Changiz Geula

Changiz Geula

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Changiz Geula

Changiz Geula

Publications by authors named "Changiz Geula"

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Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer's disease.

Brain Pathol 2019 Aug 25. Epub 2019 Aug 25.

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611.

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http://dx.doi.org/10.1111/bpa.12783DOI Listing
August 2019

Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes.

Acta Neuropathol 2019 Jul 7;138(1):167-169. Epub 2019 May 7.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1007/s00401-019-02024-wDOI Listing
July 2019

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://link.springer.com/10.1007/s00401-019-01962-9
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http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases.

Hippocampus 2019 May 5;29(5):458-467. Epub 2018 Feb 5.

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.

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http://dx.doi.org/10.1002/hipo.22828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050141PMC
May 2019

Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories.

Front Aging Neurosci 2019 14;11:94. Epub 2019 May 14.

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00094
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http://dx.doi.org/10.3389/fnagi.2019.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527736PMC
May 2019

Cortical cholinergic denervation in primary progressive aphasia with Alzheimer pathology.

Neurology 2019 04 6;92(14):e1580-e1588. Epub 2019 Mar 6.

From the Mesulam Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1212/WNL.0000000000007247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448447PMC
April 2019

Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia.

J Neuropathol Exp Neurol 2019 Mar;78(3):229-237

Feinberg School of Medicine, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1093/jnen/nlz005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380320PMC
March 2019

Word comprehension in temporal cortex and Wernicke area: A PPA perspective.

Neurology 2019 01 21;92(3):e224-e233. Epub 2018 Dec 21.

From the Mesulam Center for Cognitive Neurology and Alzheimer's Disease (M.-M.M., B.M.R., J.S., M.J.N., J.H., A.R., C.G., E.H.B., T.D.G., S.W., E.J.R.) and Departments of Neurology (M.-M.M.), Preventive Medicine (A.R.), Pathology (E.H.B.), and Psychiatry and Behavioral Sciences (T.D.G., S.W., E.J.R.), Northwestern University Feinberg School of Medicine, Chicago; and School of Communication (C.K.T.), Northwestern University, Evanston, IL.

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http://dx.doi.org/10.1212/WNL.0000000000006788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340389PMC
January 2019

The cholinergic system in the basal forebrain of the Atlantic white-sided dolphin (Lagenorhynchus acutus).

J Comp Neurol 2018 08;526(12):1910-1926

Department of Medical Neuroscience, Halifax, Dalhousie University, Nova Scotia, Canada.

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http://dx.doi.org/10.1002/cne.24460DOI Listing
August 2018

Atrophy and microglial distribution in primary progressive aphasia with transactive response DNA-binding protein-43 kDa.

Ann Neurol 2018 06 24;83(6):1096-1104. Epub 2018 May 24.

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1002/ana.25240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105542PMC
June 2018

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Authors:
Cyril Pottier Xiaolai Zhou Ralph B Perkerson Matt Baker Gregory D Jenkins Daniel J Serie Roberta Ghidoni Luisa Benussi Giuliano Binetti Adolfo López de Munain Miren Zulaica Fermin Moreno Isabelle Le Ber Florence Pasquier Didier Hannequin Raquel Sánchez-Valle Anna Antonell Albert Lladó Tammee M Parsons NiCole A Finch Elizabeth C Finger Carol F Lippa Edward D Huey Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Robert A Rissman Jaroslaw Slawek Emilia Sitek Peter Johannsen Jørgen E Nielsen Yingxue Ren Marka van Blitterswijk Mariely DeJesus-Hernandez Elizabeth Christopher Melissa E Murray Kevin F Bieniek Bret M Evers Camilla Ferrari Sara Rollinson Anna Richardson Elio Scarpini Giorgio G Fumagalli Alessandro Padovani John Hardy Parastoo Momeni Raffaele Ferrari Francesca Frangipane Raffaele Maletta Maria Anfossi Maura Gallo Leonard Petrucelli EunRan Suh Oscar L Lopez Tsz H Wong Jeroen G J van Rooij Harro Seelaar Simon Mead Richard J Caselli Eric M Reiman Marwan Noel Sabbagh Mads Kjolby Anders Nykjaer Anna M Karydas Adam L Boxer Lea T Grinberg Jordan Grafman Salvatore Spina Adrian Oblak M-Marsel Mesulam Sandra Weintraub Changiz Geula John R Hodges Olivier Piguet William S Brooks David J Irwin John Q Trojanowski Edward B Lee Keith A Josephs Joseph E Parisi Nilüfer Ertekin-Taner David S Knopman Benedetta Nacmias Irene Piaceri Silvia Bagnoli Sandro Sorbi Marla Gearing Jonathan Glass Thomas G Beach Sandra E Black Mario Masellis Ekaterina Rogaeva Jean-Paul Vonsattel Lawrence S Honig Julia Kofler Amalia C Bruni Julie Snowden David Mann Stuart Pickering-Brown Janine Diehl-Schmid Juliane Winkelmann Daniela Galimberti Caroline Graff Linn Öijerstedt Claire Troakes Safa Al-Sarraj Carlos Cruchaga Nigel J Cairns Jonathan D Rohrer Glenda M Halliday John B Kwok John C van Swieten Charles L White Bernardino Ghetti Jill R Murell Ian R A Mackenzie Ging-Yuek R Hsiung Barbara Borroni Giacomina Rossi Fabrizio Tagliavini Zbigniew K Wszolek Ronald C Petersen Eileen H Bigio Murray Grossman Vivianna M Van Deerlin William W Seeley Bruce L Miller Neill R Graff-Radford Bradley F Boeve Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Lancet Neurol 2018 06 30;17(6):548-558. Epub 2018 Apr 30.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30126-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237181PMC
June 2018

Associations of Gene Variants With Superior Memory in SuperAgers.

Front Aging Neurosci 2018 29;10:155. Epub 2018 May 29.

Cognitive Neurology & Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine (NU FSM), Chicago, IL, United States.

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http://dx.doi.org/10.3389/fnagi.2018.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987172PMC
May 2018

Variations in Acetylcholinesterase Activity within Human Cortical Pyramidal Neurons Across Age and Cognitive Trajectories.

Cereb Cortex 2018 04;28(4):1329-1337

Cognitive Neurology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1093/cercor/bhx047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059146PMC
April 2018

Von Economo neurons of the anterior cingulate across the lifespan and in Alzheimer's disease.

Cortex 2018 02 8;99:69-77. Epub 2017 Nov 8.

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Cellular and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cortex.2017.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801202PMC
February 2018

Asymmetric TDP pathology in primary progressive aphasia with right hemisphere language dominance.

Neurology 2018 01 5;90(5):e396-e403. Epub 2018 Jan 5.

From the Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1212/WNL.0000000000004891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791793PMC
January 2018

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS.

Sci Rep 2017 02 6;7:41765. Epub 2017 Feb 6.

Department of Neurology and Clinical Neurological Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1038/srep41765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292972PMC
February 2017

Postmortem Adult Human Microglia Proliferate in Culture to High Passage and Maintain Their Response to Amyloid-β.

J Alzheimers Dis 2016 10;54(3):1157-1167

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075451PMC
http://dx.doi.org/10.3233/JAD-160394DOI Listing
October 2016

Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease.

Neurobiol Aging 2015 Dec 6;36(12):3163-3170. Epub 2015 Sep 6.

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641850PMC
December 2015

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease.

Brain 2015 Jun 1;138(Pt 6):1722-37. Epub 2015 Mar 1.

1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA

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http://dx.doi.org/10.1093/brain/awv024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542619PMC
June 2015

Primary progressive aphasia and the evolving neurology of the language network.

Nat Rev Neurol 2014 Oct 2;10(10):554-69. Epub 2014 Sep 2.

Cognitive Neurology and Alzheimer's Disease Centre, 320 East Superior Street, Searle Building, 11-450, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1038/nrneurol.2014.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201050PMC
October 2014

Alterations of Ca²⁺-responsive proteins within cholinergic neurons in aging and Alzheimer's disease.

Neurobiol Aging 2014 Jun 25;35(6):1325-33. Epub 2013 Dec 25.

Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961506PMC
June 2014

Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primary progressive aphasia.

Brain 2014 Apr 25;137(Pt 4):1176-92. Epub 2014 Feb 25.

Cognitive Neurology and Alzheimer's Disease Centre, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1093/brain/awu024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959558PMC
April 2014

Neurodegenerative diversity in human cortical contusion: histological analysis of tissue derived from decompressive craniectomy.

Brain Res 2013 Nov 21;1537:86-99. Epub 2013 Sep 21.

Cognitive and Neurology Alzheimer's Disease Center, Feinberg Medical School, Northwestern University, 320 East Superior St, Chicago, IL 60610, USA; Centro de Estudios Cerebrales, Facultad de Salud, Universidad del Valle, Sede San Fernando, Calle 4 B # 36-00, Cali, Colombia. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2013.09.016DOI Listing
November 2013

In vivo AAV-mediated expression of calbindin-D₂₈k in rat basal forebrain cholinergic neurons.

J Neurosci Methods 2013 Jan 27;212(1):106-13. Epub 2012 Sep 27.

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S01650270120039
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http://dx.doi.org/10.1016/j.jneumeth.2012.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515667PMC
January 2013

Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project.

J Cogn Neurosci 2013 Jan;25(1):29-36

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, 320 E Superior Street, 11th Floor Searle Building, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1162/jocn_a_00300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541673PMC
January 2013

The 5th International Conference on Alzheimer's Disease and related disorders in the Middle East, 15-17 May 2009, Limassol Cyprus.

J Alzheimers Dis 2012 ;30(3):711-27

The Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.

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http://dx.doi.org/10.3233/JAD-2012-120116DOI Listing
October 2012

Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia.

Brain 2012 May 19;135(Pt 5):1554-65. Epub 2012 Apr 19.

Feinberg School of Medicine, Cognitive Neurology and Alzheimer's Disease Centre, Northwestern University, 320 E. Superior Street, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1093/brain/aws076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338929PMC
May 2012

Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex.

Curr Alzheimer Res 2012 Jan;9(1):138-43

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279606PMC
http://dx.doi.org/10.2174/156720512799015127DOI Listing
January 2012

Selective tau tyrosine nitration in non-AD tauopathies.

Acta Neuropathol 2012 Jan 6;123(1):119-32. Epub 2011 Nov 6.

Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1007/s00401-011-0898-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314430PMC
January 2012

Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer's disease.

Acta Neuropathol 2011 Nov 27;122(5):565-76. Epub 2011 Aug 27.

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1007/s00401-011-0865-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245740PMC
November 2011

Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex.

Neurobiol Aging 2011 Mar 5;32(3):387-97. Epub 2009 Apr 5.

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888944PMC
March 2011

Neuronal and axonal loss are selectively linked to fibrillar amyloid-{beta} within plaques of the aged primate cerebral cortex.

Am J Pathol 2010 Jul 20;177(1):325-33. Epub 2010 May 20.

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, 320 East Superior Street, Searle 11-467A, Chicago, IL 60611, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893675PMC
July 2010

The 4th International Symposium on Alzheimer's Disease and Related Disorders in the Middle East, October 26-28, 2007, Athens, Greece.

Amyloid 2010 Jun;17(2):86-90

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine Chicago, IL 60611, USA.

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http://dx.doi.org/10.3109/13506129.2010.483120DOI Listing
June 2010

Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease.

J Neuropathol Exp Neurol 2008 Apr;67(4):309-18

Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Medical School, Chicago, Illinois 60611, USA.

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https://academic.oup.com/jnen/article-lookup/doi/10.1097/NEN
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http://dx.doi.org/10.1097/NEN.0b013e31816a1df3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243760PMC
April 2008

The 3rd International Symposium on Alzheimer's Disease and Related Disorders in the Middle East, Istanbul, Turkey, October 1 - 2, 2005.

Amyloid 2007 Jun;14(2):161-8

Department of Neurology, CASE School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1080/13506120701259606DOI Listing
June 2007

Butyrylcholinesterase activity in the rat forebrain and upper brainstem: postnatal development and adult distribution.

Exp Neurol 2007 Apr 24;204(2):640-57. Epub 2006 Dec 24.

Laboratory for Neurodegenerative and Aging Research, Harvard Medical School, and Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.expneurol.2006.12.015DOI Listing
April 2007

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

Nat Med 2007 Apr 11;13(4):432-8. Epub 2007 Mar 11.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA.

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http://www.nature.com/articles/nm1555
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http://dx.doi.org/10.1038/nm1555DOI Listing
April 2007

Tomographic visualization of cholinesterase.

Ann Neurol 2006 Dec;60(6):745-6

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http://dx.doi.org/10.1002/ana.20926DOI Listing
December 2006

DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor.

J Biol Chem 2006 Jul 26;281(30):20940-8. Epub 2006 May 26.

Department of Neurology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA.

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http://dx.doi.org/10.1074/jbc.M601935200DOI Listing
July 2006

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

Nat Genet 2006 May 9;38(5):518-20. Epub 2006 Apr 9.

Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ng1778DOI Listing
May 2006

Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease.

Exp Neurol 2005 Oct;195(2):484-96

Alzheimer Disease and Memory Disorders Center, Department of Neurology, Memorial Hospital of Rhode Island, 111, Brewster Street, Pawtucket, RI 02860, USA.

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http://dx.doi.org/10.1016/j.expneurol.2005.06.020DOI Listing
October 2005

Rivastigmine is a potent inhibitor of acetyl- and butyrylcholinesterase in Alzheimer's plaques and tangles.

Brain Res 2005 Oct 5;1060(1-2):144-52. Epub 2005 Oct 5.

Laboratory for Neurodegenerative and Aging Research, Department of Medicine (Neuroscience), Harvard Medical School and Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.brainres.2005.08.039DOI Listing
October 2005

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.

Hum Mol Genet 2005 May 24;14(9):1231-41. Epub 2005 Mar 24.

Department of Neurology, Caritas St Elizabeth's Center, Tufts University School of Medicine, Boston, MA 02135, USA.

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http://dx.doi.org/10.1093/hmg/ddi134DOI Listing
May 2005

The 2nd International Symposium on Alzheimer's disease and related disorders in the Middle East, May 1-3, 2003, Istanbul, Turkey.

Amyloid 2004 Dec;11(4):276-80

Laboratory for Neurodegenerative and Aging Research, Department of Medicine, Harvard Medical School,Boston, MA 02215, USA.

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http://dx.doi.org/10.1080/13506120400016232DOI Listing
December 2004

Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease.

Drugs Today (Barc) 2004 Aug;40(8):711-21

Laboratory for Neurodegenerative and Aging Research, Department of Medicine (Neuroscience), Harvard Medical School and Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1358/dot.2004.40.8.850473DOI Listing
August 2004

Calbindin-D28K, parvalbumin and calretinin in primate lower motor neurons.

Neuroreport 2004 Mar;15(3):443-8

Laboratory for Neurodegenerative and Aging Research, Department of Medicine, Harvard Medical School and Section of Gerontology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Burlington Research Building, Boston, MA 02215, USA.

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http://dx.doi.org/10.1097/00001756-200403010-00012DOI Listing
March 2004

Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles.

Neurobiol Aging 2003 Oct;24(6):767-76

Laboratory for Neurodegenerative and Aging Research, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/s0197-4580(02)00228-2DOI Listing
October 2003

Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro.

Exp Neurol 2003 Oct;183(2):469-81

Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1016/s0014-4886(03)00222-xDOI Listing
October 2003

Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex.

Exp Neurol 2003 Jul;182(1):220-31

Laboratory for Neurodegenerative and Aging Research, Harvard Medical School, and Section of Gerontology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Burlington Research Facility, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/s0014-4886(03)00094-3DOI Listing
July 2003

Loss of calbindin-D28K from aging human cholinergic basal forebrain: relation to plaques and tangles.

J Neuropathol Exp Neurol 2003 Jun;62(6):605-16

Laboratory for Neurodegenerative and Aging Research, Section of Gerontology, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1093/jnen/62.6.605DOI Listing
June 2003

Distribution, progression and chemical composition of cortical amyloid-beta deposits in aged rhesus monkeys: similarities to the human.

Acta Neuropathol 2003 Feb 5;105(2):145-56. Epub 2002 Nov 5.

Laboratory for Neurodegenerative and Aging Research, Department of Medicine (Neuroscience), Harvard Medical School and Section of Gerontology, Beth Israel Deaconess Medical Center, 21-27 Burlington Ave., Boston, MA 02215, USA.

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http://dx.doi.org/10.1007/s00401-002-0626-5DOI Listing
February 2003

Neurobiology of butyrylcholinesterase.

Nat Rev Neurosci 2003 Feb;4(2):131-8

Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://www.nature.com/articles/nrn1035
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http://dx.doi.org/10.1038/nrn1035DOI Listing
February 2003

Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss.

J Comp Neurol 2003 Jan;455(2):249-59

Laboratory for Neurodegenerative and Aging Research, Section of Gerontology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1002/cne.10475DOI Listing
January 2003

A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.

J Biol Chem 2002 Dec 17;277(49):47373-9. Epub 2002 Sep 17.

Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.

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http://dx.doi.org/10.1074/jbc.M208788200DOI Listing
December 2002

Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition.

Acta Neuropathol 2002 Jan;103(1):48-58

Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1007/s004010100429DOI Listing
January 2002