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864455PMC
May 2016

Direct and Indirect Targeting of PP2A by Conserved Bacterial Type-III Effector Proteins.

PLoS Pathog 2016 05 18;12(5):e1005609. Epub 2016 May 18.

Department of Horticulture and Crop Science, The Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871590PMC
May 2016

Chromosome-Specific and Global Effects of Aneuploidy in Saccharomyces cerevisiae.

Genetics 2016 Apr 2;202(4):1395-409. Epub 2016 Feb 2.

Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

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http://dx.doi.org/10.1534/genetics.115.185660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905547PMC
April 2016

Liquid Growth of Arrayed Fluorescently Tagged Saccharomyces cerevisiae Strains for Live-Cell High-Throughput Microscopy Screens.

Cold Spring Harb Protoc 2016 Apr 1;2016(4):pdb.prot088799. Epub 2016 Apr 1.

The Donnelly Centre, University of Toronto, Toronto, Ontario, M5S 3E1 Canada;

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http://dx.doi.org/10.1101/pdb.prot088799DOI Listing
April 2016

Synthetic Genetic Array Analysis.

Cold Spring Harb Protoc 2016 Apr 1;2016(4):pdb.prot088807. Epub 2016 Apr 1.

Department of Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada; Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/pdb.prot088807DOI Listing
April 2016

Synthetic Genetic Arrays: Automation of Yeast Genetics.

Cold Spring Harb Protoc 2016 Apr 1;2016(4):pdb.top086652. Epub 2016 Apr 1.

Department of Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada; Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/pdb.top086652DOI Listing
April 2016

High-Throughput Microscopy-Based Screening in Saccharomyces cerevisiae.

Cold Spring Harb Protoc 2016 Apr 1;2016(4):pdb.top087593. Epub 2016 Apr 1.

The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/pdb.top087593DOI Listing
April 2016

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

Cell 2016 Feb;164(4):805-17

Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science (CEGS), Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882190PMC
February 2016

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.

Mol Biol Cell 2016 Jan 18;27(2):397-409. Epub 2015 Nov 18.

Department of Molecular Biology and Institute of Genetics and Genomics of Geneva, University of Geneva, CH-1211 Geneva, Switzerland Swiss National Centre for Competence in Research Programme Chemical Biology, 1211 Geneva, Switzerland

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http://dx.doi.org/10.1091/mbc.E15-08-0594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713140PMC
January 2016

Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.

PLoS Genet 2015 Nov 6;11(11):e1005659. Epub 2015 Nov 6.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636136PMC
November 2015

HUMAN GENOME. The indispensable genome.

Science 2015 Nov;350(6264):1028-9

Donnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1126/science.aad7925DOI Listing
November 2015

Rapid and Efficient Plasmid Construction by Homologous Recombination in Yeast.

Cold Spring Harb Protoc 2015 Sep 1;2015(9):pdb.prot085100. Epub 2015 Sep 1.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada;

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http://dx.doi.org/10.1101/pdb.prot085100DOI Listing
September 2015

Construction of Multifragment Plasmids by Homologous Recombination in Yeast.

Cold Spring Harb Protoc 2015 Sep 1;2015(9):pdb.top084111. Epub 2015 Sep 1.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada;

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http://www.cshprotocols.org/lookup/doi/10.1101/pdb.top084111
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http://dx.doi.org/10.1101/pdb.top084111DOI Listing
September 2015

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis.

Cell 2015 Jun;161(6):1413-24

The Donnelly Centre, University of Toronto, Toronto, ON M5S3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.04.051DOI Listing
June 2015

Synthetic genetic array analysis for global mapping of genetic networks in yeast.

Methods Mol Biol 2014 ;1205:143-68

The Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-1363-3_10DOI Listing
May 2015

CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae.

G3 (Bethesda) 2015 Apr 15;5(6):1223-32. Epub 2015 Apr 15.

The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, M5S3E1 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, M5S3E1

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http://g3journal.org/cgi/doi/10.1534/g3.115.017830
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http://dx.doi.org/10.1534/g3.115.017830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478550PMC
April 2015

Plant-derived antifungal agent poacic acid targets β-1,3-glucan.

Proc Natl Acad Sci U S A 2015 Mar 9;112(12):E1490-7. Epub 2015 Mar 9.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan 277-8561;

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http://dx.doi.org/10.1073/pnas.1410400112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378397PMC
March 2015

Leveraging DNA damage response signaling to identify yeast genes controlling genome stability.

G3 (Bethesda) 2015 Feb 26;5(5):997-1006. Epub 2015 Feb 26.

Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada Donnelly Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1534/g3.115.016576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426383PMC
February 2015

Protein quality control at the inner nuclear membrane.

Nature 2014 Dec;516(7531):410-3

1] Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany [2] Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://www.nature.com/articles/nature14096
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http://dx.doi.org/10.1038/nature14096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493439PMC
December 2014

Yeast systems biology: our best shot at modeling a cell.

Authors:
Charles Boone

Genetics 2014 Oct;198(2):435-7

Banting and Best Department of Medical Research, Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada M5S 3E1.

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http://dx.doi.org/10.1534/genetics.114.169128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196597PMC
October 2014

Heritability and genetic basis of protein level variation in an outbred population.

Genome Res 2014 Aug 13;24(8):1363-70. Epub 2014 May 13.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, M5S3E1, Canada;

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http://dx.doi.org/10.1101/gr.170506.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120089PMC
August 2014

Genome-wide analysis reveals novel and discrete functions for tubulin carboxy-terminal tails.

Curr Biol 2014 Jun 15;24(12):1295-1303. Epub 2014 May 15.

Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.03.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070440PMC
June 2014

Genetic interaction networks: toward an understanding of heritability.

Annu Rev Genomics Hum Genet 2013 26;14:111-33. Epub 2013 Jun 26.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544.

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http://dx.doi.org/10.1146/annurev-genom-082509-141730DOI Listing
December 2013

Global linkage map connects meiotic centromere function to chromosome size in budding yeast.

G3 (Bethesda) 2013 Oct 3;3(10):1741-51. Epub 2013 Oct 3.

Banting and Best Department of Medical Research, The Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1534/g3.113.007377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789798PMC
October 2013

A comparative genomic approach for identifying synthetic lethal interactions in human cancer.

Cancer Res 2013 Oct 26;73(20):6128-36. Epub 2013 Aug 26.

Authors' Affiliations: Department of Computer Science and Engineering; Program in Biomedical Informatics and Computational Biology, University of Minnesota, Minneapolis; Department of Surgery, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine & Pathology, Molecular Genetics Lab, Mayo Clinic, Rochester, Minnesota; Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario, Canada; Chemical Genomics Research Group, RIKEN Advance Science Institute, Saitama, Japan; and Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809957PMC
October 2013

SGAtools: one-stop analysis and visualization of array-based genetic interaction screens.

Nucleic Acids Res 2013 Jul 15;41(Web Server issue):W591-6. Epub 2013 May 15.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, M5S 3E1, Canada.

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http://dx.doi.org/10.1093/nar/gkt400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692131PMC
July 2013

Network Biology editorial 2013.

Mol Biosyst 2013 Jul 28;9(7):1557-8. Epub 2013 May 28.

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http://dx.doi.org/10.1039/c3mb90018eDOI Listing
July 2013

Focus on chemical biology in Asia.

Mol Biosyst 2013 May;9(5):825

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http://dx.doi.org/10.1039/c3mb90008hDOI Listing
May 2013

Systems-level antimicrobial drug and drug synergy discovery.

Nat Chem Biol 2013 Apr;9(4):222-31

Infectious Disease Research, Merck Research Laboratories, Kenilworth, New Jersey, USA.

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http://dx.doi.org/10.1038/nchembio.1205DOI Listing
April 2013

Simplifying the author and reader experience.

Authors:
Charles Boone

Mol Biosyst 2013 Jan 20;9(1). Epub 2012 Nov 20.

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http://dx.doi.org/10.1039/c2mb90047eDOI Listing
January 2013

Actin filament elongation in Arp2/3-derived networks is controlled by three distinct mechanisms.

Dev Cell 2013 Jan 17;24(2):182-95. Epub 2013 Jan 17.

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.

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http://dx.doi.org/10.1016/j.devcel.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562429PMC
January 2013

Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network.

Genetics 2012 Dec 10;192(4):1523-32. Epub 2012 Oct 10.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://www.genetics.org/lookup/doi/10.1534/genetics.112.1455
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http://dx.doi.org/10.1534/genetics.112.145573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512157PMC
December 2012

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

Genome Biol 2012 Sep 10;13(9):R80. Epub 2012 Sep 10.

Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, the Netherlands.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2012-13-9-r80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506951PMC
September 2012

Network evolution: rewiring and signatures of conservation in signaling.

PLoS Comput Biol 2012 15;8(3):e1002411. Epub 2012 Mar 15.

Department of Computer Science, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1371/journal.pcbi.1002411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305342PMC
June 2012

Mapping interactomes with high coverage and efficiency using the shifted transversal design.

Methods Mol Biol 2012 ;812:147-59

Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-455-1_8DOI Listing
April 2012

Chemical-genomic profiling: systematic analysis of the cellular targets of bioactive molecules.

Bioorg Med Chem 2012 Mar 21;20(6):1952-60. Epub 2011 Dec 21.

Banting and Best Department of Medical Research and Department of Molecular Genetics, Donnelly Centre, University of Toronto, 160 College St., Toronto, ON, Canada M5S 3E1.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896110102
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http://dx.doi.org/10.1016/j.bmc.2011.12.023DOI Listing
March 2012

Fostering interdisciplinary biology.

Authors:
Charles Boone

Mol Biosyst 2012 Feb 3;8(2):443-4. Epub 2012 Jan 3.

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http://dx.doi.org/10.1039/c1mb90051jDOI Listing
February 2012

PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae.

Nucleic Acids Res 2012 Jan 18;40(Database issue):D687-94. Epub 2011 Oct 18.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1093/nar/gkr827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245137PMC
January 2012

Drug-sensitive DNA polymerase δ reveals a role for mismatch repair in checkpoint activation in yeast.

Genetics 2011 Dec 16;189(4):1211-24. Epub 2011 Sep 16.

Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.

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http://dx.doi.org/10.1534/genetics.111.131938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241404PMC
December 2011

Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.

J Biol Chem 2011 Dec 1;286(51):43660-7. Epub 2011 Nov 1.

Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA.

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http://dx.doi.org/10.1074/jbc.M111.286229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243506PMC
December 2011

Systematic exploration of synergistic drug pairs.

Mol Syst Biol 2011 Nov 8;7:544. Epub 2011 Nov 8.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/msb.2011.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261710PMC
November 2011

Histone modifications influence mediator interactions with chromatin.

Nucleic Acids Res 2011 Oct 8;39(19):8342-54. Epub 2011 Jul 8.

Department of Biochemistry and Cell Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

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http://dx.doi.org/10.1093/nar/gkr551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201872PMC
October 2011

New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole.

Eur J Med Chem 2011 Sep 17;46(9):4117-24. Epub 2011 Jun 17.

Laboratoire de Chimie Appliquée et Environnement, Département de Chimie, Faculté des Sciences, Université Mohamed Premier, BP 524, 60000 Oujda, Morocco.

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http://linkinghub.elsevier.com/retrieve/pii/S022352341100488
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http://dx.doi.org/10.1016/j.ejmech.2011.06.012DOI Listing
September 2011

The future of model organisms in human disease research.

Nat Rev Genet 2011 07 18;12(8):575-82. Epub 2011 Jul 18.

Medical Research Council Clinical Sciences Centre, Imperial College, London, UK.

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http://dx.doi.org/10.1038/nrg3047DOI Listing
July 2011