Publications by authors named "Charles B Simone"

100Publications

Radiation Research Special Issue: New Beam Delivery Modalities are Shaping the Future of Radiotherapy.

Radiat Res 2020 Sep 14. Epub 2020 Sep 14.

New York Proton Center, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1667/RADE-20-FLASH.1DOI Listing
September 2020

Hydroxychloroquine for the treatment of COVID-19: the importance of scrutiny of positive trials.

Ann Palliat Med 2020 Aug 25. Epub 2020 Aug 25.

Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm-20-1538DOI Listing
August 2020

Caring for Patients With Cancer in the Face of Self-Vulnerability During the COVID-19 Pandemic.

JAMA Oncol 2020 Aug 27. Epub 2020 Aug 27.

Department of Radiation Oncology, New York Proton Center, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2020.3330DOI Listing
August 2020

Innovative enhancements for Annals of Palliative Medicine.

Authors:
Charles B Simone

Ann Palliat Med 2020 Jul;9(4):E1-E3

New York Proton Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm-2020-07DOI Listing
July 2020

Assessing Expression of PD-L1 in Tumor-Associated Macrophages-Reply.

JAMA Oncol 2020 Aug 6. Epub 2020 Aug 6.

Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2020.2722DOI Listing
August 2020

First Randomized Trial Supporting the Use of Proton Over Photon Chemoradiotherapy in Esophageal Cancer.

Authors:
Charles B Simone

J Clin Oncol 2020 Sep 24;38(26):2952-2955. Epub 2020 Jul 24.

Department of Radiation Oncology, New York Proton Center and Memorial Sloan Kettering Cancer Center, New York, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.20.01405DOI Listing
September 2020

A nomogram to predict symptomatic epilepsy in patients with radiation-induced brain necrosis.

Neurology 2020 09 6;95(10):e1392-e1403. Epub 2020 Jul 6.

From the Department of Neurology Bioland Laboratory (X.H., X. Zhang, X.R., Y.L., H.L., J.J., J.C., X. Zhuo, X.P., J.L., Z.Y., Y.T.) and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (Y.T.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University; Guangdong Province Key Laboratory of Brain Function and Disease (Y.T.), Zhongshan School of Medicine, Sun Yat-Sen University; Department of Oncology (X.W.), The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China; Division of Radiation Oncology and Medical Sciences (M.L.K.C.), National Cancer Centre Singapore; Oncology Academic Programme (M.L.K.C.), Duke-NUS Medical School, Singapore; Department of Neurology (A.A.A.), Saint Andrew's State General Hospital of Patras, Greece; Neurological Clinic, Department of Experimental and Clinical Medicine (S.L.), Marche Polytechnic University, Italy; New York Proton Center (C.B.S.), New York; Thomas Jefferson University (J.G.), Philadelphia, PA; Departments of Radiation Oncology (J.D.P.) and Neurosurgery (J.D.P.), The James Cancer Hospital at The Ohio State University Comprehensive Cancer Center, Columbus; Sunnybrook Health Sciences Centre (E.C.), University of Toronto, Canada; and Radiation Oncology (P.D.B.), Mayo Clinic, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000010190DOI Listing
September 2020

Challenges in Re-Irradiation in the Thorax: Managing Patients with Locally Recurrent Non-Small Cell Lung Cancer.

Semin Radiat Oncol 2020 Jul;30(3):223-231

Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semradonc.2020.02.001DOI Listing
July 2020

Consensus Statement on Proton Therapy in Mesothelioma.

Pract Radiat Oncol 2020 May 24. Epub 2020 May 24.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prro.2020.05.004DOI Listing
May 2020

Towards answering the optimal palliative fractionation conundrum: single- versus multi-fraction radiation therapy for spinal cord compression.

Ann Palliat Med 2020 Jul 12;9(4):1370-1374. Epub 2020 May 12.

Department of Radiation Oncology, New York Proton Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm-20-990DOI Listing
July 2020

Updating Photon-Based Normal Tissue Complication Probability Models for Pneumonitis in Patients With Lung Cancer Treated With Proton Beam Therapy.

Pract Radiat Oncol 2020 Sep - Oct;10(5):e330-e338. Epub 2020 May 13.

Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prro.2020.04.005DOI Listing
May 2020

Society for palliative radiation oncology: report from the Sixth Annual Meeting [2019].

Ann Palliat Med 2020 Jul 24;9(4):2420-2423. Epub 2020 Apr 24.

Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm-20-361DOI Listing
July 2020

Need for Caution in the Diagnosis of Radiation Pneumonitis During the COVID-19 Pandemic.

Adv Radiat Oncol 2020 Jul-Aug;5(4):617-620. Epub 2020 May 5.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.adro.2020.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199721PMC
May 2020

Combining Immunotherapy with Radiation Therapy in Non-Small Cell Lung Cancer.

Thorac Surg Clin 2020 May 2;30(2):221-239. Epub 2020 Mar 2.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 First Avenue, Mezzanine Level, New York, NY 10065, USA; New York Proton Center, 225 East 126th Street, New York, NY 10035, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thorsurg.2020.01.002DOI Listing
May 2020

Life-long-learning: the importance of Specialist Palliative Care Teams staying informed with knowledge from other disciplines.

Ann Palliat Med 2020 05 20;9(3):1290-1291. Epub 2020 Apr 20.

Department of Oncology, Princess Margaret Hospital, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2020.03.30DOI Listing
May 2020

Oligometastases: history of a hypothesis.

Ann Palliat Med 2020 Mar 31. Epub 2020 Mar 31.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2020.03.31DOI Listing
March 2020

A neuropalliative care focus on Parkinson's disease and related disorders.

Authors:
Charles B Simone

Ann Palliat Med 2020 Feb 18;9(Suppl 1):S1-S2. Epub 2020 Feb 18.

Department of Radiation Oncology, New York Proton Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2020.02.15DOI Listing
February 2020

Impact of Detecting Occult Pathologic Nodal Disease During Resection for Malignant Pleural Mesothelioma.

Clin Lung Cancer 2020 Jul 23;21(4):e274-e285. Epub 2020 Jan 23.

Department of Radiation Oncology, New York Proton Center, New York, NY. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2020.01.002DOI Listing
July 2020

Light Fluence Rate and Tissue Oxygenation (S O ) Distributions Within the Thoracic Cavity of Patients Receiving Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma.

Photochem Photobiol 2020 03 17;96(2):417-425. Epub 2020 Mar 17.

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/php.13224DOI Listing
March 2020

The inflammatory response from stereotactic body proton therapy versus stereotactic body radiation therapy: implications from early stage non-small cell lung cancer.

Ann Transl Med 2019 Dec;7(Suppl 8):S295

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2019.11.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976498PMC
December 2019

Delivering safe and effective stereotactic body radiation therapy for patients with centrally located early stage non-small cell lung cancer.

Chin Clin Oncol 2020 06 15;9(3):39. Epub 2020 Jan 15.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; New York Proton Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/cco.2019.12.17DOI Listing
June 2020

Analysis of daily goal sheets on physician-nurse collaboration attitude.

Ann Palliat Med 2020 01;9(1):1-7

Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2019.12.06DOI Listing
January 2020

Patient-reported Outcomes With Stereotactic Body Radiotherapy and Surgery for Lung Cancer.

Clin Lung Cancer 2020 May 28;21(3):e229-e230. Epub 2019 Dec 28.

Department of Radiation Oncology, New York Proton Center, New York, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2019.12.004DOI Listing
May 2020

Proton pencil beam scanning treatment with feedback based voluntary moderate breath hold.

Med Dosim 2020 Autumn;45(3):e10-e15. Epub 2019 Dec 20.

California Protons Ca Therapy Center, San Diego, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meddos.2019.11.003DOI Listing
December 2019

Photons or protons for reirradiation in (non-)small cell lung cancer: Results of the multicentric ROCOCO study.

Br J Radiol 2020 Mar 20;93(1107):20190879. Epub 2019 Dec 20.

Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1259/bjr.20190879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066965PMC
March 2020

Spatially fractionated radiation therapy: History, present and the future.

Clin Transl Radiat Oncol 2020 Jan 22;20:30-38. Epub 2019 Oct 22.

Department of Radiation Medicine, Markey Cancer Center, University of Kentucky - College of Medicine, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctro.2019.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872856PMC
January 2020

PET Imaging for Immunotherapy and Radiation Therapy.

PET Clin 2020 01;15(1):xiii-xiv

Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cpet.2019.10.001DOI Listing
January 2020

Evolving Role of Novel Quantitative PET Techniques to Detect Radiation-Induced Complications.

PET Clin 2020 Jan;15(1):89-100

Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cpet.2019.08.003DOI Listing
January 2020

The Utility of PET/Computed Tomography for Radiation Oncology Planning, Surveillance, and Prognosis Prediction of Gastrointestinal Tumors.

PET Clin 2020 Jan 29;15(1):77-87. Epub 2019 Oct 29.

Department of Radiation Oncology, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cpet.2019.08.004DOI Listing
January 2020

The Role of Positron Emission Tomography Imaging in Radiotherapy Target Delineation.

PET Clin 2020 Jan;15(1):45-53

Department of Radiation Oncology, New York Proton Center, 225 East 126th Street, New York, NY 10035, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cpet.2019.08.002DOI Listing
January 2020

Posterior Intercostal Lymph Nodes Double Recurrence and Death Risk in Malignant Pleural Mesothelioma.

Ann Thorac Surg 2020 07 18;110(1):241-250. Epub 2019 Oct 18.

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2019.07.097DOI Listing
July 2020

Stereotactic body radiation therapy for prostate cancer: systematic review and meta-analysis of prospective trials.

Oncotarget 2019 09 24;10(54):5660-5668. Epub 2019 Sep 24.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.27177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771455PMC
September 2019

Stereotactic body radiation therapy for oligometastatic renal cell carcinoma: improving outcomes in an otherwise radioresistant malignancy.

Ann Transl Med 2019 Jul;7(Suppl 3):S98

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2019.04.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685837PMC
July 2019

Building more accurate decision trees with the additive tree.

Proc Natl Acad Sci U S A 2019 10 16;116(40):19887-19893. Epub 2019 Sep 16.

Department of Radiation Oncology, University of California, San Francisco, CA 94115;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1816748116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778203PMC
October 2019

Early palliative care and the opioid crisis: ten pragmatic steps towards a more rational use of opioids.

Ann Palliat Med 2019 Sep 16;8(4):490-497. Epub 2019 Aug 16.

Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2019.08.01DOI Listing
September 2019

Stereotactic body radiation therapy versus multi-fraction radiation therapy for bone metastases.

Authors:
Charles B Simone

Ann Palliat Med 2019 Sep 25;8(4):360-363. Epub 2019 Jul 25.

New York Proton Center, New York, NY 10035, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2019.07.06DOI Listing
September 2019

One & done: treating cord compression with single-fraction radiation therapy.

Ann Palliat Med 2019 Sep 5;8(4):356-359. Epub 2019 Aug 5.

Department of Radiation Oncology and Brookdale, Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2019.07.05DOI Listing
September 2019

Annals of Palliative Medicine earns its first official impact factor.

Authors:
Charles B Simone

Ann Palliat Med 2019 Jul;8(3):352-354

New York Proton Center, New York, NY 10035, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2019.07.03DOI Listing
July 2019

Proton Beam Therapy and Immune Checkpoint Inhibitors in Malignant Pleural Mesothelioma.

J Thorac Oncol 2019 09 22;14(9):e185-e187. Epub 2019 Jun 22.

University of Maryland Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, Maryland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2019.05.013DOI Listing
September 2019

Management of Clinically Lymph Node-Positive Malignant Pleural Mesothelioma.

Semin Thorac Cardiovasc Surg 2019 Jun 19. Epub 2019 Jun 19.

New York Proton Center, New York, NY. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.semtcvs.2019.06.004DOI Listing
June 2019

First-ever Abscopal Effect after Palliative Radiotherapy and Immuno-gene Therapy for Malignant Pleural Mesothelioma.

Cureus 2019 02 20;11(2):e4102. Epub 2019 Feb 20.

Radiation Oncology, University of Maryland School of Medicine, Baltimore, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.4102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476617PMC
February 2019

Clinical significance of pretreatment tumor growth rate for locally advanced non-small cell lung cancer.

Ann Transl Med 2019 Mar;7(5):95

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2019.02.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462644PMC
March 2019

Management of Malignant Pleural Mesothelioma in the Elderly Population.

Ann Surg Oncol 2019 Aug 22;26(8):2357-2366. Epub 2019 Apr 22.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1245/s10434-019-07351-6
Publisher Site
http://dx.doi.org/10.1245/s10434-019-07351-6DOI Listing
August 2019

Chemotherapy Versus Supportive Care for Unresected Malignant Pleural Mesothelioma.

Clin Lung Cancer 2019 07 26;20(4):263-269. Epub 2019 Mar 26.

Department of Radiation Oncology, New York Proton Center, New York, NY. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15257304193007
Publisher Site
http://dx.doi.org/10.1016/j.cllc.2019.03.003DOI Listing
July 2019

Patterns of Care and Survival in Stage III NSCLC Among Black and Latino Patients Compared With White Patients.

Clin Lung Cancer 2019 07 28;20(4):248-257.e4. Epub 2019 Feb 28.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2019.02.015DOI Listing
July 2019

Downstream Effect of a Proton Treatment Center on an Academic Medical Center.

Int J Radiat Oncol Biol Phys 2019 07 15;104(4):756-764. Epub 2019 Mar 15.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03603016193037
Publisher Site
http://dx.doi.org/10.1016/j.ijrobp.2019.03.016DOI Listing
July 2019

A nomogram for the prediction of cerebrovascular disease among patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma.

Radiother Oncol 2019 03 21;132:34-41. Epub 2018 Dec 21.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01678140183360
Publisher Site
http://dx.doi.org/10.1016/j.radonc.2018.11.008DOI Listing
March 2019

Society for Palliative Radiation Oncology: report from the Fifth Annual Meeting (2018).

Ann Palliat Med 2019 Feb;8(Suppl 1):S61-S63

New York Proton Center, New York, NY 10035, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2019.02.01DOI Listing
February 2019

The importance of nurses in the care of and research advancements for patients with advanced diseases.

Authors:
Charles B Simone

Ann Palliat Med 2019 Feb;8(Suppl 1):S1-S2

New York Proton Center, New York, NY 10035, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2019.01.04DOI Listing
February 2019

Cancer cachexia: definitions, outcomes, and treatments.

Authors:
Charles B Simone

Ann Palliat Med 2019 Jan;8(1):E1-E3

Department of Radiation Oncology, New York Proton Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2019.02.03DOI Listing
January 2019

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies.

J Vis Exp 2019 02 6(144). Epub 2019 Feb 6.

Department of Medicine, University of Maryland School of Medicine, University of Maryland Greenebaum Comprehensive Cancer Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/58372DOI Listing
February 2019

Approaches to stereotactic body radiation therapy for large (≥5 centimeter) non-small cell lung cancer.

Transl Lung Cancer Res 2019 Feb;8(1):70-77

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/tlcr.2018.06.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351404PMC
February 2019

The current and future faces of stereotactic body radiation therapy for thoracic malignancies.

Transl Lung Cancer Res 2019 Feb;8(1):1-4

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/tlcr.2018.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351400PMC
February 2019