Charani Ranasinghe

Charani Ranasinghe

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Charani Ranasinghe

Charani Ranasinghe

Publications by authors named "Charani Ranasinghe"

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Mucosal and systemic SIV-specific cytotoxic CD4 T cell hierarchy in protection following intranasal/intramuscular recombinant pox-viral vaccination of pigtail macaques.

Sci Rep 2019 Apr 5;9(1):5661. Epub 2019 Apr 5.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra ACT, 2601, Australia.

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http://dx.doi.org/10.1038/s41598-019-41506-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450945PMC
April 2019

Is host heparanase required for the rapid spread of heparan sulfate binding viruses?

Virology 2019 Mar 3;529:1-6. Epub 2019 Jan 3.

Cancer & Vascular Biology Group, ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1016/j.virol.2019.01.001DOI Listing
March 2019

Unexpected involvement of IL-13 signalling via a STAT6 independent mechanism during murine IgG2a development following viral vaccination.

Eur J Immunol 2018 07 10;48(7):1153-1163. Epub 2018 May 10.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology and infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1002/eji.201747463DOI Listing
July 2018

Vaccination route can significantly alter the innate lymphoid cell subsets: a feedback between IL-13 and IFN-γ.

NPJ Vaccines 2018 12;3:10. Epub 2018 Mar 12.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology and Infectious Disease, The John Curtin School of Medical Research (JCSMR), The Australian National University, Canberra, ACT 2601 Australia.

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http://dx.doi.org/10.1038/s41541-018-0048-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847557PMC
March 2018

Emerging Targets for Developing T Cell-Mediated Vaccines for Human Immunodeficiency Virus (HIV)-1.

Front Microbiol 2017 25;8:2091. Epub 2017 Oct 25.

Virology Laboratory, Basil Hetzel Institute for Translational Medicine, Discipline of Surgery, University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.3389/fmicb.2017.02091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660999PMC
October 2017

Heparan sulfate as a receptor for poxvirus infections and as a target for antiviral agents.

J Gen Virol 2017 Sep 21. Epub 2017 Sep 21.

2​Cancer and Vascular Biology Group, ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia.

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http://www.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/jgv.0.000921DOI Listing
September 2017

Recombinant fowlpox virus vector-based vaccines: expression kinetics, dissemination and safety profile following intranasal delivery.

J Gen Virol 2017 Mar 1;98(3):496-505. Epub 2017 Apr 1.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia.

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http://dx.doi.org/10.1099/jgv.0.000702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797952PMC
March 2017

The Influence of Immunization Route, Tissue Microenvironment, and Cytokine Cell Milieu on HIV-Specific CD8+ T Cells Measured Using Fluidigm Dynamic Arrays.

PLoS One 2015 6;10(5):e0126487. Epub 2015 May 6.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra ACT, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126487PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422706PMC
April 2016

Identification of biomarkers to measure HIV-specific mucosal and systemic CD8(+) T-cell immunity using single cell Fluidigm 48.48 Dynamic arrays.

Vaccine 2015 Dec 11;33(51):7315-7327. Epub 2015 Nov 11.

The John Curtin School of Medical Research (JCSMR), The Australian National University, Canberra, ACT 2601, Australia; Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The Australian National University, Canberra, ACT 2601, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.10.085DOI Listing
December 2015

IL-17A expression in HIV-specific CD8 T cells is regulated by IL-4/IL-13 following HIV-1 prime-boost immunization.

J Interferon Cytokine Res 2015 Mar 10;35(3):176-85. Epub 2014 Dec 10.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University , Canberra, Australia .

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http://dx.doi.org/10.1089/jir.2014.0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350450PMC
March 2015

Progresses in DNA-based heterologous prime-boost immunization strategies.

Methods Mol Biol 2014 ;1143:61-90

Molecular Mucosal Vaccine Immunology group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia.

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http://dx.doi.org/10.1007/978-1-4939-0410-5_5DOI Listing
November 2014

Different HIV pox viral vector-based vaccines and adjuvants can induce unique antigen presenting cells that modulate CD8 T cell avidity.

Virology 2014 Nov 28;468-470:479-489. Epub 2014 Sep 28.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.virol.2014.09.004DOI Listing
November 2014

New advances in mucosal vaccination.

Immunol Lett 2014 Oct 21;161(2):204-6. Epub 2014 Jan 21.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01652478140001
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http://dx.doi.org/10.1016/j.imlet.2014.01.006DOI Listing
October 2014

Novel HIV IL-4R antagonist vaccine strategy can induce both high avidity CD8 T and B cell immunity with greater protective efficacy.

Vaccine 2014 Sep 20;32(43):5703-14. Epub 2014 Aug 20.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.08.023DOI Listing
September 2014

Unraveling the convoluted biological roles of type I interferons in infection and immunity: a way forward for therapeutics and vaccine design.

Front Immunol 2014 29;5:412. Epub 2014 Aug 29.

Molecular Mucosal Vaccine Immunology Group, The John Curtin School of Medical Research, The Australian National University , Canberra, ACT , Australia.

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http://dx.doi.org/10.3389/fimmu.2014.00412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148647PMC
September 2014

IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants.

Cytokine Growth Factor Rev 2014 Aug 23;25(4):437-42. Epub 2014 Jul 23.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.cytogfr.2014.07.010DOI Listing
August 2014

Cytokines and cytokine receptors as immunotherapeutics: humble beginnings and exciting futures.

Cytokine Growth Factor Rev 2014 Aug 4;25(4):351-3. Epub 2014 Aug 4.

The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S13596101140008
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http://dx.doi.org/10.1016/j.cytogfr.2014.07.021DOI Listing
August 2014

The use of fluorescent target arrays for assessment of T cell responses in vivo.

J Vis Exp 2014 Jun 19(88):e51627. Epub 2014 Jun 19.

Department of Immunology, John Curtin School of Medical Research, Australian National University.

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http://dx.doi.org/10.3791/51627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195613PMC
June 2014

IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination.

Vaccine 2013 Sep 6;31(41):4548-55. Epub 2013 Aug 6.

The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2013.07.062DOI Listing
September 2013

Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity.

PLoS One 2013 31;8(1):e55788. Epub 2013 Jan 31.

The Molecular Mucosal Vaccine Immunology Group, The Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Acton, Canberra, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055788PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561338PMC
July 2013

CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse.

Immunol Cell Biol 2013 May 16;91(5):335-9. Epub 2013 Apr 16.

Comparative Genomics Center, James Cook University, Townsville, Queensland, Australia.

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http://dx.doi.org/10.1038/icb.2013.14DOI Listing
May 2013

Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo.

J Immunol Methods 2013 Jan 30;387(1-2):181-90. Epub 2012 Oct 30.

Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1016/j.jim.2012.10.013DOI Listing
January 2013

Role of novel type I interferon epsilon in viral infection and mucosal immunity.

Mucosal Immunol 2012 Nov 23;5(6):610-22. Epub 2012 May 23.

Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

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http://dx.doi.org/10.1038/mi.2012.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481022PMC
November 2012

Fluorescent target array killing assay: a multiplex cytotoxic T-cell assay to measure detailed T-cell antigen specificity and avidity in vivo.

Cytometry A 2012 Aug 27;81(8):679-90. Epub 2012 Jun 27.

Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia.

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http://dx.doi.org/10.1002/cyto.a.22084DOI Listing
August 2012

Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.

Immunol Cell Biol 2011 Aug 21;89(6):706-15. Epub 2010 Dec 21.

Emerging Pathogens and Vaccines Program, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.

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http://dx.doi.org/10.1038/icb.2010.157DOI Listing
August 2011

A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations.

Vaccine 2011 Apr 23;29(16):3008-20. Epub 2011 Feb 23.

The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1016/j.vaccine.2011.01.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244379PMC
April 2011

Human immunodeficiency virus-1 vaccine design: where do we go now?

Immunol Cell Biol 2011 Mar 19;89(3):367-74. Epub 2010 Oct 19.

Department Emerging Pathogens and Vaccines, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

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http://dx.doi.org/10.1038/icb.2010.118DOI Listing
March 2011

Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity.

Expert Rev Vaccines 2009 Sep;8(9):1171-81

The Emerging Pathogens & Vaccines Program, The John Curtin School of Medical Research, The Australian National University, ACT, Australia.

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http://dx.doi.org/10.1586/erv.09.86DOI Listing
September 2009

Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity.

Eur J Immunol 2009 Jul;39(7):1819-30

The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1002/eji.200838995DOI Listing
July 2009

Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy.

J Immunol 2008 Jun;180(11):7158-66

Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.

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http://dx.doi.org/10.4049/jimmunol.180.11.7158DOI Listing
June 2008

Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles.

J Immunol 2007 Feb;178(4):2370-9

Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia.

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http://dx.doi.org/10.4049/jimmunol.178.4.2370DOI Listing
February 2007

4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine.

Vaccine 2006 Nov 22;24(47-48):6867-74. Epub 2006 Jun 22.

Department of Immunology and Genetics, The John Curtin School of Medical Research, Canberra City, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S0264410X0600713
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http://dx.doi.org/10.1016/j.vaccine.2006.06.007DOI Listing
November 2006

Prime-boost strategies in DNA vaccines.

Methods Mol Med 2006 ;127:171-97

Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1385/1-59745-168-1:171DOI Listing
October 2006

Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1.

Vaccine 2006 Jul 2;24(31-32):5881-95. Epub 2006 May 2.

Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1016/j.vaccine.2006.04.023DOI Listing
July 2006

Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use.

Vaccine 2005 Sep;23(38):4647-57

Division of Immunology and Genetics, John Curtin School of Medical Research (JCSMR), Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1016/j.vaccine.2005.04.045DOI Listing
September 2005

Matrix assisted laser desorption ionisation time of flight mass spectrometry (MALDI-TOF MS) for detecting novel Bt toxins.

J Invertebr Pathol 2002 Jan;79(1):51-8

Division of Entomology, CSIRO, GPO Box 1700, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1016/S0022-2011(02)00004-6DOI Listing
January 2002