Publications by authors named "Changsheng Guo"

60 Publications

Enantioselective recognition of chiral acids by supramolecular interactions with chiral AIEgens.

Chem Commun (Camb) 2021 Nov 23. Epub 2021 Nov 23.

Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.

Novel chiral AIEgens bearing optically pure amino groups were synthesized and showed excellent discrimination for a series of chiral acidic compounds and amino acids. Interestingly, after supramolecular assembly with 4-sulfocalix[4]arene, the obtained complexes showed enhanced enantioselectivity for chiral acids.
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http://dx.doi.org/10.1039/d1cc05618bDOI Listing
November 2021

Vertical profile and assessment of soil pollution from a typical coking plant by suspect screening and non-target screening using GC/QTOF-MS.

Sci Total Environ 2021 Oct 28:151278. Epub 2021 Oct 28.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Center for Environmental Health Risk Assessment and Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

A comprehensive workflow for suspect screening and non-target screening with gas chromatography coupled with quadrupole time-of-flight mass spectrometry (GC/QTOF-MS) was used to characterize the pollution characteristics of soil samples in a typical coking plant in China. Suspect screening confirmed 57 chemicals including PAHs, alkyl PAHs, and phthalates contained in high-resolution personal compound database and library (PCDL). Non-target screening detected 88 chemicals from soil samples in the NIST 17 library. A total of 122 chemicals were screened in soil samples, and many of them were of emerging concern. Their presence in the soil obtained from coking operations has been underestimated, such as the oxygenated PAHs (naphtho[2,1-b]furan and 9H-fluoren-9-one), and the alkyl biphenyls compounds (4,4'-dimethylbiphenyl, 3,3'-dimethylbiphenyl, 4-methyl-1,1'-biphenyl and 2,2',5,5'-tetramethyl-1,1'-biphenyl). Toxicity assays by luminescent bacteria proved that the extracts from soil samples at different depths showed varying toxicity to V. qinghaiensis sp.-Q67. Soil extracts from a depth of 20-40 cm exhibited the greatest toxicity to luminescent bacteria compared with the other six-layered soil samples, which was correlated with the number of detectable pollutants and total organic carbon content. This study provided a screening method for suspect and non-target contaminants in urban industrial soil sites, which was important in identifying localized contamination sources.
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http://dx.doi.org/10.1016/j.scitotenv.2021.151278DOI Listing
October 2021

A MUCINs expression signature impacts overall survival in patients with clear cell renal cell carcinoma.

Cancer Med 2021 Sep 29;10(17):5823-5838. Epub 2021 Jul 29.

Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Background: Kidney cancer, especially clear cell renal cell carcinoma (ccRCC), is one of the most common cancers in the urinary system. Previous studies suggested that certain members of MUCINs could serve as independent predictors for the survival of ccRCC patients. None of them, however, is robust enough to predict prognosis accurately.

Objective: To analyze the correlation of MUCINs alterations and their expression levels with the prognosis of ccRCC patients and develop a prognosis-related predictor.

Methods: We applied whole-exome sequencing in samples from 22 Chinese ccRCC patients to identify genetic alterations in MUCIN genes and analyzed their genetic alterations, expression, and correlation with survival using the TCGA, GSE73731, and GSE29069 datasets.

Result: Genetic alternations in MUCINs were identified in 91% and 51% of ccRCC patients in our cohort and the TCGA database, respectively. No correlation with survival was found for the genetic alterations. Using unsupervised clustering analysis of gene expression, we identified two major clusters of MUCIN expression patterns. Cluster 1 was characterized by a global overexpression of MUC1, MUC12, MUC13, MUC16, and OVGP1; and cluster 2 was characterized by a global overexpression of MUC4, MUC5B, MUC6, MUC20, EMCN, and MCAM. Patients with cluster 1 expression pattern had significantly shorter overall survival time and worse clinical features, including higher tumor grades and metastasis. Meanwhile, they had a higher level of mutation counts and more infiltrated immune cells, but lower enrichment in angiogenesis signature genes. A five-MUCINs expression signature was constructed from cluster 1, and notably, it was demonstrated to be associated with shorter overall survival. A similar worse clinical feature, lower angiogenesis but the more immune signature, was identified in samples presented with signature 1. In the validation data set GSE29069, patients with signature 1 were also associated with a trend of poor survival outcomes.

Conclusion: We established a five-MUCINs expression signature as a new prognostic marker for ccRCC. The distinct tumor microenvironment feature between the two signatures may further affect ccRCC patients' clinical management.
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http://dx.doi.org/10.1002/cam4.4128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419780PMC
September 2021

Occurrence, sources, and ecological risks of three classes of insecticides in sediments of the Liaohe River basin, China.

Environ Sci Pollut Res Int 2021 Nov 2;28(44):62726-62735. Epub 2021 Jul 2.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

The frequent and extensive use of insecticides has caused serious aquatic pollution, thus posing a great threat to ecosystems and public health. In this study, three classes of insecticides including 20 organochlorine pesticides (OCPs), 6 organophosphorus pesticides (OPs), and 8 pyrethroids were analyzed in 24 sediments from the Liaohe River basin. The results showed that all sediment samples were contaminated with insecticides, with the total concentrations ranging from 7.3 ng/g dry weight (dw) to 242.8 ng/g dw. Among them, pyrethroids (2.2-102.5 ng/g dw) contributed 55% of the total insecticide concentration, followed by OCPs (1.3-94.8 ng/g dw) and OPs (2.6-45.5 ng/g dw), representing 24% and 21% of the total concentrations, respectively. For OCPs, hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethanes (DDTs) showed the highest concentrations of 0.37-37.5 ng/g dw and 0.05-23.2 ng/g dw, respectively. Historical inputs of lindane and technical DDT were the major sources of HCHs and DDTs, respectively, as indicated by isomer or metabolite ratios. Additionally, dichlorvos (0.26-17.1 ng/g dw) was the main OP, while cypermethrin dominated the pyrethroids with the concentrations of 1.6-32.6 ng/g dw. The spatial distribution revealed that significantly higher residues of insecticides were observed in sediments from the Daliao River system than those from the Liao River. This implied that these insecticides were most likely from the discharge of highly polluted sewage and industrial wastewater from adjacent industrial and populous cities as well as urban applications (e.g., landscape maintenance and household pest control). An ecological risk assessment based on risk quotients suggested that the three classes of insecticides analyzed here pose a low risk to aquatic organisms in the study area.
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http://dx.doi.org/10.1007/s11356-021-15060-5DOI Listing
November 2021

Tissue-specific accumulation, elimination, and toxicokinetics of illicit drugs in adult zebrafish (Danio rerio).

Sci Total Environ 2021 Oct 31;792:148153. Epub 2021 May 31.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

The abuse of illicit drugs has led to their extensive detection worldwide and subsequently exerted adverse effects upon aquatic organisms and ecosystem. However, less attention has been paid to the uptake, biotransformation, internal distribution, and toxicokinetic processes in the exposed organisms. In this study, zebrafish (Danio rerio) was exposed to methamphetamine (METH) and ketamine (KET) at three different concentrations in a semi-static exposure system. METH and KET, together with their metabolites, amphetamine (AMP) and norketamine (NK), were consistently detected in zebrafish. Over 14-day exposure, the relative magnitude of mean concentrations of illicit drugs in zebrafish generally followed the order of brain > liver > intestine > ovary > muscle. The uptake rate constants (K) of METH and KET were in the range of 0.590-1.38 × 10 L/(kg·d), the elimination rate constants (K) were in the range of 0.18-6.98 1/d, and the half-lives were in the range of 0.18-6.98 d, respectively. METH and KET demonstrated relatively rapid uptake and elimination kinetics and short half-lives, and concentrations in organs were driven by external concentrations. Illicit drugs were not persistent within zebrafish organs when there were no substantial external contaminant sources. The observed values of bioconcentration factor (BCF, L/kg) and kinetically-derived bioconcentration factor (BCF, L/kg) were at the similar level. The ability of different zebrafish organs accumulating target chemicals from the aquatic environment was different, and brain was the target organ of the test illicit drugs.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148153DOI Listing
October 2021

Occurrence, bioaccumulation and toxicological effect of drugs of abuse in aquatic ecosystem: A review.

Environ Res 2021 09 26;200:111362. Epub 2021 May 26.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address:

Drugs of abuse are a group of emerging contaminants. As the prevalence of manufacture and consumption, there is a growing global environmental burden and ecological risk from the continuous release of these contaminants into environment. The widespread occurrence of drugs of abuse in waste wasters and surface waters is due to the incomplete removal through traditional wastewater treatment plants in different regions around the world. Although their environmental concentrations are not very high, they can potentially influence the aquatic organisms and ecosystem function. This paper reviews the occurrence of drugs of abuse and their metabolites in waste waters and surface waters, their bioaccumulation in aquatic plants, fishes and benthic organisms and even top predators, and the toxicological effects such as genotoxic effect, cytotoxic effect and even behavioral effect on aquatic organisms. In summary, drugs of abuse occur widely in aquatic environment, and may exert adverse impact on aquatic organisms at molecular, cellular or individual level, and even on aquatic ecosystem. It necessitates the monitoring and risk assessment of these compounds on diverse aquatic organisms in the further study.
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http://dx.doi.org/10.1016/j.envres.2021.111362DOI Listing
September 2021

Differentially expressed genes, lncRNAs, and competing endogenous RNAs in Kawasaki disease.

PeerJ 2021 12;9:e11169. Epub 2021 May 12.

Department of Pediatrics, Affiliated Taikang Xianlin Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Background: Kawasaki disease (KD) is an acute and febrile systemic vasculitis of unknown etiology. This study aimed to identify the competing endogenous RNA (ceRNA) networks of lncRNAs, miRNAs, and genes in KD and explore the molecular mechanisms underlying KD.

Methods: GSE68004 and GSE73464 datasets were downloaded from the Gene Expression Omnibus. Differentially expressed lncRNAs (DElncRNAs) and genes (DEGs) in KD were identified using the criteria of  < 0.05 and | log (fold change) | ≥ 1. MicroRNAs (miRNAs) related to KD were searched from databases. The lncRNA-miRNA-mRNA networks involving the DElncRNAs and DEGs were constructed.

Results: A total of 769 common upregulated, 406 common downregulated DEGs, and six DElncRNAs were identified in the KD samples. The lncRNA-miRNA-mRNA network consisted of four miRNAs, three lncRNAs (including the upregulated , , and the downregulated ) and four DEGs (including the downregulated and the upregulated , , and ). Validation in the GSE18606 dataset showed that intravenous immunoglobulin treatment significantly alleviated the deregulated profiles of the above RNAs in KD patients. Three ceRNA networks of , -, and /--- were identified. Four genes were associated with functional categories, such as inflammatory response and vascular endothelial cell.

Conclusions: The ceRNA networks involve genes, such as , , and , and lncRNAs, including , , and , which might play a key role in the pathogenesis and development of KD by regulating inflammation.
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http://dx.doi.org/10.7717/peerj.11169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123229PMC
May 2021

Constructing dense and hydrophilic forward osmosis membrane by cross-linking reaction of graphene quantum dots with monomers for enhanced selectivity and stability.

J Colloid Interface Sci 2021 May 9;589:486-499. Epub 2021 Jan 9.

State Key Laboratory of Separation Membranes and Membrane Processes, School of Textiles Science and Engineering, Tiangong University, Tianjin 300387, China.

This paper reports a novel thin-film nanocomposite (TFN) membrane with a dense, flat, and hydrophilic polyamide (PA) layer. The atypical PA structure was obtained by the cross-linking reaction of graphene oxide quantum dots containing amino groups (NH-GOQDs) with triacyl chloride and polyamide oligomers. And the resulting TFN membrane showed a flat (small-scale ridge structure) and smooth surface. Meanwhile, the introduction of oxygen-containing and amino functional groups increased surface hydrophilicity. The reaction of amino groups on the NH-GOQDs with acid chloride groups and the carboxyl groups (in the linear part of the polyamide) enhanced the degree of cross-linking of the PA layer, forming a compact surface. Owning to the dense surface structure, excellent hydrophilicity, and small water transmission distance, the optimized TFN membrane exhibited an enhanced water flux of 26.57 L⋅m⋅h with a low reverse salt flux of 6.0 g⋅m⋅h. Furthermore, nano-indentation/scratch results showed the interface adhesion between substrate and PA layer was improved due to the physical anchoring of NH-GOQDs in the substrate. And in the long-term FO test, the TFN membrane showed stable selectivity. This work proves that the targeted structural design of the PA layer at the nanoscale will have a positive impact on desalination field.
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http://dx.doi.org/10.1016/j.jcis.2021.01.004DOI Listing
May 2021

Simultaneous enantioselective analysis of illicit drugs in wastewater and surface water by chiral LC-MS/MS: A pilot study on a wastewater treatment plant and its receiving river.

Environ Pollut 2021 Jan 8;273:116424. Epub 2021 Jan 8.

State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; College of Water Sciences, Beijing Normal University, Beijing, 100875, China. Electronic address:

An enantioselective method for quantifying amphetamine-type chiral illicit drugs (CIDs) in wastewater and surface water was developed, validated, and applied to samples from a wastewater treatment plant (WWTP) and its effluent-receiving river in Beijing, China. Water samples were subjected to solid-phase extraction (SPE) and then quantified via liquid chromatography-tandem mass spectrometry. The enantioseparation of CIDs was performed with a CHIRALPAK CBH column. Chromatographic parameters, including mobile phase composition and flow rates, were tested to identify the satisfactory enantiomeric resolution. The SPE method was optimized by evaluating variables, including SPE cartridge types, extraction solvents, and solvent volumes. The Oasis HLB sorbent showed good performance with recoveries exceeding 60% and matrix effects ranging from -19.6% to 26.6% for most target enantiomers, except for norephedrine (NE), in three different aquatic matrixes. The established method was superior to previously reported methods and had a low limit of detection, low limit of quantification, and short runtime (<45 min). The repeatability and reproducibility of the method reached 19.1% and 17.8%, respectively. The method was successfully utilized to monitor the daily variations in CIDs in the influent, effluent, and effluent-receiving river of a WWTP in Beijing over 1 week. The common occurrence of 1 R,2 S-(-)-ephedrine (1 R,2 S-(-)-EPH), 1 S,2 S-(+)-pseudoephedrine (1 S,2 S-(+)-PEPH), R-(-)-methamphetamine (METH), and S-(+)-METH in wastewater samples was observed. Ephedrines (1 R,2 S-(-)-EPH and 1 S,2 S-(+)-PEPH) were the most abundant CIDs in the influent, effluent, upstream, and downstream samples with concentrations of 725.8 ± 181.2 ng/L, 22.9 ± 4.9 ng/L, 12.96 ± 0.79 ng/L, and 11.6 ± 6.7 ng/L, respectively. METH was detectable in most water samples and was present in excess in S-enantiomer form in the influent and in R-enantiomer form in the effluent and surface water. R-(-)-MDMA was detected at a concentration of up to 2.4 ng/L in the influent. The metabolites norketamine (NK), amphetamine(AMP), MDA, and NE were not detected in water samples given the low concentration of their parent drugs.
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http://dx.doi.org/10.1016/j.envpol.2021.116424DOI Listing
January 2021

Spatial distribution, historical trend, and ecological risk assessment of phthalate esters in sediment from Taihu Lake, China.

Environ Sci Pollut Res Int 2021 May 16;28(20):25207-25217. Epub 2021 Jan 16.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

In this study, the distribution of phthalate esters (PAEs) in twenty surface sediment and five core sediment samples in Taihu Lake, China, was investigated, and their ecological risks were assessed. Of the 10 PAE congeners, five PAEs including diethyl phthalate (DEP), dimethyl phthalate (DMP), di-n-butyl phthalate (DBP), di-iso-butyl phthalate (DIBP), and bis(2-ethylhexyl) phthalate (DEHP) were identified and quantified, and the rest 5 PAEs were below the limits of quantification. The concentrations of the total PAEs (ΣPAEs) in surface sediments and core sediments varied from 1.12 × 10 to 18.71 × 10 ng/g and 0.23 × 10 to 5.22 × 10 ng/g, respectively. The dominant PAEs were DBP and DIBP, contributing 85.90% to the ΣPAEs. Overall, the highest concentrations of ΣPAEs occurred in northern lake, followed by eastern lake and western lake, and southern lake was the least polluted area. The spatial distribution of ΣPAEs in sediments showed that the PAE distribution pattern was influenced by the riverside environment. The historical trend of the past 100 years was reconstructed in the core sediment via a Pb dating technique. The vertical profile of the PAE congeners indicated that concentrations of PAEs started to increase since the 1990s in northern core sediments. It was estimated that the inventories of ΣPAEs in Taihu Lake was 4868.01 t. The potential ecological risk assessment by hazard quotient (HQ) method revealed that DBP posed a moderate risk due to its relatively high concentrations, with DIBP posed a low risk, while DEP, DMP, and DEHP exhibited no risk to the aquatic system.
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http://dx.doi.org/10.1007/s11356-021-12421-yDOI Listing
May 2021

Silicate glass [email protected]/CuVO p-n heterojunction for enhanced visible light photo-degradation of sulfamethoxazole: High charge separation and interfacial transfer.

J Hazard Mater 2021 01 29;402:123790. Epub 2020 Aug 29.

College of Materials Science and Engineering, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Laboratory for Biopolymers and Safety Evaluation, Shenzhen University, Shenzhen, 518055, PR China. Electronic address:

Focusing on the treatment of pharmaceuticals contaminated water by advanced oxidation processes, a novel three dimensional silicate glass matrix (3-DG) coupled CuO/CuVO p-n heterojunction was constructed by in-situ hydrothermal technique. The optimal CuO/CuVO with 30 wt % CuVO (CV-30) degrades 90.1 % sulfamethoxazole (SMX) in 60 min and nearly 100 % removal in 45 min via coupling with 3-DG. Under natural sunlight ∼ 80 % SMX removal was observed. The internal electric field of the p-n junction facilitates the electron flow via the interface. 3-D silicate glass increases the visible light absorption dramatically via internal reflection which facilitates higher exposure for the junction and shortens the diffusion length of charge carriers. The effect of reaction parameters suggests that HCO and CO ions substantially escalate the SMX removal rate. Scavenging experiments and ESR probe suggest O as the main active species followed by OH radicals. The degradation products were detected by LC-MS analysis and a degradation mechanism was also predicted. The photocatalytic mechanism was explained in terms of the electron transfer facilitated by conventional transfer and Z-scheme. This strategy to construct such highly visible and solar active p-n heterojunctions will pave way for future opportunities for the degradation of recalcitrant pharmaceutical pollutants.
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http://dx.doi.org/10.1016/j.jhazmat.2020.123790DOI Listing
January 2021

Analysis of Mg/Li separation mechanism by charged nanofiltration membranes: visual simulation.

Nanotechnology 2021 Feb;32(8):085703

State Key Laboratory of Separation Membranes and Membrane Processes, School of Textiles Science and Engineering, Tiangong University, Tianjin 300387, People's Republic of China.

The mechanism of the nanofiltration (NF) membrane separation of Mg and Li needs to be further investigated, but some commonly used model theories are abstract, which makes them difficult to understand. More importantly, the relationship between the membrane charge and separation performance of Mg and Li cannot be quantitatively analyzed. It is worth studying these challenges and providing a performance boost for Mg/Li filtration applications of NF membranes. Here, various NF membranes, with the membrane volumetric charge density increasing from -4.69 to 7.02 mol · m, were fabricated via interfacial polymerization. For these membranes, the separation factor S was decreased from 0.41 to 0.20. Importantly, the visual simulation results were consistent with the experimental results as a whole. The separation factor S decreased with the increase of volumetric charge density, and the minimum separation factor S of the NF membranes was 0.20 (experiment) and 0.17 (simulation), respectively. This meant that the performance of the positively charged NF membrane was not fully developed. Furthermore, we analyzed the relationship between the membrane charge and separation performance, and visualized the simulation of the NF membrane filtration and separation.
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http://dx.doi.org/10.1088/1361-6528/abc98bDOI Listing
February 2021

Efficient removal of levofloxacin from different water matrices via simultaneous adsorption and photocatalysis using a magnetic AgPO/rGO/CoFeO catalyst.

Chemosphere 2021 Apr 4;268:128834. Epub 2020 Nov 4.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address:

A magnetic AgPO/rGO/CoFeO ternary catalyst was firstly prepared and used for removing levofloxacin (LVF) from different water matrices via simultaneous adsorption and photocatalysis. Compared with AgPO and AgPO/CoFeO, AgPO/rGO/CoFeO shows a superior adsorption-photocatalysis performance for LVF elimination since rGO component not only improves the adsorption ability but also enhances the charge separation efficiency of the catalyst. About 90.7% of LVF in distilled water (10 mg/L) was removed by the ternary catalyst after adsorption for 0.5 h and photocatalysis for 1.0 h, and the removal of LVF performed well in the pH range of 3.51-9.47. Singlet oxygen (O) was the major reactive oxygen species for LVF degradation in AgPO/rGO/CoFeO system under visible light, as confirmed by the quenching experiments and ESR study. Based on the detected intermediates in the photocatalytic process, the possible LVF degradation pathways were well-established. As-synthesized AgPO/rGO/CoFeO can also efficiently remove LVF from the different real water matrices (river water, lake water and secondary effluent) via simultaneous adsorption and photocatalysis. Moreover, magnetic AgPO/rGO/CoFeO can be easily recovered and effectively reused for the removal of LVF in actual water bodies.
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http://dx.doi.org/10.1016/j.chemosphere.2020.128834DOI Listing
April 2021

Aqueous chlorination of ephedrine: Kinetic, reaction mechanism and toxicity assessment.

Sci Total Environ 2020 Oct 12;740:140146. Epub 2020 Jun 12.

State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

Ephedrine (EPH) is widely detected in the water environment, because it is the major ingredient in drugs treating influenza, asthma or hypotension, and is also a highly sought-after chemical precursor in the illicit manufacture of methamphetamine. In this study, transformation of EPH during the chlorination process was investigated for the first time, and the impact of water parameters including pH, different cations and anions on EPH transformation was evaluated as well. The degradation of EPH in the presence of NaClO fit the second order reaction kinetics, with a rate constant of 7.43 × 10 ((mol·L)·min). Increasing the dosage of NaClO increased the observed pseudo first order rate constant for EPH degradation (k). Degradation rate of EPH decreased with the increasing pH from 2.0 to 10.0, due to the formation of a chlorammonium intermediate that reacted with NaClO. Low concentration of Br and I did not exert significant influence on the degradation of EPH, while at high concentrations a promotive effect was observed. Other ions including Fe, Cu, NO, SO, Mg and Ca exerted negative effects even at relatively low concentrations. Based on the degradation products/intermediates identified by UPLC-MS/MS, the EPH degradation pathways were proposed. The reaction mechanism involved in the EPH degradation included dehydration, hydroxylation, deamination and demethylation. Toxicity assays by V. qinghaiensis sp. nov proved that the EPH transformation products were much more toxic than the parent compound. Results indicated that chlorination is an effective approach for the elimination of EPH in the aquatic environment, however, attention should be paid to its toxicity involvement during the chlorination process.
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http://dx.doi.org/10.1016/j.scitotenv.2020.140146DOI Listing
October 2020

Improvement of PVDF nanofiltration membrane potential, separation and anti-fouling performance by electret treatment.

Sci Total Environ 2020 Jun 9;722:137816. Epub 2020 Mar 9.

State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China.

Electret treatment was a simple method to enhance the charge-electrode properties of polyvinylidene fluoride (PVDF) materials due to the increase of space charge and polarization charge of PVDF materials. The polarization charge was due to the electric dipole orientation change in loose nanofiltration PVDF membrane, which increased the electric dipole moment and improved the polarity of surface potential. Importantly, electret charges were less affected by ambient humidity. Therefore, the electret treatment could improve the surface negative potential of loose nanofiltration PVDF membrane, so as to improve its anti-fouling performance under certain conditions. Based on the above theoretical analysis, the influence and mechanism of the electret treatment on the surface potential, morphology, structure, hydrophilicity and anti-pollution performance of PVDF membrane were studied in this manuscript. When the electret time was 7.5 min and the electret voltage was 30 kV, the surface negative potential was the highest. The content of β phase crystals was 39.1%, which was 12.18% higher than that of untreated membrane. In addition, the surface morphology of PVDF membrane did not change significantly, but the water contact angle decreased slightly, and the pore size increased by 0.36-0.75 nm. Importantly, the flux and the rejection of dye and BSA increased to some extent, and the maximum rejection rate and water flux were increased by 10.34% and 20.25%, respectively. Through the cyclic filtration test and analysis, the anti-fouling performance of membrane was increased due to electrostatic repulsion.
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http://dx.doi.org/10.1016/j.scitotenv.2020.137816DOI Listing
June 2020

Occurrence and Risk Assessment of Antibiotics in Manure, Soil, Wastewater, Groundwater from Livestock and Poultry Farms in Xuzhou, China.

Bull Environ Contam Toxicol 2019 Oct 5;103(4):590-596. Epub 2019 Sep 5.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

Antibiotics in manure, soil, wastewater, and groundwater samples from the livestock and poultry farms in Xuzhou City were investigated in the present study. The concentrations of antibiotics in all matrices varied greatly among farms. Total concentrations of fluoroquinolones and macrolides were much higher than those of sulfonamides in manures and soil samples. Total concentrations of antibiotics in wastewater of livestock farms were higher than those of poultry farm. Josamycin (JM) and tilmicosin (TIL) accounted for more than 74% of the nine macrolides in all groundwater samples. Sulfamethizole (SMT), fleroxacin (FLE), cinoxacin (CIN) and JM were the main antibiotics detected in manure and soil samples, while sulfamethoxypyridazine (SMP), sulfameter (SME), SMT, FLE, JM and TIL accounted for a large proportion of antibiotics in surface and groundwater. The risk assessment of target antibiotics revealed that JM in wastewater showed relatively high RQs for aquatic organisms.
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http://dx.doi.org/10.1007/s00128-019-02692-0DOI Listing
October 2019

Development and application of the analytical method for illicit drugs and metabolites in fish tissues.

Chemosphere 2019 Oct 3;233:532-541. Epub 2019 Jun 3.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; College of Water Sciences, Beijing Normal University, Beijing 100875, China. Electronic address:

In this study, we developed a screening method for highly accurate and sensitive analysis of 12 illicit drugs and metabolites in fish tissues. The approach was based on ultrasonic-assisted extraction and solid phase extraction, followed by ultra-performance liquid chromatography-tandem mass spectrometry analysis. The homogenized samples were ultrasonic-assisted extracted with 1% acetic acid in methanol followed by SPE cleanup with Oasis MCX cartridge. The method was validated in accordance with the European Medicines Agency guidelines by evaluating the following required parameters: the limits of detection and limits of quantification, linearity, accuracy, repeatability, recovery of extraction, and matrix effect. For the tissues involved in this study, the recoveries ranged from 60% to 127%, and the matrix effect ranged from -19% to 83% with the inter- and intra-day variability below 12%. The method has been successfully applied to wild fish caught from six sampling sites of four urban rivers in Beijing, China. The analysis showed that the target compounds, including amphetamine, 3,4-methylenedioxyamphetamine, codeine and heroin were detected with high detection frequencies. Codeine exhibited the highest bioaccumulation factor (up to 73,986) in the muscle of Crucian carp, while ketamine tended to accumulate in the skin, 3,4-methylenedioxyamphetamine and heroin tended to accumulate in gastrointestinal tract, respectively.
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http://dx.doi.org/10.1016/j.chemosphere.2019.06.018DOI Listing
October 2019

Tetracycline degradation by persulfate activated with magnetic Cu/CuFeO composite: Efficiency, stability, mechanism and degradation pathway.

J Hazard Mater 2019 07 19;373:85-96. Epub 2019 Mar 19.

North China University of Science and Technology, Tangshan 063210, Hebei, China. Electronic address:

Magnetically separable Cu/CuFeO composite obtained by a solvothermal method was used to active persulfate (PS) for the removal of tetracycline (TC). Under different pH conditions, Cu/CuFeO catalyst exhibited a higher catalytic activity for PS activation to degrade TC than that of CuFeO. The effects of some key parameters including initial pH value, PS concentration, catalyst dosage, reaction temperature and coexisting ions on TC degradation were investigated in Cu/CuFeO/PS system. The reuse of Cu/CuFeO catalyst at pH 3.50, 7.00 and 11.00 indicated that the catalyst showed a low stability due to the corrosion of metallic copper (Cu°), but bicarbonate ions could enhance the stability and recyclability of this catalyst through the suppression of copper leaching. Both sulfate and hydroxyl radicals were the main reactive species in Cu/CuFeO/PS system. Cu° can not only work as electron donor to active PS to produce the reactive radicals but also act as an electron bridge to facilitate the fast electron transfer between PS and catalyst. The structural cuprous and ferrous ions on the surface of CuFeO participated in the PS activation process through the redox reactions, as confirmed by XPS analysis. The possible degradation pathways of TC were proposed based on the identified intermediates.
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http://dx.doi.org/10.1016/j.jhazmat.2019.03.075DOI Listing
July 2019

In-situ fabrication of Ag/P-g-CN composites with enhanced photocatalytic activity for sulfamethoxazole degradation.

J Hazard Mater 2019 03 29;366:219-228. Epub 2018 Nov 29.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address:

A series of Ag/P-g-CN composites with different Ag content were synthesized for the first time by thermal polymerization combined with photo-deposition method. The composites were characterized by X-ray powder diffraction, field emission scanning electron microscope coupled with energy-dispersive X-ray spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, ultraviolet-visible diffuse reflectance spectra, N absorption-desorption and X-ray photoelectron spectroscopy. Ag was successfully dispersed on the surface of P-g-CN. The photocatalytic performance of P-g-CN and Ag/P-g-CN was evaluated by degrading sulfamethoxazole (SMX) under visible light irradiation. In the presence of 5% Ag/P-g-CN, 100% of SMX was degraded within 20 min. The enhanced photocatalytic activity of Ag/P-g-CN was attributed to the surface plasmon resonance effect of metallic Ag and Schottky barrier formed on the interface between Ag and P-g-CN, which could speed up the generation rate of electrons and holes and inhibit the recombination of photogenerated electron-hole pairs. The radical quenching tests indicated that holes and superoxide radicals were the dominant active species involved in SMX degradation. The synthesized materials maintained high catalytic activity after five cycle runs. The concentration and the intermediates during the degradation process were determined by LC-MS/MS, and the tentative degradation pathways of SMX in photocatalytic system were proposed.
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http://dx.doi.org/10.1016/j.jhazmat.2018.11.104DOI Listing
March 2019

High-Performance Photocatalytic Hydrogen Production and Degradation of Levofloxacin by Wide Spectrum-Responsive Ag/FeO Bridged SrTiO/g-CN Plasmonic Nanojunctions: Joint Effect of Ag and FeO.

ACS Appl Mater Interfaces 2018 Nov 13;10(47):40474-40490. Epub 2018 Nov 13.

College of Materials Science and Engineering, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Laboratory for Biopolymers and Safety Evaluation , Shenzhen University , Shenzhen , 518055 , PR China.

Highly photoresponsive semiconductor photocatalysis for energy and environmental applications require judicious choice and optimization of semiconductor interfaces for wide spectral capabilities. This work aims at rational designing of highly active SrTiO/g-CN junctions bridged with Ag/FeO nanoparticles for utilizing Z-scheme transfer and surface plasmon resonance effect of Ag augmented by iron oxide. The SrTiO/(Ag/FeO)/g-CN (SFC) catalyst was employed for photocatalytic hydrogen production and photodegradation of levofloxacin (LFC; 20 mg/L) under UV, visible, near infra-red, and natural solar light exhibiting high performance. Under visible light (<780 nm), SFC-3 sample (30 wt % g-CN and 3% Ag/FeO) shows a H evolution of 2008 μmol g h which is ∼14 times that of bare g-CN. In addition, 99.3% removal of LFC was degraded in 90 min under visible light with retention of activity under sun. The inherent topological properties, complete, higher charge separation, and reduced recombination allowed this catalyst for a high photocatalytic response which was proved by UV-diffuse reflectance spectroscopy, photoluminescence, electrochemical impedance spectroscopy, and photocurrent response measurements. Scavenging experiments and electron spin resonance analysis reveal that the mechanism shifts from a dual charge transfer in case of binary junction to essential Z-scheme with incorporation of Ag/FeO. Both O and OH are main active radicals in visible light, whereas O majorly participate under UV. The synergistic effect of SrTiO, g-CN, and plasmon resonance of Ag/FeO not only improves light response and reduce recombination but also enhances the redox-ability of charge carriers. A H production mechanism and LFC degradation pathway (degradation, defluorination, and hydrolysis) has been predicted. This work paves a way for development of photocatalysts working in practical conditions for pollution and energy issues.
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http://dx.doi.org/10.1021/acsami.8b12753DOI Listing
November 2018

Dynamic transport of antibiotics and antibiotic resistance genes under different treatment processes in a typical pharmaceutical wastewater treatment plant.

Environ Sci Pollut Res Int 2018 Oct 28;25(30):30191-30198. Epub 2018 Aug 28.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

The propagation of antibiotic resistance is a challenge for human health worldwide, which has drawn much attention on the reduction of the resistance genes. To understand their occurrence during different treatment processes, in this study, four classes of antibiotics (tetracyclines, sulfonamides, quinolones, and macrolides), eight antibiotic resistance genes (ARGs) (tetB, tetW, sul1, sul2, gyrA, qepA, ermB, and ermF), and two mobile elements (int1 and int2) were investigated in a typical pharmaceutical plant. The total concentrations of antibiotics were detected in the range of 2.6 × 10 to 2.5 × 10 ng/L in the treatment processes, and the high abundance of ARGs was detected in the biological treatment unit. The dynamic trend analysis showed that antibiotics were partially removed in the anaerobic/aerobic processes, where ARGs were proliferated. The abundance of tetB and gyrA genes was positively correlated with pH and EC (p < 0.05), and the tetW, sul1 and sul2 genes were significantly correlated with TOC, TN, and DO (p < 0.05), indicating the influence of physicochemical properties of the solution on the levels of ARG subtypes. The phylogenetic analysis showed that the tetW clones had high homology with some pathogenic microorganisms, such as Klebsiella pneumonia and Neisseria meningitides, which would threaten human health. Results indicated that the horizontal transfer acted as a major driver in the ARGs evolution.
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http://dx.doi.org/10.1007/s11356-018-2913-2DOI Listing
October 2018

Spatiotemporal profile of tetracycline and sulfonamide and their resistance on a catchment scale.

Environ Pollut 2018 Oct 19;241:1098-1105. Epub 2018 Jun 19.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

Tetracyclines and sulfonamides are the two classes of antibiotics commonly used in the medical, industrial and agricultural activities. Their extensive usage has caused the proliferation and propagation of resistant bacteria (ARB) and resistance genes (ARGs) in the environment. In this study, the occurrence and distribution of tetracyclines (TC, OTC and CTC) and sulfonamides (SMX, SCX and TMP), their associated ARB and ARGs were quantified in water and sediments collected from the mainstream of Liaohe River, northeast China. The average concentration of tetracyclines was higher in May, while the concentration of sulfonamides was slightly higher in October. The highest concentrations of the total tetracyclines and sulfonamides in sediments were 2.7×10 ng/g and 2.1×10 ng/g respectively detected in May. All detected ARGs were found generally with high abundance. The tetA, tetB and tetE genes were dominant (4.4×10 to 9.8×10 copies of tet genes/copies of 16S rRNA genes) in total communities, and the average abundance of sul genes was expressed above 10 in the water samples in May and October. Redundance analysis (RDA) and principle component analysis (PCA) indicated that the antibiotic residue was the most important contributor to the level of tetracycline and sulfonamide resistance genes, and some hydrogeological conditions (e.g. flow rate, intersection settlement) influenced the distribution of resistance genes. Results from this study could help understand the proliferation and propagation of antibiotic resistance on a river catchment scale and mitigate the potential risks to public health.
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http://dx.doi.org/10.1016/j.envpol.2018.06.050DOI Listing
October 2018

Primary hemosiderotic fibrolipomatous tumor in bone: a case report and review of the literature.

Int J Clin Exp Pathol 2018 1;11(5):2497-2505. Epub 2018 May 1.

Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University Sanghai, China.

Hemosiderotic fibrolipomatous tumor (HFLT) is a locally invasive tumor composed of mature adipocytes accompanied by spindle cells containing hemosiderin deposition. In 2013, it was categorized by WHO as a soft tissue tumor with uncertain differentiation. So far, the literature has reported 60 cases but primary HFLT in bone has never before been reported. We set out to investigate the clinicopathological features of primary HFLT in bone. We retrospectively reviewed the clinical, imaging, histological, and immunophenotypic features and treatment of 1 case of primary HFLT in bone, and combined this with literature discussion. HFLT occurred in the lateral femoral condyle of a 50-year-old male patient, which might have been overlooked were it not for the knee-joint pain and dysfunction. CT and MRI showed osteolytic bone destruction with a clear 4.0-cm diameter boundary, diagnosed as cystic damage of the lateral condyle of the left femur. SPECT metabolism was not active. Histologically, the lesion was composed of different proportions of mature fat cells, spindle cells, and hemosiderin. Immunohistochemistry revealed spindle cells expressing vimentin, p63, but not CD34, calponin, and others. The tumor tissue was thoroughly removed by curetting, and a bone graft was carried out after immersion in anhydrous ethanol. At the 11-month postoperative follow-up, the patient was recovering well. Primary HFLT in bone is extremely rare. In imaging, it can easily be misdiagnosed as a bone cyst. Histological morphology of the current case is similar to that of soft tissue HFLT.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958266PMC
May 2018

Predicting trace metal bioavailability to chironomids in sediments by diffusive gradients in thin films.

Sci Total Environ 2018 Sep 25;636:134-141. Epub 2018 Apr 25.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

The technique of diffusive gradients in thin films (DGT) has been developed as a promising tool to assess metal bioavailability in sediment. However, it has yet to be determined whether the DGT-labile metal in sediment is representative of bioavailable fraction for benthic organisms. In this study, the performance of DGT for predicting metal bioavailability was evaluated by exposing DGT and chironomids Chironomus tentans to a series of metal-contaminated natural sediments in the laboratory. Conventional methods, including acid-volatile sulfides and simultaneously extracted metals method, and total recoverable and dilute-acid extractable metal concentrations were also used to assess the availability of Zn, Cu and Pb to chironomids. The bioassay results showed that >70% of the larvae (73 ± 1.7%-98 ± 0.5%) survived in all sediment samples, however, an enhanced uptake of Zn, Cu and Pb by C. tentans in contaminated sediments was observed compared to control sediments. The correlation analyses indicated that the total recoverable metal concentrations and DGT-metal fluxes in the surficial sediment (-1 cm) were all significantly associated with metal bioaccumulation in C. tentans (p < 0.01). Given the advantages of DGT devices for in situ and time-averaged measurement of the potentially bioavailable fraction, DGT-metal fluxes were proved to be a better surrogate to predict C. tentans response to metal contamination. The results further supported the applicability of the DGT technique as an alternative method to assess the bioavailability of metals in sediment to benthic invertebrates.
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http://dx.doi.org/10.1016/j.scitotenv.2018.04.285DOI Listing
September 2018

Development and application of the diffusive gradients in thin films technique for simultaneous measurement of methcathinone and ephedrine in surface river water.

Sci Total Environ 2018 Mar 10;618:284-290. Epub 2017 Nov 10.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

In this study, a passive sampling technique, diffusive gradients in thin films (DGT) was developed to simultaneously measure two drugs, methcathinone (MC) and ephedrine (EPH) in surface water. Four types of binding gels and four types of filter membranes were tested for the optimal configuration. XAD18 agarose binding gel and agarose diffusive gel, together with polyethersulfone filter membrane were used for measuring MC and EPH in the DGT device. 5% NH in acetonitrile was used as the elution solvent, with the elution efficiency for MC and EPH higher than 71%. At 25°C, the diffusion coefficients of MC and EPH in the diffusive gel were 7.60×10cms and 6.62×10cms, respectively. The DGT was effective in a wide range of pH (4-11) and ionic strength (NaCl: 0.001-0.5M). The DGT device was deployed in Beijing urban surface water for successive 7days to measure the time-weighted concentrations of MC and EPH. Results showed that EPH was detected in all samples, while MC was below its detection limit. DGT concentrations were comparable to the concentrations determined by SPE. This study demonstrated that the developed DGT method was effective to monitor the two drugs in surface water in situ.
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http://dx.doi.org/10.1016/j.scitotenv.2017.11.068DOI Listing
March 2018

Investigation and Application of a New Passive Sampling Technique for in Situ Monitoring of Illicit Drugs in Waste Waters and Rivers.

Environ Sci Technol 2017 Aug 4;51(16):9101-9108. Epub 2017 Aug 4.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences , 100012 Beijing, China.

Illicit drugs constitute a class of emerging contaminants that has been drawing significant concern due to its potent pharmacological and biological activities. In this study, an in situ passive sampling approach that uses diffusive gradients in thin films (DGT) was successfully tested for measuring ketamine (KET), methamphetamine (METH), and amphetamine (AMP) in water. The diffusion coefficients of KET, METH, and AMP in diffusive gel were (8.13 ± 0.12) × 10, (8.55 ± 0.14) × 10, and (7.72 ± 0.18) × 10 cm s at 22 °C, respectively. The capacities of an XAD binding gel for KET, METH, and AMP were 92, 57, and 45 μg per binding gel disc, which were suitable for long-term environmental monitoring. The DGT measurement of these drugs was not influenced by the pH (4 to 9) and the ionic strength (0.001 M - 0.1 M) and unaffected by the water flow, demonstrating the effectiveness of the XAD-based DGT for the in situ monitoring of illicit drugs. DGT samplers were deployed in a WWTP influent and natural rivers in Beijing, China. The ng L levels of the drugs were high in the wastewater influent and low in river waters, with an insignificant fluctuation during the seven-day monitoring. The DGT-measured concentrations were comparable to the average concentrations determined by SPE method, which suggested that the average data measured by DGT could be substituted for high-frequency grab sampling. This study has demonstrated systematically for the first time that DGT is effective and accurate for monitoring illicit drugs in wastewater and surface waters, and provides a powerful tool to investigating the presence, transport, and environmental behaviors of these drugs in the aquatic ecosystem.
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http://dx.doi.org/10.1021/acs.est.7b00731DOI Listing
August 2017

Photocatalytic removal of tetrabromobisphenol A by magnetically separable flower-like BiOBr/BiOI/FeO hybrid nanocomposites under visible-light irradiation.

J Hazard Mater 2017 Jun 20;331:1-12. Epub 2017 Feb 20.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

A novel flower-like three-dimensional BiOBr/BiOI/FeO heterojunction photocatalyst was synthesized using a simple in situ co-precipitation method at room temperature. The hybrid composites were characterized by a couple of techniques including X-ray powder diffraction, scanning electron microscope, transmission electron microscopy, ultraviolet-visible diffuse reflection spectroscopy, Brunauer-Emmett-Teller, X-ray photo-electron spectroscopy, photoluminescence technique, and vibrating sample magnetometer. FeO nanoparticles were perfectly loaded on the surface of BiOBr/BiOI microspheres. The recyclable magnetic BiOBr/BiOI/FeO was employed to degrade TBBPA under visible light irradiation. The optimal removal efficiency of the ternary BiOBr/BiOI/FeO (2:2:0.5) nanocomposite reached up to 98.5% for TBBPA in aqueous solution. The superior photocatalytic activity of BiOBr/BiOI/FeO was mainly ascribed to large surface area and appropriate energy gaps, resulting in the effective adsorption and separation of electrons-hole pairs. The photogenerated reactive species determined by free radicals trapping experiments revealed that the excellent catalytic activity was primarily driven by O radical. The photocatalytic degradation kinetics and a detailed mechanism were also proposed. Result demonstrated that the BiOBr/BiOI/FeO can be magnetically recycled, and maintain high photocatalytic activity after reuse over five cycles. It suggested that the synthesized material had a potentially promising application for TBBPA removal by photocatalytic degradation from wastewater.
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http://dx.doi.org/10.1016/j.jhazmat.2017.02.030DOI Listing
June 2017

X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-ß1/Smad3 and p38 MAPK pathway.

Anatol J Cardiol 2017 May 17;17(5):367-373. Epub 2017 Jan 17.

Department of Cardiovascular Medicine, The 152nd Central Hospital of PLA, Pingdingshan, Henan 467000-China.

Objective: Xindening oral liquid (Xin) is a widely used traditional Chinese medicine for the treatment of chronic heart failure (CHF). However, the exact mechanisms related to its therapeutic effects against CHF remain unclear. In the present study, we investigate the effects of Xin on cardiac function in CHF rats and the possible mechanisms involved.

Methods: Transverse aortic constriction (TAC) was conducted to induce a CHF rat model in this study. Sixty male Wistar rats were randomly assigned to six groups 28 days after TAC: sham; CHF model; Xin at concentrations of 5 ml/kg, 10 mL/kg, and 20 mL/kg; and QiLi 0.6 g/kg. After four weeks, the rats were treated with Xin (5, 10, or 20 mL/kg/d) for six weeks consecutively. At the end of the study, the cardiac function, heart weight index (HWI) and left ventricular mass index (LVMI), serum level of LDH, B-type natriuretic peptide (BNP), cTnI and CK-MB, and collagen volume fraction were studied. The expression of transforming growth factor-ß1 (TGF-ß1), drosophila mothers against decapentaplegic protein 3 (Smad3), and p38 mitogen activated protein kinase (p38 MAPK) were detected.

Results: The results showed that Xin treatment significantly improved cardiac function but decreased the serum level of LDH, BNP, cTnI, and CKMB of CHF rats. In addition, it reduced the HWI, LVMI, and collagen volume fraction compared with the model group. Xin treatment significantly improved cardiac function and attenuated cardiac fibrosis by suppressing the p38 MAPK and TGF-ß1/Smad3 signaling pathway in CHF rats.

Conclusion: These results suggested that Xin might be a promising complementary treatment for CHF. More detailed experimental studies will be carried out in our subsequent research.
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http://dx.doi.org/10.14744/AnatolJCardiol.2016.7438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469083PMC
May 2017

Drugs of abuse and their metabolites in the urban rivers of Beijing, China: Occurrence, distribution, and potential environmental risk.

Sci Total Environ 2017 Feb 22;579:305-313. Epub 2016 Nov 22.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

The occurrence and distribution of five drugs of abuse and their metabolites, namely, methamphetamine (METH), amphetamine (AMP), ketamine (KET), ephedrine (EPH), and hydroxylimine (HY), were investigated in the surface water in urban rivers in Beijing, China. A total of 117 surface water samples were collected from the seven rivers in the Beijing urban areas during four different seasons. Laboratory analyses revealed that EPH and METH were the most predominant drugs, with detection frequency ranging from 94% to 100% and from 65% to 100%, respectively. High levels of METH and KET were observed in the center part of the urban areas, which was likely associated with the drug abuse and the entertainment activities. Seasonal variation of the drug occurrence showed that the highest concentration of drugs of abuse was found during winter, which was likely due to the high consumption, low temperature, and low water flows during the cold weather. By contrast, the concentration and detection frequency of AMP and HY were relatively low. Risk assessment by the risk quotient method indicated that the five drugs of abuse and their metabolites were not likely to exert biological effects on the aquatic ecosystems at current levels in the surface water. However, the potential adverse effect of drugs of abuse and their metabolites on ecosystem functioning and human health should not be neglected.
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http://dx.doi.org/10.1016/j.scitotenv.2016.11.101DOI Listing
February 2017

HO and/or TiO photocatalysis under UV irradiation for the removal of antibiotic resistant bacteria and their antibiotic resistance genes.

J Hazard Mater 2017 Feb 19;323(Pt B):710-718. Epub 2016 Oct 19.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

Inactivating antibiotic resistant bacteria (ARB) and removing antibiotic resistance genes (ARGs) are very important to prevent their spread into the environment. Previous efforts have been taken to eliminate ARB and ARGs from aqueous solution and sludges, however, few satisfying results have been obtained. This study investigated whether photocatalysis by TiO was able to reduce the two ARGs, mecA and ampC, within the host ARB, methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, respectively. The addition of HO and matrix effect on the removal of ARB and ARGs were also studied. TiO thin films showed great effect on both ARB inactivation and ARGs removal. Approximately 4.5-5.0 and 5.5-5.8 log ARB reductions were achieved by TiO under 6 and 12mJ/cm UV fluence dose, respectively. For ARGs, 5.8 log mecA reduction and 4.7 log ampC reduction were achieved under 120mJ/cm UV fluence dose in the presence of TiO. Increasing dosage of HO enhanced the removal efficiencies of ARB and ARGs. The results also demonstrated that photocatalysis by TiO was capable of removing both intracellular and extracellular forms of ARGs. This study provided a potential alternative method for the removal of ARB and ARGs from aqueous solution.
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http://dx.doi.org/10.1016/j.jhazmat.2016.10.041DOI Listing
February 2017
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