Charles B Epstein

Charles B Epstein

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Charles B Epstein

Charles B Epstein

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Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq.

Epigenetics Chromatin 2016 4;9:49. Epub 2016 Nov 4.

Broad Technology Labs, Broad Institute of MIT and Harvard, Cambridge, MA 02142 USA ; Department of Medicine, University of California San Diego, La Jolla, CA 92093 USA.

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http://epigeneticsandchromatin.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s13072-016-0100-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097419PMC
January 2018

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.

Cell 2017 Jul;170(3):522-533.e15

Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785707PMC
July 2017

Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma.

Cancer Discov 2015 Oct 30;5(10):1058-71. Epub 2015 Jul 30.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Broad Institute of Harvard University and MIT, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592453PMC
October 2015

Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Nature 2015 Feb 29;518(7539):337-43. Epub 2014 Oct 29.

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA [3] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA [4] Center for Systems Biology and Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature13835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336207PMC
February 2015

Integrative analysis of 111 reference human epigenomes.

Nature 2015 Feb;518(7539):317-30

1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, Massachusetts 02139, USA. [2] The Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010PMC
February 2015

Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.

Nat Cell Biol 2015 Jan 15;17(1):44-56. Epub 2014 Dec 15.

1] Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA [2] Broad Institute, Cambridge, Massachusetts 02142, USA [3] Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncb3080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281178PMC
January 2015

Comparative analysis of metazoan chromatin organization.

Nature 2014 Aug;512(7515):449-52

1] Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Informatics Program, Children's Hospital, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature13415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227084PMC
August 2014

Impact of sequencing depth in ChIP-seq experiments.

Nucleic Acids Res 2014 May 5;42(9):e74. Epub 2014 Mar 5.

Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA Division of Genetics, Brigham and Women's Hospital & Harvard Medical School, Boston, MA 02115, USA Informatics Program, Children's Hospital, Boston, MA 02115, USA

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http://nar.oxfordjournals.org/content/42/9/e74.full.pdf
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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gku178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027199PMC
May 2014

Recommendations for the design and analysis of epigenome-wide association studies.

Nat Methods 2013 Oct;10(10):949-55

1] Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://search.proquest.com/openview/9eb6080ebfd0ecdda97a57d6
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http://dx.doi.org/10.1038/nmeth.2632DOI Listing
October 2013

SIT4 regulation of Mig1p-mediated catabolite repression in Saccharomyces cerevisiae.

FEBS Lett 2007 Dec 20;581(29):5658-63. Epub 2007 Nov 20.

Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

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http://dx.doi.org/10.1016/j.febslet.2007.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247712PMC
December 2007

An empirical Bayesian significance test of cDNA library data.

J Comput Biol 2004 ;11(6):1175-88

LO/LG/DG Biostatistics, Aventis, Mail Stop B-203C, P. O. Box 6800, Bridgewater, NJ 08807-6800, USA.

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http://dx.doi.org/10.1089/cmb.2004.11.1175DOI Listing
May 2005