Publications by authors named "Chao Yang"

1,991 Publications

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The role of anti-tumor immunity of focused ultrasound for the malignancies: depended on the different ablation categories.

Int J Clin Oncol 2022 Aug 9. Epub 2022 Aug 9.

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing Key Laboratory of Biomedical Engineering, Chongqing, 400016, China.

Improving anti-tumor immunity has promising outcomes in eradicating malignant tumors. Tumor cells can escape from immune surveillance and killing; therefore, various strategies are continuously developing to inhibit immune escape. Focused ultrasound (FUS) has recently emerged to play an important role in immune modulation. After FUS therapy, various tumor antigens and related signals are released. The non-thermal effect of FUS strengthens the blood and lymph circulation, increases cell permeability, and helps in crossing the physical barrier like the blood-brain barrier and blood-tumor barrier. However, the different ablation of FUS is proposed to have a different anti-tumor immune effect. Therefore, we categorized the FUS ablation into thermal and non-thermal ablation and summarized possible anti-tumor immunity mechanisms.
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http://dx.doi.org/10.1007/s10147-022-02219-4DOI Listing
August 2022

[Using modified Delphi method to determine the clinical questions in the ].

Zhongguo Zhen Jiu 2022 Aug;42(8):927-31

Department of Acupuncture and Moxibustion, Dongzhimen Hospital of Beijing University of CM, Beijing 100700, China.

With the expert consensus during the clinical questions determination in the World Federation of Acupuncture and Moxibustion Societies (WFAS) standard as an example, this paper focused on the specific process and results of three rounds of Delphi survey on clinical issues by experts of the guideline development group, and systematically analyzed the consistency of the modified Delphi method with the consensus of acupuncture and moxibustion experts, as well as the reflection and limitation of this consensus process, hoping to provide reference for the development of acupuncture guidelines in the same field.
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http://dx.doi.org/10.13703/j.0255-2930.20211007-k0003DOI Listing
August 2022

Identification of the histone demethylases gene family in Glycyrrhiza inflata reveals genes responding to abiotic stresses.

J Cell Biochem 2022 Aug 7. Epub 2022 Aug 7.

Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.

Glycyrrhiza inflata Bat. is a type of abiotic-stress-resistant plant with extremely high medicinal value. Histone demethylases (HDMTs) have been known to play crucial roles in the regulation of abiotic stress response. However, the molecular functions of HDMTs has not been studied in G. inflata. Here we identified 34 GiHDMT genes in G. inflata, which could be divided into the 6 groups through phylogenetic analysis. We further found that the gene structure and conserved protein motifs exhibit high conservation in each group of GiHDMT genes. Various abiotic-stress-related elements are detected in GiHDMT promoters, especially for the light-responsive element and abscisic acid-responsive element. Collinearity analysis indicated that segmental duplication contributed to the expansion of the GiHDMT family in licorice. Subcellular localization analysis revealed that green fluorescent protein-tagged GiHDMT2 and GiHDMT18 were predominantly localized in the nucleus, whereas GiHDMT1 were found in both the cytoplasm and nucleus. Real-time quantitative polymerase chain reaction showed that GiHDMTs presented differential expression patterns across different tissues. Moreover, changes in transcription level of GiHDMTs under abiotic stress indicate the potential role of GiHDMTs in the stress response in licorice. Finally, we found the histone methylation levels probably mediated by GiHDMT genes are changed with the treatment of NaCl and Na CO . Our study will lay the foundation for future research on the regulatory roles of GiHDMT genes in the environmental stress.
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http://dx.doi.org/10.1002/jcb.30315DOI Listing
August 2022

Topological Gradients for Metal Film-Based Strain Sensors.

Nano Lett 2022 Aug 5. Epub 2022 Aug 5.

State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, P.R. China.

Metal film-based stretchable strain sensors hold great promise for applications in various domains, which require superior sensitivity-stretchability-cyclic stability synergy. However, the sensitivity-stretchability trade-off has been a long-standing dilemma and the metal film-based strain sensors usually suffer from weak cyclic durability, both of which significantly limit their practical applications. Here, we propose an extremely facile, low-cost and spontaneous strategy that incorporates topological gradients in metal film-based strain sensors, composed of intrinsic (grain size and interface) and extrinsic (film thickness and wrinkle) microstructures. The topological gradient strain sensor exhibits an ultrawide stretchability of 100% while simultaneously maintaining a high sensitivity at an optimal topological gradient of 4.5, due to the topological gradients-induced multistage film cracking. Additionally, it possesses a decent cyclic stability for >10 000 cycles between 0 and 40% strain enabled by the gradient-mixed metal/elastomer interfaces. It can monitor the full-range human activities from subtle pulse signals to vigorous joint movements.
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http://dx.doi.org/10.1021/acs.nanolett.2c01967DOI Listing
August 2022

The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids.

Sci Total Environ 2022 Aug 2:157815. Epub 2022 Aug 2.

Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, China. Electronic address:

The potential uses of graphene-based nanomaterials (NMs) in various fields lead to the concern about their neurotoxicity, considering that graphene-based NMs are capable to cross blood brain barrier (BBB) and enter central nervous system (CNS). Although previous studies reported the possibility of graphene-based NM exposure to alter lipid homeostasis in animals or cultured neurons, recent studies suggested the need to use 3D human brain organoids for mechanism-based toxicological studies as this model might better recapitulate the complex human brains. Herein, we used multi-omics techniques to investigate the mechanisms of graphene oxide (GO) on lipid homeostasis in a novel 3D brain organoid model. We found that 50 μg/mL GO induced cytotoxicity but not superoxide. RNA-sequencing data showed that 50 μg/mL GO significantly up-regulated and down-regulated 80 and 121 genes, respectively. Furthermore, we found that GO exposure altered biological molecule metabolism pathways including lipid metabolism. Consistently, lipidomics data supported dose-dependent alteration of lipid profiles by GO in 3D brain organoids. Interestingly, co-exposure to GO and endoplasmic reticulum (ER) stress inhibitor 4-phenylbutyric acid (4-PBA) decreased most of the lipid classes compared with the exposure of GO only. We further verified that exposure to GO promoted ER stress marker GRP78 proteins, which in turn activated IRE1α/XBP-1 axis, and these changes were partially or completely inhibited by 4-PBA. These results proved that direct contact with GO disrupted lipid homeostasis through the activation of ER stress. As 3D brain organoids resemble human brains, these data might be better extrapolated to humans.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157815DOI Listing
August 2022

Alkyl group-decorated g-CN for enhanced gas-phase CO photoreduction.

Nanoscale 2022 Aug 5. Epub 2022 Aug 5.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.

With excellent physical/chemical stability and feasible synthesis, g-CN has attracted much attention in the field of photocatalysis. However, its weak photoactivity limits its practical applications. Herein, by easily planting hydrophobic alkyl groups onto g-CN, the hydrophilicity of g-CN can be well regulated and its specific surface area be enlarged simultaneously. Such a modification ensures enhanced CO capture and increased active sites. In addition, the introduction of alkyl groups endows g-CN with abundant charge density and efficient separation of photoinduced excitons. All these advantages synergistically contribute to the enhanced photocatalytic CO reduction performance over the optimized catalyst (DCN90), and the total CO conversion is 7.4-fold that of pristine g-CN (CN).
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http://dx.doi.org/10.1039/d2nr02551eDOI Listing
August 2022

Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study.

Signal Transduct Target Ther 2022 Aug 5;7(1):263. Epub 2022 Aug 5.

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.

Psoriasis is a common, chronic immune-mediated systemic disease that had no effective and durable treatment. Mesenchymal stem cells (MSCs) have immunomodulatory properties. Therefore, we performed a phase 1/2a, single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs (UMSCs) in the treatment of psoriasis and to preliminarily explore the possible mechanisms. Seventeen patients with psoriasis were enrolled and received UMSC infusions. Adverse events, laboratory parameters, PASI, and PGA were analyzed. We did not observe obvious side effects during the treatment and 6-month follow-up. A total of 47.1% (8/17) of the psoriasis patients had at least 40% improvement in the PASI score, and 17.6% (3/17) had no sign of disease or minimal disease based on the PGA score. And the efficiency was 25% (2/8) for males and 66.7% (6/9) for females. After UMSC transplantation (UMSCT), the frequencies of Tregs and CD4 memory T cells were significantly increased, and the frequencies of T helper (Th) 17 and CD4 naive T cells were significantly decreased in peripheral blood (PB) of psoriasis patients. And all responders showed significant increases in Tregs and CD4 memory T cells, and significant decreases in Th17 cells and serum IL-17 level after UMSCT. And baseline level of Tregs in responders were significantly lower than those in nonresponders. In conclusion, allogeneic UMSCT is safe and partially effective in psoriasis patients, and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT. Trial registration Clinical Trials NCT03765957.
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http://dx.doi.org/10.1038/s41392-022-01059-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352692PMC
August 2022

Circ_0,007,331 Promotes the PTX Resistance and Progression of Breast Cancer via miR-200b-3p/ANLN.

J Surg Res 2022 Aug 1;279:619-632. Epub 2022 Aug 1.

Department of Breast Cancer, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address:

Introduction: The objective of our study was to explore the expression pattern of circular ribonucleic acid (RNA)_0,007,331 (circ_0,007,331) in breast cancer (BC) and its functional association with cellular paclitaxel (PTX) resistance and proliferation, migration, invasion and apoptosis.

Methods: Real-time quantitative polymerase chain reaction was applied to measure RNA expression. The PTX resistance of BC cells was analyzed by cell counting kit-8 assay. Flow cytometry was applied to assess cell cycle progression and cell apoptosis. Transwell assays were utilized to analyze cell migration and invasion abilities. Protein expression was determined by Western blot assay. The target relationship between microRNA-200b-3p (miR-200b-3p) and circ_0,007,331 or Anillin (ANLN) was verified by dual-luciferase reporter assay and RNA-pull down assay. The in vivo role of circ_0,007,331 was analyzed using xenograft tumor model.

Results: Circ_0,007,331 expression was elevated in PTX-resistant BC cell lines relative to parental BC cell lines. Circ_0,007,331 contributed to the PTX resistance, proliferation, migration, invasion and suppressed the apoptosis of BC cells. Circ_0,007,331 interacted with miR-200b-3p in BC cells. Circ_0,007,331 silencing-mediated effects in BC cells were largely overturned by the knockdown of miR-200b-3p. ANLN was a target of miR-200b-3p in BC cells. Circ_0,007,331 silencing reduced ANLN expression partly through upregulating miR-200b-3p in BC cells. miR-200b-3p overexpression-induced effects in BC cells were largely counteracted by the accumulation of ANLN. Circ_0,007,331 silencing aggravated PTX-mediated inhibitory effect on tumor growth in vivo.

Conclusions: Circ_0,007,331 contributed to the PTX resistance, proliferation and motility and inhibited the apoptosis of BC cells through mediating miR-200b-3p/ANLN signaling.
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http://dx.doi.org/10.1016/j.jss.2022.05.004DOI Listing
August 2022

Outbreak dynamics of foodborne pathogen Vibrio parahaemolyticus over a seventeen year period implies hidden reservoirs.

Nat Microbiol 2022 Aug 2;7(8):1221-1229. Epub 2022 Aug 2.

Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong Province, China.

Controlling foodborne diseases requires robust outbreak detection and a comprehensive understanding of outbreak dynamics. Here, by integrating large-scale phylogenomic analysis of 3,642 isolates and epidemiological data, we performed 'data-driven' outbreak detection and described the long-term outbreak dynamics of the leading seafood-associated pathogen, Vibrio parahaemolyticus, in Shenzhen, China, over a 17-year period. Contradictory to the widely accepted notion that sporadic patients and independent point-source outbreaks dominated foodborne infections, we found that 71% of isolates from patients grouped into within-1-month clusters that differed by ≤6 single nucleotide polymorphisms, indicating putative outbreaks. Furthermore, we showed that despite the long time spans between clusters, 70% of them were genomically closely related and were inferred to arise from a small number of common sources, which provides evidence that hidden persistent reservoirs generated most of the outbreaks rather than independent point-sources. Phylogeographical analysis further revealed the geographical heterogeneity of outbreaks and identified a coastal district as the potential hotspot of outbreaks and as the hub and major source of cross-district spread events. Our findings provide a comprehensive picture of the long-term spatiotemporal dynamics of foodborne outbreaks and present a different perspective on the major source of foodborne infections, which will inform the design of future disease control strategies.
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http://dx.doi.org/10.1038/s41564-022-01182-0DOI Listing
August 2022

Trend in the incidence of hepatitis A in mainland China from 2004 to 2017: a joinpoint regression analysis.

BMC Infect Dis 2022 Aug 1;22(1):663. Epub 2022 Aug 1.

School of Public Health, Southwest Medical University, No.1, Section 1, Xianglin Road, Longmatan District, Luzhou, 646000, Sichuan, People's Republic of China.

Background: China has experienced a continuous decreasing trend in the incidence of hepatitis A in recent years. Temporal trend analyses are helpful in exploring the reasons for the changing trend. Thus, this study aims to analyse the incidence trend of viral hepatitis A by region and age group in mainland China from 2004 to 2017 to evaluate the effectiveness of prevention and control measures.

Methods: Data on hepatitis A and population information were collected and analysed with a joinpoint regression model. Annual percentage changes (APCs) and average annual percentage changes (AAPCs) were estimated for the whole country and for each region and age group.

Results: From 2004 to 2017, the seasonality and periodicity of hepatitis A case numbers were obvious before 2008 but gradually diminished from 2008 to 2011 and disappeared from 2012-2017. The national incidence of hepatitis A (AAPC =  - 12.1%) and the incidence rates for regions and age groups showed decreasing trends, with differences in the joinpoints and segments. Regarding regions, the hepatitis A incidence in the western region was always the highest among all regions, while a nonsignificant rebound was observed in the northeastern region from 2011 to 2017 (APC = 14.2%). Regarding age groups, the hepatitis A incidence showed the fastest decrease among children (AAPC =  - 15.3%) and the slowest decrease among elderly individuals (AAPC =  - 6.6%). Among all segments, the hepatitis A incidence among children had the largest APC value in 2007-2017, at - 20.4%.

Conclusion: The national annual incidence of hepatitis A continually declined from 2004 to 2017 and the gaps in hepatitis A incidence rates across different regions and age groups were greatly narrowed. Comprehensive hepatitis A prevention and control strategies, including the use of routine vaccination during childhood in mainland China, especially the implementation of the national Expanded Program on Immunization (EPI) in 2008, resulted in substantial progress from 2004 to 2017. However, gaps remain. Regular monitoring and analysis of hepatitis A epidemic data and prompt adjustment of hepatitis A prevention and control strategies focusing on children, elderly individuals and those living in certain regions are recommended.
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http://dx.doi.org/10.1186/s12879-022-07651-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341093PMC
August 2022

Effects of autotoxicity and allelopathy on seed germination and seedling growth in .

Front Plant Sci 2022 15;13:908426. Epub 2022 Jul 15.

Key Laboratory of National Forestry and Grassland Administration on Grassland Resources and Ecology in the Yellow River Delta, College of Grassland Science, Qingdao Agricultural University, Qingdao, China.

Autotoxicity is a form of intraspecific allelopathy, in which a plant species inhibits the establishment or growth of the same species through the release of toxic chemical compounds into the environment. The phenomenon of autotoxicity in crops is best traced in alfalfa (). A close relative of alfalfa, has been developed into an excellent model species for leguminous plants. However, it is not known whether has autotoxicity. In this study, root exudates showed a negative impact on the growth of seedlings, indicating autotoxicity. Detailed analyses with plant extracts from and alfalfa revealed varying degrees of suppression effects in the two species. The extracts negatively affected seed germination potential, germination rate, radicle length, hypocotyl length, synthetic allelopathic effect index, plant height, root growth, fresh weight, dry weight, net photosynthetic rate, transpiration rate, and stomatal conductance in both and alfalfa. The results demonstrated that autotoxicity and allelopathic effects exist in . This opens up a new way to use as a model species to carry out in-depth studies of autotoxicity and allelopathy to elucidate biochemical pathways of allelochemicals and molecular networks controlling biosynthesis of the chemicals.
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http://dx.doi.org/10.3389/fpls.2022.908426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335049PMC
July 2022

Vapor-Assisted In Situ Recrystallization for Efficient Tin-Based Perovskite Light-Emitting Diodes.

Adv Mater 2022 Jul 29:e2203180. Epub 2022 Jul 29.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, Jiangsu, 211816, China.

Tin-based perovskites are a promising candidates to replace their toxic lead-based counterparts in optoelectronic applications, such as light-emitting diodes (LEDs). However, the development of tin perovskite LEDs is slow due to the challenge of obtaining high-quality tin perovskite films. Here, a vapor-assisted spin-coating method is developed to achieve high-quality tin perovskites and high-efficiency LEDs. It is revealed that solvent vapor can lead to in situ recrystallization of tin perovskites during the film-formation process, thus significantly improving the crystalline quality with reduced defects. An antioxidant additive is further introduced to suppress the oxidation of Sn and increase the photoluminescence quantum efficiency up to ≈30%, which is an approximately fourfold enhancement in comparison with that of the control method. As a result, efficient tin perovskite LEDs are achieved with a peak external quantum efficiency of 5.3%, which is among the highest efficiency of lead-free perovskite LEDs.
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http://dx.doi.org/10.1002/adma.202203180DOI Listing
July 2022

Effects of Early TACE Refractoriness on Survival in Patients with Hepatocellular Carcinoma: A Real-World Study.

J Hepatocell Carcinoma 2022 21;9:621-631. Epub 2022 Jul 21.

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Purpose: To investigate the effect of early transarterial chemoembolization (TACE) refractoriness on hepatocellular carcinoma (HCC) patient survival and to explore whether viable lesions > 50% after two consecutive TACE treatments negatively affect the prognosis of HCC patients.

Patients And Methods: From January 2014 to August 2017, 323 HCC patients who received TACE as the initial treatment were analyzed. TACE refractoriness was diagnosed according to the Japan Society of Hepatology 2021 version. Propensity score matching (PSM) was used to create a 1:1 matched group (nonrefractoriness vs refractoriness). To determine survival outcomes and prognostic factors, the Kaplan-Meier method and Cox proportional hazards model were used.

Results: In total, 51.1% of patients developed early TACE refractoriness (n = 165). After PSM, 120 patients from each group were matched and analyzed. The median overall survival (OS) time of the early TACE refractoriness group was significantly shorter than that of the nonrefractory group [21 months (95% CI: 15.7-26.3) vs 34 months (95% CI: 27.5-40.5), = 0.002]. Thirty-eight patients with viable lesions >50% after two consecutive TACE procedures were identified and matched with patients of non-refractoriness. No significant difference in median OS was observed [35 months (95% CI: 21.6-48.5) vs 31 months (95% CI: 25.4-36.6), = 0.611]. Multivariate analysis revealed that the BCLC stage, tumor size, tumor capsule, tumor distribution, α-fetoprotein level (AFP), and early TACE refractoriness were independent risk factors for prognosis in HCC patients.

Conclusion: Early TACE refractoriness may shorten the OS of HCC patients. However, viable lesions >50% after two consecutive TACE treatments did not impair the survival of patients. It may be inappropriate to consider these patients as having developed TACE refractoriness.
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http://dx.doi.org/10.2147/JHC.S373112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317376PMC
July 2022

Intraoperative incision irrigation with high-volume saline reduces surgical site infection for abdominal infections.

Front Surg 2022 12;9:927896. Epub 2022 Jul 12.

Emergency Department, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.

Purpose: Surgical site infection (SSI) remains one of the most common postoperative complications for patients with abdominal infections. This study aimed at investigating the effectiveness of high-volume normal saline (NS) irrigation in preventing postoperative SSI for patients with abdominal infections.

Methods: In this retrospective before-after clinical study, patients who underwent emergency laparotomy due to abdominal infections between Jan 2015 and Dec 2021 were included consecutively. A cohort of 207 patients with NS irrigation was compared to historical controls. A propensity score matching (PSM) with a 1:1 ratio was performed to reduce potential bias. The primary outcome was the 30-day SSI rate.

Results: Irrigation (207) and control (207) matched patients were statistically identical on baseline characteristics, perioperative, and intraoperative parameters. Irrigation patients had lower overall SSI rates (10.6% vs. 26.1%,  < 0.001), mainly due to reduction in superficial (4.3% vs. 17.9%) and deep (1.4% vs. 3.9%) SSIs, rather than space/organ SSIs (4.8% vs. 4.3%). Irrigation patients also had lower rates of incision seroma (4.8% vs. 11.6%,  = 0.012), shorter duration of antibiotics use (5.2 ± 1.7 d vs. 7.2 ± 2.0 d,  < 0.001), and unplanned readmission (1.0% vs. 8.7%,  < 0.001). Length of hospital stay showed a declining trend with irrigation intervention, while no significant difference was observed. Moreoever, logistic regression revealed that NS irrigationwas an independent protector against SSI ( 0.309; 0.207-0.462;  < 0.001).

Conclusion: Intraoperative incision irrigation with high-volume NS is associated with a lower rate of SSI for patients with abdominal infections.
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http://dx.doi.org/10.3389/fsurg.2022.927896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314743PMC
July 2022

Microvascular decompression for trigeminal neuralgia caused by persistent trigeminal artery associated with craniosynostosis: a case report.

J Med Case Rep 2022 Jul 29;16(1):292. Epub 2022 Jul 29.

Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-Sen University, No 58th, Zhongshan Er Road, Guangzhou, 510080, China.

Background: Persistent trigeminal artery (PTA) is a rare arterial anastomosis between the basilar artery (BA) and internal carotid artery (ICA). It plays an indispensable role in a number of neurological disorders, including trigeminal neuralgia (TN).

Case Presentation: We report a unique case of a 58-year-old Han female patient with TN caused by PTA associated with craniosynostosis. Preoperative three-dimensional time-of-flight (3D-TOF) magnetic resonance (MR) and 3D constructive inference in steady state (3D-CISS) imaging showed that the PTA run though Meckel's cave. Complete pain relief was immediately achieved after microvascular decompression (MVD), without facial numbness and other complications. No recurrence was recorded at the 1-year follow up.

Conclusions: Microvascular decompression is a feasible option for the treatment of complex TN combined with other abnormalities. For patients deemed suitable for percutaneous balloon compression, PTA should be ruled out. Preoperative 3D-TOF and 3D-CISS MR imaging were essential to identify PTA neurovascular conflicts.
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http://dx.doi.org/10.1186/s13256-022-03490-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336082PMC
July 2022

Calcination-regulated Microstructures of Donor-Acceptor Polymers towards Enhanced and Stable Photocatalytic H2O2 Production in Pure Water.

Angew Chem Int Ed Engl 2022 Jul 28. Epub 2022 Jul 28.

Wuhan University of Technology, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, 122 Luoshi Road, 430070, Wuhan, CHINA.

Regulating molecular structure of donor-acceptor (D-A) polymer is a promising strategy to improve photoactivity. Herein, a porous nanorod-like D-A polymer is synthesized via a strategy of supramolecular chemistry combined with subsequent calcination treatment. This polymer consists of benzene rings (D) and triazine (A) that are linked by amido bond (-CONH-). -CONH- further partially cracks into cyano groups (-C≡N) (A) under calcination. The ratio of benzene to triazine could be tuned to adjust the -C≡N content by varying the calcination atmosphere. Such regulation of molecular structure could modulate the band structure of D-A polymer and endow it with unique porous nanorod-like morphology, leading to the achievement of two-electron oxygen reduction and two-electron water oxidation and the improvement of exciton splitting, O 2 adsorption and activation. These merits synergistically ensure a highly efficient and stable photocatalytic H 2 O 2 production in pure water.
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http://dx.doi.org/10.1002/anie.202208438DOI Listing
July 2022

Transport Property and Spin-Orbit Torque in 2D Rashba Ferromagnetic Electron Gas.

Materials (Basel) 2022 Jul 25;15(15). Epub 2022 Jul 25.

School of Physical Sciences, University of Chinese Academy of Sciences, Beijng 100049, China.

In this paper, we investigate the spin-orbit torque and transport property in a 2D Rashba ferromagnetic electron gas. The longitudinal conductivity can be divided into two parts: the first term is determined by the charge density and is independent of the spin degrees of freedom. The second term depends on the two bands that spin in the opposite directions, and it is directly proportional to spin-orbit torque regardless of the band structure and temperature. This is a general and underlying relation between the transport property and spin-orbit torque. Moreover, we show the impacts of the spin-orbit coupling constant and Fermi energy on transverse conductivity and spin-orbit torque, which is helpful for relevant experiments.
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http://dx.doi.org/10.3390/ma15155149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331862PMC
July 2022

Empowering carbon materials robust gas desulfurization capability through an inclusion of active inorganic phases: A review of recent approaches.

J Hazard Mater 2022 Sep 20;437:129414. Epub 2022 Jun 20.

Department of Chemistry and Biochemistry, The City College of New York, NY 1000312,10031, New York, United States. Electronic address:

Gas-phase desulfurization on carbon materials is an important process attracting the attention of scientists and engineers. When involving physical adsorption, reactive adsorption and catalytic oxidation combined, the process is considered as energy-efficient. Recent developments in materials science directed the attention of researchers to inorganic phases which react with HS and participate to its oxidation to elemental sulfur. To fully utilize their capability, a developed surface area is needed and this feature is delivered by carbons. This review presents examples of recent advances in this field with focus not only on the activity of inorganic phases, dispersed on the surface or introduced as nanoparticles, but also on the important contribution of a carbon support as providing specific synergistic effects. The active phase promotes the HS oxidation and participates in the reactions with HS, while the carbon phase ensures its high dispersion, adds to oxygen activation and to an efficient electron transfer.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129414DOI Listing
September 2022

Protein-Ligand Docking in the Machine-Learning Era.

Molecules 2022 Jul 18;27(14). Epub 2022 Jul 18.

Department of Chemistry, New York University, New York, NY 10003, USA.

Molecular docking plays a significant role in early-stage drug discovery, from structure-based virtual screening (VS) to hit-to-lead optimization, and its capability and predictive power is critically dependent on the protein-ligand scoring function. In this review, we give a broad overview of recent scoring function development, as well as the docking-based applications in drug discovery. We outline the strategies and resources available for structure-based VS and discuss the assessment and development of classical and machine learning protein-ligand scoring functions. In particular, we highlight the recent progress of machine learning scoring function ranging from descriptor-based models to deep learning approaches. We also discuss the general workflow and docking protocols of structure-based VS, such as structure preparation, binding site detection, docking strategies, and post-docking filter/re-scoring, as well as a case study on the large-scale docking-based VS test on the LIT-PCBA data set.
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http://dx.doi.org/10.3390/molecules27144568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323102PMC
July 2022

Quantitative Assessment of Road Performance of Recycled Asphalt Mixtures Incorporated with Steel Slag.

Materials (Basel) 2022 Jul 19;15(14). Epub 2022 Jul 19.

Department of Civil and Environmental Engineering, Norwegian University of Science and Technology, 7491 Trondheim, Norway.

Circular utilization of reclaimed asphalt pavement (RAP) has received extensive attention for its economic and environmental benefits. The application of recycled asphalt mixtures (RAM) in the upper layer of asphalt pavement faces the issue of inferior anti-slip performance and durability. This study aims to recycle steel slag as virgin aggregates in RAM and quantitatively evaluate the service performance of RAM with steel slag. Steel slag and basalt RAM were firstly fabricated and the five different RAP contents were involved. Then tests of Marshall stability, indirect tensile strength and Cantabro spatter loss were conducted to investigate the moisture susceptibility of RAM. Moreover, their high temperature stability, crack resistance and skid resistance were characterized. Indirect tensile fatigue test combined with Hamburg wheel tracking test were carried out to discuss the durability of RAM. The comprehensive performance of RAM with steel slag were quantitatively assessed based on an improved radar chart evaluation method. The results show that involving steel slag reveals a remarkable enhancement function on water stability, high and low temperature performance, skid resistance and fatigue resistance of RAM. Steel slag RAM with 50% RAP content demonstrates a rutting depth of 7.60 mm and a creep slope of 2.54 × 10, indicating its superior durability in high temperature and water environment. Compared with the comprehensive evaluation function of 0.5336 for basalt RAM with 30% RAP dosage, steel slag RAM reaches 0.7801, which represents its preferable road performance.
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http://dx.doi.org/10.3390/ma15145005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318539PMC
July 2022

Role and Mechanisms of Tumor-Associated Macrophages in Hematological Malignancies.

Front Oncol 2022 7;12:933666. Epub 2022 Jul 7.

Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, China.

Mounting evidence has revealed that many nontumor cells in the tumor microenvironment, such as fibroblasts, endothelial cells, mesenchymal stem cells, and leukocytes, are strongly involved in tumor progression. In hematological malignancies, tumor-associated macrophages (TAMs) are considered to be an important component that promotes tumor growth and can be polarized into different phenotypes with protumor or antitumor roles. This Review emphasizes research related to the role and mechanisms of TAMs in hematological malignancies. TAMs lead to poor prognosis by influencing tumor progression at the molecular level, including nurturing cancer stem cells and laying the foundation for metastasis. Although detailed molecular mechanisms have not been clarified, TAMs may be a new therapeutic target in hematological disease treatment.
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http://dx.doi.org/10.3389/fonc.2022.933666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301190PMC
July 2022

Pegylated Liposomal Doxorubicin, Docetaxel, and Trastuzumab as Neoadjuvant Treatment for HER2-Positive Breast Cancer Patients: A Phase II and Biomarker Study.

Front Oncol 2022 8;12:909426. Epub 2022 Jul 8.

Breast Center, Fourth Hospital of Hebei Medical University, Key Laboratory for Breast Cancer Molecular Medicine of Hebei Province, Shijiazhuang, China.

Background: Combined neoadjuvant chemotherapy with trastuzumab and pertuzumab is the standard regimen for human epidermal growth receptor 2 (HER2)-positive breast cancer (BC). However, pertuzumab is not available because it is not on the market or covered by medicare in some regions or poor economy. Anthracyclines and taxanes are cornerstones in BC chemotherapy, and their combination contributes to satisfactory efficiency in neoadjuvant settings. Nonetheless, concomitant administration of trastuzumab and an anthracycline is generally avoided clinically due to cardiotoxicity. Pegylated liposomal doxorubicin (PLD) is less cardiotoxic compared with traditional anthracyclines. Here, we conducted this prospective study to evaluate the efficacy, safety, and potential biomarkers for PLD plus trastuzumab and docetaxel as neoadjuvant treatment in HER2-positive BC.

Patients And Methods: Patients with stage II or III HER2-positive BC were recruited in this multicenter, open-label, single-arm, phase II study. Eligible patients were given 6 cycles of PLD plus docetaxel and trastuzumab. Primary endpoint was total pathological complete response (tpCR, ypT0/is ypN0). Secondary endpoints were breast pathological complete response (bpCR, ypT0/is), objective response rate (ORR), operation rate, breast-conserving surgery rate, and safety. Metadherin (MTDH), glutaminyl-peptide cyclotransferase (QPCT), topoisomerase II alpha (TOP2A), programmed death ligand 1 (PD-L1), and tumor-infiltrating lymphocytes (TILs) were evaluated in BC tissues pre-neoadjuvant for potential biomarkers.

Results: Between March 2019 and February 2021, 54 patients were enrolled, 50 were included in the analysis, and 35 (70.0%) completed 6 cycles of neoadjuvant treatment. Forty-nine (98.0%) patients underwent surgery with a breast-conserving rate of 44.0%. The tpCR rate, bpCR rate, and ORR were 48.0% (95% CI, 33.7%-62.6%), 60.0% (95% CI, 45.2%-73.6%), and 84.0% (95% CI, 70.9%-92.8%), respectively. tpCR was associated with MTDH ( = 0.002) and QPCT ( = 0.036) expression but not with TOP2A ( = 0.75), PD-L1 ( = 0.155), or TILs ( = 0.76). Patients with HR-negative status were more likely to achieve bpCR compared with those with HR-positive status (76.2% vs. 48.3%, = 0.047). Grade ≥3 adverse events occurred in 38.0% of patients. Left ventricular ejection fraction decline by ≥10% was reported in 18.0% of patients, and no patient experienced congestive heart failure.

Conclusions: PLD plus docetaxel and trastuzumab might be a potential neoadjuvant regimen for HER2-positive BC with a high tpCR rate and manageable tolerability. MTDH and QPCT are potential predictive markers for tpCR.
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http://dx.doi.org/10.3389/fonc.2022.909426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304895PMC
July 2022

KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway.

Anal Cell Pathol (Amst) 2022 12;2022:2552397. Epub 2022 Jul 12.

Department of Neurosurgery, The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.

Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was reported as an oncogene in several malignant tumor types, its role in medulloblastoma has not been studied so far. The PCR results of our study showed that KIF26B is highly expressed in medulloblastoma, and its high expression is associated with a high clinical stage. Knockdown the expression of KIF26B could significantly impair the proliferation and migration of medulloblastoma cells. KIF26B promotes the malignant progression of medulloblastoma by affecting the expression of phosphorylation of key proteins in the PI3K/AKT signaling pathway. With the help of 740 Y-P, activating the pi3k signaling pathway can partially rescue the phenotype. Therefore, our experimental results suggest that KIF26B is a potential target for medulloblastoma.
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http://dx.doi.org/10.1155/2022/2552397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296275PMC
July 2022

Artemisinin attenuated ischemic stroke induced cell apoptosis through activation of ERK1/2/CREB/BCL-2 signaling pathway and .

Int J Biol Sci 2022 11;18(11):4578-4594. Epub 2022 Jul 11.

Faculty of Health Science, University of Macau, Taipa, Macau, China.

Ischemic stroke is characterized by the presence of both brain ischemic and reperfusion-induced injuries in the brain, leading to neuronal dysfunction and death. Artemisinin, an FDA-approved antimalarial drug, has been reported to have neuroprotective properties. However, the effect of artemisinin on ischemic stroke is not known. In the present study, we investigated the effect of artemisinin on ischemic stroke using an oxygen-glucose deprivation/reperfusion (OGD/RP) cellular model and a mouse middle cerebral artery occlusion (MCAO) animal model and examined the underlying mechanisms. The obtained results revealed that a subclinical antimalarial concentration of artemisinin increased cell viability and decreased LDH release and cell apoptosis. Artemisinin also attenuated the production of reactive oxygen species (ROS) and the loss of mitochondrial membrane potential (Δψm). Importantly, artemisinin attenuated the infarction volume and the brain water content in the MCAO animal model. Artemisinin also improved neurological and behavioural outcomes and restored grasp strength and the recovery of motor function in MCAO animals. Furthermore, artemisinin treatment significantly inhibited the molecular indices of apoptosis, oxidative stress and neuroinflammation and activated the ERK1/2/CREB/BCL-2 signaling pathway. Further validation of the involved signaling pathway by the ERK1/2 inhibitor PD98059 revealed that inhibiting the ERK1/2 signaling pathway or silencing ERK1/2 reversed the neuroprotective effects of artemisinin. These results indicate that artemisinin provides neuroprotection against ischemic stroke via the ERK1/2/CREB/BCL-2 signaling pathway. Our study suggests that artemisinin may play an important role in the prevention and treatment of stroke.
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http://dx.doi.org/10.7150/ijbs.69892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295073PMC
July 2022

Pioneer Factor Improves CRISPR-Based C-To-G and C-To-T Base Editing.

Adv Sci (Weinh) 2022 Jul 21:e2202957. Epub 2022 Jul 21.

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Base editing events in eukaryote require a compatible chromatin environment, but there is little research on how chromatin factors contribute to the editing efficiency or window. By engineering BEs (base editors) fused with various pioneer factors, the authors found that SOX2 substantially increased the editing efficiency for GBE and CBE. While SoxN-GBE (SOX2-NH3-GBE) improved the editing efficiency at overall cytosines of the protospacer, SoxM-GBE/CBE (SOX2-Middle-GBE/CBE) enabled the higher base editing at PAM-proximal cytosines. By separating functional domains of SOX2, the SadN-GBE (SOX2 activation domain-NH3-GBE) is constructed for higher editing efficiency and SadM-CBE for broader editing window to date. With the DNase I assay, it is also proved the increased editing efficiency is most likely associated with the induction of chromatin accessibility by SAD. Finally, SadM-CBE is employed to introduce a stop codon in the proto-oncogene MYC, at a locus rarely edited by previous editors with high efficiency. In this work, a new class of pioneer-BEs is constructed by fusion of pioneer factor or its functional domains, which exhibits higher editing efficiency or broader editing window in eukaryote.
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http://dx.doi.org/10.1002/advs.202202957DOI Listing
July 2022

Enhancing glycosylase base-editor activity by fusion to transactivation modules.

Cell Rep 2022 Jul;40(3):111090

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China. Electronic address:

Base editors (BEs) are a group of genetic tools with potential in both scientific and medical research. Recently, a glycosylase BE (GBE), which converts C to G, has been constructed. However, the editing efficiency and targeting scope remains to be further exploited. Here, we renovate the GBE by first fusing it to various transactivation modules including Vp64, leading to a higher conversion of C to G relative to GBE in HEK293T cells. Further, higher editing efficiency, enhanced editing purity, and an enlarged editing window are acquired by the combination of SunTag system, GBE, and VP64. Finally, a SpRY-Cas9 variant is used to expand the targeting scope for Vp64-GBE. Vp64-SpRY-GBE and SpRY-GBE target genomic sites with non-NGG PAM, and Vp64-SpRY-GBE demonstrates better performance compared with SpRY-GBE. The construction of GBE variants with superior performance and versatile editing scope broadens the toolbox of BEs and may contribute to genetic therapies with C-to-G mutation.
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http://dx.doi.org/10.1016/j.celrep.2022.111090DOI Listing
July 2022

Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome.

Sci Immunol 2022 Jul 8;7(73):eabg3208. Epub 2022 Jul 8.

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Despite being the most abundantly secreted immunoglobulin isotype, the pattern of reactivity of immunoglobulin A (IgA) antibodies toward each individual's own gut commensal bacteria still remains elusive. By colonizing germ-free mice with defined commensal bacteria, we found that the binding specificity of bulk fecal and serum IgA toward resident gut bacteria resolves well at the species level and has modest strain-level specificity. IgA hybridomas generated from lamina propria B cells of gnotobiotic mice showed that most IgA clones recognized a single bacterial species, whereas a small portion displayed cross-reactivity. Orally administered hybridoma-produced IgAs still retained bacterial antigen binding capability, implying the potential for a new class of therapeutic antibodies. Species-specific IgAs had a range of strain specificities. Given the distinctive bacterial species and strain composition found in each individual's gut, our findings suggest the IgA antibody repertoire is shaped uniquely to bind "self" gut bacteria.
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http://dx.doi.org/10.1126/sciimmunol.abg3208DOI Listing
July 2022

Arabidopsis Flowering Integrator SOC1 Transcriptionally Regulates Autophagy in Response to Long-term Carbon Starvation.

J Exp Bot 2022 Jul 19. Epub 2022 Jul 19.

Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou 510631, China.

Autophagy is a highly conserved self-digestion process, which is essential for plant adaptations to various environmental stresses. Although the core components of autophagy have been well established, the molecular basis for the transcriptional regulation of autophagy in plants remains to be further characterized. In this study, we demonstrate that SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1), a MADS-box family transcription factor that determines flowering transition in Arabidopsis thaliana, functions as a transcriptional repressor of autophagy. Electrophoretic mobility shift, chromatin immunoprecipitation-qPCR and dual-luciferase receptor assays demonstrate that SOC1 can bind to the promoters of ATG4b, ATG7, and ATG18c via the conserved cArG box. qRT-PCR analysis shows that 3 ATG genes (ATG4b, ATG7, and ATG18c) are up-regulated in the soc1-2 mutant. In line with this, the soc1-2 mutant displays enhanced autophagy activity as revealed by more autophagosome formation and elevated autophagic flux detected in this mutant when compared with that in wild-type plant. More importantly, SOC1 negatively affects the tolerance of plants to long-term carbon starvation and this process requires a functional autophagy pathway. Finally, we find that SOC1 is repressed upon carbon starvation both at transcription and protein layers. Collectively, our study not only uncovers an important transcriptional mechanism that contributes to plant autophagy regulation in response to nutrient starvation but also highlights novel cellular functions of the flowering integrator SOC1.
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http://dx.doi.org/10.1093/jxb/erac298DOI Listing
July 2022

Cognitive-Behavioral Differences Between Officials and Folks in China's Targeted Poverty Alleviation: An Evolutionary Game Theory Perspective.

Authors:
Zhi Chen Chao Yang

Front Psychol 2022 29;13:916030. Epub 2022 Jun 29.

Institute of Economic Research, Hubei Academy of Social Sciences, Wuhan, China.

China has historically eliminated absolute poverty and built a comprehensive well-off society through targeted poverty alleviation, at the end of which, however, many issues are worthy of scholars' attention kept emerging. A significant one was cognitive-behavioral differences between officials and folks regarding the procedure, standards, and methods of removing the poverty hats, which formed a new social dilemma called the official-folk game. Officials did not carry out targeted poverty alleviation work in strict accordance with the criteria specified by the government. In comparison, folks who have reached poverty elimination standards were unwilling to take off their poverty hats after targeted assistance due to the fear of returning to poverty. To fully explain this social dilemma, this study analyzes the causes of cognitive-behavioral differences between officials and folks in China's targeted poverty alleviation from the perspective of evolutionary game theory. The results show that bounded rational officials and folks will eventually get caught up in the prisoner's dilemma without exogenous factors' intervention. Furthermore, the study proposes that the government establish reasonable punishment, incentives, and supervision mechanisms to guide officials and folks and eliminate their cognitive-behavioral differences by investigating the influence of exogenous policy factors on the evolutionarily stable strategy (ESS) of the official-folk game. This finding not only reveals the formation mechanism of the cognitive-behavioral differences between officials and folks and presents an effective solution at the individual level but also provides a reference for other developing countries to overcome similar social dilemmas in the process of eliminating absolute poverty.
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http://dx.doi.org/10.3389/fpsyg.2022.916030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278326PMC
June 2022

Event-Related Potential Assessment of Visual Perception Abnormality in Patients With Obstructive Sleep Apnea: A Preliminary Study.

Front Hum Neurosci 2022 30;16:895826. Epub 2022 Jun 30.

Department of Respiratory Medicine, Civil Aviation General Hospital, Beijing, China.

This study investigated the effect of obstructive sleep apnea (OSA) on the neural mechanism of visual perception. A preliminary case-control study was conducted. Seventeen patients with moderate to severe OSA in the sleep center of Civil Aviation General Hospital and 20 healthy controls matched for age, sex, and education were recruited. The participants accepted the perceptual contour integration task, compared the differences in behavioral indicators between the two groups, and compared the differences in electroencephalography (EEG) data between the two groups through event-related potential (ERP) technology. The groups did not differ significantly in age and gender, but they differed significantly in body mass index (BMI) (OSA higher than healthy controls, < 0.05). The groups were not statistically different in terms of sleep structure and total sleep time. AHI, sleep efficiency, and minimal SaO value in the OSA group were significantly different from those of the control group. The results showed that the average reaction time of the OSA group was significantly longer than that of the healthy control group in the contour integration task. There was no significant difference in the accuracy rate. The results of EEG showed that the amplitudes of N100 of the OSA group were significantly higher than those of the control group at O1, Oz, and O2 electrodes. There was no significant difference in latency between the two groups. At the FCz electrode, the amplitudes of N200 of the OSA group were significantly higher than those of the control group. Therefore, we concluded that in the early stage of the perceptual integration task, although the neural response activity of patients with moderate and severe OSA was not accelerated, they need to call on more psychological resources, activate more neurons in the contour global recognition processing stage, and the compensatory effect of frontal lobe appeared in the stage of visual perception.
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http://dx.doi.org/10.3389/fnhum.2022.895826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280288PMC
June 2022
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