Publications by authors named "Chantal Guillemette"

100Publications

Reply to Comment on "UGT2B17 modifies drug response in chronic lymphocytic leukaemia".

Br J Cancer 2020 Oct 24;123(8):1347-1348. Epub 2020 Jul 24.

Faculty of Medicine, CHU de Québec Research Centre, Department of Medicine, Laval University, Québec city, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41416-020-1006-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553966PMC
October 2020

Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression.

Br J Cancer 2020 Apr 12;122(9):1277-1287. Epub 2020 Feb 12.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec Research Center-Laval University, Québec, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41416-019-0722-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188667PMC
April 2020

Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation.

Drug Metab Dispos 2020 02 14;48(2):75-84. Epub 2019 Nov 14.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center - Université Laval and Faculty of Pharmacy (J.V., V.T., P.C., L.V., C.G.), CHU de Québec Research Center - Université Laval, Division of Urology, Faculty of Medicine, Surgery Department (L.L., F.P.), and CHU de Québec Research Center - Université Laval, Division of Hematology-Oncology, Faculty of Medicine (E.L.), Laval University, Québec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.119.088229DOI Listing
February 2020

Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients.

Pharmacogenomics 2019 11 8;20(17):1179-1187. Epub 2019 Nov 8.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center & Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2019-0091DOI Listing
November 2019

Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients.

Sci Rep 2019 09 10;9(1):13008. Epub 2019 Sep 10.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center - Laval University and Faculty of Pharmacy, Laval University, Québec, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-49477-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736932PMC
September 2019

Inactivation of Prostaglandin E as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia.

Front Oncol 2019 4;9:606. Epub 2019 Jul 4.

Pharmacogenomics Laboratory, Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center - Université Laval, Laval University, Québec City, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2019.00606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621974PMC
July 2019

Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody.

Drug Metab Dispos 2019 05 28;47(5):444-452. Epub 2019 Feb 28.

Centre Hospitalier Universitaire (CHU) de Québec Research Centre and Faculty of Medicine (J.-P.É., S.D., H.H., H.B., L.L., M.P., B.T., E.L.) and CHU de Québec Research Centre and Faculty of Pharmacy, Laval University (A.L., M.R., L.V., P.C., C.G.), and Statistical and Clinical Research Platform, CHU de Québec Research Centre (D.S.), Québec, Canada.); Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S.); and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (K.K., U.M.Z.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.119.086330DOI Listing
May 2019

A Comprehensive Analysis of Steroid Hormones and Progression of Localized High-Risk Prostate Cancer.

Cancer Epidemiol Biomarkers Prev 2019 04 7;28(4):701-706. Epub 2019 Feb 7.

CHU de Québec Research Centre and Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-18-1002DOI Listing
April 2019

Discordance between testosterone measurement methods in castrated prostate cancer patients.

Endocr Connect 2019 Feb;8(2):132-140

Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EC-18-0476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376995PMC
February 2019

An LC-MS/MS method for quantification of abiraterone, its active metabolites D(4)-abiraterone (D4A) and 5α-abiraterone, and their inactive glucuronide derivatives.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 4;1104:249-255. Epub 2018 Dec 4.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec, - Université Laval Research Center and Faculty of Pharmacy, Laval University, Québec city, QC, Canada; Canada Research Chair in Pharmacogenomics, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2018.12.003DOI Listing
January 2019

Sex-dependent association of circulating sex steroids and pituitary hormones with treatment-free survival in chronic lymphocytic leukemia patients.

Ann Hematol 2018 Sep 21;97(9):1649-1661. Epub 2018 May 21.

Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-018-3356-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097785PMC
September 2018

Identification of Metabolomic Biomarkers for Endometrial Cancer and Its Recurrence after Surgery in Postmenopausal Women.

Front Endocrinol (Lausanne) 2018 12;9:87. Epub 2018 Mar 12.

Centre Hospitalier Universitaire (CHU) de Québec Research Center, Faculty of Pharmacy, Laval University, Québec, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2018.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857535PMC
March 2018

Post-transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing.

Drug Metab Dispos 2018 May 9;46(5):514-524. Epub 2018 Feb 9.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Faculty of Pharmacy, Québec, Canada Research Chair in Pharmacogenomics, Université Laval, Québec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.117.079921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894810PMC
May 2018

Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery.

J Steroid Biochem Mol Biol 2018 04 29;178:45-54. Epub 2017 Oct 29.

Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center and Faculty of Pharmacy, Laval University, Québec, Canada; Canada Research Chair in Pharmacogenomics, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2017.10.021DOI Listing
April 2018

Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics.

Front Pharmacol 2017 3;8:23. Epub 2017 Feb 3.

Pharmacogenomics Laboratory, Canada Research Chair in Pharmacogenomics, Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec Research Center, Laval University Québec, QC, Canada.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fphar.2017.00
Publisher Site
http://dx.doi.org/10.3389/fphar.2017.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290407PMC
February 2017

Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism.

Mol Pharmacol 2017 03 3;91(3):167-177. Epub 2017 Jan 3.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Faculty of Pharmacy (Y.A.-D., Mi.R., Me.R., J.R., C.G.), Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (S.M., F.P.), and Centre Hospitalier Universitaire de Québec Research Center and Faculty of Medicine (B.T.), Laval University, Québec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.116.106161DOI Listing
March 2017

Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit.

Mol Cell Endocrinol 2017 02 24;442:32-39. Epub 2016 Nov 24.

INRS-Institut Armand-Frappier, 531, Boul. des Prairies, Laval, QC, H7V 1B7, Canada; BioMed Research Centre, Université du Québec à Montréal, C.P. 8888, Succ. Centre-ville, Montréal, QC, H3C 3P8, Canada; Center for Interdisciplinary Research on Well-Being, Health, Society and Environment (CINBIOSE), Université du Québec à Montréal, C.P. 8888, Succ. Centre-ville, Montréal, QC, H3C 3P8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2016.11.021DOI Listing
February 2017

A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity.

Drug Metab Dispos 2016 12 9;44(12):1867-1871. Epub 2016 Sep 9.

Pharmacogenomics Laboratory, Canada Research Chair in Pharmacogenomics, Centre Hospitalier Universitaire de Québec Research Center and Faculty of Pharmacy, Laval University, Québec City (C.G.B., L.V., S.D., C.G.), and Département de Pathologie et de Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, (M.O.B.B.), Québec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.116.071860DOI Listing
December 2016

Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing.

Cell Rep 2016 09;17(1):114-124

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Québec, QC G1V 4G2, Canada; Faculty of Pharmacy, Laval University, Québec, QC G1V 0A6, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.08.077DOI Listing
September 2016

Phase II Drug-Metabolizing Polymorphisms and Smoking Predict Recurrence of Non-Muscle-Invasive Bladder Cancer: A Gene-Smoking Interaction.

Cancer Prev Res (Phila) 2016 Feb 8;9(2):189-95. Epub 2015 Dec 8.

Centre Hospitalier Universitaire (CHU) de Québec Research Center, Laval University, Québec, Canada. Pharmacogenomics Laboratory, Canada Research Chair in Pharmacogenomics, Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1940-6207.CAPR-15-0069DOI Listing
February 2016

Assay reproducibility of serum androgen measurements using liquid chromatography-tandem mass spectrometry.

J Steroid Biochem Mol Biol 2016 Jan 28;155(Pt A):56-62. Epub 2015 Sep 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09600760153009
Publisher Site
http://dx.doi.org/10.1016/j.jsbmb.2015.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663146PMC
January 2016

Evidences of Biological Functions of Biliverdin Reductase A in the Bovine Epididymis.

J Cell Physiol 2016 May 30;231(5):1077-89. Epub 2015 Sep 30.

Département d'obstétrique, gynécologie et reproduction, Faculté de Médecine, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Université Laval, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.25200DOI Listing
May 2016

Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.

J Steroid Biochem Mol Biol 2016 Jan 15;155(Pt A):85-93. Epub 2015 Sep 15.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec Research Center, and Faculty of Pharmacy, Laval University, G1V 4G2 Quebec, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09600760153008
Publisher Site
http://dx.doi.org/10.1016/j.jsbmb.2015.09.021DOI Listing
January 2016

ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients.

Pharmacogenet Genomics 2015 Dec;25(12):573-83

aPharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center and Faculty of Pharmacy bCHU de Québec Research Center and Faculty of Medicine, Laval University cCanada Research Chair in Pharmacogenomics, CHU de Québec Research Center, Québec, Canada dDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada eDepartment of Molecular Biology and Translational Research, Division of Experimental and Clinical Pharmacology, National Cancer Institute and Cancer for Molecular Biomedicine, Aviano, Italy fEshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, North Carolina, USA.

View Article

Download full-text PDF

Source
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/FPC.0000000000000168DOI Listing
December 2015

A chromatography/tandem mass spectrometry method for the simultaneous profiling of ten endogenous steroids, including progesterone, adrenal precursors, androgens and estrogens, using low serum volume.

Steroids 2015 Dec 6;104:16-24. Epub 2015 Aug 6.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Faculty of Pharmacy, Laval University, Québec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.steroids.2015.07.009DOI Listing
December 2015

The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.

Eur Urol 2016 Apr 26;69(4):601-609. Epub 2015 Jul 26.

Centre Hospitalier Universitaire de Québec Research Center, Faculty of Medicine, Laval University, Québec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2015.06.054DOI Listing
April 2016

Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.

Drug Metab Dispos 2015 Sep 15;43(9):1331-5. Epub 2015 Jun 15.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec and Faculty of Pharmacy, Université Laval, Québec, Canada (G.M., M.R., P.C., L.V., C.G.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (K.K., U.M.Z.); Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S.); Canada Research Chair in Pharmacogenomics (C.G.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.115.065391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538857PMC
September 2015

Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk.

J Clin Oncol 2015 Jun 11;33(18):2041-50. Epub 2015 May 11.

Louise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.

View Article

Download full-text PDF

Source
http://jco.ascopubs.org/content/33/18/2041.full.pdf
Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.1602
Publisher Site
http://dx.doi.org/10.1200/JCO.2014.59.1602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461805PMC
June 2015

Quantitative profiling of human renal UDP-glucuronosyltransferases and glucuronidation activity: a comparison of normal and tumoral kidney tissues.

Drug Metab Dispos 2015 Apr 3;43(4):611-9. Epub 2015 Feb 3.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, and Faculty of Pharmacy, Laval University, Quebec, Canada (G.M., M.R., P.C., L.V., V.T., C.G.); Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.F., P.C.S.); and University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Boulder, Colorado (M.S.J.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.114.062877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366751PMC
April 2015

The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy.

Endocr Relat Cancer 2015 Feb 1;22(1):77-85. Epub 2014 Dec 1.

Pharmacogenomics LaboratoryCentre Hospitalier Universitaire de Québec (CHU de Québec) Research Center and Faculty of Pharmacy, Laval University, R4720, 2705 Boulevard Laurier, Québec, Québec, Canada G1V 4G2CHU de Québec Research Center and Faculty of MedicineLaval University, Québec, Québec, CanadaCanada Research Chair in PharmacogenomicsQuébec, Québec, Canada Pharmacogenomics LaboratoryCentre Hospitalier Universitaire de Québec (CHU de Québec) Research Center and Faculty of Pharmacy, Laval University, R4720, 2705 Boulevard Laurier, Québec, Québec, Canada G1V 4G2CHU de Québec Research Center and Faculty of MedicineLaval University, Québec, Québec, CanadaCanada Research Chair in PharmacogenomicsQuébec, Québec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-14-0423DOI Listing
February 2015

Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer.

Int J Cancer 2014 Dec 22;135(11):2661-7. Epub 2014 Apr 22.

Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.28904DOI Listing
December 2014

Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.

Clin Cancer Res 2014 Jun 28;20(11):2971-83. Epub 2014 Mar 28.

Authors' Affiliations: Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center and Faculty of Pharmacy; and CHU de Québec Research Center and Faculty of Medicine, Laval University, Québec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-13-2567DOI Listing
June 2014

Importance of 5α-reductase gene polymorphisms on circulating and intraprostatic androgens in prostate cancer.

Clin Cancer Res 2014 Feb 25;20(3):576-84. Epub 2013 Nov 25.

Authors' Affiliations: Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center and Faculty of Pharmacy; and Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center and Faculty of Medicine, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-13-1100DOI Listing
February 2014

Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism.

Mol Pharmacol 2014 Jan 18;85(1):29-36. Epub 2013 Oct 18.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Faculty of Pharmacy, Laval University, Québec City, Québec, Canada.

View Article

Download full-text PDF

Source
http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.113.08
Publisher Site
http://dx.doi.org/10.1124/mol.113.089227DOI Listing
January 2014

Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues: changes from prenatal life to adulthood and in kidney cancer.

Pharmacogenet Genomics 2013 Dec;23(12):684-96

aPharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval de Québec (CHU de Québec) Research Center and Faculty of Pharmacy bCHU de Québec Research Center and Faculty of Medicine, Laval University, Quebec, Canada cSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado dSchool of Medicine, Kidney Center, University of North Carolina, Chapel Hill, North Carolina, USA eDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=01213011-201312000-000
Publisher Site
http://dx.doi.org/10.1097/FPC.0000000000000008DOI Listing
December 2013

Modulation of the UGT2B7 enzyme activity by C-terminally truncated proteins derived from alternative splicing.

Drug Metab Dispos 2013 Dec 2;41(12):2197-205. Epub 2013 Oct 2.

Pharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval de Québec (CHU de Québec) Research Center, Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.113.053876DOI Listing
December 2013

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.

J Pharm Pharmacol 2013 Jun 21;65(6):874-83. Epub 2013 Mar 21.

Comparative and Molecular Pharmacogenomics Laboratory, Tufts University School of Medicine, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.12053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195312PMC
June 2013

The relative protein abundance of UGT1A alternative splice variants as a key determinant of glucuronidation activity in vitro.

Drug Metab Dispos 2013 Apr 29;41(4):694-7. Epub 2013 Jan 29.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Faculty of Pharmacy, Laval University, Québec City, Québec, Canada.

View Article

Download full-text PDF

Source
http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.112.050468
Publisher Site
http://dx.doi.org/10.1124/dmd.112.050468DOI Listing
April 2013

Testosterone challenge and androgen receptor activity in relation to UGT2B17 genotypes.

Eur J Clin Invest 2013 Mar 7;43(3):248-55. Epub 2013 Jan 7.

Laboratory Medicine, Division Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/eci.12037DOI Listing
March 2013

Molecular markers in key steroidogenic pathways, circulating steroid levels, and prostate cancer progression.

Clin Cancer Res 2013 Feb 27;19(3):699-709. Epub 2012 Nov 27.

Pharmacogenomics Laboratory and L'Hôtel-Dieu de Québec, Centre Hospitalier Universitaire de Québec (CHUQ) Research Center, Faculty of Medicine, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-12-2812DOI Listing
February 2013

Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia.

Blood 2013 Feb 20;121(7):1175-83. Epub 2012 Nov 20.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-08-447359DOI Listing
February 2013

Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing.

Biochem J 2013 Feb;450(1):107-14

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ) Research Center, 2705 Boul. Laurier, Québec, Canada, G1V 4G2, and Faculty of Pharmacy, Laval University, Pavillon Ferdinand-Vandry, Université Laval, Québec, Canada, G1V 0A6.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20121594DOI Listing
February 2013

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for monitoring drug exposure in hematopoietic stem cell transplant recipients.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Feb 9;885-886:131-7. Epub 2012 Jan 9.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ) Research Center, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2011.12.029DOI Listing
February 2012

The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy.

Eur Urol 2012 Jul 21;62(1):88-96. Epub 2011 Dec 21.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ) Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2011.12.021DOI Listing
July 2012

Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants.

Pharmacogenet Genomics 2011 Oct;21(10):631-41

Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e3283498147DOI Listing
October 2011

Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer.

J Clin Endocrinol Metab 2011 Sep 6;96(9):E1550-7. Epub 2011 Jul 6.

Pharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval CHUQ Research Center, and Faculty of Pharmacy, and L'Hôtel-Dieu de Quebec, CHUQ Research Center and Faculty of Medicine, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2011-1049DOI Listing
September 2011

SRD5A polymorphisms and biochemical failure after radical prostatectomy.

Eur Urol 2011 Dec 29;60(6):1226-34. Epub 2011 Jun 29.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ) Research Centre and Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2011.06.020DOI Listing
December 2011

Correlation between circulatory, local prostatic, and intra-prostatic androgen levels.

Prostate 2011 Jun 6;71(9):909-14. Epub 2010 Dec 6.

Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.21307DOI Listing
June 2011

In vitro investigation of human UDP-glucuronosyltransferase isoforms responsible for tacrolimus glucuronidation: predominant contribution of UGT1A4.

Drug Metab Dispos 2011 Jul 12;39(7):1127-30. Epub 2011 Apr 12.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.111.039040DOI Listing
July 2011

Bioavailability of testosterone enanthate dependent on genetic variation in the phosphodiesterase 7B but not on the uridine 5'-diphospho-glucuronosyltransferase (UGT2B17) gene.

Pharmacogenet Genomics 2011 Jun;21(6):325-32

Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e328344c5c6DOI Listing
June 2011

Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans.

J Pathol 2011 Feb 29;223(3):425-35. Epub 2010 Oct 29.

Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University, G1V 4G2 Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.2805DOI Listing
February 2011

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.

Drug Metab Dispos 2010 Oct 7;38(10):1785-9. Epub 2010 Jul 7.

Pharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval Research Center and Faculty of Pharmacy, Laval University, Boulevard Laurier, Québec, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.110.034835DOI Listing
October 2010

Circulating estrogens in endometrial cancer cases and their relationship with tissular expression of key estrogen biosynthesis and metabolic pathways.

J Clin Endocrinol Metab 2010 Jun 6;95(6):2689-98. Epub 2010 Apr 6.

Centre Hospitalier Universitaire de Québec Research Center and Faculty of Pharmacy, Laval University, Québec, Canada G1V 4G2.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2010-2648DOI Listing
June 2010

Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation.

Pharmacogenet Genomics 2010 Mar;20(3):195-210

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ), Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e328336ef1cDOI Listing
March 2010

Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells.

BMC Mol Biol 2010 Jan 22;11. Epub 2010 Jan 22.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec, 2705 Laurier, Quebec, G1V 4G2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2199-11-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835698PMC
January 2010

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.

J Biol Chem 2010 Feb 8;285(6):3600-7. Epub 2009 Dec 8.

Pharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval Research Center and Faculty of Pharmacy, Laval University, Québec G1V 4G2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.083139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823500PMC
February 2010

Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry.

Anal Chem 2009 Dec;81(24):10143-8

Centre Hospitalier Universitaire du Quebec Research Center, Laval University, Quebec, Canada G1V 4G2.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/ac9019126
Publisher Site
http://dx.doi.org/10.1021/ac9019126DOI Listing
December 2009

A pharmacogenetics study of the human glucuronosyltransferase UGT1A4.

Pharmacogenet Genomics 2009 Dec;19(12):945-54

Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University, G1V 4G2 Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e3283331637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177227PMC
December 2009

The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver.

J Biol Chem 2010 Jan 4;285(2):1113-21. Epub 2009 Nov 4.

Laboratory of Molecular Pharmacology, CHUQ Research Center, and the Faculty of Pharmacy, Laval University, Québec, Québec G1V 4G2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.073908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801239PMC
January 2010

UGT genomic diversity: beyond gene duplication.

Drug Metab Rev 2010 Feb;42(1):24-44

Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University, Quebec City, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/03602530903210682DOI Listing
February 2010

In vitro glucuronidation of fenofibric acid by human UDP-glucuronosyltransferases and liver microsomes.

Drug Metab Dispos 2009 Nov 6;37(11):2236-43. Epub 2009 Aug 6.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de L'Université Laval Research Center and Faculty of Pharmacy, Laval University, Québec, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.109.029058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774983PMC
November 2009

Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism.

Hum Mutat 2009 Sep;30(9):1310-9

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ) Research Center, and Pharmacy Department, Laval University, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.21054DOI Listing
September 2009

Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine.

Drug Metab Dispos 2009 Sep 1;37(9):1793-6. Epub 2009 Jun 1.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.109.027706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729325PMC
September 2009

Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk.

Pharmacogenet Genomics 2009 Mar;19(3):239-43

Department of Epidemiology, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e328323f66cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667627PMC
March 2009

Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.

Hum Mutat 2009 Apr;30(4):677-87

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Quebec (CHUQ) Research Center and Laval University, Faculty of Pharmacy, Québec, Québec City, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.20946DOI Listing
April 2009

Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants.

Drug Metab Dispos 2009 Feb 29;37(2):322-9. Epub 2008 Oct 29.

CHUQ Research Center, 2705, boul. Laurier, T3-48, G1V 4G2, Québec, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.108.023101DOI Listing
February 2009

UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans.

Mutat Res 2008 Sep 16;644(1-2):56-63. Epub 2008 Jul 16.

Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University, G1V 4G2 Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mrfmmm.2008.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570038PMC
September 2008

Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers.

Pharmacogenomics 2008 Jul;9(7):869-79

Laboratory of Pharmacogenomics, Oncology & Molecular Endocrinology Research Center, CHUL Research Center and Faculty of Pharmacy, Laval University, T3-48, 2705 Boul. Laurier, Québec, G1V 4G2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/14622416.9.7.869DOI Listing
July 2008

Downregulation of hepatic acetylation of drugs in chronic renal failure.

J Am Soc Nephrol 2008 Jul 16;19(7):1352-9. Epub 2008 Apr 16.

Service de néphrologie et Centre de recherche de l'Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2007090974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440299PMC
July 2008

Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.

Pharmacogenet Genomics 2007 Dec;17(12):1077-89

Laboratory of Pharmacogenomics, Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e3282f1f118DOI Listing
December 2007

Sensitive high-performance liquid chromatography-tandem mass spectrometry method for quantitative analysis of mycophenolic acid and its glucuronide metabolites in human plasma and urine.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Oct 24;858(1-2):159-67. Epub 2007 Aug 24.

Canada Research Chair in Pharmacogenomics, Laboratory of Pharmacogenomics, Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Faculty of Pharmacy, Laval University, G1V 4G2 Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2007.08.023DOI Listing
October 2007

A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3.

Pharmacogenet Genomics 2007 Jul;17(7):481-95

Laboratory of Pharmacogenomics, Oncology and Molecular Endocrinology Research Center, CHUQ Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e32806d87a4DOI Listing
July 2007