Publications by authors named "Chao Pang"

48 Publications

Study of the Correlation between the Amorphous Indium-Gallium-Zinc Oxide Film Quality and the Thin-Film Transistor Performance.

Nanomaterials (Basel) 2021 Feb 18;11(2). Epub 2021 Feb 18.

Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510641, China.

In this work, we performed a systematic study of the physical properties of amorphous Indium-Gallium-Zinc Oxide (a-IGZO) films prepared under various deposition pressures, O2/(Ar+O2) flow ratios, and annealing temperatures. X-ray reflectivity (XRR) and microwave photoconductivity decay (μ-PCD) measurements were conducted to evaluate the quality of a-IGZO films. The results showed that the process conditions have a substantial impact on the film densities and defect states, which in turn affect the performance of the final thin-film transistors (TFT) device. By optimizing the IGZO film deposition conditions, high-performance TFT was able to be demonstrated, with a saturation mobility of 8.4 cm2/Vs, a threshold voltage of 0.9 V, and a subthreshold swing of 0.16 V/dec.
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http://dx.doi.org/10.3390/nano11020522DOI Listing
February 2021

Acceleration of α-synuclein fibril formation and associated cytotoxicity stimulated by silica nanoparticles as a model of neurodegenerative diseases.

Int J Biol Macromol 2021 Feb 19;169:532-540. Epub 2020 Dec 19.

Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address:

A wide range of biophysical and theoretical analysis were employed to explore the formation of (α-syn) amyloid fibril formation as a model of Parkinson's disease in the presence of silica oxide nanoparticles (SiO NPs). Also, different cellular and molecular assays such as MTT, LDH, caspase, ROS, and qPCR were performed to reveal the α-syn amyloid fibrils-associated cytotoxicity against SH-SY5Y cells. Fluorescence measurements showed that SiO NPs accelerate the α-syn aggregation and exposure of hydrophobic moieties. Congo red absorbance, circular dichroism (CD), and transmission electron microscopy (TEM) analysis depicted the SiO NPs accelerated the formation of α-syn amyloid fibrils. Molecular docking study showed that SiO clusters preferably bind to the N-terminal of α-syn as the helix folding site. We also realized that SiO NPs increase the cytotoxicity of α-syn amyloid fibrils through a significant decrease in cell viability, increase in membrane leakage, activation of caspase-9 and -3, elevation of ROS, and increase in the ratio of Bax/Bcl2 mRNA. The cellular assay indicated that α-syn amyloid fibrils formed in the presence of SiO NPs induce their cytotoxic effects through the mitochondrial-mediated intrinsic apoptosis pathway. We concluded that these data may reveal some adverse effects of NPs on the progression of Parkinson's disease.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.12.130DOI Listing
February 2021

3D Printed Microfluidic Devices for Solid-Phase Extraction and On-Chip Fluorescent Labeling of Preterm Birth Risk Biomarkers.

Anal Chem 2020 09 3;92(18):12322-12329. Epub 2020 Sep 3.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602 United States.

Solid-phase extraction (SPE) is a general preconcentration method for sample preparation that can be performed on a variety of specimens. The miniaturization of SPE within a 3D printed microfluidic device further allows for fast and simple extraction of analytes while also enabling integration of SPE with other sample preparation and separation methods. Here, we present the development and application of a reversed-phase lauryl methacrylate-based monolith, formed in 3D printed microfluidic devices, which can selectively retain peptides and proteins. The effectiveness of these SPE monoliths and 3D printed microfluidic devices was tested using a panel of nine preterm birth biomarkers of varying hydrophobicities and ranging in mass from 2 to 470 kDa. The biomarkers were selectively retained, fluorescently labeled, and eluted separately from the excess fluorescent label in 3D printed microfluidic systems. These are the first results demonstrating microfluidic analysis processes on a complete panel of preterm birth biomarkers, an important step toward developing a miniaturized, fully integrated analysis system.
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http://dx.doi.org/10.1021/acs.analchem.0c01970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494619PMC
September 2020

Influence of immersion depth of membrane on filtration performance of anaerobic membrane bioreactor.

Environ Sci Pollut Res Int 2020 Aug 21;27(23):29433-29440. Epub 2020 May 21.

Department of Municipal Engineering, School of Civil Engineering, Hefei University of Technology, Hefei, 230009, China.

Membrane fouling is still the main obstacle that hinders the development and implementation of anaerobic membrane bioreactor (AnMBR). In conventional upflow anaerobic reactors, sludge at different height usually presents certain differences in characteristics in terms of particle size, etc. The immersion depth of membrane modules in anaerobic reactors can also influence the fouling of membrane. Thus, it is of great interest to investigate the fouling mechanism with the membrane installed at different heights in reactors. The filtration performance and sludge properties were investigated at different heights of AnMBR. The fouling of membrane in the middle position was severer than that in the top and bottom positions. The total resistance of membrane in the top, middle, and bottom positions was 27.31 × 10 m, 34.67 × 10 m, and 25.29 × 10 m, respectively. By comparing the characteristics and structure of bulk sludge and cake layer at three heights, the bulk sludge in the middle position presented higher content of soluble microbial products (SMP) and finer flocs, and the cake layer was also denser. The results obtained in this study indicated that small size of sludge flocs as well as adhesion of SMP might be the major factors governing membrane fouling at different height in the AnMBR.
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http://dx.doi.org/10.1007/s11356-020-09213-1DOI Listing
August 2020

Microfluidics: Innovations in Materials and Their Fabrication and Functionalization.

Anal Chem 2020 01 2;92(1):150-168. Epub 2019 Dec 2.

Department of Chemistry and Biochemistry , Brigham Young University , Provo , Utah 84602-5700 , United States.

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http://dx.doi.org/10.1021/acs.analchem.9b04986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034066PMC
January 2020

Primary Central Nervous System Angiosarcoma.

World Neurosurg 2019 Dec 27;132:41-46. Epub 2019 Aug 27.

Department of Neurosurgery, First Hospital of China Medical University, Shenyang, China. Electronic address:

Background: Primary angiosarcoma of the brain is an extremely rare malignant tumor that that arises from vascular endothelial cells of the brain or meninges. The presentation, characteristics, and prognosis of this disease are not well understood. Here we report such a case.

Case Description: A 68-year-old Chinese man presented with confusion and progressive impairment of right limb movement. Magnetic resonance imaging (MRI) revealed a hemorrhagic lesion in the left frontal lobe. Exploratory surgery revealed a hematoma-like lesion and extensive superficial hemosiderin deposition. The postoperative pathological diagnosis was angiosarcoma. The tumor recurred at 1 month after the operation, with extensive tumor regrowth in the left hemisphere. The patient died after 4 weeks.

Conclusions: Although accurate preoperative diagnosis of angiosarcoma of the brain is difficult, radiologists and neurosurgeons need to be aware of this rare entity. The prognosis of intracranial angiosarcoma is heterogenous. Intraoperatively, the presence of extensive superficial hemosiderosis may aid in its diagnosis.
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http://dx.doi.org/10.1016/j.wneu.2019.08.128DOI Listing
December 2019

Single-shot BOTDA based on an optical chirp chain probe wave for distributed ultrafast measurement.

Light Sci Appl 2018 11;7:32. Epub 2018 Jul 11.

4Fiber Optics Group, Department of Physics, University of Ottawa, Ottawa, ON K1N 6N5 Canada.

Brillouin optical time-domain analysis (BOTDA) requires frequency mapping of the Brillouin spectrum to obtain environmental information (e.g., temperature or strain) over the length of the sensing fiber, with the finite frequency-sweeping time-limiting applications to only static or slowly varying strain or temperature environments. To solve this problem, we propose the use of an optical chirp chain probe wave to remove the requirement of frequency sweeping for the Brillouin spectrum, which enables distributed ultrafast strain measurement with a single pump pulse. The optical chirp chain is generated using a frequency-agile technique via a fast-frequency-changing microwave, which covers a larger frequency range around the Stokes frequency relative to the pump wave, so that a distributed Brillouin gain spectrum along the fiber is realized. Dynamic strain measurements for periodic mechanical vibration, mechanical shock, and a switch event are demonstrated at sampling rates of 25 kHz, 2.5 MHz and 6.25 MHz, respectively. To the best of our knowledge, this is the first demonstration of distributed Brillouin strain sensing with a wide-dynamic range at a sampling rate of up to the MHz level.
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http://dx.doi.org/10.1038/s41377-018-0030-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107018PMC
July 2018

Membrane fouling and performance of anaerobic ceramic membrane bioreactor treating phenol- and quinoline-containing wastewater: granular activated carbon vs polyaluminum chloride.

Environ Sci Pollut Res Int 2019 Nov 27;26(33):34167-34176. Epub 2018 Nov 27.

Department of Municipal Engineering, School of Civil Engineering, Hefei University of Technology, Hefei, 230009, China.

Although anaerobic membrane bioreactor (AnMBR) has been proposed for the treatment of phenolic wastewater, the membrane fouling is still a major obstacle. The effects of dosing of granular activated carbon (GAC) and polyaluminum chloride (PACl) on the treatment performance and membrane fouling of anaerobic ceramic membrane bioreactor were investigated for treating phenol- and quinoline-containing wastewater. The results suggested that the one-off dosing of GAC resulted in a decrease of protein/carbohydrate ratio, which might account for the aggravation of membrane fouling alongside with the decreased flocs size. Nevertheless, the substrate uptake rates (SUR) of phenol and quinoline, and the specific methanogenic activity of sludge at the GAC dosing stage of experimental reactor (R1) were 8.79 ± 0.63 mg phenol g MLVSS d, 7.01 ± 0.09 mg quinoline g MLVSS d and 0.27 ± 0.01 g COD g MLVSS d, which were 1.69, 3.59 and 1.93 times higher than that of the control reactor (R2). The dosing of PACl reduced the membrane fouling rate by changing the floc structure of sludge, as well as the component of SMP and EPS. However, the substrate uptake rate of quinoline was declined. This work provides a comprehensive evaluation on the effect of GAC and PACl dosing on membrane fouling and performance of anaerobic ceramic membrane bioreactor treating phenol-and quinoline-containing wastewater.
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http://dx.doi.org/10.1007/s11356-018-3802-4DOI Listing
November 2019

150  km fast BOTDA based on the optical chirp chain probe wave and Brillouin loss scheme.

Opt Lett 2018 Oct;43(19):4679-4682

Distributed long-range Brillouin optical time domain analysis (BOTDA) is an extremely time-consuming sensing scheme, which requires frequency mapping of the Brillouin spectrum and a large number of average times. Here, we propose a fast long-range BOTDA based on the optical chirp chain (OCC) probe wave and Brillouin loss scheme. The OCC-modulated probe wave is enabled by cascading fast-frequency-changing microwave chirp segments head-to-tail, which covers a large frequency range around the anti-Stokes frequency relative to the pump wave. The combination of the OCC technique and Brillouin loss scheme provides several advantages, i.e., fast measurement, a high Brillouin threshold, no additional amplification scheme, and freedom from the nonlocal effect. In the experiment, 6 m spatial resolution, 3.2 s measurement time, and 3 MHz measurement precision were achieved over a 150 km single-mode fiber.
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http://dx.doi.org/10.1364/OL.43.004679DOI Listing
October 2018

MOLGENIS research: advanced bioinformatics data software for non-bioinformaticians.

Bioinformatics 2019 03;35(6):1076-1078

Genomics Coordination Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.

Motivation: The volume and complexity of biological data increases rapidly. Many clinical professionals and biomedical researchers without a bioinformatics background are generating big '-omics' data, but do not always have the tools to manage, process or publicly share these data.

Results: Here we present MOLGENIS Research, an open-source web-application to collect, manage, analyze, visualize and share large and complex biomedical datasets, without the need for advanced bioinformatics skills.

Availability And Implementation: MOLGENIS Research is freely available (open source software). It can be installed from source code (see http://github.com/molgenis), downloaded as a precompiled WAR file (for your own server), setup inside a Docker container (see http://molgenis.github.io), or requested as a Software-as-a-Service subscription. For a public demo instance and complete installation instructions see http://molgenis.org/research.
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http://dx.doi.org/10.1093/bioinformatics/bty742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419911PMC
March 2019

Performance and recovery of a completely separated partial nitritation and anammox process treating phenol-containing wastewater.

Environ Sci Pollut Res Int 2019 Nov 7;26(33):33917-33926. Epub 2018 Jul 7.

Department of Municipal Engineering, School of Civil and Hydraulic Engineering, Hefei University of Technology, Hefei, 230009, China.

Anammox process is considered as a promising technology for removing total nitrogen from low-strength ammonium and phenol-containing wastewater. However, it is still a challenge for the anammox process to treat high-strength ammonium and phenol-containing wastewater. A completely separated partial nitritation and anammox (CSPN/A) process was developed to remove total nitrogen from high-strength phenol-containing wastewater. About 92% of COD, 100% of phenol, and 82.4% of total nitrogen were successfully removed at a NH-N concentration of 200 mg L with a phenol/NH-N mass ratio of 0.5 in the CSPN/A process. Furthermore, a shock loading of 300 mg phenol L with a phenol/NH-N mass ratio of 1.5 led to a complete failure of partial nitritation, but the performance was rapidly recovered by the increase of NH-N concentration. Although the activities of ammonium-oxidizing bacteria and anammox bacteria were severely inhibited at a phenol/NH-N mass ratio of 1.5, the enrichment of efficient phenol degraders in the CSPN stage could strengthen the performance robustness of partial nitritation and anammox process. Therefore, this study presented a new insight on the feasibility of the anammox process for treating high-strength ammonium and phenol-containing wastewater.
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http://dx.doi.org/10.1007/s11356-018-2701-zDOI Listing
November 2019

Comparison of body mass index, waist circumference, conicity index, and waist-to-height ratio for predicting incidence of hypertension: the rural Chinese cohort study.

J Hum Hypertens 2018 03 7;32(3):228-235. Epub 2018 Feb 7.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

This study compared the ability of body mass index (BMI), waist circumference (WC), conicity index, and waist-to-height ratio (WHtR) to predict incident hypertension and to identify the cutoffs of obesity indices for predicting hypertension in rural Chinese adults. This prospective cohort study recruited 9905 participants aged 18-70 years during a median follow-up of 6 years in rural China. Logistic regression and receiver operating characteristic (ROC) curve analyses were used to assess the association, predictive ability, and optimal cutoffs (in terms of hypertension risk factors) of the four obesity indices: BMI, WC, conicity index, and WHtR. The 6-year cumulative incidence of hypertension was 19.89% for men and 18.68% for women, with a significant upward trend of increased incident hypertension with increasing BMI, WC, conicity index, and WHtR (P for trend < 0.001) for both men and women. BMI and WHtR had the largest area under the ROC curve for identifying hypertension for both genders. The optimal cutoff values for BMI, WC, conicity index, and WHtR for predicting hypertension were 22.65 kg/m, 82.70 cm, 1.20, and 0.49, respectively, for men, and 23.80 kg/m, 82.17 cm, 1.20, and 0.52, respectively, for women. BMI, WC, conicity index, and WHtR cutoffs may offer a simple and effective way to screen hypertension in rural Chinese adults. BMI and WHtR were superior to WC and conicity index for predicting incident hypertension for both genders.
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http://dx.doi.org/10.1038/s41371-018-0033-6DOI Listing
March 2018

Utility of three novel insulin resistance-related lipid indices for predicting type 2 diabetes mellitus among people with normal fasting glucose in rural China.

J Diabetes 2018 Aug 9;10(8):641-652. Epub 2018 Feb 9.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.

Background: Inexpensive and easily measured indices are needed for the early prediction of type 2 diabetes mellitus (T2DM) in rural areas of China. The aim of this study was to compare triglyceride glucose (TyG), visceral adiposity (VAI), and lipid accumulation product (LAP) with traditional individual measures and their ratios for predicting T2DM.

Methods: Data for 11 113 people with baseline normal fasting glucose in a rural Chinese cohort were followed for a median of 6.0 years. Cox proportional hazards regression was used to calculate covariate-adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs) and receiver operating characteristic analysis was used to compare the ability of traditional measures and TyG, VAI, and LAP at baseline to predict T2DM at follow-up.

Results: Among individual measures, fasting plasma glucose (FPG) and waist circumference (WC) were strongly associated with T2DM. Of all lipid ratios, an elevated triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio was associated the most with T2DM. Compared with the first quartiles of TyG, VAI, and LAP, their fourth quartiles were associated with T2DM for men (aHR 3.54 [95% CI 2.08-6.03], 2.89 [1.72-4.87], and 5.02 [2.85-8.85], respectively) and women (6.15 [3.48-10.85], 4.40 [2.61-7.42], and 6.49 [3.48-12.12], respectively). For predicting T2DM risk, TyG, VAI, and LAP were mostly superior to the TG:  HDL-C ratio, but did not differ from FPG and WC.

Conclusions: Prediction of T2DM was not improved by TyG, VAI, and LAP versus FPG or WC alone. Therefore, TyG, VAI, and LAP may not be inexpensive tools for predicting T2DM in rural Chinese people.
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http://dx.doi.org/10.1111/1753-0407.12642DOI Listing
August 2018

Dynamic status of metabolically healthy overweight/obesity and metabolically unhealthy and normal weight and the risk of type 2 diabetes mellitus: A cohort study of a rural adult Chinese population.

Obes Res Clin Pract 2018 Jan - Feb;12(1):61-71. Epub 2017 Oct 31.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address:

Objective: We aimed to determine dynamic status of metabolically healthy overweight or obesity (MHO) and metabolically unhealthy and normal weight (MUNW) and the risk of incident type 2 diabetes mellitus (T2DM).

Methods: Body mass index and metabolic health were assessed on 11,865 eligible participants ≥18 years from 6-year follow-up cohort study of a rural Chinese population. Participants were classified as metabolically healthy and normal weight (MHNW), MHO, MUNW and metabolically unhealthy overweight or obesity (MUO) at both baseline and follow-up examinations. Hazard ratio (HR) and 95% confidence interval (CI) were used to assess baseline and their changes of BMI-metabolic status and the risk of incident T2DM.

Results: Risk of T2DM was increased for all participants with baseline MHO, MUNW, and MUO (adjusted HR 1.94, 95% CI 1.33-2.81; 3.10, 95% CI 2.19-4.39; and 6.63, 95% CI 4.94-8.90, all P<0.001, respectively). However, risk of T2DM was increased for participants with transformation from MHO to MUO (4.52, 95% CI 2.42-8.47, P<0.001) as compared with stable MHNW, but not stable MHO (0.53, 95CI 0.20-1.40, P=0.20). Risk of T2DM did not differ between participants with transformation from MUNW to metabolically healthy and those with stable MHNW (P>0.05), but was increased with stable MUNW (5.78, 95% CI 3.15-10.62, P<0.001). The results were consistent when analyses were restricted to participants without baseline impaired fasting glucose level.

Conclusions: Our findings provide understanding for differentiating high-risk individuals for incident T2DM in Chinese population.
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http://dx.doi.org/10.1016/j.orcp.2017.10.005DOI Listing
March 2019

Secular trend of the leading causes of death in China from 2003 to 2013.

Afr Health Sci 2017 Jun;17(2):532-537

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.

Background: To analyze the epidemiological characteristics and secular trends of the leading causes of death in China.

Methods: Data on the leading causes of death was collected from the Statistical Yearbook of China. Data for 11 years, from 2003 to 2013, was analyzed by regression analysis and chi-square test.

Results: The top 3 causes of death from 2009 to 2013 were cancer, cerebrovascular disease, and cardiopathy, with the role of cardiopathy increasing over time (P<0.01). The proportion of deaths related to cardio-cerebrovascular diseases in urban and rural areas increased to 41.9% and 44.8%, respectively, in 2013, and was significantly higher than that for cancer, 25.5% and 22.4% (both P<0.01). Injury and poisoning in urban or rural areas represented the fifth leading cause of death. In 2006, endocrine, nutritional, and metabolic diseases were the sixth main cause of death, with 3.3% in urban areas. The role of genito-urinary, respiratory, and digestive system diseases in urban areas and genito-urinary system diseases in rural areas decreased during this period (all P<0.05).

Conclusion: Cancer, cerebrovascular disease, and cardiopathy accounted for more than 67% of all deaths from 2007 to 2013 in China, and significantly increased in proportion from 2003 to 2013.
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http://dx.doi.org/10.4314/ahs.v17i2.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637040PMC
June 2017

BiobankUniverse: automatic matchmaking between datasets for biobank data discovery and integration.

Bioinformatics 2017 Nov;33(22):3627-3634

Department of Genetics, Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Motivation: Biobanks are indispensable for large-scale genetic/epidemiological studies, yet it remains difficult for researchers to determine which biobanks contain data matching their research questions.

Results: To overcome this, we developed a new matching algorithm that identifies pairs of related data elements between biobanks and research variables with high precision and recall. It integrates lexical comparison, Unified Medical Language System ontology tagging and semantic query expansion. The result is BiobankUniverse, a fast matchmaking service for biobanks and researchers. Biobankers upload their data elements and researchers their desired study variables, BiobankUniverse automatically shortlists matching attributes between them. Users can quickly explore matching potential and search for biobanks/data elements matching their research. They can also curate matches and define personalized data-universes.

Availability And Implementation: BiobankUniverse is available at http://biobankuniverse.com or can be downloaded as part of the open source MOLGENIS suite at http://github.com/molgenis/molgenis.

Contact: m.a.swertz@rug.nl.

Supplementary Information: Supplementary data are available at Bioinformatics online.
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http://dx.doi.org/10.1093/bioinformatics/btx478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870622PMC
November 2017

Association of change in waist circumference and dyslipidaemia risk: The rural Chinese cohort study.

Diabetes Metab Res Rev 2018 01 19;34(1). Epub 2017 Oct 19.

Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, China.

Objective: To investigate the association of change in waist circumference (WC) and incidence of dyslipidaemia in a cohort study of a rural Chinese population.

Methods: Change in WC (ΔWC) was defined as the value at follow-up minus the corresponding value at baseline. Risk of dyslipidaemia associated with ΔWC was assessed by odds ratios and 95% confidence intervals in a logistic regression model, and the odds ratios were transformed to relative risks (RRs).

Results: Among 7691 participants without dyslipidaemia at baseline, 3213 (41.78%) showed dyslipidaemia at 6 year follow-up. Risk of dyslipidaemia was decreased for participants with the first quartile of ΔWC and normal baseline WC (adjusted RR [aRR] = 0.79 [95% confidence interval: 0.64-0.98]) and was increased with the fourth quartile of ΔWC and male gender, age 18 to 30 years, age 31 to 50 years, or normal baseline WC (aRR = 1.55 [1.19-2.03], 2.40 [1.16-4.95], 1.32 [1.06-1.64], and 1.66 [1.35-2.04], respectively). The risk of dyslipidaemia increased with change in WC from normal at baseline to abnormal at follow-up for both genders (aRR = 1.88 [1.39-2.55] for men and 1.60 [1.30-1.97] for women) and decreased with abnormal baseline WC changed to normal WC for women (aRR = 0.61 [0.45-0.83]).

Conclusions: Dynamic change in waist circumference was closely related to the incidence of dyslipidaemia in a rural Chinese population. Waist circumference reduction could decrease dyslipidaemia risk, whereas WC increase may increase the risk. Interventions to control or reduce WC to within the normal range are important for early prevention of dyslipidaemia.
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http://dx.doi.org/10.1002/dmrr.2949DOI Listing
January 2018

Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study.

Sci Rep 2017 08 22;7(1):9072. Epub 2017 Aug 22.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Limited information is available on the effect of hypertriglyceridemia-waist (HTGW) combination and its dynamic status on the risk of type 2 diabetes mellitus (T2DM) in rural China. A cohort of 12,086 participants 18 to 92 years old was retained in this study. Kaplan-Meier analysis yielded the cumulative incidence of T2DM for each phenotype group (based on TG level and waist circumference [WC] at baseline). Cox regression yielded hazard ratios relating HTGW (based on TG level and WC at baseline and follow-up) to risk of developing T2DM. After a median follow-up of 6.0 years (71,432 person-years of follow-up), T2DM developed in 621 participants. For HTGW participants, the incidence of T2DM was 26.4/1000, 20.6/1000, and 21.9/1000 person-years for males, females, and overall, respectively. The adjusted HR for HTGW associated with T2DM was 7.63 (95% CI 4.32-13.49) for males and 7.75 (4.71-12.78) for females. Compared with consistent HTGW, with transformation from baseline HTGW to normal WC and normal triglycerides level at follow-up, the risk of developing T2DM was reduced by 75% and 78% for males and females. HTGW is a major risk factor for T2DM, but the risk could be reduced by improved triglycerides level and WC.
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http://dx.doi.org/10.1038/s41598-017-09136-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567308PMC
August 2017

A Method for Gray-Scale Imaging of Blood Flow Using High-Frequency Ultrasound.

Ultrason Imaging 2018 01 13;40(1):3-14. Epub 2017 Jul 13.

2 MEDA Co., Ltd., Tianjin, China.

This paper presents a new method that complements current techniques available in the high-frequency blood imaging field. A comprehensive scattering model was established to determine the feasibility and frequency range of the blood flow imaging of superficial organs and tissues using high-frequency ultrasound. The transmitting and receiving modes and an algorithm were designed to obtain blood flow information based on differentiation between tissues and blood flow. The system was created and tested first with a model that simulates blood flow and was then used on human tissue. A fine-scale image of a blood vessel could be obtained with this system. Moreover, this method can obtain weak blood flow signal using single pulse rather than the traditional pulse-code method and maintains a high resolution that can be matched to high-frequency structural imaging. This study provides a reliable method for further applications related to diagnoses of superficial organs.
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http://dx.doi.org/10.1177/0161734617717427DOI Listing
January 2018

A risk-score model for predicting risk of type 2 diabetes mellitus in a rural Chinese adult population: A cohort study with a 6-year follow-up.

Diabetes Metab Res Rev 2017 10 13;33(7). Epub 2017 Jul 13.

Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China.

Background: Several prediction tools have been developed to identify people with type 2 diabetes mellitus (T2DM) and to quantify the probability of developing T2DM. However, most of the risk models were constructed based on cross-sectional studies and tea-drinking was not included.

Methods: A total of 15 768 participants without known T2DM were followed up from 2007-2008 to 2013-2014; 12 654 were randomly assigned to the derivation dataset and 3114 to the validation dataset. We constructed a risk-score model for T2DM by using a Cox proportional-hazards model. Risk scores were calculated by multiplying β by 10 in the derivation cohort and were verified in the validation dataset. The model's accuracy was assessed by the area under the receiver operating characteristic curve (AUC).

Results: Predictors for T2DM risk in the derivation dataset were drinking tea frequently, body mass index ≥28.0 kg/m , waist to height ratio ≥ 0.5, triglycerides level 1.70 to 2.25 and ≥2.26 mmol/L, and fasting plasma glucose 5.6 to 6.0 and ≥6.1 mmol/L. The corresponding scores were -2, 7, 7, 4, 6, 11, and 25, respectively. The sensitivity, specificity, and AUC (95% confidence interval) for this full model were 69.63%, 75.56%, and 0.791 (0.783-0.799), respectively. The ability of the non-invasive models to predict T2DM was not superior to that of the full model. With the validation dataset, the predictive performance was better for our full model than the Framingham risk-score model (AUC 0.731 vs 0.525, P < .001).

Conclusions: Our risk-score model has fair efficacy for predicting 6-year risk of T2DM in a rural adult Chinese population.
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http://dx.doi.org/10.1002/dmrr.2911DOI Listing
October 2017

Impaired fasting glucose predicts the development of hypertension over 6years in female adults: Results from the rural Chinese cohort study.

J Diabetes Complications 2017 Jul 11;31(7):1090-1095. Epub 2017 Apr 11.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address:

Aims: To investigate whether impaired fasting glucose (IFG) is an independent risk factor for incident hypertension in a rural Chinese population.

Methods: We selected 9583 eligible participants 18 to 75years old, who were without hypertension and diabetes at baseline (from 2007 to 2008) and were from a rural area in the middle of China. Concentration of fasting glucose at baseline was assessed in quartiles to predict hypertension risk by gender. Odds ratios (ORs) and 95% confidence intervals (CIs) for IFG (fasting glucose of 100 to 125mg/dl) associated with hypertension were estimated by logistic regression models.

Results: Risk of hypertension was increased for females with glucose levels in quartile 2 (90-96mg/dl), quartile 3 (96-102mg/dl), and quartile 4 (102-125mg/dl) versus quartile 1 (<90mg/dl): OR=1.27 (95% CI=1.01-1.60), 1.30 (1.04-1.63), and 1.55 (1.24-1.93), respectively. During the 6-year follow-up, the cumulative incidence of hypertension was greater for people with IFG than normal fasting glucose (NFG) at baseline (23.9% vs 18.4%, p<0.001 for males and 23.8% vs 16.4%, p<0.001 for females). Risk of incident hypertension was significantly increased for females with IFG versus NFG (OR=1.23 95% CI=1.05-1.45).

Conclusions: IFG may be an independent risk factor for hypertension in normotensive nondiabetic Chinese females.
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http://dx.doi.org/10.1016/j.jdiacomp.2017.04.006DOI Listing
July 2017

Association of 6-year waist circumference gain and incident hypertension.

Heart 2017 09 7;103(17):1347-1352. Epub 2017 Apr 7.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.

Objective: The risk of incident hypertension with gain in waist circumference (WC) has not been fully addressed among Chinese adults.

Methods: A total of 10 265 non-hypertensive participants ≥18 years old who underwent health examinations in rural China were recruited in 2007-2008 and followed up in 2013-2014. Participants were classified by gender according to categories of per cent WC gain at follow-up: ≤-2.5%, -2.5% to 2.5%, 2.5% to 5% and >5%. Relative risk (RR) and 95% CI values for effect of WC gain on the incident hypertension were calculated by using modified Poisson regression models.

Results: During 6 years of follow-up, we identified 2027 hypertension cases (1213 women). From baseline to follow-up, the prevalence of abdominal obesity increased from 21.1% to 29.6% for men and 49.8% to 61.9% for women. As compared with participants who were not abdominally obese at both baseline and follow-up, both genders who were abdominally obese at follow-up showed greater risk of hypertension regardless of abdominal obesity status at baseline. Compared with the reference group of -2.5% to 2.5% change in WC, with >5% WC gain, risk of incident hypertension was increased for men (RR=1.34, 95% CI 1.15 to 1.57) and women (RR=1.28, 95% CI 1.10 to 1.50). The hypertension risk decreased for men with WC loss ≥2.5% (RR=0.81, 95% CI 0.67 to 0.98).

Conclusions: Abdominal obesity is seriously prevalent in China. The risk of hypertension increased significantly with increasing WC for both genders in a rural Chinese population.
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http://dx.doi.org/10.1136/heartjnl-2016-310760DOI Listing
September 2017

Effect of dynamic change in body mass index on the risk of hypertension: Results from the Rural Chinese Cohort Study.

Int J Cardiol 2017 Jul 9;238:117-122. Epub 2017 Mar 9.

Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. Electronic address:

Objectives: To examine the effect of change in body mass index (BMI) on incident hypertension by gender and age groups.

Methods: A total of 10,145 non-hypertensive participants 18-75years old from rural areas in the middle of China were selected for this cohort study. Questionnaire interview and anthropometric and laboratory measurements were performed at baseline (during July to August 2007 and July to August 2008) and follow-up (during July to August 2013 and July to October 2014). Multiple logistic regression analysis was used to examine the relationship between change in BMI and incident hypertension.

Results: During a mean follow-up of 6.03±0.69years, hypertension developed in 794 of 3986 men and 1184 of 6159 women. Both genders who were obese (BMI ≥28kg/m for Chinese people) at follow-up, regardless of their obesity status at baseline, showed greater risk of hypertension than those who were non-obese (BMI <28kg/m) at both baseline and follow-up. We found a dose-response relationship between change in BMI and incident hypertension. Risk of hypertension was markedly greater with a BMI gain of the highest quartile or more as compared with a BMI reduction of the lowest quartile or more, except for women 60-75years old.

Conclusions: Risk of hypertension was high for non-hypertensive people in rural China with stable obesity. BMI dynamic gain may be related to incident hypertension for men of all ages and young and middle-aged women.
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http://dx.doi.org/10.1016/j.ijcard.2017.03.025DOI Listing
July 2017

[Inhibitory effect of overexpressed kisspeptin on proliferation and migration of MKN-45 gastric cancer cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2017 Feb;33(2):225-30

Objective: To investigate the expression of kisspeptin in gastric adenocarcinoma and its effect on the proliferation and migration of gastric cancer cells.

Methods: The level of kisspeptin in 50 gastric cancer tissues and their paracancerous tissues were detected by quantitative real-time PCR and Western blotting. Kisspeptin-siRNA,control-siRNA,p EGFP-N1-kisspeptin,p EGFP-N1 were separately transfected into MKN-45 gastric cancer cells. After 48-hour culture,the levels of matrix metalloproteinase-2( MMP-2),β-catenin,C-myc,MMP-9,kisspeptin were detected by Western blotting; MTT assay was used to detect the proliferation of MKN-45 cells; wound healing assay was performed to assess the migration ability of MKN-45 cells. After MKN-45 cells were treated with Wnt / β-catenin signal pathway inhibitor FH535,MTT assay and flow cytometry were used to evaluate cell proliferation ability and cell apoptosis,respectively.

Results: Kisspeptin expression in gastric adenocarcinoma tissues was significantly lower than that of the adjacent normal tissues. The cell survival rate and migration rate of p EGFP-N1-kisspeptin group were significantly lower than those of p EGFP-N1 group. Cell survival rate and migration rate of kisspeptin-siRNA group were significantly higher than those of control siRNA group. The levels of MMP-9,MMP-2,β-catenin and C-myc in p EGFP-N1-kisspeptin group were significantly lower than those in p EGFP-N1 group. The levels of MMP-9, MMP-2, β-catenin and C-myc in kisspeptin-siRNA group were significantly higher than those in control-siRNA group. The proliferation and migration trend of gastric cancer cells treated with FH535 was similar to that of the p EGFP-N1-kisspeptin group.

Conclusion: The expression of kisspeptin decreases in gastric cancer tissues,and kisspeptin can interact with Wnt / β-catenin signaling pathway to inhibit the proliferation and migration of gastric cancer cells.
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February 2017

Age-related alterations of neuronal excitability and voltage-dependent Ca current in a spontaneous mouse model of Alzheimer's disease.

Behav Brain Res 2017 03 6;321:209-213. Epub 2017 Jan 6.

Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China; Brain Aging and Cognitive Neuroscience Laboratory of Hebei province, Shijiazhuang 050031, Hebei, PR China. Electronic address:

Alzheimer's disease (AD) is the most common age-dependent neurodegenerative disorder, characterized by a progressive dysfunction of central neurons, and senescence-accelerated mouse prone 8 (SAMP8), a spontaneous AD mouse model, appears to be an excellent model to investigate the process of AD. Previous studies have indicated that neuronal excitability is impaired in transgenic AD mice. In this study, the cognition of SAMP8 mice was tested using the passive avoidance task and Morris water maze; whole-cell current-clamp recordings were used to evaluate the neuronal excitability, including the resting membrane potential, the number of action potentials, and after-hyperpolarization; and the voltage-dependent Ca current in hippocampal slices was measured using whole-cell voltage-clamp recordings. We found that compared to the young mice, the performance in the learning and memory behavior tasks was impaired in aged mice, and the hippocampal CA1 pyramidal neurons of the aged mice showed a significantly depolarized resting membrane potential, increased numbers of action potentials after injection of depolarizing current, and increased after-hyperpolarization after the action potentials. Consistent with the above changes, the voltage-dependent Ca current was larger in aged mice than in young mice. These data suggested that the aged SAMP8 neurons were hyperexcitable, and the alterations in the voltage-dependent Ca current of aged neurons occurred in parallel to the elevation in excitability.
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http://dx.doi.org/10.1016/j.bbr.2017.01.009DOI Listing
March 2017

Association of type 2 diabetes mellitus with the interaction between low-density lipoprotein receptor-related protein 5 (LRP5) polymorphisms and overweight and obesity in rural Chinese adults.

J Diabetes 2017 Nov 2;9(11):994-1002. Epub 2017 Mar 2.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.

Background: Low-density lipoprotein receptor-related protein 5 (LRP5) plays an important role in glucose and cholesterol metabolism. The present cohort study evaluated associations of LRP5 variants with the incidence of type 2 diabetes mellitus (T2DM) in a rural adult Chinese population.

Methods: In all, 7751 subjects aged ≥18 years without T2DM underwent genotyping at baseline; 6326 subjects (81.62%) were followed-up, and 5511 with a clear disease outcome were eligible for analysis. The same questionnaire was administered and the same anthropometric and blood biochemical examinations were performed at baseline and follow-up. Association analysis was performed for five single nucleotide polymorphisms and haplotypes of LRP5.

Results: Cox proportional hazards testing of three different genetic models found no significant association between T2DM and LRP5 after adjusting for potential risk factors (P > 0.05). However, the incidence of T2DM in subjects with LRP5 mutational genotypes was higher in the overweight/obese than normal weight population. Under the dominant model, the risk of T2DM was increased with an interaction between rs11228303 and the waist-to-height ratio adjusted for baseline age, sex, and family history of T2DM (synergy index [SI] = 4.172; 95% confidence interval [CI] 1.014-17.166)], and body mass index (SI = 3.237; 95% CI 1.102-9.509). Furthermore, the A allele of rs3758644 was related to decreased fasting plasma insulin and homeostatic model assessment of β-cell function levels, whereas the T allele of rs12363572 was related to increased high-density lipoprotein cholesterol levels in new-onset diabetes patients (P < 0.05).

Conclusions: The risk of T2DM may be associated with interactions between the LRP5 gene and overweight and obesity. Polymorphisms of LRP5 are related to β-cell function and lipid metabolism.
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http://dx.doi.org/10.1111/1753-0407.12522DOI Listing
November 2017

Association of TCF7L2 and GCG Gene Variants with Insulin Secretion, Insulin Resistance, and Obesity in New-onset Diabetes.

Biomed Environ Sci 2016 Nov;29(11):814-817

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China; Department of Preventive Medicine, Shenzhen University; Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, China.

This cohort study was designed to evaluate the association of transcription factor 7-like 2 (TCF7L2) and proglucagon gene (GCG) variants with disordered glucose metabolism and the incidence of type 2 diabetes mellitus (T2DM) in a rural adult Chinese population. A total of 7,751 non-T2DM participants ⋝18 years old genotyped at baseline were recruited. The same questionnaire interview and physical and blood biochemical examinations were performed at both baseline and follow-up. During a median 6 years of follow-up, T2DM developed in 227 participants. After adjustment for potential contributory factors, nominally significant associations were seen between TT genotype and the recessive model of TCF7L2 rs7903146 and increased risk of T2DM [hazard ratio (HR)=4.068, 95% confidence interval (CI): 1.270-13.026; HR=4.051, 95% CI: 1.268-12.946, respectively]. The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes. In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.
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http://dx.doi.org/10.3967/bes2016.108DOI Listing
November 2016

Association of resting heart rate and cardiovascular disease mortality in hypertensive and normotensive rural Chinese.

J Cardiol 2017 05 28;69(5):779-784. Epub 2016 Nov 28.

Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. Electronic address:

Background: Studies have demonstrated an increased risk of cardiovascular disease (CVD)-associated death (CVD death) with increased resting heart rate (RHR); however, whether the association is consistent in rural Chinese with hypertension and normotension is unknown. We examined the association of RHR and CVD death by hypertension and normotension status in rural Chinese people.

Methods: Baseline data for 20,069 participants ≥18 years old were collected during July to August of 2007 and July to August of 2008; 17,151 (85.5%) participants were followed up in July to August of 2013 and July to October of 2014. The association of RHR and CVD death was determined by Cox proportional hazards regression.

Results: During a mean of 5.88 years (100,889 person-years) of follow-up, we recorded 479 CVD deaths (309 in hypertensive participants). CVD death increased significantly with increasing RHR, beginning from 80 beats per minute (bpm), for hypertensive and normotensive participants. After adjusting for pulse pressure and other covariates, for hypertensive participants, risk of CVD death was increased with RHR 80-89 and ≥90bpm. However, for normotensive participants, risk of CVD death was increased with only RHR≥90bpm.

Conclusions: Risk of CVD death was associated with elevated RHR for both hypertensive and normotensive rural Chinese, and for hypertensive participants, even slightly elevated RHR was associated with CVD death.
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http://dx.doi.org/10.1016/j.jjcc.2016.07.015DOI Listing
May 2017

Body mass index and waist circumference combined predicts obesity-related hypertension better than either alone in a rural Chinese population.

Sci Rep 2016 08 22;6:31935. Epub 2016 Aug 22.

Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China.

Limited information is available on the association of obesity defined by both body mass index (BMI) and waist circumference (WC) with incident hypertension in rural China. A total of 9,174 participants ≥18 years old from rural areas in middle of China, free of hypertension, diabetes, myocardial infarction and stroke, were selected in this cohort study. Questionnaire interview and anthropometric and laboratory measurements were performed at baseline (2007-2008) and follow-up (2013-2014). During the 6 years of follow-up, hypertension developed in 733/3,620 men and 1,051/5,554 women. After controlling for age, education level, smoking, drinking, physical activity, and family history of hypertension, the relative risk of hypertension was lower for participants with high BMI but normal WC than those with both BMI and WC obesity for men 18-39 and 40-59 years old. Women 18-39 years old with normal BMI but high WC showed a 1.96-fold risk of hypertension, and being female with age 40-59 years and high BMI but normal WC was independently associated with hypertension incidence as compared with both normal BMI and WC. BMI is more associated with hypertension as compared with WC in both genders. High WC tends to add additional risk of hypertension in young women.
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http://dx.doi.org/10.1038/srep31935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992958PMC
August 2016

Secular trends in the prevalence of type 2 diabetes in adults in China from 1995 to 2014: A meta-analysis.

J Diabetes 2017 May 22;9(5):450-461. Epub 2016 Aug 22.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.

Background: The aim of the present study was to estimate trends in the prevalence of type 2 diabetes mellitus (T2DM) in adults in China.

Methods: A systematic search was conducted for studies of T2DM prevalence in adults in China from 2000 to 2014. Pooled prevalence was calculated by a random-effects model. Subgroup and sensitivity analyses were performed. Chi-squared and Cochran-Mantel-Haenszel tests were used to assess differences among subgroups and pooled prevalence, respectively.

Results: Forty-six studies (data from 1995 to 2014; 1 463 079 adults) were included in the meta-analysis. The overall prevalence of T2DM was 7.9 %. The pooled prevalence overall and by location (urban and rural), gender (male and female), and age category (18-39, 40-59, and ≥60 years) was 4.5 %, 5.1 % and 3.0 %, 4.0 % and 4.2 %, and 1.4 %, 5.0 %, and 10.3 %, respectively, from 1995 to 1999; 6.6 %, 9.3 % and 5.6 %, 7.4 % and 7.5 %, and 1.8 %, 5.9 %, and 12.4 %, respectively, from 2000 to 2004; 10.3 %, 11.8 % and 6.8 %, 10.0 % and 8.6 %, and 2.8 %, 10.3 %, and 20.0 %, respectively, from 2005 to 2009; and 8.3 %, 12.5 % and 7.6 %, 8.6 % and 8.0 %, and 3.5 %, 8.5 %, and 15.3 %, respectively, from 2010 to 2014. The prevalence increased from 5.8 % to 11.6 % with per-capita gross domestic product and differed by diagnostic criteria.

Conclusions: There was a trend of increasing prevalence of T2DM in adults in China from 1995 to 2009, with a decrease in 2010-14 and a greater increase over time in urban versus rural areas, males versus females, and older versus younger adults.
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http://dx.doi.org/10.1111/1753-0407.12440DOI Listing
May 2017