Charles A Mein

Charles A Mein

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Charles A Mein

Charles A Mein

Publications by authors named "Charles A Mein"

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53Publications

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Quizalofop-p-Ethyl Induces Adipogenesis in 3T3-L1 Adipocytes.

Toxicol Sci 2019 Aug;170(2):452-461

Department of Medical and Molecular Genetics, School of Basic and Biomedical Sciences, Faculty of Life Sciences & Medicine, Gene Expression and Therapy Group, King's College London, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1093/toxsci/kfz097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657571PMC
August 2019

Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages.

Physiol Genomics 2019 Aug 7;51(8):323-332. Epub 2019 Jun 7.

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1152/physiolgenomics.00012.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732415PMC
August 2019

Vitamin D receptor genotype influences risk of upper respiratory infection.

Br J Nutr 2018 10 22;120(8):891-900. Epub 2018 Aug 22.

1Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry,Queen Mary University of London,London E1 2AB,UK.

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http://dx.doi.org/10.1017/S000711451800209XDOI Listing
October 2018

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.

Neurobiol Aging 2018 09 17;69:151-166. Epub 2018 May 17.

Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075941PMC
September 2018

Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126.

Arch Toxicol 2018 08 14;92(8):2533-2547. Epub 2018 Jun 14.

Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences and Medicine, Department of Medical and Molecular Genetics, 8th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.

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http://dx.doi.org/10.1007/s00204-018-2235-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063328PMC
August 2018

Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line.

Toxicol Rep 2018 11;5:819-826. Epub 2018 Aug 11.

Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, Guy's Hospital, 8th Floor, Tower Wing, Great Maze Pond, London SE1 9RT, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S22147500183042
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http://dx.doi.org/10.1016/j.toxrep.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098220PMC
August 2018

Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird.

Ecol Evol 2018 Jul 30;8(13):6547-6557. Epub 2018 May 30.

French Research Institute for the Exploitation of the Sea Plouzané France.

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http://dx.doi.org/10.1002/ece3.4132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053554PMC
July 2018

Mutations in EDA and EDAR Genes in a Large Mexican Hispanic Cohort with Hypohidrotic Ectodermal Dysplasia.

Ann Dermatol 2015 Aug 29;27(4):474-7. Epub 2015 Jul 29.

Facultad de Medicina, Departamento de Bioquímica y Medicina Molecular, Universidad Autonoma de Nuevo Leon, Monterrey, NL, Mexico. ; Vitagenesis, Monterrey, NL, Mexico.

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http://dx.doi.org/10.5021/ad.2015.27.4.474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530170PMC
August 2015

Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs).

Thorax 2015 May 27;70(5):451-7. Epub 2015 Feb 27.

Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK Asthma UK Centre for Applied Research, Blizard Institute, Queen Mary University of London, London, UK MRC and the Asthma UK Centre for Allergic Mechanisms in Asthma, King's College London, London, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2014-206449DOI Listing
May 2015

Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients.

Ann Surg 2015 Apr;261(4):751-9

*Adult Critical Care Unit, Royal London Hospital, Barts Health NHS Trust, London †Centre for Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London ‡Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London §Genome Centre, John Vane Science Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, United Kingdom.

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http://dx.doi.org/10.1097/SLA.0000000000000653DOI Listing
April 2015

Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells.

Schizophr Res 2014 Mar 18;153(1-3):225-30. Epub 2014 Feb 18.

Department of Neuroscience, Institute of Psychiatry, King's College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2014.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988999PMC
March 2014

CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma.

Epigenetics 2013 Jul 24;8(7):739-47. Epub 2013 May 24.

Institute of Biomedical and Biomolecular Science (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.

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http://dx.doi.org/10.4161/epi.25075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781193PMC
July 2013

Blood pressure loci identified with a gene-centric array.

Authors:
Toby Johnson Tom R Gaunt Stephen J Newhouse Sandosh Padmanabhan Maciej Tomaszewski Meena Kumari Richard W Morris Ioanna Tzoulaki Eoin T O'Brien Neil R Poulter Peter Sever Denis C Shields Simon Thom Sasiwarang G Wannamethee Peter H Whincup Morris J Brown John M Connell Richard J Dobson Philip J Howard Charles A Mein Abiodun Onipinla Sue Shaw-Hawkins Yun Zhang George Davey Smith Ian N M Day Debbie A Lawlor Alison H Goodall F Gerald Fowkes Gonçalo R Abecasis Paul Elliott Vesela Gateva Peter S Braund Paul R Burton Christopher P Nelson Martin D Tobin Pim van der Harst Nicola Glorioso Hani Neuvrith Erika Salvi Jan A Staessen Andrea Stucchi Nabila Devos Xavier Jeunemaitre Pierre-François Plouin Jean Tichet Peeter Juhanson Elin Org Margus Putku Siim Sõber Gudrun Veldre Margus Viigimaa Anna Levinsson Annika Rosengren Dag S Thelle Claire E Hastie Thomas Hedner Wai K Lee Olle Melander Björn Wahlstrand Rebecca Hardy Andrew Wong Jackie A Cooper Jutta Palmen Li Chen Alexandre F R Stewart George A Wells Harm-Jan Westra Marcel G M Wolfs Robert Clarke Maria Grazia Franzosi Anuj Goel Anders Hamsten Mark Lathrop John F Peden Udo Seedorf Hugh Watkins Willem H Ouwehand Jennifer Sambrook Jonathan Stephens Juan-Pablo Casas Fotios Drenos Michael V Holmes Mika Kivimaki Sonia Shah Tina Shah Philippa J Talmud John Whittaker Chris Wallace Christian Delles Maris Laan Diana Kuh Steve E Humphries Fredrik Nyberg Daniele Cusi Robert Roberts Christopher Newton-Cheh Lude Franke Alice V Stanton Anna F Dominiczak Martin Farrall Aroon D Hingorani Nilesh J Samani Mark J Caulfield Patricia B Munroe

Am J Hum Genet 2011 Dec 17;89(6):688-700. Epub 2011 Nov 17.

Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.1016/j.ajhg.2011.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234370PMC
December 2011

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

PLoS Genet 2011 Sep 29;7(9):e1002300. Epub 2011 Sep 29.

Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183089PMC
September 2011

Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain.

Connect Tissue Res 2010 Dec 24;51(6):434-44. Epub 2010 May 24.

Medical Engineering Division and IRC in Biomedical Materials, School of Engineering and Materials Science, Queen Mary, University of London, London, UK.

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http://www.tandfonline.com/doi/full/10.3109/0300820100359705
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http://dx.doi.org/10.3109/03008201003597056DOI Listing
December 2010

Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children.

J Invest Dermatol 2010 Jun 4;130(6):1543-50. Epub 2010 Feb 4.

Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, London, UK.

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http://dx.doi.org/10.1038/jid.2010.7DOI Listing
June 2010

Multiple common variants for celiac disease influencing immune gene expression.

Nat Genet 2010 Apr 28;42(4):295-302. Epub 2010 Feb 28.

Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/ng.543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847618PMC
April 2010

WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis.

Eur J Cancer 2010 Mar 13;46(4):818-25. Epub 2010 Jan 13.

Ovarian cancer action (HHMT) Research Centre and Section of Molecular Therapeutics, Department of Oncology, Imperial College London Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1016/j.ejca.2009.12.021DOI Listing
March 2010

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.

Hum Mol Genet 2010 Jan;19(1):122-34

Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1093/hmg/ddp473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792152PMC
January 2010

A novel protective prion protein variant that colocalizes with kuru exposure.

N Engl J Med 2009 Nov;361(21):2056-65

Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, United Kingdom.

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http://www.nejm.org/doi/abs/10.1056/NEJMoa0809716
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http://dx.doi.org/10.1056/NEJMoa0809716DOI Listing
November 2009

Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.

J Cell Sci 2009 Jun 12;122(Pt 11):1788-99. Epub 2009 May 12.

Centre for Cutaneous Research, Cancer Research UK Skin Tumour Laboratory, Institute of Cell and Molecular Science, William Harvey Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London E1 2AT, UK.

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http://dx.doi.org/10.1242/jcs.042895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684833PMC
June 2009

Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity.

Obesity (Silver Spring) 2009 Apr 22;17(4):745-54. Epub 2009 Jan 22.

Department of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/oby.2008.589DOI Listing
April 2009

Successful amplification of degraded DNA for use with high-throughput SNP genotyping platforms.

Hum Mutat 2008 Dec;29(12):1452-8

Medical Research Council (MRC) Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, London, United Kingdom.

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http://dx.doi.org/10.1002/humu.20782DOI Listing
December 2008

ABCA12 is the major harlequin ichthyosis gene.

J Invest Dermatol 2006 Nov 10;126(11):2408-13. Epub 2006 Aug 10.

Centre for Cutaneous Research, Institute of Cell and Molecular Science, Queen Mary's School of Medicine and Dentistry, Queen Mary, University of London, London, UK.

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http://dx.doi.org/10.1038/sj.jid.5700455DOI Listing
November 2006

Selection of candidate genes in hypertension.

Methods Mol Med 2005 ;108:107-29

The Genome Centre and Clinical Pharmacology, The William Harvey Research Institute, Barts and The London, Charterhouse Square, London, UK.

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September 2005

PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity.

Pediatr Res 2005 Jan 5;57(1):138-40. Epub 2004 Nov 5.

Endocrinology, Department of Clinical Sciences, University of Rome La Sapienza, Viale del Policlinico 155, 00161, Rome, Italy.

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http://dx.doi.org/10.1203/01.PDR.0000147728.62185.21DOI Listing
January 2005

The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity.

Eur J Hum Genet 2004 Dec;12(12):1050-4

Endocrinology, Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy. raffaella.buzzetti@uniroma1@it

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http://dx.doi.org/10.1038/sj.ejhg.5201283DOI Listing
December 2004

A molecular genetic and statistical approach for the diagnosis of dual-site cancers.

J Natl Cancer Inst 2004 Oct;96(19):1441-6

Gynaecology Cancer Research Unit, St. Bartholomew's and The London, Queen Mary's School of Medicine and Dentistry, University of London, London, UK.

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http://dx.doi.org/10.1093/jnci/djh272DOI Listing
October 2004

Genetics of essential hypertension.

Hum Mol Genet 2004 Apr 5;13 Spec No 1:R169-75. Epub 2004 Feb 5.

Clinical Pharmacology and the Genome Centre, The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddh078DOI Listing
April 2004

Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes.

Hum Genet 2003 Jul 17;113(2):99-105. Epub 2003 Apr 17.

Department of Medical Genetics, JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1007/s00439-003-0940-6DOI Listing
July 2003

A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children.

J Clin Endocrinol Metab 2002 Aug;87(8):4005-8

Department of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE, United Kingdom.

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http://dx.doi.org/10.1210/jcem.87.8.8881DOI Listing
August 2002