Publications by authors named "Changqing Zhao"

102 Publications

Livin promotes Th2-type immune response in airway allergic diseases.

Immunol Res 2022 Jun 18. Epub 2022 Jun 18.

Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.

Objectives: To investigate the effects of livin on the Th2 immune response in airway allergic diseases (AAD) and explore the interaction among livin, GATA3, IL-4 in peripheral blood CD4 T cells of AAD patients.

Methods: WT mice and livin KO mice were developed for model of AAD. Th2 cell levels in the lung tissues and spleen were assessed by flow cytometry. Also, it was assessed in the culture after exposing to livin inhibitor (Lp-15); the protein and mRNA levels of livin, GATA3 and IL-4 in peripheral blood CD4 T cells isolated from patients with or without AAD were measured by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting, respectively. Finally, Co-immunoprecipitation (Co-IP) was employed to identify the interaction between livin and GATA3.

Results: Compared with WT mouse, Th2 cell frequency in lung tissues and spleen was significantly decreased in livin KO mouse; after adding Lp-15, the differentiation from Naive CD4T cells in spleen to Th2 cells was blocked; the protein and mRNA levels of livin, GATA3 and IL-4 in AAD group were higher than that in control group. The levels of livin were positively correlated with IL-4, and GATA3 was also positively correlated with IL-4 and livin. GATA3 was detected in the protein complex co-precipitated with livin antibody, and livin was also detected in the protein complex co-precipitated by GATA3 antibody.

Conclusion: Livin increases the expression of IL-4 and facilitates naive CD4 T cells to differentiate into Th2 cells, which triggers airway allergy.
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http://dx.doi.org/10.1007/s12026-022-09294-9DOI Listing
June 2022

Unilateral versus bilateral pedicle screw fixation with transforaminal lumbar interbody fusion for treatment of lumbar foraminal stenosis.

Spine J 2022 Jun 7. Epub 2022 Jun 7.

Department of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, People's Republic of China. Electronic address:

Background Context: Transforaminal lumbar interbody fusion (TLIF) with bilateral pedicle screw fixation (BPSF) is an effective treatment for lumbar foraminal stenosis (LFS). However, the effects of TLIF with unilateral pedicle screw fixation (UPSF) on LFS treatment have not been clearly elucidated.

Purpose: We conducted this study to compare clinical outcomes and radiographic results of TLIF with UPSF and BPSF 2 years after the surgical treatment.

Design: Prospective randomized study.

Patient Sample: This study included 23 patients undergoing TLIF with UPSF and 25 patients undergoing TLIF with BPSF.

Outcome Measures: Clinical outcomes were evaluated by visual analog scale (VAS) for low back pain and leg pain and Oswestry Disability Index (ODI) score. Radiographic outcomes included foraminal height, disc space height, segmental lordosis, and final fusion rates.

Methods: The clinical and radiographic outcomes were compared between the UPSF and BPSF group. The postoperative improvements were evaluated in either group. Intraoperative data such as duration of operation and estimated blood loss were collected. This study was registered at clinicaltrials.gov.

Results: Analysis of the VAS and ODI scores showed significant improvements in clinical outcomes within each group. No significant differences between the 2 groups were noted in the improvements of the VAS and ODI scores. The mean operative duration and blood loss were significantly greater in the BPSF group than in the UPSF group. There were significant improvements in the height of the foramen and intervertebral space and segmental lordosis in both groups, while there was no significant difference between the groups in amount of the improvements. No significant difference was found in the final fusion rates.

Conclusions: TLIF is an appropriate procedure for LFS treatment. With balanced intervertebral support using a cage, UPSF could achieve similar and satisfactory effects on lumbar segmental stability and fusion compared to BPSF. The unilateral approach appears to be associated with slightly shorter operative time and less blood loss.
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http://dx.doi.org/10.1016/j.spinee.2022.05.011DOI Listing
June 2022

Structural Elucidation and genetic identification of the O-antigen from a novel serogroup of Escherichia coli strain 2017LL031.

Carbohydr Res 2022 Jul 29;517:108577. Epub 2022 Apr 29.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China.

The O-antigen is an important virulence factor involved in the survival, virulence and invasion of bacteria. The bacterial serological types are highly dependent on these surface-exposed and structurally unique O-antigen structures. In this work, the structure of O-antigen from an Escherichia coli strain 2017LL031 was elucidated as a hexasaccharide repeating unit: →3)-[β-D-Glcp-(1 → 2)]-α-L-Rhap-(1 → 3)-[α-D-Quip-(1 → 3)-α-D-GlcpA-(1 → 2)]-β-L-Fucp-(1 → 3)-β-D-GlcpNAc-(1→, which is completely different from all known E. coli serogroups. The O-antigen gene cluster (O-AGC) of 2017LL031 was also analyzed and correlates well to its O-Ag. Moreover, the O-AGC of 2017LL031 was deleted and its role in O-Ag biosynthesis was confirmed experimentally. Taken together, our results present that a novel E.coli serotype 2017LL031 is identified.
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http://dx.doi.org/10.1016/j.carres.2022.108577DOI Listing
July 2022

Clinical Efficacy of Single Vidian Neurectomy in Chronic Rhinosinusitis with Nasal Polyps and Allergic Rhinitis.

J Coll Physicians Surg Pak 2022 May;32(5):618-622

Department of Otolaryngology-Head & Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, China.

Objective: To investigate the clinical efficacy of single Vidian neurectomy (sVN) in the treatment of chronic rhinosinusitis with nasal polyps and allergic rhinitis (CRSwNP &AR).

Study Design: Descriptive study.   Place and Duration of Study: Otolaryngology-Head &Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, China, February 2016 to February 2019.

Methodology: Patients meeting the diagnostic criteria for AR and CRSwNP confirmed after assessment by an ENT physician; moderately severe and persistent AR, aged ≥18 years to ≤70 years; and testing positive for sIgE and were regularly treated with medications for three months or more before surgery with unsatisfactory symptom control. Exclusion criteria were patients with acute exacerbations of sinusitis or fungal sinusitis combined with nasal polyps, intolerant to aspirin, acute infection or sinus tumours; contraindications to general anaesthetic surgery or oral corticosteroids; and those who have received allergen immunotherapy, corticosteroids and antihistamines within one year. The relevant epidemiological data were collected, including IgE level, VAS, RQLQ, and the Lund-Kennedy scores, to assess patients' clinical symptoms and quality of life before and after surgery.

Results: Fifty-five patients were followed up for two years after surgery, and statistical analysis was performed using SPSS version 25.0. It was found that VAS scores, RQLQ scores, and Lund-Kennedy scores of the patients who underwent sVN were significantly lower at six months (all p <0.01), one year (all p <0.01, and two years all p <0.01) after surgery compared with those before surgery.

Conclusion: sVN has better efficacy in patients with CRSwNP&AR, has the potential to reduce its recurrence rate, and seems to be a safe and effective treatment.

Key Words: Chronic rhinosinusitis with nasal polyps, Allergic rhinitis, Eosinophilic chronic rhinosinusitis with nasal polyps, Single Vidian neurectomy, Clinical efficacy.
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http://dx.doi.org/10.29271/jcpsp.2022.05.618DOI Listing
May 2022

[Granulomatosis with polyangiitis with head and neck symptoms as the first clinical manifestation: clinical analysis of 28 cases].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 May;36(5):362-368

Department of Otolaryngology Head and Neck Surgery,the Second Hospital of Shanxi Medical University,Key Research Laboratory of Airway Neuroimmunology,Taiyuan,030001,China.

To investigate the early clinical features and diagnosis of granulomatous polyangiitis(GPA) with head and neck symptoms as the first presentation. The data of 28 patients with GPA diagnosed in the Second Hospital of Shanxi Medical University from 2014 to 2021, whose first symptoms appeared on the head and neck, were collected. All patients underwent relevant imaging examinations, laboratory tests, endoscopy, and pathological tissue biopsies. Systemic glucocorticoid or combined immunosuppressive therapy was administered and followed up for 1-5 years. Two patients refused treatment and were lost to follow-up; 26 patients were discharged with improved symptoms, complaining of nasal ventilation, resolution of supraorbital swelling, reduced dyspnoea, and renal symptoms. Five patients were repeatedly admitted to the hospital due to recurrent renal involvement. Although GPA often begins with head and neck symptoms, it is non-specific and can easily be confused with chronic inflammatory disease, leading to misdiagnosis. If suspicious cases are identified, they should be combined with endoscopy, pathological tissue biopsy, and special laboratory tests as early as possible to shorten the time to diagnosis, and obtain early diagnosis and treatment.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2022.05.008DOI Listing
May 2022

Acupuncture for allergic rhinitis: a systematic review and meta-analysis.

Eur J Med Res 2022 Apr 25;27(1):58. Epub 2022 Apr 25.

Department of Otolaryngology, Shanxi Medical University Second Affiliated Hospital, Taiyuan, Shanxi, People's Republic of China.

Background: In this study, we attempted to assess the efficacy and safety of acupuncture for allergic rhinitis (AR), and to test the robustness of the estimated effects.

Methods: The Cochrane methodology standard was followed to conduct this systematic review. Randomized controlled trials (RCTs) comparing acupuncture with other therapies for AR were included. Furthermore, trial sequential analysis was conducted to test the robustness of pooled results. Thirty trials with 4413 participants were included.

Results: Acupuncture improved the nasal symptoms on Total Nasal Symptom Score (TNSS) and quality of life measured by Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) in adults with AR, compared to acupuncture with no intervention. Acupuncture was also shown to be more effective than sham acupuncture for nasal symptom (RQLQ subscale, n = 489, MD - 0.60, 95% CI - 1.16 to - 0.04) and quality of life (RQLQ, n = 248, - 8.47 95% CI - 14.91, - 2.03). No clear difference was observed between acupuncture and cetirizine or loratadine. Interestingly, trial sequential analysis (TSA) failed to confirm the aforementioned results. The effect of acupuncture for children/adolescents with AR remains unclear due to insufficient data. The performance bias and attrition bias are serious in most studies that were included. Selection bias may also have affected the quality of the evidence.

Conclusion: Acupuncture may have an advantage over no intervention and sham acupuncture in improving nasal symptoms and quality of life for adults with AR. The effect of acupuncture and cetirizine or loratadine for AR may be similar. Additional trials are necessary to confirm these results.
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http://dx.doi.org/10.1186/s40001-022-00682-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036742PMC
April 2022

Insights Into the Research Status of Neuromedin U: A Bibliometric and Visual Analysis From 1987 to 2021.

Front Med (Lausanne) 2022 22;9:773000. Epub 2022 Feb 22.

Department of Otolaryngology, Head and Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, China.

Neuromedin U (NMU) is a regulatory peptide that is widely distributed throughout the body and performs a variety of physiological functions through its corresponding receptors. In recent years, NMU has become the focus of attention in various fields of research as its diverse and essential functions have gradually been elucidated. However, there have been no bibliometrics studies on the development trend and knowledge structure of NMU research. Therefore, in this study, we used VOSviewer software to statistically analyze scientific data from articles related to NMU to track the developmental footprint of this research field, including relevant countries, institutions, authors, and keywords. We retrieved a total of 338 papers related to NMU, written by 1,661 authors from 438 organizations of 41 countries that were published in 332 journals. The first study on NMU was reported by a group in Japan in 1985. Subsequently, nine articles on NMU were published from 1987 to 2006. A small leap in this field could be detected in 2009, with 30 articles published worldwide. Among the various countries in which this research has been performed, Japan and the United States have made the most outstanding contributions. Miyazato M, Kangawa K, and Mori K from the Department of Biochemistry, National Retrain and Cardiovascular Center Research Institute in Japan were the most productive authors who have the highest number of citations. Keyword analysis showed six clusters: central-nervous-system, homeostasis, energy metabolism, cancer, immune inflammation, and food intake. The three most highly cited articles were associated with inflammation. Overall, this study demonstrates the research trends and future directions of NMU, providing an objective description of the contributions in this field along with reference value for future research.
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http://dx.doi.org/10.3389/fmed.2022.773000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901607PMC
February 2022

The study on psychological resilience of tinnitus and associated influencing factors.

J Otol 2022 Jan 28;17(1):13-17. Epub 2021 Aug 28.

Departments of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital, Shanxi Medical University, Taiyuan, PR China.

The association between tinnitus and psychological resilience is an underdeveloped area of research. This cross-sectional study investigated such associations and factors potentially affecting resilience in 61 patients. Demographic and psychometric data were collected by questionnaires. The Connor-Davidson Resilience Scale (CD-RISC), Medical Coping Modes Questionnaire (MCMQ), Satisfaction with Life Scale (SWLS), General Self-Efficacy Scale (GSES), Big Five Inventory (BFI) and Perceived Social Support Scale (PSSS) were completed by participants. Data were analyzed using independent test and Pearson's correlation analysis and multiple linear regression modeling. The CD-RISC score was relatively low (66.97 ± 15.71), negatively correlated with tinnitus (r = -0.276,  < 0.001) and associated with age (r = 0.270,P<0.001). As protective factors, SWLS (r = 0.486,  < 0.001), GSES (r = 0.555,  < 0.001), PSSS (r = 0.538,  < 0.001) and extraversion were positively correlated with CD-RISC and BFI scores (r = 0.287,  < 0.001). We also detected a negative correlation with neuroticism (r = -0.395,  < 0.001), which is a known risk factor for worse CD-RISC scores. Identifying protective and risk factors for psychological resilience can be used to predict treatment outcomes in tinnitus patients, which will help devise personalized solutions and improve patients' quality of life.
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http://dx.doi.org/10.1016/j.joto.2021.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811394PMC
January 2022

Chinese expert recommendation on transnasal corticosteroid nebulization for the treatment of chronic rhinosinusitis 2021.

J Thorac Dis 2021 Nov;13(11):6217-6229

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Corticosteroids are efficacious in treating chronic rhinosinusitis (CRS), but concerns on the potential side effects remain, especially for long-term usage of systemic corticosteroids. Accumulated evidence shows that transnasal nebulization may be a reasonable solution in balancing both efficacy and safety. However, no consensus or guideline has been formulated on the use of steroid transnasal nebulization in treating CRS. The consensus is achieved through literature review and exchange of Chinese experts in Group of Otorhinolaryngology and Ophthalmology, Chinese Society of Allergy (CSA). This document covers the development, equipment, pharmacological mechanism, and evidence-based efficacy and safety, as well as the special concern of the application of steroid transnasal nebulization during the coronavirus disease (COVID-19) pandemic. The expert consensus clarifies the application of steroid transnasal nebulization in treating CRS and common comorbidities during the perioperative and postoperative periods.
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http://dx.doi.org/10.21037/jtd-21-1142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662474PMC
November 2021

Case Report: Identifying Andersson-Like Lesions in Diffuse Idiopathic Skeletal Hyperostosis.

Front Endocrinol (Lausanne) 2021 30;12:766209. Epub 2021 Nov 30.

Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Andersson lesions (ALs) in ankylosing spondylitis (AS) pose a severe risk to the stability of ankylosed spine, which might result in significant deterioration of spinal cord function after traumatic or inflammatory causes. Herein, erosive discovertebral lesions in diffuse idiopathic skeletal hyperostosis (DISH) presented important clinical similarities to AL in AS, but failed to completely recognize unstable spinal lesions. Therefore, we pioneered to identify spinal discovertebral lesions similar to Andersson-like lesions (ALLs) in DISH, followed by the characterization and summarization of the etiology, radiology, laboratory results, clinical symptoms, and treatment strategies for AL in AS with ALL in DISH. By characterizing the ALL in DISH cases, we showed that the ALL was mainly traumatic and established at the junction of focal stress between two adjacent ossified level arms. Erosive discovertebral ALLs were formed after trivial stress of direct impact and could be subdivided into transdiscal, transvertebral, and discovertebral types radiologically. Patients who presented with ALL frequently suffered from consistent back pain clinically and experienced a decrease in motion ability that could reflect skeletal stability, which received treatment effectiveness after conservative external spinal immobilization or further surgical internal fixation, indicating the significance of recognizing ALL in the ankylosed DISH spine to further maintain spinal stability in order to prevent catastrophic neurologic sequelae. Our work highlighted the clinical relevance of ALL in DISH in comparison with AL in AS, which provided broader insight to identify ALL in DISH, thus facilitating early intervention against DISH deterioration.
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http://dx.doi.org/10.3389/fendo.2021.766209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669740PMC
February 2022

2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis.

Clin Gastroenterol Hepatol 2021 Dec 7. Epub 2021 Dec 7.

Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong, China.

Background & Aims: The increasing rates of obesity and type 2 diabetes mellitus may lead to increased prevalence of nonalcoholic fatty liver disease (NAFLD). We aimed to determine the current and recent trends on the global and regional prevalence of NAFLD.

Methods: Systematic search from inception to March 26, 2020 was performed without language restrictions. Two authors independently performed screening and data extraction. We performed meta-regression to determine trends in NAFLD prevalence.

Results: We identified 17,244 articles from literature search and included 245 eligible studies involving 5,399,254 individuals. The pooled global prevalence of NAFLD was 29.8% (95% confidence interval [CI], 28.6%-31.1%); of these, 82.5% of included articles used ultrasound to diagnose NAFLD, with prevalence of 30.6% (95% CI, 29.2%-32.0%). South America (3 studies, 5716 individuals) and North America (4 studies, 18,236 individuals) had the highest NAFLD prevalence at 35.7% (95% CI, 34.0%-37.5%) and 35.3% (95% CI, 25.4%-45.9%), respectively. From 1991 to 2019, trend analysis showed NAFLD increased from 21.9% to 37.3% (yearly increase of 0.7%, P < .0001), with South America showing the most rapid change of 2.7% per year, followed by Europe at 1.1%.

Conclusions: Despite regional variation, the global prevalence of NAFLD is increasing overall. Policy makers must work toward reversing the current trends by increasing awareness of NAFLD and promoting healthy lifestyle environments.
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http://dx.doi.org/10.1016/j.cgh.2021.12.002DOI Listing
December 2021

[Progress of IgG4 related sino-nasal diseases].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Nov;35(11):1042-1047

IgG4 related disease(IgG4-RD)is a newly recognized chronic fibroinflammatory disease in recent years.It is often accompanied by the significant elevation of serum IgG4 level,but the diagnostic specificity of the elevation is not high.The diagnosis is mainly based on histopathology,which is characterized by dense IgG4 positive plasma cell infiltration,storiform fibrosis and obliteran phlebitis.IgG4-RDcan involve various organs of the body,but less involve the nasal cavity and paranasal sinuses.The nasal symptoms of IgG4-RD are lack of specificity,so it is easier to be missed and misdiagnosed.PET/CT has important value in the diagnosis and differential diagnosis of the disease.We reviewed the relevant studies of IgG4-RD in nasal cavity and paranasal sinus in recent years,in order to improve the understanding of IgG4-RD in nasal cavity and paranasal sinuses and to improve the diagnosis and treatment rate.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2021.11.018DOI Listing
November 2021

Tert-butylhydroquinone attenuates osteoarthritis by protecting chondrocytes and inhibiting macrophage polarization.

Bone Joint Res 2021 Nov;10(11):704-713

Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.

Aims: Tert-butylhydroquinone (tBHQ) has been identified as an inhibitor of oxidative stress-induced injury and apoptosis in human neural stem cells. However, the role of tBHQ in osteoarthritis (OA) is unclear. This study was carried out to investigate the role of tBHQ in OA.

Methods: OA animal model was induced by destabilization of the medial meniscus (DMM). Different concentrations of tBHQ (25 and 50 mg/kg) were intraperitoneally injected in ten-week-old female mice. Chondrocytes were isolated from articular cartilage of mice and treated with 5 ng/ml lipopolysaccharide (LPS) or 10 ng/ml interleukin 1 beta (IL-1β) for 24 hours, and then treated with different concentrations of tBHQ (10, 20, and 40 μM) for 12 hours. The expression levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in blood were measured. The expression levels of interleukin 6 (IL-6), IL-1β, and tumour necrosis factor alpha (TNF-α) leptin in plasma were measured using enzyme-linked immunoabsorbent assay (ELISA) kits. The expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathway proteins, and macrophage repolarization-related markers, were detected by western blot.

Results: Tert-butylhydroquinone significantly attenuated cartilage destruction in DMM-induced mice in vivo. It demonstrated clear evidence of inhibiting IL-1β-induced chondrocyte apoptosis, inflammation, and differentiation defect in vitro. Meanwhile, tBHQ inhibited LPS-induced activation of NF-κB and MAPK signalling pathways, and also inhibited LPS-induced reactive oxygen species production and macrophages repolarization in vitro.

Conclusion: Taken together, tBHQ might be a potential therapeutic strategy for protecting against OA development. Cite this article:  2021;10(11):704-713.
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http://dx.doi.org/10.1302/2046-3758.1011.BJR-2020-0242.R4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636180PMC
November 2021

Application of a modified biological flocculant in total nitrogen treatment of leather wastewater.

Water Sci Technol 2021 Jun;83(12):2901-2910

College of Bioengineering, Sichuan University of Science and Engineering, Yibin 644000, China E-mail:

Leather wastewater harms the ecological environment and human health. In this study, a modified bio-flocculant was prepared to facilitate treatment of leather wastewater. A bio-flocculant produced by Bacillus cereus was combined with amphoteric starch and modified using a cerium ammonium nitrate initiator. Single factor optimization and orthogonal optimization were used to determine the optimal preparation conditions as follows: amphoteric starch-to-flocculant ratio = 22:30; reaction temperature = 64 °C; initiator dosage = 2.00%; reaction time = 15 min; stirring speed = 600 rpm; and flocculation system pH = 8.0. At a dosage of 1 g/L added to simulated leather industry wastewater, the flocculation efficiency (98.17%) and the total nitrogen removal efficiency (100.00%) of modified bio-flocculant was superior to that achieved by 1 g/L of unmodified bio-flocculant (72.16% and 50.00%, respectively), amphoteric starch (8.50% and 0.00%) and polyacrylamide (95.55% and 75.00%). Analysis of natural and flocculated precipitates in the wastewater showed that the modified bio-flocculant significantly changed several characteristics of the flocculated particles; in addition, it promoted the removal of nitrogenous substances in the process of denitrification. These changes helped explain the material's flocculating ability. The results confirmed that the modified bio-flocculant was an effective additive for treating leather wastewater.
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http://dx.doi.org/10.2166/wst.2021.192DOI Listing
June 2021

Application of ε-polylysine in extending the storage period of pork jerky.

Food Sci Nutr 2021 Jun 4;9(6):3250-3257. Epub 2021 May 4.

College of Bioengineering Sichuan University of Science and Engineering Yibin China.

In this experiment, natural nontoxic preservative ε-polylysine (ε-PL) was used as a natural preservative in pork jerky. The pork jerky samples with ε-PL (experimental group) and without ε-PL (blank group) were stored at the 27 and 37℃. Then, the number of microorganisms, total volatile basic nitrogen (TVB-N), pH, and water activity (Aw) of each group were tested to test the antiseptic effect of ε-PL. The results showed that due to the was detected, the storage period of the blank group at 27 and 37°C was 15 and 9 days, respectively. However, , , , and were not detected in the experimental group on the 60th day. The experimental group all accord with the national standard for the quantity of microorganisms in meat jerky. The TVB-N content of the blank group reached 14.00 mg/100 g (15th day, 27°C) and 14.93 mg/100 g (9th day, 37°C) at the end of the storage period, while the TVB-N content of the experimental group was 11.20 mg/100 g (60th day, 27℃) and 15.86 mg/100 g (60th day, 37℃), and the increase rate of TVB-N in the blank group was greater than the experimental group, indicating that ε-PL can play a better microbial stabilization effect in pork jerky. The test of pH and Aw showed that ε-PL can stabilize the quality of pork jerky. Finally, the antiseptic effect of ε-PL was comparable to many chemical preservatives. This experiment confirms that ε-PL played an important role in extending the storage period of pork jerky.
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http://dx.doi.org/10.1002/fsn3.2289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194761PMC
June 2021

Progression Rates by Age, Sex, Treatment, and Disease Activity by AASLD and EASL Criteria: Data for Precision Medicine.

Clin Gastroenterol Hepatol 2022 04 2;20(4):874-885.e4. Epub 2021 Jun 2.

Department of Internal Medicine, Saga University Hospital, Saga, Japan.

Background & Aims: Antiviral treatment criteria are based on disease progression risk, and hepatocellular carcinoma (HCC) surveillance recommendations for patients with chronic hepatitis B (CHB) without cirrhosis is based on an annual incidence threshold of 0.2%. However, accurate and precise disease progression estimate data are limited. Thus, we aimed to determine rates of cirrhosis and HCC development stratified by age, sex, treatment status, and disease activity based on the 2018 American Association for the Study of Liver Diseases and 2017 European Association for the Study of the Liver guidelines.

Methods: We analyzed 18,338 patients (8914 treated, 9424 untreated) from 6 centers from the United States and 27 centers from Asia-Pacific countries. The Kaplan-Meier method was used to estimate annual progression rates to cirrhosis or HCC in person-years.

Results: The cohort was 63% male, with a mean age of 46.19 years, with baseline cirrhosis of 14.3% and median follow up of 9.60 years. By American Association for the Study of Liver Diseases criteria, depending on age, sex, and disease activity, annual incidence rates ranged from 0.07% to 3.94% for cirrhosis, from 0.04% to 2.19% for HCC in patients without cirrhosis, and from 0.40% to 8.83% for HCC in patients with cirrhosis. Several subgroups of patients without cirrhosis including males younger than 40 years of age and females younger than 50 years of age had annual HCC risk near or exceeding 0.2%. Similar results were found using European Association for the Study of the Liver criteria.

Conclusion: There is great variability in CHB disease progression rates even among "lower-risk" populations. Future CHB modeling studies, public health planning, and HCC surveillance recommendation should be based on more precise disease progression rates based on sex, age, and disease activity, plus treatment status.
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http://dx.doi.org/10.1016/j.cgh.2021.05.062DOI Listing
April 2022

Salidroside Inhibits CCl-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1.

Front Pharmacol 2021 13;12:677810. Epub 2021 May 13.

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Sphingosine kinase 1 (SphK1)/Sphingosine-1-phosphate (S1P)/S1PRs signaling pathway is known to involve the advancement of liver fibrosis. Exosomal SphK1 promotes hepatic stellate cells (HSC) migration. Salidroside (Sal) inhibits liver fibrosis, but its mechanism is yet to be elucidated. This study was to explore the influences of Sal on the SphK/S1P/S1PRs signaling pathway in liver fibrosis induced by carbon tetrachloride (CCl) , and investigated the mechanism of Sal affecting the migration and activation of HSC triggered by exosomal SphK1 . Our data showed that Sal reduced the activities of alanine transaminase (ALT), aspartate aminotransferase (AST) in serum, and hydroxyproline (Hyp) content in the liver tissue. Sal subdued the expression of α-smooth muscle actin (α-SMA), fibronectin (FN) and type I collagen (Col I) of the liver. Sal also reduced mitochondria-induced hepatocyte apoptosis and to inhibit JNK activation. Furthermore, Sal remarkably eradicated the influence of SphK1, SphK2, S1P, and S1PRs triggered by CCl, whether stimulating or hindering. Compared with serum-derived exosomes from model group mice, serum-derived exosomes from Sal group mice expressed lower SphK1 and reduced JS 1 (mouse HSC cell line) migration. In addition, Sal was also observed to subdue Col I expression, AKT activation, and LX-2 migration induced by exosomal SphK1 from SK-HEP-1 (a kind of liver sinusoidal endothelial cells (LSEC) cell line). In conclusion, Sal could effectively alleviate liver injury, hepatocyte apoptosis, and liver fibrosis , providing supports that the protective effects of Sal might be realized by suppressing JNK activation and modulating the SphK/S1P/S1PRs axis. , it was observed that Sal might alleviate LX-2 migration and activation induced by exosomal SphK1 by inhibiting the AKT activation.
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http://dx.doi.org/10.3389/fphar.2021.677810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155673PMC
May 2021

Laminoplasty with selective fusion at unstable segment versus laminectomy with fusion for multilevel cervical myelopathy: a case-control study.

BMC Musculoskelet Disord 2021 May 7;22(1):426. Epub 2021 May 7.

Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, 200011, Shanghai, People's Republic of China.

Background: Segmental cervical instability is a risk factor for the progression of osteophytic bone spurs and development of myelopathy, and is treated as a relative contraindication of cervical laminoplasty. The aim of this study was to compare laminoplasty with selective fixation (LPSF) versus laminectomy with fusion (LCF) in patients with multilevel cervical myelopathy accompanied by segmental instability.

Methods: A case-control study was conducted by reviewing data from 63 patients who underwent LPSF (n = 30) or LCF (n = 33). Cervical alignment, range of motion (ROM), neurologic status and axial symptom severity pre-operation, 3-days after operation, and at the final follow-up (minimum 24 months) were measured and compared between groups.

Results: Postoperation, patients in the LPSF group lost 31.1 ± 17.3 % of cervical lordosis and 43.2 ± 10.9 % cervical ROM while patients in the LCF group lost 5.7 ± 8.2 % and 67.9 ± 15.5 %, respectively. Both LPSF and LCF groups significantly improved neurologic status and axial symptom severity at the final follow-up with similar between-group results(P > 0.05). Blood loss, operation time, hospital stay, and medical cost in the LPSF group were significantly less than in the LCF group(P < 0.05).

Conclusions: In 2 years of clinical observation, LPSF was effective in maintaining the stability of the cervical spine with less sacrifice of mobility and surgical trauma for multilevel myelopathy with segmental instability compared to LCF.
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http://dx.doi.org/10.1186/s12891-021-04297-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105929PMC
May 2021

A novel COL2A1 mutation causing spondyloepiphyseal dysplasia congenita in a Chinese family.

J Clin Lab Anal 2021 Apr 16;35(4):e23728. Epub 2021 Feb 16.

Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implants, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Spondyloepiphyseal dysplasia congenita is an autosomal dominant cartilaginous dysplasia characterized by short trunk, abnormal epiphysis, and flattened vertebral body. Skeletal features of SEDC are present at birth and evolve over time. Other features of SEDC include myopia and/or retinal degeneration with retinal detachment and cleft palate. A mutation in the COL2A1 gene located in 12q13.11 is considered as one of the important causes of SEDC. In 2016, Barat-Houari et al. reported a large number of COL2A1 mutations. Among them, a non-synonymous mutation in COL2A1 exon 37, c.2437G>A (p. Gly813Arg), has been reported to cause SEDC in only one patient from France so far.

Methods: We followed up a patient with SEDC phenotype and his family members. The clinical manifestations, physical examination and imaging examination, including X-ray, CT and MRI, were recorded. The whole-exome sequencing was used to detect the patients' genes, and the pathogenic genes were screened out by comparing with many databases.

Results: We report a Chinese patient with SEDC phenotype characterized by short trunk, abnormal epiphysis, flattened vertebral body, narrow intervertebral space, dysplasia of the odontoid process, chicken chest, scoliosis, hip and knee dysplasia, and joint hypertrophy. Gene sequencing analysis showed that the patient had a heterozygous mutation (c.2437G>A; p. Gly813Arg) in the COL2A1 gene. No COL2A1 mutation or SEDC phenotype was observed in his family members. This is the first report of SEDC caused by this mutation in an East Asian family.

Conclusion: This report provides typical clinical, imaging, and genetic evidence for SEDC, confirming that a de novo mutation in the COL2A1 gene, c.2437G>A (p. Gly813Arg), causes SEDC in Chinese population.
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http://dx.doi.org/10.1002/jcla.23728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059726PMC
April 2021

A 49-Year-Old Man Presents With Fever of Unknown Origin and Cough.

Chest 2021 01;159(1):e25-e28

Department of Otolaryngology Head and Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, Shanxi, China. Electronic address:

Case Presentation: A 49-year-old man presented with 3 months of persistent fever, cough, shortness of breath, and chest tightness. He had no response to treatment with antibiotics. He had been treated with an empiric 2-week course of steroids approximately 2 months before presentation, with mild and transient improvement. He did not use tobacco and had not experienced any weight loss, hemoptysis, arthralgia, or myalgia, and was otherwise in good health. He denied contact with anyone with pulmonary TB or other respiratory illnesses.
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http://dx.doi.org/10.1016/j.chest.2020.08.2094DOI Listing
January 2021

Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients.

Hepatol Int 2021 Feb 4;15(1):71-81. Epub 2021 Jan 4.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Hepatitis Research Center, College of Medicine and Cohort Research Center and Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Increasing hepatitis-related mortality has reignited interest to fulfill the World Health Organization's goal of viral hepatitis elimination by 2030. However, economic barriers have enabled only 28% of countries to implement countermeasures. Given the high disease burden among Asians, we aimed to present age, sex, disease activity and treatment-specific annual progression rates among Asian chronic hepatitis B (CHB) patients to inform health economic modeling efforts and cost-effective public health interventions.

Methods: We analyzed 18,056 CHB patients from 36 centers across the U.S. and seven countries/regions of Asia Pacific (9530 treated; 8526 untreated). We used Kaplan-Meier methods to estimate annual incidence of cirrhosis and hepatocellular carcinoma (HCC). Active disease was defined by meeting the APASL treatment guideline criteria.

Results: Over a median follow-up of 8.55 years, there were 1178 incidences of cirrhosis and 1212 incidences of HCC (297 without cirrhosis, 915 with cirrhosis). Among the 8526 untreated patients (7977 inactive, 549 active), the annual cirrhosis and HCC incidence ranged from 0.26% to 1.30% and 0.04% to 3.80% in inactive patients, and 0.55 to 4.05% and 0.19 to 6.03% in active patients, respectively. Of the 9530 treated patients, the annual HCC rates ranged 0.03-1.57% among noncirrhotic males and 2.57-6.93% among cirrhotic males, with lower rates for females. Generally, transition rates increased with age, male sex, the presence of fibrosis/cirrhosis, and active disease and/or antiviral treatment.

Conclusion: Using data from a large and diverse real-world cohort of Asian CHB patients, the study provided detailed annual transition rates to inform practice, research and public health planning.
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http://dx.doi.org/10.1007/s12072-020-10113-2DOI Listing
February 2021

Babao Dan improves neurocognitive function by inhibiting inflammation in clinical minimal hepatic encephalopathy.

Biomed Pharmacother 2021 Mar 28;135:111084. Epub 2020 Dec 28.

Shuguang Hospital, Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:

Background And Purpose: Inflammation has been considered a precipitating event that contributes to neurocognitive dysfunction in minimal hepatic encephalopathy (MHE). Inhibition TLR-4 related inflammation can effectively improve neurocognitive dysfunction of MHE. Our previous study showed that Babao Dan (BBD) effectively inhibited inflammation and ameliorated neurocognitive function in rats with acute hepatic encephalopathy (HE) and chronic HE. The mechanism may lie in the regulation of TLR4 signaling pathway. Therefore, this study aimed to evaluate the role of BBD in the treatment of MHE patients with cirrhosis and to elucidate the underlying mechanism by which BBD regulated TLR4 pathway to alleviate inflammation.

Methods: A randomized controlled trial (n = 62) was conducted to evaluate the clinical efficacy between BBD plus lactulose (n = 31) and lactulose alone (n = 31) in MHE patients by testing neurocognitive function (NCT-A and DST), blood ammonia, liver function (ALT, AST and TBIL) and blood inflammation (IL-1β, IL-6 and TNF-α). Afterward, we detected NO, inflammatory cytokines (IL-1β, IL-6 and TNF-α) and the phosphorylation of P65, JNK, ERK as well as P38 in LPS-activated rat primary bone marrow-derived macrophages (BMDMs), peritoneal macrophages (PMs), and mouse primary BMDMs/PMs/microglia/astrocytes, to investigate the underlying mechanism of BBD inhibiting inflammation through TLR4 pathway. Also, the survival rate of mice, liver function (ALT, AST), blood inflammation (IL-1β, IL-6 and TNF-α), inflammatory cytokines (IL-1β, IL-6 and TNF-α) and histopathological changes in the liver, brain and lung were measured to assess the anti-inflammatory effect of BBD on neurocognitive function in endotoxin shock/endotoxemia mice.

Results: BBD combined with lactulose significantly ameliorated neurocognitive function by decreasing NCT-A (p<0.001) and increasing DST (p<0.001); inhibited systemic inflammation by decreasing IL-1β (p<0.001), IL-6(p<0.001) and TNF-α (p<0.001); reduced ammonia level (p = 0.005), and improved liver function by decreasing ALT(p = 0.043), AST(p = 0.003) and TBIL (p = 0.026) in MHE patients. Furthermore, BBD inhibited gene and protein expression of IL-1β, IL-6 and TNF-α as well as NO in rat primary BMDMs/PMs, and mouse primary BMDMs/PMs/microglia/astrocytes in a dose-dependent manner. BBD inhibited the activation of mouse primary BMDMs/PMs/microglia/astrocytes by regulating TLR4 pathway involving the phosphorylation of P65, JNK, ERK and P38. Also, BBD reduced the mortality of mice with endotoxin shock/endotoxemia; serum levels of ALT, AST, IL-1β, IL-6 and TNF-α; gene expression of IL-1β, IL-6 and TNF-α in the liver, brain and lung, and tissue damage in the liver and lung.

Conclusion: Our study provided for the first time clinical and experimental evidence supporting the use of BBD in MHE, and revealed that BBD could play a crucial role in targeting and regulating TLR4 inflammatory pathway to improve neurocognitive function in MHE patients.
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http://dx.doi.org/10.1016/j.biopha.2020.111084DOI Listing
March 2021

Attachment-Oriented Endoscopic Treatment of Inverted Papilloma Involving the Frontal Sinus/Recess.

J Craniofac Surg 2020 Nov/Dec;31(8):e778-e781

Department of Otolaryngology Head and Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, China.

Purpose: Sinonasal inverted papilloma (IP) is a benign but locally aggressive tumor for which an endoscopic or external surgical approach is the treatment of choice. Complete resection of IP involving the frontal sinus/recess forms one of the most challenging procedures in the field of sinonasal surgery. This study aims to present our experience in the management of extensive frontal sinus IP based on the attachment sites of the tumor.

Methods: Thirteen patients with IP involving the frontal sinus/recess between 2010 and 2018 were presented. The data collected include demographic data, tumor attachment sites, tumor extension, tumor staging according to Meng's staging system, surgical approach, recurrence, and follow-up.

Results: The patients were successfully treated by endoscopic surgery without any additional external approaches. The attachment sites of the IP were multifocal in some patients. No recurrence was identified after an average follow-up period of 52.88 months. No major intra- or postoperative complications were observed.

Conclusion: The present study shows that attachment-oriented excision for IP involving the frontal sinus/recess is an acceptable approach. Surgeons should select the surgical approach based on the attachment sites of the tumor rather than the extension of the tumor. Even more importantly, the tumor attachment sites should include the sites of adhesion to the bone wall and the site of origin.
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http://dx.doi.org/10.1097/SCS.0000000000006742DOI Listing
March 2021

sublingual immunotherapy for seasonal allergic rhinitis: A multicenter, randomized trial.

World Allergy Organ J 2020 Sep 8;13(9):100458. Epub 2020 Sep 8.

Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730, China.

Background: is the most common outdoor aeroallergen throughout Northern China; however, no multicenter study has investigated sublingual immunotherapy (SLIT) as a treatment option for -induced allergic rhinitis (AR). The aim of this study was to evaluate the efficacy and safety of an innovative SLIT for -related AR.

Methods: This was a randomized, double-blind, placebo-controlled, multicenter, phase 3 clinical trial conducted in China (NCT XXX). A total of 702 -sensitized eligible patients were randomized in a ratio of 2:1 to receive -SLIT or placebo. The treatment lasted 32 weeks; including 5-weeks up-dosing phase and 27-weeks maintenance phase. The primary endpoint was the daily combined score of medication and rhinoconjunctivitis symptom (CSMRS), and secondary endpoints were daily total nasal symptom score (dTNSS) and daily rescue medication score (dRMS) during peak pollen period. Safety of treatment was evaluated according to adverse events (AEs) experienced.

Results: Mean daily CSMRS was significantly improved during the peak pollen period in the SLIT group compared with the placebo group (1.46 ± 0.47 vs 1.88 ± 0.42, P < 0.0001 in full analysis set [FAS]; 1.49 ± 0.52 vs 1.95 ± 0.46, P < 0.0001 in per protocol set [PPS]); representing a 22.3% and 23.6% reduction, respectively, relative to placebo. In specifically monosensitized patients, mean daily CSMRS reductions were demonstrated as 24.1% and 27.0% in the FAS and PPS populations, respectively, when comparing the active treatment to placebo treatment. Similarly, SLIT decreased dTNSS in peak pollen period by 19.0% in FAS and 22.3% in PPS, respectively, relative to placebo. In coincidence, dRMS in peak pollen period was reduced by 22.0% in FAS and 26.0% in PPS. 65.8% patients in SLIT group experienced treatment-related AEs, none of which was serious.

Conclusion: This study indicates that SLIT with drops is an effective and safe treatment option in Chinese patients with -induced AR.
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http://dx.doi.org/10.1016/j.waojou.2020.100458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490724PMC
September 2020

[A comparative study on treatment of severe OSA with UPPP combined with endoscopic low-temperature plasma tongue root resection].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Apr;34(4):324-328

Department of Otorhinolaryngology Head and Neck Surgery,Second Hospital of Shanxi Medical University,Taiyuan,030001,China.

The aim of this study is to investigate the effect of modified uvulopalatopharyngoplasty (UPPP) combined with endoscopic hypothermic Plasma glossectomy (Eco-TBR) on the severe Obstructive sleep apnea syndrome. Sixty patients with severe OSAHS were diagnosed by polysomnography, and their obstructive plane located in the oropharynx and tongue base. Patients were divided into the control group (30 cases of simple H-UPPP) and the experimental group (30 cases of H-UPPP combined with Eco-TBR) according to their random hospital sequence. SPSS 20.0 software package was used to analyze the preoperative and postoperative data of the two groups. Fifty-seven OSAHS patients had full data and a minimum 6 month follow up to assess the efficacy. The total effective rate in the control group was 41.38% lower than that in the experimental group 67.85%, and the difference was statistically significant (χ²=4.03, <0.05). The postoperative data of the control group, AHI was 28.07±10.283, LSaO2 was 72.660±6.405, ESS was 12.620±2.731, and snoring VAS were 3.93±1.307. After the operation, in the experimental group, AHI was 25.74±14.140, LSaO2 was 75.360±7.299, ESS was 11.320±3.209, and snoring VAS were 3.00±1.305. The differences in AHI, LSaO2, ESS and snoring VAS before and after surgery in the two groups were statistically significant (<0.001). After surgery, compared between the two groups, except for snoring VAS, the differences of AHI, LSaO2 and ESS were not statistically significant(>0.05). The effect of H-UPPP combined with Eco-TBR on severe OSAHS patients with obstructive plane of oropharynx and tongue root is definite.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2020.04.009DOI Listing
April 2020

High hepatitis C virus cure rates with approved interferon-free direct-acting antivirals among diverse mainland Chinese patients including genotypes 3a and 3b.

J Gastroenterol Hepatol 2021 Mar 5;36(3):767-774. Epub 2020 Aug 5.

Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA.

Background And Aim: Globally, China has the highest chronic hepatitis C (CHC) burden, but its real-world direct-acting antiviral (DAA) data are limited. Our aim is to investigate the real-world outcome of China Food and Drug Administration-approved DAA therapies across mainland China including those with genotype (GT) 3.

Methods: The REAL-C is a multinational real-world interferon-free DAA-treated CHC registry of several mainland China and other Asian centers. We evaluated the sustained virological response rate 12 weeks after end of treatment (SVR12), adverse events, and treatment effect on liver function and fibrosis (fibrosis-4 index).

Results: We analyzed 859 DAA-treated CHC patients (6/1/2017-5/30/2019) from 12 mainland China centers (three municipalities and nine provinces): median age 52, 49.9% male, 33.1% cirrhosis, 95% treatment naïve, and 2.5% HBsAg . The most common GT was GT1b (523, 62.2%), followed by GT2a (156, 18.5%), GT3b (74, 8.8%), GT3a (41, 4.9%), and GT6 (37, 4.4%). SVR12 rates were 98.0% overall (95% confidence interval 96.9-98.8%), 98.1% for GT1b, 96.8% GT2a, 100% GT3a, 97.3% GT3b, and 100% GT6. Baseline cirrhosis and male sex but not prior treatment history, renal dysfunction, age, and GTs were associated with SVR12. For both cirrhotic and non-cirrhotic patients, there were significant improvement in liver function tests, alpha fetoprotein, and fibrosis-4 index with SVR12. Serious adverse events were rare (1.1%) with only nine patients discontinuing therapy prematurely and anemia being the most common adverse event (13.1%, mostly with ribavirin).

Conclusions: In real-world Chinese patients with diverse GTs, Chinese Food and Drug Administration-approved interferon-free DAAs were well tolerated, provided high cure rates (98.0% overall) including GT3a/3b, and led to improvement of liver function.
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http://dx.doi.org/10.1111/jgh.15192DOI Listing
March 2021

Response to "IgG4-Related Midline Destructive Disease" by Akiyama M.

J Clin Rheumatol 2021 12;27(8S):S886

Department of Otolaryngology Head and Neck Surgery Shanxi Medical University Second Affiliated Hospital Taiyuan, Shanxi, China

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http://dx.doi.org/10.1097/RHU.0000000000001522DOI Listing
December 2021

[Sinus balloon dilation for treatment of chronic sinusitis: a systematic review and Meta-analysis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 May;34(5):406-410;416

Department of Otolaryngology Head and Neck Surgery,the Second Hospital of Shanxi Medical University.

To systematically assess the efficacy of sinus balloon dilation(SBCD) for patients with chronic rhinosinusitis(CRS). To research the references whose the contents were related to the randomized controlled trials of sinus balloon dilation for treatment of chronic sinusitis from PubMed, Embase, Cochrane Library, WanFang, CNKI and other databases from January 2000 to June 2019. Assessed the quality and extracted the data of these included references and made Meta analysis by RevMan5.3 software. A total of 11 references in English and Chinese were included. Of Meta analysis showed that the difference had no statistical significance between the SNOT-20 score which were based on the statistics measured 3 months later and 6 months later [3 months later, SMD=-0.30, 95%(-1.01-0.41), =0.40, 6 months later, SMD=-0.53, 95%(-3.22-2.16), =0.70]and the score in the control group. Lund-Mackay CT score [SMD=-0.69, 95%(-0.72--0.66, <0.00001) ]and VAS symptom score [SMD=-1.67, 95%(-1.91--1.44), <0.00001]following SBCD versus FESS in the treatment of CRS had statistical significance. Besides, SBCD had a lower incidence [OR=0.29, 95%(0.14-0.59), =0.0007]to develop postoperative complications compared with that in the control group. Balloon dilation of sinuses can significantly relieve the symptoms of patients with chronic sinusitis, this effect is equal or even better. Moreover, the incidence of developing the postoperative complications is lower, which SBCD of CRS is worthy of clinical popularization.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2020.05.005DOI Listing
May 2020

LogEvent2vec: LogEvent-to-Vector Based Anomaly Detection for Large-Scale Logs in Internet of Things.

Sensors (Basel) 2020 Apr 26;20(9). Epub 2020 Apr 26.

Computer Science Department, Community College, King Saud University, Riyadh 11437, Saudi Arabia.

Log anomaly detection is an efficient method to manage modern large-scale Internet of Things (IoT) systems. More and more works start to apply natural language processing (NLP) methods, and in particular word2vec, in the log feature extraction. Word2vec can extract the relevance between words and vectorize the words. However, the computing cost of training word2vec is high. Anomalies in logs are dependent on not only an individual log message but also on the log message sequence. Therefore, the vector of words from word2vec can not be used directly, which needs to be transformed into the vector of log events and further transformed into the vector of log sequences. To reduce computational cost and avoid multiple transformations, in this paper, we propose an offline feature extraction model, named LogEvent2vec, which takes the log event as input of word2vec to extract the relevance between log events and vectorize log events directly. LogEvent2vec can work with any coordinate transformation methods and anomaly detection models. After getting the log event vector, we transform log event vector to log sequence vector by bary or tf-idf and three kinds of supervised models (Random Forests, Naive Bayes, and Neural Networks) are trained to detect the anomalies. We have conducted extensive experiments on a real public log dataset from BlueGene/L (BGL). The experimental results demonstrate that LogEvent2vec can significantly reduce computational time by 30 times and improve accuracy, comparing with word2vec. LogEvent2vec with bary and Random Forest can achieve the best F1-score and LogEvent2vec with tf-idf and Naive Bayes needs the least computational time.
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http://dx.doi.org/10.3390/s20092451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249657PMC
April 2020
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