Publications by authors named "Chao Tan"

133 Publications

RNA sequencing identifies two novel liver-specific long noncoding RNAs with potential diagnostic value in hepatocellular carcinoma.

Biomark Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Epidemiology & Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, PR China.

To explore the expression profiles of long noncoding RNAs (lncRNAs) and identify novel lncRNAs as biomarkers for early diagnosis and therapy of hepatocellular carcinoma (HCC). Expression profiles of lncRNAs and mRNAs in five paired HCC and adjacent normal tissues were obtained by RNA sequencing. Eight lncRNAs, including two novel liver-specific lncRNAs (NONHSAT059247.2 and NONHSAT013897.2), were validated in another 74 pairs of HCC and adjacent normal tissues by quantitative reverse transcription PCR. The results of quantitative reverse transcription PCR showed that NONHSAT252133.1, NONHSAT112116.2 and NONHSAT242657.1 were significantly upregulated in HCC tissues, whereas NONHSAT169790.1, NONHSAT059247.2 and NONHSAT013897.2 were significantly downregulated. Two liver-specific lncRNAs demonstrated excellent diagnostic performance: NONHSAT059247.2 (area under the curve = 0.941, 95% CI: 0.902-0.979, p < 0.0001), NONHSAT013897.2 (area under the curve = 0.944, 95% CI: 0.906-0.983, p < 0.0001). The liver-specific lncRNAs NONHSAT059247.2 and NONHSAT013897.2, may provide new biomarkers for the future study on diagnosis, therapy, and mechanisms of HCC.
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http://dx.doi.org/10.2217/bmm-2020-0825DOI Listing
June 2021

Electrode Materials for Chronic Electrical Microstimulation.

Adv Healthc Mater 2021 May 24:e2100119. Epub 2021 May 24.

Department of Bioengineering, University of Pittsburgh, 3501 Fifth Ave. Pittsburgh, Pittsburgh, PA, 15213, USA.

Electrical microstimulation has enabled partial restoration of vision, hearing, movement, somatosensation, as well as improving organ functions by electrically modulating neural activities. However, chronic microstimulation is faced with numerous challenges. The implantation of an electrode array into the neural tissue triggers an inflammatory response, which can be exacerbated by the delivery of electrical currents. Meanwhile, prolonged stimulation may lead to electrode material degradation., which can be accelerated by the hostile inflammatory environment. Both material degradation and adverse tissue reactions can compromise stimulation performance over time. For stable chronic electrical stimulation, an ideal microelectrode must present 1) high charge injection limit, to efficiently deliver charge without exceeding safety limits for both tissue and electrodes, 2) small size, to gain high spatial selectivity, 3) excellent biocompatibility that ensures tissue health immediately next to the device, and 4) stable in vivo electrochemical properties over the application period. In this review, the challenges in chronic microstimulation are described in detail. To aid material scientists interested in neural stimulation research, the in vitro and in vivo testing methods are introduced for assessing stimulation functionality and longevity and a detailed overview of recent advances in electrode material research and device fabrication for improving chronic microstimulation performance is provided.
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http://dx.doi.org/10.1002/adhm.202100119DOI Listing
May 2021

Increasing Stability of SnO-Based Perovskite Solar Cells by Introducing an Anionic Conjugated Polyelectrolyte for Interfacial Adjustment.

ACS Appl Mater Interfaces 2021 Jun 19;13(21):24575-24581. Epub 2021 May 19.

Jiangsu National Synergistic Innovation Centre for Advanced Materials (SICAM), Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, P.R. China.

Despite the fact that power conversion efficiency (PCE) has been greatly improved in recent years, perovskite solar cells (PSCs) need to overcome some challenges, like stability, for the commercial application. Herein, an anionic conjugated polyelectrolyte, sulfonic-containing polyfluorene (abbreviated to SPF), has been developed to modify the interface between the electron-transporting layer (ETL) SnO and the optoelectronic active layer MAPbI in the cells. After 40 days of storage in atmospheric environment in the dark with exposure to a controlled humidity of about 10%, PCE of the SPF-modified cells with the structure of ITO/SnO/SPF/MAPbI/spiro-OMeTAD/Au still remained 94% of the initial value. In contrast, the control cell without SPF only remained 31.1% of its initial efficiency after 29 days. The main reason for the stability enhancement is the adjustment of interfacial energy level, the crystallinity enhancement, and the removal of the interfacial defect of the perovskite layer by introducing the hydrophobic and smooth SPF interfacial layer. Deep electrical study on the PSCs discloses that the cell has low carrier transfer resistance, low leakage current density, and minor interfacial charge accumulation. What's more, the short-circuit current density is improved, and PCE of 20.47% is achieved.
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http://dx.doi.org/10.1021/acsami.1c00410DOI Listing
June 2021

Integrated profiling identifies ITGB3BP as prognostic biomarker for hepatocellular carcinoma.

Bosn J Basic Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Department of Epidemiology and Statistics, School of Public Health, Guangxi Medical University, Nanning, China; Key Laboratory of High-Incidence-Tumor Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, China.

Hepatocellular carcinoma (HCC) is a highly malignant tumor. In this study, we sought to identify a novel biomarker for HCC by analyzing transcriptome and clinical data. The R software was used to analyze the differentially expressed genes (DEGs) in the datasets GSE74656 and GSE84598 downloaded from the Gene Expression Omnibus database, followed by a functional annotation. A total of 138 shared DEGs were screened from two datasets. They were mainly enriched in the "Metabolic pathways" pathway (Padj = 8.21E-08) and involved in the carboxylic acid metabolic process (Padj = 0.0004). The top 10 hub genes were found by protein-protein interaction analysis and were upregulated in HCC tissues compared to normal tissues in The Cancer Genome Atlas database. Survival analysis distinguished 8 hub genes CENPE, SPDL1, Hyaluronan-mediated motility receptor, Rac GTPase activating protein 1, Thyroid hormone receptor interactor 13, cytoskeleton-associated protein (CKAP) 2, CKAP5, and Integrin subunit beta 3 binding protein (ITGB3BP) were considered as prognostic hub genes. Multivariate cox regression analysis indicated that all the prognostic hub genes were independent prognostic factors for HCC. Furthermore, the receiver operating characteristic curve revealed that the 8-hub genes model had better prediction performance for overall survival compared to the T stage (p = 0.008) and significantly improved the prediction value of the T stage (p = 0.002). The Human Protein Atlas showed that the protein expression of ITGB3BP was upregulated in HCC, so the expression of ITGB3BP was further verified in our cohort. The results showed that ITGB3BP was upregulated in HCC tissues and was significantly associated with lymph node metastasis.
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http://dx.doi.org/10.17305/bjbms.2021.5690DOI Listing
April 2021

Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis.

J Toxicol Sci 2021 ;46(5):209-222

Graduate School of Hunan University of Chinese Medicine, China.

Objective: To seek out the effect of curcumin on cholesterol efflux in THP-1 macrophages and clarify its specific mechanism.

Methods: THP-1 macrophages were cultured with curcumin at different concentrations, followed by detection of the toxicity of curcumin to cells utilizing CCK-8 assay. Following culturing with serum-free ox-LDL, THP-1 macrophages were transfected with mi-miR-125a-5p, or in-miR-125a-5p, or pcDNA3.1-SIRT6, or si-SIRT6 for 24 hr, prior to treatment with curcumin at different concentrations. Oil red O staining was applied to examine the formation rate of foam cells, the kits were used for measuring intracellular lipid content of THP-1 macrophages, and the fluorescence detection kit for observing the cholesterol efflux rate. The expressions of miR-125a-5p, SIRT6, and ABCA1 were assayed by qRT-PCR and Western blot. ELISA was adopted to assess the contents of TNF-α, IL-6, and MCP-1. The interaction between miR-125a-5p and SIRT6 was evaluated by dual-luciferase reporter gene assay.

Results: The optimal dosage of curcumin could reduce foam cell formation and intracellular lipid content, and promote cholesterol efflux in THP-1 macrophages. Meanwhile, curcumin markedly suppressed the expression of miR-125a-5p and upregulated the expression of SIRT6. MiR-125a-5p negatively targeted SIRT6. Overexpression of SIRT6 partially reversed the inhibition role of miR-125a-5p mimic in the biological function of curcumin. Silencing of SIRT6 could partially reverse the effect of the miR-125a-5p inhibitor on the biological function of curcumin.

Conclusion: urcumin could promote cholesterol efflux of THP-1 macrophages through miR-125a-5p/SIRT6 axis and regulate the expression of ABCA1.
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http://dx.doi.org/10.2131/jts.46.209DOI Listing
January 2021

Detection of glibenclamide adulterated in antidiabetic Chinese patent medicine by attenuated total reflectance -infrared spectroscopy and chemometrics.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 19;255:119723. Epub 2021 Mar 19.

Key Lab of Process Analysis and Control of Sichuan Universities, Yibin University, Yibin, Sichuan 644000, China; Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan 610041, China.

There have been many reports of adulterated Chinese patent medicine with synthetic prescription that are claimed to be "pure natural". The present work investigates the feasibility of combining attenuated total reflectance-Mid-infrared (ATR-MIR) spectroscopy and several interval-based PLS algorithms for detecting the glibenclamide illegally adulterated in antidiabetic Chinese patent medicine (Jiangtangning). The full-spectrum PLS, four kinds of traditional interval PLS algorithms (iPLS, biPLS, siPLS and mwPLS) and a modified algorithm, i.e., a combination of mwPLS and window size optimization, named cmwPLS, were used for building calibration models. A total of 21 samples adulterated with 0-3.5% glibenclamide were prepared. The dataset was equally split into a training set and a test set for building and testing the prediction models, respectively. For those interval-based PLS, the whole wavenumber axis was divided into 20 sub-intervals. In terms of the prediction on the test set, the new cmwPLS produce the best model, followed by mwPLS. The modified algorithm can optimize automatically the window width (i.e., the number of adjacent variables used for modeling) and position. It can be concluded that cmwPLS coupled with ATR-MIR technique is a good alternative to other traditional chemical analysis for detecting the adulteration of Chinese patent medicine.
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http://dx.doi.org/10.1016/j.saa.2021.119723DOI Listing
July 2021

Public awareness and anxiety during COVID-19 epidemic in China: A cross-sectional study.

Compr Psychiatry 2021 May 11;107:152235. Epub 2021 Mar 11.

The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: The study aims to investigate public awareness of coronavirus disease 2019 (COVID-19) and measure levels of anxiety during the outbreak.

Method: A total of 2115 subjects from 34 provinces in China were evaluated. A questionnaire was designed, which covers demographic characteristics, knowledge of COVID-19, and factors that influenced anxiety during the outbreak to test public awareness and determine the impact of the outbreak on people's lives. In addition, a generalized anxiety disorder (GAD) scale was utilized to assess anxiety levels during the outbreak. Lastly, the chi-square test and multiple logistic regression analysis were used to identify factors associated with levels of public anxiety.

Results: A majority of respondents reported high levels of awareness of COVID-19. A total of 1107 (52.3%), 707 (33.4%), 154 (7.3%), and 147 (7%) respondents exhibited no, mild, moderate, and severe levels of anxiety, respectively. Results of the chi-square test and multiple logistic regression analysis demonstrated that respondents (a) with no college education, (b) are unaware of neighbors who may have been infected, (c) who spent considerable time collecting information and browsing negative information related to the virus, (d) are unhealthy, and (e) displayed low levels of awareness of the transmission routes were highly likely to be anxious.

Conclusion: During the outbreak, the majority of people exhibited high levels of awareness and knowledge regarding preventive measures from COVID-19. The absence of psychological anxiety was observed in more than half of the respondents. Adaptive responses to anxiety and high levels of awareness about COVID-19 may have protected the public during the outbreak.
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http://dx.doi.org/10.1016/j.comppsych.2021.152235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946536PMC
May 2021

CircRNA profiling identifies circRNF180 as a tumor suppressor in hepatocellular carcinoma.

Epigenomics 2021 Apr 8;13(7):513-530. Epub 2021 Mar 8.

Department of Occupational & Environmental Health, School of Public Health, Guangxi Medical University, Nanning, PR China.

 To explore the expression profiles and functions of circRNAs in hepatocellular carcinoma (HCC).  We obtained circRNA expression profiles through RNA sequencing. Expression levels of circRNAs were confirmed by quantitative real-time PCR. The effects on HCC progression were determined using Cell Counting Kit 8, clone formation and transwell assays. We identified 114 upregulated and 144 downregulated circRNAs in HCC tissues. The results of quantitative real-time PCR showed that circGNAO1, circRNF180 and circMERTK were significantly downregulated in HCC tissues, whereas circSNX6 was significantly upregulated. CircRNF180 was associated with microvascular invasion. Overexpression of circRNF180 inhibits the proliferation, colony formation, migration and invasion of HCC cells.  CircRNF180 may function as a tumor suppressor and could serve as a potential biomarker and therapeutic target in HCC.
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http://dx.doi.org/10.2217/epi-2020-0385DOI Listing
April 2021

Recent Advances in In Vivo Neurochemical Monitoring.

Micromachines (Basel) 2021 Feb 18;12(2). Epub 2021 Feb 18.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.

The brain is a complex network that accounts for only 5% of human mass but consumes 20% of our energy. Uncovering the mysteries of the brain's functions in motion, memory, learning, behavior, and mental health remains a hot but challenging topic. Neurochemicals in the brain, such as neurotransmitters, neuromodulators, gliotransmitters, hormones, and metabolism substrates and products, play vital roles in mediating and modulating normal brain function, and their abnormal release or imbalanced concentrations can cause various diseases, such as epilepsy, Alzheimer's disease, and Parkinson's disease. A wide range of techniques have been used to probe the concentrations of neurochemicals under normal, stimulated, diseased, and drug-induced conditions in order to understand the neurochemistry of drug mechanisms and develop diagnostic tools or therapies. Recent advancements in detection methods, device fabrication, and new materials have resulted in the development of neurochemical sensors with improved performance. However, direct in vivo measurements require a robust sensor that is highly sensitive and selective with minimal fouling and reduced inflammatory foreign body responses. Here, we review recent advances in neurochemical sensor development for in vivo studies, with a focus on electrochemical and optical probes. Other alternative methods are also compared. We discuss in detail the in vivo challenges for these methods and provide an outlook for future directions.
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http://dx.doi.org/10.3390/mi12020208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922317PMC
February 2021

Myb10-D confers PHS-3D resistance to pre-harvest sprouting by regulating NCED in ABA biosynthesis pathway of wheat.

New Phytol 2021 06 30;230(5):1940-1952. Epub 2021 Mar 30.

Triticeae Research Institute, Sichuan Agricultural University, Chengdu, 611130, China.

Pre-harvest sprouting (PHS), the germination of grain before harvest, is a serious problem resulting in wheat yield and quality losses. Here, we mapped the PHS resistance gene PHS-3D from synthetic hexaploid wheat to a 2.4 Mb presence-absence variation (PAV) region and found that its resistance effect was attributed to the pleiotropic Myb10-D by integrated omics and functional analyses. Three haplotypes were detected in this PAV region among 262 worldwide wheat lines and 16 Aegilops tauschii, and the germination percentages of wheat lines containing Myb10-D was approximately 40% lower than that of the other lines. Transcriptome and metabolome profiling indicated that Myb10-D affected the transcription of genes in both the flavonoid and abscisic acid (ABA) biosynthesis pathways, which resulted in increases in flavonoids and ABA in transgenic wheat lines. Myb10-D activates 9-cis-epoxycarotenoid dioxygenase (NCED) by biding the secondary wall MYB-responsive element (SMRE) to promote ABA biosynthesis in early wheat seed development stages. We revealed that the newly discovered function of Myb10-D confers PHS resistance by enhancing ABA biosynthesis to delay germination in wheat. The PAV harboring Myb10-D associated with grain color and PHS will be useful for understanding and selecting white grained PHS resistant wheat cultivars.
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http://dx.doi.org/10.1111/nph.17312DOI Listing
June 2021

Association between medical resources and the proportion of oldest-old in the Chinese population.

Mil Med Res 2021 02 16;8(1):14. Epub 2021 Feb 16.

Department of Military Medical Geography, Army Medical Service Training Base, Army Medical University, Chongqing, 400038, China.

The potential association between medical resources and the proportion of oldest-old (90 years of age and above) in the Chinese population was examined, and we found that the higher proportion of oldest-old was associated with the higher number of beds in hospitals and health centers.
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http://dx.doi.org/10.1186/s40779-021-00307-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888075PMC
February 2021

Classification of different liquid milk by near-infrared spectroscopy and ensemble modeling.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 14;251:119460. Epub 2021 Jan 14.

Key Lab of Process Analysis and Control of Sichuan Universities, Yibin University, Yibin, Sichuan 644000, China.

Dairy products are necessary components of a healthy diet for human and nowadays, liquid milk become very popular because of its convenience. The identification of a brand of liquid milk is of importance. In this study, near-infrared (NIR) spectroscopy is used for rapid and objective classification of different brands of liquid milk. Chemometric methods including extreme learning machine (ELM) and its ensemble version (EELM) are investigated and compared. A dataset containing 144 samples from 6 brands are collected for experiment. A model-independent filter algorithm, i.e., relief-based feature selection, was used for variable reduction. Principal component analysis (PCA) is used as a tool of exploratory analysis for visualizing the difference among liquid milk samples of different brands. All samples were divided into three subsets, i.e., the training set, validation set and test set, for constructing, optimizing and testing the model, respectively. The model developed by the EELM procedure achieved 100% of classification accuracy, indicating that NIR spectroscopy combined with variable reduction and the EELM algorithm is feasible for classifying the brands of liquid milk.
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http://dx.doi.org/10.1016/j.saa.2021.119460DOI Listing
April 2021

The complete mitochondrial genome of (Hemiptera:Cicadellidae:Typhlocybinae) with phylogenetic consideration.

Mitochondrial DNA B Resour 2019 Dec 13;5(1):260-261. Epub 2019 Dec 13.

School of Karst Science, Guizhou Normal University/State Engineering Technology Institute for Karst Desertification Control, Guiyang, China.

The complete mitochondrial genome of the leafhopper Dworakowska, 1980 was sequenced and annotated from this study. The circular molecule is 14,827 bp in length, including 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes, and one AT-rich region. The base composition of the genome is as follows: A (42.6%), T (33.9%), G (10.0%), and C (13.4%). 11 PCGs have ATN as the start codon, except for and genes have TTG. The conventional termination codons (TAA or TAG) occur in 11 PCGs, whereas and use incomplete codon (T--) as termination codon. Phylogenetic analysis using 13 PCGs showed that was clustered with two Typhlocybinae species, which was consistent with the conventional classification.
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http://dx.doi.org/10.1080/23802359.2019.1698990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748818PMC
December 2019

An Initial Alignment Technology of Shearer Inertial Navigation Positioning Based on a Fruit Fly-Optimized Kalman Filter Algorithm.

Comput Intell Neurosci 2020 13;2020:8876918. Epub 2020 Oct 13.

School of Mechatronic Engineering, China University of Mining & Technology, No. 1 Daxue Road, Xuzhou 221116, China.

The shearer is one of the core equipment of the fully mechanized coal face. The fast and accurate positioning of the shearer is the prerequisite for its memory cutting, intelligent height adjustment, and intelligent speed adjustment. Inertial navigation technology has many advantages such as strong autonomy, good concealment, and high reliability. The accurate positioning of the shearer based on inertial navigation can not only determine its operating position but also measure the direction of movement. However, when inertial navigation is used to locate the shearer in motion, the cumulative errors will occur, resulting in inaccurate positioning of the shearer. The accuracy of the initial alignment is directly related to the working precision of the inertial navigation system. In order to improve the efficiency and accuracy of initial alignment, an improved initial alignment method is proposed in this paper, which uses a fruit fly-optimized Kalman filter algorithm for initial alignment. In order to improve the filtering performance, the fruit fly-optimized Kalman filter algorithm uses an improved fruit fly algorithm to realize the adaptive optimization of system noise variance. Finally, simulation and experiments verify the effectiveness of the fruit fly-optimized Kalman filter algorithm.
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http://dx.doi.org/10.1155/2020/8876918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578721PMC
October 2020

Multilabel Distribution Learning Based on Multioutput Regression and Manifold Learning.

IEEE Trans Cybern 2020 Oct 23;PP. Epub 2020 Oct 23.

Real-world multilabel data are high dimensional, and directly using them for label distribution learning (LDL) will incur extensive computational costs. We propose a multilabel distribution learning algorithm based on multioutput regression through manifold learning, referred to as MDLRML. By exploiting smooth, similar spaces' information provided by the samples' manifold learning and LDL, we link the two spaces' manifolds. This facilitates using the topological relationship of the manifolds in the feature space to guide the manifold construction of the label space. The smoothest regression function is used to fit the manifold data, and a locally constrained multioutput regression is designed to improve the data's local fitting. Based on the regression results, we enhance the logical labels into the label distributions, thereby mining and revealing the label's hidden information regarding importance or significance. Extensive experimental results using real-world multilabel datasets show that the proposed MDLRML algorithm significantly improves the multilabel distribution learning accuracy and efficiency over several existing state-of-the-art schemes.
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http://dx.doi.org/10.1109/TCYB.2020.3026576DOI Listing
October 2020

Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated with Medium- and Long-Chain Triglycerides Based on Lean Body Weight.

Pain Med 2021 Jun;22(6):1246-1252

Department of Anesthesiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.

Objective: To determine the median effective dose (ED50) of prophylactic intravenous lidocaine for the prevention of propofol medium-chain triglyceride/long-chain triglyceride (MCT/LCT) emulsion injection pain.

Design: Prospective trial, Dixon up-and-down sequential method.

Setting: Operating room of a single hospital.

Patients: Thirty patients aged 18-65 years with American Society of Anesthesiologists (ASA) status I or II who were scheduled for elective surgery under general anesthesia (GA) were included.

Interventions: The initial dose of prophylactic lidocaine before propofol MCT/LCT emulsion injection was set at 0.5 mg/kg lean body weight (LBW). The lidocaine dose was adjusted according to the degree of patients' injection pain using the Dixon up-and-down sequential method.

Measurements: The ED50 and 95% confidence intervals (CIs) of lidocaine were calculated using the Dixon-Massey formula. Vital signs and adverse effects were recorded. In the postanesthesia care unit (PACU), patients were asked if they recalled feeling any injection pain with visual analog scale (VAS) evaluation.

Results: The ED50 of lidocaine for the prevention of propofol MCT/LCT emulsion injection pain was 0.306 mg/kg LBW (95% CI, 0.262-0.357 mg/kg LBW). No adverse reactions to lidocaine occurred. In the PACU, 90.9% of patients who experienced injection pain recalled this pain (VAS score, 2.8±1.8).

Conclusions: Prophylactic intravenous lidocaine (0.306 mg/kg LBW) effectively prevented propofol MCT/LCT emulsion injection pain in 50% of patients scheduled for elective surgery under GA with no adverse reaction occurring.
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http://dx.doi.org/10.1093/pm/pnaa316DOI Listing
June 2021

Secondary peak of downstream light field modulation caused by Gaussian mitigation pits on the rear KDP surface.

Opt Express 2020 Sep;28(19):28479-28490

Micro-milling has been proved to be the most effective method to mitigate the growth of laser-induced surface damage on potassium dihydrogen phosphate (KDP) crystals used in high power laser systems. However, the secondary peak of downstream light field modulation caused by Gaussian mitigation pits on the rear KDP surface would cause potential risk to damage downstream optics. In order to explore the effect of the mitigation pits on the secondary peak, we numerically calculated the downstream light field modulations caused by Gaussian mitigation pits on the rear KDP surface based on the angular spectrum diffraction theory. The results suggest that the secondary peaks are dependent on the parameters of the width, depth, depth error and title error. Among them, the tilt error and depth have greater influence on the mitigation effect. To reduce the laser damage risk caused by the secondary peak, the depth of the pre-designed mitigated contour should be optimized according to the actual operating conditions. The tilt error and depth error are proposed to be controlled within 1' and 2 μm, respectively, during the micro-milling. Also, the experiments verified the calculation results of downstream modulations and the effects of these parameters on the secondary peak. This work can not only provide available models for evaluating the laser damage risk of secondary peak caused by mitigation pits on the KDP surface but also contribute to the development of optimal micro-milling parameters for laser damage mitigation as well as the installation strategy of optical components employed in the high power laser systems.
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http://dx.doi.org/10.1364/OE.403172DOI Listing
September 2020

A Portable Support Attitude Sensing System for Accurate Attitude Estimation of Hydraulic Support Based on Unscented Kalman Filter.

Sensors (Basel) 2020 Sep 23;20(19). Epub 2020 Sep 23.

School of Mechatronic Engineering, China University of Mining and Technology, Daxue Road, Xuzhou 221116, China.

To measure the support attitude of hydraulic support, a support attitude sensing system composed of an inertial measurement unit with microelectromechanical system (MEMS) was designed in this study. Yaw angle estimation with magnetometers is disturbed by the perturbed magnetic field generated by coal rock structure and high-power equipment of shearer in automatic coal mining working face. Roll and pitch angles are estimated using the MEMS gyroscope and accelerometer, and the accuracy is not reliable with time. In order to eliminate the measurement error of the sensors and obtain the high-accuracy attitude estimation of the system, an unscented Kalman filter based on quaternion according to the characteristics of complementation of the magnetometer, accelerometer and gyroscope is applied to optimize the solution of sensor data. Then the gradient descent algorithm is used to optimize the key parameter of unscented Kalman filter, namely process noise covariance, to improve the accuracy of attitude calculation. Finally, an experiment and industrial application show that the average measurement error of yaw angle is less than 2° and that of pitch angle and roll angle is less than 1°, which proves the efficiency and feasibility of the proposed system and method.
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http://dx.doi.org/10.3390/s20195459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583894PMC
September 2020

Hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells are involved in overactive bladder syndrome in rats.

BMC Urol 2020 Sep 2;20(1):140. Epub 2020 Sep 2.

Department of Urology, Xijing Hospital, Air Force Medical University, 15 Changle West Road, Xi'an, 710032, Shaanxi, China.

Background: To investigate the functions of the hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells in a rat model of overactive bladder syndrome.

Methods: Rats with OAB were screened using a urodynamic testing device. The whole-cell patch clamp technique was used to investigate changes in excitability and hyperpolarization-activated cation current (I) of medium-size cells in the L6 dorsal root ganglia (DRG) of the OAB rats. Intrathecal injection of the specific I inhibitor ZD7288 was used to investigate changes of voiding function and I of medium-size cells in the L6 DRG.

Results: The urinary bladder weight of the OAB rats was significantly increased (p < 0.01); However, 7 days after intrathecally administration of ZD7288 (2 μM), the weight of rat bladder was significantly reduced (p < 0.01). The excitability of the medium-size cells in the L6 DRG of the OAB rats was significantly increased, and the number of action potentials elicited by a 500 pA stimulus was also markedly increased. Furthermore, ZD7288 significantly reduced the excitability of the medium-size DRG cells. The medium-size cells in the DRG of the OAB rats had a significantly increased I current density, which was blocked by ZD7288.

Conclusions: The I current density significantly increased in medium-size cells of the L6 DRG in the OAB model. A decrease of the I current was able to significantly improve the voiding function of the OAB rats, in addition to lowering their urinary bladder weight. Our finding suggested that the observed increase of I current in the medium-size DRG neurons might play an important role in the pathological processes of OAB.
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http://dx.doi.org/10.1186/s12894-020-00698-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466781PMC
September 2020

Measurement of Particle Concentration by Multifrequency Ultrasound Attenuation in Liquid-Solid Dispersion.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Mar 25;68(3):843-853. Epub 2021 Feb 25.

In mineral transportations, it is essential to measure the gas hydrate particle concentration to manage the risk of flowline blockage. Traditional single-frequency ultrasonic methods measure the particle concentration by treating the mixtures with an average particle size, which ignores the influence of the particle size distribution, and thus, measurement accuracy is limited. Therefore, this research studies the multifrequency ultrasound attenuation method to measure the particle concentration through the prior estimate of particle size distribution. First, considering the large particle size and low-density contrast characteristics of the hydrate-water dispersion, the influence of multiple scattering among particles cannot be ignored apart from the scattering attenuation caused by each particle, so the ultrasonic scattering attenuation mechanism considering multiple scattering effects is established to solve the attenuation prediction problem of the hydrate-water dispersion. Since the solution of the equation obtained by the ultrasonic attenuation model produces a Fredholm integral equation of the first kind, an inversion algorithm combining simulated annealing with genetic algorithm based on ultrasonic attenuation mechanism is proposed to solve the ill-posed problem in the inversion calculation of particle concentration. Finally, considering the characteristics of hydrate-water dispersion, the experiments were carried out with millimeter-sized acrylic spheres and saltwater as substitute materials of the hydrate-water dispersion. The results show that the method based on the multifrequency attenuation of ultrasound in the range 1-5 MHz has a good discrimination for the particle size, and the measurement error of particle concentration is less than 3% under different particle size distributions.
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http://dx.doi.org/10.1109/TUFFC.2020.3020361DOI Listing
March 2021

Model Development for Nanosecond Laser-Induced Damage Caused by Manufacturing-Induced Defects on Potassium Dihydrogen Phosphate Crystals.

ACS Omega 2020 Aug 29;5(31):19884-19895. Epub 2020 Jul 29.

State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin 150001, China.

Nanosecond laser-induced damage on (potassium dihydrogen phosphate) KDP crystals is a complex process, which involves coupled actions of multi-physics fields. However, the mechanisms governing the laser damage behaviors have not been fully understood and there have been no available models to accurately describe this complex process. In this work, based on the theories of electromagnetic, thermodynamic, and hydrodynamic fields, a coupled multi-physics model is developed to describe the transient behavior of laser-supported energy deposition and diffusion accompanied by the surface defect (e.g., surface cracks)-initiated laser damage process. It is found that the light intensification caused by the defects near the crystal surface plays a significant role in triggering the laser-induced damage, and a large amount of energy is quickly deposited via the light intensity-activated nonlinear excitation. Using the developed model, the maximum temperature of the crystal material irradiated by a 3 ns pulse laser is calculated, which agrees well with previously reported experimental results. Furthermore, the modeling results suggest that physical processes such as material melting, boiling, and flowing have effects on the evolution of the laser damage process. In addition, the experimentally measured morphology of laser damage sites exhibits damage features of boiling cores, molten regions, and fracture zones, which are direct evidence of bowl-shaped high-temperature expansion predicted by the model. These results well validate that the proposed coupled multi-physics model is competent to describe the dynamic behaviors of laser damage, which can serve as a powerful tool to understand the general mechanisms of laser interactions with KDP optical crystals in the presence of different defects.
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http://dx.doi.org/10.1021/acsomega.0c02950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424745PMC
August 2020

Potential role of CFTR in bisphenol A-induced malignant transformation of prostate cells via mitochondrial apoptosis.

Toxicol Ind Health 2020 Aug 30;36(8):531-539. Epub 2020 Jul 30.

Department of Epidemiology and Statistics, School of Public Health, 74716Guilin Medical University, Guilin, China.

Bisphenol A (BPA) is an environmental endocrine disruptor and a risk factor for prostate cancer. The cystic fibrosis transmembrane conductance regulator (CFTR) is proposed to be a prostate cancer suppressor in some recent researches. However, the potential role and mechanism of CFTR in BPA-induced prostate cancer cells has not been well identified. In this study, BPA decreased the viability of human normal prostate RWPE-1 cells detected with a CCK-8 kit. The capacity of the cell line on soft agar colony formation, wound healing, and transwell invasion indicated malignant transformation induced by BPA. Western blot analysis demonstrated that the levels of CFTR and Bcl-2 decreased, whereas Bax level increased, and ELISA detection showed a decreased ATP level in BPA-exposed cells. Cell apoptosis was analyzed with Annexin V-FITC Detection Kit by flow cytometry. However, no significant difference was observed in cell viability and apoptosis rates compared to normal RWPE-1 cells. Our research revealed a potential role of CFTR in BPA-induced malignant transformation via mitochondrial apoptosis of normal prostate cells.
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http://dx.doi.org/10.1177/0748233720943750DOI Listing
August 2020

Genome-wide identification of microRNAs involved in the regulation of fruit ripening and climacteric stages in melon ().

Hortic Res 2020 1;7:106. Epub 2020 Jul 1.

Key Laboratory of Herbage and Endemic Crop Biotechnology, Ministry of Education, School of Life Sciences, Inner Mongolia University, 010070 Hohhot, China.

Fruit ripening is influenced by multiple plant hormones and the regulation of genes. However, studies on posttranscriptional regulators (e.g., miRNAs) of fruit growth and ripening are limited. We used miRNA sequencing and degradome methods to identify miRNAs and their target genes in melon ( cv. Hetao melon). A total of 61 conserved miRNAs and 36 novel miRNAs were identified from fruit growth, ripening, climacteric, and postclimacteric developmental stage samples, of which 32 conserved miRNAs were differentially expressed between developmental stage samples. Sixty-two target genes of 43 conserved miRNAs and 1 novel miRNA were identified from degradome sequencing. To further investigate miRNA influencing fruit ripening, transgenic melon plants overexpressing pre-cme-miR393 (cme-miR393OE) were generated and characterized. The results showed that fruit ripening was delayed in cme-miR393-OE transgenic lines compared to nontransgenic fruits. The target of cme-miR393 was also identified, and the expression of was repressed in transgenic plants. These results provide evidence that miRNA regulates melon fruit ripening and provide potential targets to improve the horticultural traits of melon fruit.
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http://dx.doi.org/10.1038/s41438-020-0331-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327070PMC
July 2020

New species and two new records of Erythroneurini from China (Hemiptera, Cicadellidae, Typhlocybinae).

Zootaxa 2020 Jan 22;4728(2):zootaxa.4728.2.8. Epub 2020 Jan 22.

School of Karst Science, Guizhou Normal University/ State Engineering Technology Institute for Karst Desertification Control, Guiyang, Guizhou 550001, China.

In the present paper, one new species and two new records of Erythroneurini from Guizhou Province, China are reported. The new species, Seriana bacilla sp. n. is described and illustrated. A key to distinguish all species of the genus is given. Another two species newly recorded from China, Empoascanara gracilis Dworakowska, 1992 and Tautoneura mayarami Mathew Ramakrishnan, 1996, are redescribed and illustrated.
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http://dx.doi.org/10.11646/zootaxa.4728.2.8DOI Listing
January 2020

Multiple mA RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis.

BMC Cancer 2020 Feb 28;20(1):165. Epub 2020 Feb 28.

Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

Background: Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N-methyladenosine (mA) RNA methylation is dynamically regulated by mA RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. The purpose of this study was to explore the relationships between mA RNA methylation modulators and HCC.

Methods: First, using data from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases, we compared the expression levels of 13 major m6A RNA methylation modulators between HCC and normal tissues. Second, we applied consensus clustering to the expression data on the mA RNA methylation modulators to divide the HCC tissues into two subgroups (clusters 1 and 2), and we compared the clusters in terms of overall survival (OS), World Health Organization (WHO) stage, and pathological grade. Third, using least absolute shrinkage and selection operator (LASSO) regression, we constructed a risk signature involving the mA RNA methylation modulators that affected OS in TCGA and ICGC analyses.

Results: We found that the expression levels of 12 major m6A RNA methylation modulators were significantly different between HCC and normal tissues. After dividing the HCC tissues into clusters 1 and 2, we found that cluster 2 had poorer OS, higher WHO stage, and higher pathological grade. Four mA RNA methylation modulators (YTHDF1, YTHDF2, METTL3, and KIAA1429) affecting OS in the TCGA and ICGC analyses were selected to construct a risk signature, which was significantly associated with WHO stage and was also an independent prognostic marker of OS.

Conclusions: In summary, mA RNA methylation modulators are key participants in the malignant progression of HCC and have potential value in prognostication and treatment decisions.
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http://dx.doi.org/10.1186/s12885-020-6638-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047390PMC
February 2020

LINC02499, a novel liver-specific long non-coding RNA with potential diagnostic and prognostic value, inhibits hepatocellular carcinoma cell proliferation, migration, and invasion.

Hepatol Res 2020 Jun 2;50(6):726-740. Epub 2020 Mar 2.

Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, China.

Aim: Liver-specific non-coding RNAs have been reported to play crucial roles in hepatocellular carcinoma (HCC). We investigated the possible biological performance of a novel liver-specific long non-coding RNA, LINC02499, in HCC.

Methods: The association between LINC02499 expression and HCC was evaluated based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and then confirmed in a HCC cohort by quantitative real-time polymerase chain reaction. The effects of LINC02499 on HCC cells were verified by gain- and loss-of-function assays. Pathway enrichment analyses were used to explore the potential mechanism of LINC02499 in HCC.

Results: LINC02499 expression was remarkably decreased in HCC tissues compared to adjacent non-tumor tissues based on TCGA (P < 0.001) and GEO databases (P < 0.001) and our HCC cohort (P < 0.001). Decreased LINC02499 was also significantly associated with poorer overall survival in both the TCGA database (P = 0.009) and our HCC cohort (P = 0.002). Furthermore, the receiver operating characteristic analysis indicated that LINC02499 showed a good performance in HCC diagnosis (area under the curve = 0.879, P < 0.001), and both sensitivity and specificity were 83.8%. In addition, up- and downregulated LINC02499 significantly impacted proliferation, migration, and invasion abilities of HCC cells in vitro. Pathway enrichment analyses revealed that the potential target genes of LINC02499 were involved in "Complement and coagulation cascades" and "Butanoate metabolism" pathways.

Conclusion: LINC02499 could be a potential novel diagnostic and prognostic biomarker for HCC patients, and it could exert a tumor suppressor role in the progression of HCC.
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http://dx.doi.org/10.1111/hepr.13491DOI Listing
June 2020

Ensemble of extreme learning machines for multivariate calibration of near-infrared spectroscopy.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Mar 24;229:117982. Epub 2019 Dec 24.

Key Lab of Process Analysis and Control of Sichuan Universities, Yibin University, Yibin, Sichuan 644000, China; Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan 610041, China.

Inspired by the attractive features of extreme learning machine (ELM), a simple ensemble ELM algorithm, named EELM, is proposed for multivariate calibration of near-infrared spectroscopy. Such an algorithm takes full advantage of random initialization of the weights of the hidden layer in ELM for obtaining the diversity between member models. Also, by combining a large number of member models, the stability of the final prediction can be greatly improved and the ensemble model outperforms its best member model. Compared with partial least-squares (PLS), the superiority of EELM is attributed to its inherent characteristics of high learning speed, simple structure and excellent predictive performance. Three NIR spectral datasets concerning solid samples are used to verify the proposed algorithm in terms of both the accuracy and robustness. The results confirmed the superiority of EELM to classic PLS. Also, even if the experiment is done on NIR datasets, it provides a good reference for other spectral calibration.
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http://dx.doi.org/10.1016/j.saa.2019.117982DOI Listing
March 2020

A new possible megalosauroid theropod from the Middle Jurassic Xintiangou Formation of Chongqing, People's Republic of China and its implication for early tetanuran evolution.

Sci Rep 2020 01 10;10(1):139. Epub 2020 Jan 10.

Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, 100044, China.

Tetanurae is a special group of theropod dinosaurs that originated by the late Early Jurassic. It includes several early-diverging groups of generally large-bodied predators (megalosauroids, allosauroids, tyrannosauroid coelurosaurs) as well as morphologically disparate small-bodied coelurosaurs, including birds. Aspects of the evolutionary history of tetanurans remain contested, including the topology of their deep phylogenetic divergences (among Megalosauroidea, Allosauroidea and Coelurosauria). We report a new theropod, Yunyangosaurus puanensis gen. et sp. nov., based on a fragmentary specimen recovered from the Middle Jurassic Xintiangou Formation of Chongqing, southwestern China. It shares several features uniquely with some megalosauroids (the clade of megalosaurids + spinosaurids + piatnitzkysaurids), such as prominent rims around the anterior articular surfaces of cervical centra and bifurcated anterior dorsal neural spines (present in piatnitzkysaurids). Nevertheless, it also shows several features that are rare or absent among megalosauroids and more crownward tetanurans, including prominent spinopostyzgopophyseal laminae (also present in non-tetanurans and metriacanthosaurid allosauroids), flat anterior articular surfaces of the cervical centra (also present in piatnitzkysaurids and some earlier-diverging tetanurans), and the presence of a posterior pneumatic foramen or fossa (absent in most tetanurans, but sporadically present in some cervical vertebrae of piatnitzkysaurids). Yunyangosaurus therefore presents a combination of derived and apparently primitive character states that are not seen in other theropods. This suggests that patterns of morphological evolution associated with deep tetanuran divergences were more complex than currently recognized, with implications for understanding the character evolution in theropods.
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http://dx.doi.org/10.1038/s41598-019-56959-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954265PMC
January 2020

Optimal Dose of Dexmedetomidine for Perioperative Blood Glucose Regulation in Non-Diabetic Patients Undergoing Gastrointestinal Malignant Tumor Resection: A Randomized Double-Blinded Controlled Trial.

J Invest Surg 2020 Jan 6:1-6. Epub 2020 Jan 6.

Department of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, China.

To evaluate the optimal dose of dexmedetomidine for perioperative blood glucose regulation in non-diabetic patients with gastrointestinal malignant tumor. One hundred patients were randomly divided into four groups: control group (group C), dexmedetomidine 1 μg/kg + 0.25 mcg/kg/h (group D); + 0.5 mcg/kg/h (group D); and + 1 mcg/kg/h (group D). Blood glucose concentrations were measured before dexmedetomidine infusion (T), 1 h after surgery beginning (T), at the end of surgery (T), and 1 h in PACU (T). Duration of surgery, extubation time, anesthetics doses, adverse reactions, postoperative pulmonary infection, total peritoneal drainage 2 days after surgery and hospital stay were recorded. Compared with T, blood glucose concentrations were higher at T in group C and at T in groups D, D, and D ( < 0.01). Compared with group C, blood glucose concentrations were higher at T and T in groups D and D ( < 0.05), but significantly lower at T in groups D, D, and D ( < 0.01). Propofol and remifentanil consumption in groups D, D, and D decreased significantly compared with group C ( < 0.01). In group D, doses of ephedrine ( < 0.05) and atropine ( < 0.01) were higher, and extubation time was prolonged ( < 0.01) compared with the other groups. The incidence of bradycardia was higher in group D than that in group C ( < 0.05). Dexmedetomidine loading dose of 1 mcg/kg followed by maintenance with 0.25 mcg/kg/h can regulate perioperative blood glucose well in non-diabetic patients undergoing gastrointestinal malignant tumor resection and reduce doses of anesthetics without extending extubation time.
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http://dx.doi.org/10.1080/08941939.2019.1706673DOI Listing
January 2020

Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis.

Mil Med Res 2019 12 9;6(1):38. Epub 2019 Dec 9.

Department of Military Medical Geography, Army Medical Service Training Base, Army Medical University, Chongqing, 400038, China.

Background: When lowlanders rapidly ascend to altitudes > 2500 m, they may develop acute mountain sickness (AMS). The individual susceptibility, ascending velocity, time spent at altitude, activity levels and altitude reached are considered risk factors for AMS. However, it is not clear whether sex is a risk factor. The results have been inconclusive. We conducted a meta-analysis to test whether there were sex-based differences in the prevalence of AMS using Lake Louise Scoring System.

Methods: Systematic searches were performed in August 2019 in EMBASE, PubMed, and Web of Science for prospective studies with AMS data for men and women. The titles and abstracts were independently checked in the primary screening step, and the selected full-text articles were independently assessed in the secondary screening step by the two authors (YPH and JLW) based on pre-defined inclusion criteria. The meta-analysis was performed using by the STATA 14.1 software program. A random-effects model was employed.

Results: Eighteen eligible prospective studies were included. A total of 7669 participants (2639 [34.4%] women) were tested. The results showed that there was a statistically significant higher prevalence rate of AMS in women than in men (RR = 1.24, 95%CI 1.09-1.41), regardless of age or race. Howerver, the heterogeneity was significant in the analysis (Tau = 0.0403, Chi = 50.15, df = 17; I = 66.1%, P = 0.000), it was main caused by different numbers of subjects among the studies (coefficient = - 2.17, P = 0.049). Besides, the results showed that there was no evidence of significant publication bias in the combined studies on the basis of Egger's test (bias coefficient = 1.48, P = 0.052) and Begg's test (P = 0.130).

Conclusions: According to this study, the statistically significant finding emerging from this study was that women have a higher prevalence of AMS. However, the authors could not exclude studies where patients were on acetazolamide. Our analysis provided a direction for future studies of the relationship of sex and the risk of AMS, such as the pathological mechanism and prevention research.
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http://dx.doi.org/10.1186/s40779-019-0228-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900850PMC
December 2019