Chantal Loirat

Chantal Loirat

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Chantal Loirat

Publications by authors named "Chantal Loirat"

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Successful treatment of a associated haemolytic uraemic syndrome by eculizumab.

Clin Kidney J 2019 Feb 20;12(1):106-109. Epub 2018 Mar 20.

Department of Nephrology and Kidney Transplantation, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.

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http://dx.doi.org/10.1093/ckj/sfy019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366139PMC
February 2019

Anticomplement Treatment in Atypical and Typical Hemolytic Uremic Syndrome.

Semin Hematol 2018 07 20;55(3):150-158. Epub 2018 Apr 20.

Department of Pediatric Nephrology, Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Robert Debré, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2018.04.009DOI Listing
July 2018

Haemolytic uraemic syndrome.

Lancet 2017 Aug 25;390(10095):681-696. Epub 2017 Feb 25.

Assistance Publique-Hôpitaux de Paris, Department of Pediatric Nephrology, Hôpital Robert Debré, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(17)30062-4DOI Listing
August 2017

Hemolytic Uremic Syndrome in Pregnancy and Postpartum.

Clin J Am Soc Nephrol 2017 Aug 8;12(8):1237-1247. Epub 2017 Jun 8.

Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.

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http://dx.doi.org/10.2215/CJN.00280117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544502PMC
August 2017

Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy.

Lancet Haematol 2016 Nov 3;3(11):e537-e546. Epub 2016 Oct 3.

Service d'Hématologie biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris and EA3518, Institut Universitaire d'Hématologie-Hôpital Saint Louis, Université Paris Diderot, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(16)30125-9DOI Listing
November 2016

Observations of a large Dent disease cohort.

Kidney Int 2016 08 22;90(2):430-439. Epub 2016 Jun 22.

INSERM, UMR970, Paris-Cardiovascular Research Center, Paris, France; Reference Centre of Hereditary Renal Disease of the Child and Adult (MARHEA), Paris, France; Assistance Publique-Hôpitaux de Paris, European Georges Pompidou University Hospital, Genetics Department, Paris, France.

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http://dx.doi.org/10.1016/j.kint.2016.04.022DOI Listing
August 2016

Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1.

Hum Mutat 2015 Aug 11;36(8):743-52. Epub 2015 Jun 11.

Assistance Publique-Hôpitaux de Paris, Service de Génétique, Hôpital Européen Georges Pompidou, Paris, France.

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http://dx.doi.org/10.1002/humu.22804DOI Listing
August 2015

Macrovascular involvement in a child with atypical hemolytic uremic syndrome.

Pediatr Nephrol 2014 Jul 19;29(7):1273-7. Epub 2013 Dec 19.

Vilnius University, Vilnius, Lithuania.

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http://dx.doi.org/10.1007/s00467-013-2713-3DOI Listing
July 2014

Anti-factor H autoantibody-associated hemolytic uremic syndrome: the earlier diagnosed and treated, the better.

Kidney Int 2014 May;85(5):1019-22

1] Laboratory of Immunology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France [2] INSERM Unité Mixte de Recherche en Santé 872, Paris, France.

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http://dx.doi.org/10.1038/ki.2013.447DOI Listing
May 2014

A new gel formulation of topical cysteamine for the treatment of corneal cystine crystals in cystinosis: the Cystadrops OCT-1 study.

Mol Genet Metab 2014 Mar 9;111(3):314-320. Epub 2014 Jan 9.

Department of Pediatric Nephrology, Necker-Enfants Malades Hospital, AP-HP, Paris, France.

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http://dx.doi.org/10.1016/j.ymgme.2013.12.298DOI Listing
March 2014

Adult social and professional outcomes of pediatric renal transplant recipients.

Transplantation 2014 Jan;97(2):196-205

1 Inserm, CIE 5, Paris, France. 2 Unité d'Epidémiologie Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France. 3 Université Paris Diderot, Sorbonne Paris Cité, Paris, France. 4 Agence de la Biomédecine, Direction Médicale et Scientifique, Saint-Denis-La Plaine, France. 5 Service de Néphrologie, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France. 6 Address correspondence to: Chantal Loirat, M.D., Pediatric Nephrology Department, Hôpital Robert Debré, 48 Boulevard Sérurier, 75019 Paris, France.

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http://dx.doi.org/10.1097/TP.0b013e3182a74de2DOI Listing
January 2014

[Adult socioprofessional status of childhood kidney transplant recipients].

Bull Acad Natl Med 2013 Nov;197(8):1607-8

Service de néphrologic pédiatrique, CHU Paris - Hôpital Robert Debré, 48 boulevard Sérurier - 75019 Paris.

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November 2013

Targeted strategies in the prevention and management of atypical HUS recurrence after kidney transplantation.

Transplant Rev (Orlando) 2013 Oct 12;27(4):117-25. Epub 2013 Aug 12.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Service de Transplantation Rénale adulte, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.trre.2013.07.003DOI Listing
October 2013

Eculizumab in atypical hemolytic-uremic syndrome.

N Engl J Med 2013 10;369(14):1379-80

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http://dx.doi.org/10.1056/NEJMc1308826DOI Listing
October 2013

Atypical hemolytic uremic syndrome: from the rediscovery of complement to targeted therapy.

Eur J Intern Med 2013 Sep 5;24(6):492-5. Epub 2013 Jun 5.

Department of Nephrology and Immunology, CHU de Nantes, ITUN and INSERM UMR S-1064, Nantes, France.

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http://dx.doi.org/10.1016/j.ejim.2013.05.008DOI Listing
September 2013

Thrombotic thrombocytopenic purpura in children.

Curr Opin Pediatr 2013 Apr;25(2):216-24

Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de Néphrologie, Université Paris VII, Paris, France.

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http://dx.doi.org/10.1097/MOP.0b013e32835e7888DOI Listing
April 2013

Post-partum atypical haemolytic-uraemic syndrome treated with eculizumab: terminal complement activity assessment in clinical practice.

Clin Kidney J 2013 Apr;6(2):243-4

Service de Néphrologie Transplantation Dialyse , Centre Hospitalier Universitaire de Bordeaux , Bordeaux , France ; Unité INSERM 1026 , Université Bordeaux Segalen , Bordeaux , France.

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http://dx.doi.org/10.1093/ckj/sfs185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432440PMC
April 2013

[Hemolytic uremic syndrome caused by Shiga-toxin-producing Escherichia coli].

Authors:
Chantal Loirat

Rev Prat 2013 Jan;63(1):11-6

Service de néphrologie, AP-HP, hôpital Robert-Debré, 75019 Paris, France.

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January 2013

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies.

Nat Rev Nephrol 2012 Nov 2;8(11):643-57. Epub 2012 Oct 2.

Service de Transplantation Rénale Adulte, Hôpital Necker, 161 rue de Sèvres, 75015 Paris, France.

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https://www.rareconnect.org/uploads/documents/use-of-eculizu
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http://www.nature.com/doifinder/10.1038/nrneph.2012.214
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http://dx.doi.org/10.1038/nrneph.2012.214DOI Listing
November 2012

Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura.

Blood 2012 Jul 23;120(2):440-8. Epub 2012 Apr 23.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Unitá Operativa Semplice Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Università degli Studi di Milano and Luigi Villa Foundation, Via Pace 9, Milan, Italy. 5P01HL078826-06

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http://www.bloodjournal.org/content/bloodjournal/early/2012/
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-01-40
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http://dx.doi.org/10.1182/blood-2012-01-403113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721603PMC
July 2012

Mycophenolate mofetil for steroid-dependent nephrotic syndrome: a phase II Bayesian trial.

Pediatr Nephrol 2012 Mar 28;27(3):389-96. Epub 2011 Sep 28.

Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Pediatric Nephrology Department, Université Paris 7, 48 Boulevard Sérurier, 75019, Paris, France.

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http://link.springer.com/10.1007/s00467-011-2006-7
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http://dx.doi.org/10.1007/s00467-011-2006-7DOI Listing
March 2012

Management of hemolytic uremic syndrome.

Presse Med 2012 Mar 27;41(3 Pt 2):e115-35. Epub 2012 Jan 27.

Assistance publique-Hôpitaux de Paris, Hôpital Robert-Debré, Nephrology Department, 75019 Paris, France.

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http://dx.doi.org/10.1016/j.lpm.2011.11.013DOI Listing
March 2012

Atypical hemolytic uremic syndrome.

Orphanet J Rare Dis 2011 Sep 8;6:60. Epub 2011 Sep 8.

Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Université Paris VII, Pediatric Nephrology Department, Paris, France.

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http://dx.doi.org/10.1186/1750-1172-6-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198674PMC
September 2011

Cyclophosphamide in steroid-dependent nephrotic syndrome.

Pediatr Nephrol 2011 Jun 12;26(6):927-32. Epub 2011 Mar 12.

Pediatric Nephrology Department, Assistance Publique-Hôpitaux de Paris, Université Paris 7, Hôpital Robert Debré, Paris, France.

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http://dx.doi.org/10.1007/s00467-011-1830-0DOI Listing
June 2011

Alternative complement pathway assessment in patients with atypical HUS.

J Immunol Methods 2011 Feb 6;365(1-2):8-26. Epub 2011 Jan 6.

Cordeliers Research Center, INSERM UMRS 872, 75006 Paris, France.

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http://dx.doi.org/10.1016/j.jim.2010.12.020DOI Listing
February 2011

New insights into postrenal transplant hemolytic uremic syndrome.

Nat Rev Nephrol 2011 Jan 23;7(1):23-35. Epub 2010 Nov 23.

Service de Transplantation Rénale Adulte, Université Paris Descartes, Hôpital Necker, 161 rue de Sèvres, Paris F-75015, France.

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http://dx.doi.org/10.1038/nrneph.2010.155DOI Listing
January 2011

Non-atheromatous arterial stenoses in atypical haemolytic uraemic syndrome associated with complement dysregulation.

Nephrol Dial Transplant 2010 Oct 8;25(10):3421-5. Epub 2010 Jun 8.

Pediatric Nephrology Department, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Université Paris 7, Paris, France.

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https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/
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http://dx.doi.org/10.1093/ndt/gfq319DOI Listing
October 2010

Autism in three patients with cystic or hyperechogenic kidneys and chromosome 17q12 deletion.

Nephrol Dial Transplant 2010 Oct 28;25(10):3430-3. Epub 2010 Jun 28.

Department of Pediatric Nephrology, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Université Paris-Diderot, Paris, France.

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http://dx.doi.org/10.1093/ndt/gfq380DOI Listing
October 2010

Plasmatherapy in atypical hemolytic uremic syndrome.

Semin Thromb Hemost 2010 Sep 23;36(6):673-81. Epub 2010 Sep 23.

Assistance Publique-Hôpitaux de Paris, Pediatric Nephrology Department, Université Paris-Diderot, Hôpital Robert Debré, Paris, France.

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http://dx.doi.org/10.1055/s-0030-1262890DOI Listing
September 2010

Rituximab efficiency in children with steroid-dependent nephrotic syndrome.

Pediatr Nephrol 2010 Jun 18;25(6):1109-15. Epub 2010 Mar 18.

Pediatric Nephrology Department, Hôpital Robert Debré, APHP, Université Paris VII, 48 Boulevard Sérurier, 75019, Paris, France.

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http://dx.doi.org/10.1007/s00467-010-1465-6DOI Listing
June 2010

Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease.

Nephron Physiol 2009 20;112(4):p53-62. Epub 2009 Jun 20.

Nuffield Department of Clinical Medicine, Academic Endocrine Unit, University of Oxford, and Churchill Hospital, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK.

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http://dx.doi.org/10.1159/000225944DOI Listing
January 2010

Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment.

Pediatr Nephrol 2009 Dec 11;24(12):2393-400. Epub 2009 Aug 11.

Assistance publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de Néphrologie Pédiatrique, Paris, France.

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http://dx.doi.org/10.1007/s00467-009-1266-yDOI Listing
December 2009

Varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases.

Nephrol Dial Transplant 2009 Sep 17;24(9):2752-4. Epub 2009 Apr 17.

Pediatric Nephrology Department, Hôpital Robert Debré, Université Paris, France.

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http://dx.doi.org/10.1093/ndt/gfp166DOI Listing
September 2009

Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome.

Nephrol Dial Transplant 2009 May 18;24(5):1455-64. Epub 2008 Dec 18.

Hôpitaux de Toulouse, Université Paul Sabathier, Département de Pédiatrie, Centre de Référence des Maladies Rénales Rares, Toulouse F31000, France.

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http://dx.doi.org/10.1093/ndt/gfn689DOI Listing
May 2009

In vivo confocal microscopy and anterior segment optical coherence tomography analysis of the cornea in nephropathic cystinosis.

Ophthalmology 2009 May;116(5):870-6

Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, 28 rue de Charenton, Paris, France.

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http://dx.doi.org/10.1016/j.ophtha.2008.11.021DOI Listing
May 2009

Enteric-coated mycophenolate sodium in de novo pediatric renal transplant patients.

Pediatr Nephrol 2009 Feb 5;24(2):395-402. Epub 2008 Nov 5.

Pediatric Nephrology, Necker Hospital, 161 rue de Sevres, 75743, Paris, Cedex, France.

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http://dx.doi.org/10.1007/s00467-008-1031-7DOI Listing
February 2009

Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children.

Pediatr Nephrol 2009 Jan 24;24(1):19-29. Epub 2008 Jun 24.

Service de Néphrologie, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Université Paris VII, 48 Boulevard Sérurier, 75019, Paris, France.

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http://dx.doi.org/10.1007/s00467-008-0863-5DOI Listing
January 2009

[Hemolytic-uremic syndrome: what is the mechanism?].

Rev Prat 2008 Dec;58(19):2093-6

Service d'immunologie biologique, hôpital Européen Georges-Pompidou, 75908 Paris Cedex 15.

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December 2008

Complement and the atypical hemolytic uremic syndrome in children.

Pediatr Nephrol 2008 Nov 2;23(11):1957-72. Epub 2008 Jul 2.

Hôpitaux de Paris, Université Paris 7, Hôpital Robert Debré, Pediatric Nephrology, Paris, France.

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http://dx.doi.org/10.1007/s00467-008-0872-4DOI Listing
November 2008

Hemolytic uremic syndrome recurrence after renal transplantation.

Pediatr Transplant 2008 Sep 10;12(6):619-29. Epub 2008 May 10.

Assistance Publique, Hôpitaux de Paris, Hôpital Robert Debré, Université Paris, Faculté de Médecine Denis Diderot, Service de Néphrologie, Paris, France.

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http://doi.wiley.com/10.1111/j.1399-3046.2008.00910.x
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http://dx.doi.org/10.1111/j.1399-3046.2008.00910.xDOI Listing
September 2008

Multicenter trial of everolimus in pediatric renal transplant recipients: results at three year.

Pediatr Transplant 2008 Jun;12(4):456-63

Department of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA 90095-1752, USA.

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http://dx.doi.org/10.1111/j.1399-3046.2007.00832.xDOI Listing
June 2008

Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation.

J Immunol 2008 Feb;180(4):2669-78

INSERM Unité 699, Universite Paris 7-Denis Diderot, Faculte de Medecine, Site Xavier Bichat, 16 rue Henri Huchard, Paris, France.

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http://dx.doi.org/10.4049/jimmunol.180.4.2669DOI Listing
February 2008

Darbepoetin, effective treatment of anaemia in paediatric patients with chronic renal failure.

Pediatr Nephrol 2007 May 11;22(5):708-14. Epub 2007 Jan 11.

Pediatric Nephrology Unit, Hôpital d'Enfants, CHU de Nancy, Rue du Morvan, 54511, Vandoeuvre les Nancy, France.

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http://dx.doi.org/10.1007/s00467-006-0402-1DOI Listing
May 2007

Renal transplantation in HUS patients with disorders of complement regulation.

Pediatr Nephrol 2007 Jan 21;22(1):10-6. Epub 2006 Oct 21.

Univ. Klinik für Kinder-und Jugendheikunde, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00467-006-0210-7DOI Listing
January 2007

[Hereditary hemolytic uremic syndromes and thrombotic thrombocytopenic purpura].

Nephrol Ther 2006 Jan;2 Suppl 2:S149-61

Service de néphrologie, hôpital Robert-Debré, 48 boulevard Serrurier, 75019 Paris, Assistance-publique-Hôpitaux-de-Paris, Paris, France.

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January 2006

Recurrence of nephrotic syndrome after renal transplantation: influence of increased immunosuppression.

Pediatr Nephrol 2005 Dec 14;20(12):1801-4. Epub 2005 Oct 14.

Pediatric Nephrology Unit, Hôpital Armand-Trousseau, Paris, France.

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http://dx.doi.org/10.1007/s00467-005-2053-zDOI Listing
December 2005

[Corticosensitive nephrotic syndrome (or nephrosis) in children. Therapeutic guideline proposed by the Pediatric Society of Nephrology].

Nephrol Ther 2005 Jul 14;1(3):150-6. Epub 2005 Jul 14.

Service de pédiatrie, hôpital de l'Archet-II, 151 avenue Saint-Antoine-de-Ginestière, BP 3079, 06202 Nice cedex, France.

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http://dx.doi.org/10.1016/j.nephro.2005.06.003DOI Listing
July 2005

Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome.

J Am Soc Nephrol 2005 Feb 8;16(2):555-63. Epub 2004 Dec 8.

Service d'Immunologie Biologique, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France.

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http://dx.doi.org/10.1681/ASN.2004050380DOI Listing
February 2005

Escherichia coli strains causing urinary tract infection in uncircumcised infants resemble urosepsis-like adult strains.

J Urol 2005 Jan;173(1):195-7; discussion 197

Laboratoire d'Etudes de Génétique Bactérienne Dans les Infections de l'Enfant (EA3105), Université Denis Diderot-Paris 7, Paris, France.

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http://dx.doi.org/10.1097/01.ju.0000148606.07267.7dDOI Listing
January 2005

HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment.

Hum Mol Genet 2004 Dec 27;13(24):3139-49. Epub 2004 Oct 27.

Biologie du Développement, UMR 7622, CNRS, Université Pierre et Marie Curie, 9 quai St Bernard, 75005 Paris, France.

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http://dx.doi.org/10.1093/hmg/ddh338DOI Listing
December 2004

Glucocorticoid pharmacokinetics and growth retardation in children with renal transplants.

Pediatr Nephrol 2004 Aug 3;19(8):898-904. Epub 2004 Jun 3.

Service Pharmacie, Hôpital Necker Enfants Malades, 149 rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1007/s00467-004-1497-xDOI Listing
August 2004

Relationship between CD8+ T-cell phenotype and function, Epstein-Barr virus load, and clinical outcome in pediatric renal transplant recipients: a prospective study.

Transplantation 2004 Jun;77(11):1706-13

Department of Nephrology, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Université Denis Diderot-Paris VII, Paris, France.

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http://dx.doi.org/10.1097/01.tp.0000131168.21930.5cDOI Listing
June 2004

A pediatric cluster of Shigella dysenteriae serotype 1 diarrhea with hemolytic uremic syndrome in 2 families from France.

Clin Infect Dis 2004 May 15;38(9):e96-9. Epub 2004 Apr 15.

Services de Microbiologie, Hôpital Robert Debré, Paris, France.

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http://dx.doi.org/10.1086/383474DOI Listing
May 2004

[Renovascular hypertension in childhood].

Bull Acad Natl Med 2003 ;187(6):1067-77; discussion 1078-9

Service de Néphrologie Pédiatrique, Hôpital d'Enfants Armand Trousseau-26, avenue du Docteur Arnold Netter-75012 Paris.

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April 2004

Sudden blindness caused by anterior ischemic optic neuropathy in 5 children on continuous peritoneal dialysis.

Am J Kidney Dis 2003 Nov;42(5):E3-9

Service de Néphrologie and the Service d'Ophtalmologie, Hopital Robert Debré, Assistance Publique-Hopitaux de Paris, Paris, France.

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http://dx.doi.org/10.1016/j.ajkd.2003.07.009DOI Listing
November 2003