Changgui Li

Changgui Li

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Changgui Li

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Chitosan alters inactivated respiratory syncytial virus vaccine elicited immune responses without affecting lung histopathology in mice.

Vaccine 2019 Jun 8. Epub 2019 Jun 8.

Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Sir Frederick G. Banting Research Centre, AL: 2201E, 251 Sir Frederick Banting Driveway, Ottawa, Ontario K1A 0K9, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, Roger Guindon Campus, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2019.06.003DOI Listing
June 2019

Mouse models for human hyperuricaemia: a critical review.

Nat Rev Rheumatol 2019 May 22. Epub 2019 May 22.

Department of Women's and Children's Health, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1038/s41584-019-0222-xDOI Listing
May 2019

Amplicon targeted resequencing for SLC2A9 and SLC22A12 identified novel mutations in hypouricemia subjects.

Mol Genet Genomic Med 2019 May 26:e722. Epub 2019 May 26.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiaric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, P.R. China.

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http://dx.doi.org/10.1002/mgg3.722DOI Listing
May 2019

A neuraminidase activity-based microneutralization assay for evaluating antibody responses to influenza H5 and H7 vaccines.

PLoS One 2018 15;13(11):e0207431. Epub 2018 Nov 15.

Division of Viral Vaccine III, National Institutes for Food and Drug Control and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, P.R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207431PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237356PMC
April 2019

Fresh Perspectives on the CARES Trial and the Use of Febuxostat in an Asian Population: Comment on the Article by Choi et al.

Arthritis Rheumatol 2019 Mar;71(3):479-481

Qingdao University and Affiliated Hospital of Qingdao University, Qingdao, China.

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http://doi.wiley.com/10.1002/art.40741
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http://dx.doi.org/10.1002/art.40741DOI Listing
March 2019

Common variants in the gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese.

Hereditas 2019 16;156. Epub 2019 Jan 16.

1Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiaric Disorders (Ministry of Education), Shanghai Jiao Tong University, No. 1954 Huashan Road, Shanghai, 200030 People's Republic of China.

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http://dx.doi.org/10.1186/s41065-018-0078-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335706PMC
March 2019

Unveiling Integrated Functional Pathways Leading to Enhanced Respiratory Disease Associated With Inactivated Respiratory Syncytial Viral Vaccine.

Front Immunol 2019 29;10:597. Epub 2019 Mar 29.

Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Products and Food Branch (HPFB), Health Canada and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.

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http://dx.doi.org/10.3389/fimmu.2019.00597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449435PMC
March 2019

Increased serum CA724 levels in patients suffering gout vs cancers.

Prog Mol Biol Transl Sci 2019 20;162:177-186. Epub 2019 Feb 20.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2018.12.005DOI Listing
February 2019

Antigenic Drift of Influenza A(H7N9) Virus Hemagglutinin.

J Infect Dis 2019 Jan;219(1):19-25

Division of HIV/AIDS and Sexually Transmitted Virus Vaccines, Beijing, China.

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http://dx.doi.org/10.1093/infdis/jiy408DOI Listing
January 2019

Immunogenicity and Safety of an F-Genotype Attenuated Mumps Vaccine in Healthy 8- to 24-Month-Old Children.

J Infect Dis 2019 Jan;219(1):50-58

Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China.

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http://dx.doi.org/10.1093/infdis/jiy469DOI Listing
January 2019

Targeting CD40 enhances antibody- and CD8-mediated protection against respiratory syncytial virus infection.

Sci Rep 2018 Nov 9;8(1):16648. Epub 2018 Nov 9.

Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.

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http://www.nature.com/articles/s41598-018-34999-z
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http://dx.doi.org/10.1038/s41598-018-34999-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226510PMC
November 2018

Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: A phase II, randomized, dose-finding trial.

Vaccine 2018 10 21;36(45):6782-6789. Epub 2018 Sep 21.

Jiangsu Province Center for Disease Control and Prevention, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2018.09.023DOI Listing
October 2018

A simple and safe antibody neutralization assay based on polio pseudoviruses.

Hum Vaccin Immunother 2019 16;15(2):349-357. Epub 2018 Oct 16.

a National Institutes for Food and Drug Control and WHO Collaborating Center for Standardization and Evaluation of Biologicals , Beijing , China.

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http://dx.doi.org/10.1080/21645515.2018.1526553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422504PMC
October 2018

Renal hypouricemia caused by novel compound heterozygous mutations in the SLC22A12 gene: a case report with literature review.

BMC Med Genet 2018 08 10;19(1):142. Epub 2018 Aug 10.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, No. 1954 Huashan Road, Shanghai, 200030, People's Republic of China.

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-018-0595-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086067PMC
August 2018

Glucose and Insulin-Related Traits, Type 2 Diabetes and Risk of Schizophrenia: A Mendelian Randomization Study.

EBioMedicine 2018 Aug 9;34:182-188. Epub 2018 Aug 9.

The Affiliated Hospital of Qingdao University, The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, No. 16 Jiangsu Road, Qingdao 266003, PR China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, No. 1954 Huashan Road, Shanghai 200030, PR China; Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, PR China; Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, No. 1954 Huashan Road, Shanghai 200030, PR China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 Wanping Nan Road, Shanghai 200030, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116472PMC
August 2018

Identification of immunodominant CD8 epitope in the stalk domain of influenza B viral hemagglutinin.

Biochem Biophys Res Commun 2018 07 24;502(2):226-231. Epub 2018 May 24.

Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada and WHO Collaborating Center for Standardization and Evaluation of Biologicals, 251 Sir Frederick Banting Driveway, K1A 0K9, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Campus, Ottawa, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.05.148DOI Listing
July 2018

Clinical characteristics associated with subcutaneous tophi formation in Chinese gout patients: a retrospective study.

Clin Rheumatol 2018 May 22;37(5):1359-1365. Epub 2018 Jan 22.

The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, 16 Jiangsu Rd, Qingdao, 266003, China.

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http://link.springer.com/10.1007/s10067-017-3969-y
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http://dx.doi.org/10.1007/s10067-017-3969-yDOI Listing
May 2018

Development of in vitro and in vivo neutralization assays based on the pseudotyped H7N9 virus.

Sci Rep 2018 May 31;8(1):8484. Epub 2018 May 31.

Division of HIV/AIDS and Sexually-transmitted Virus Vaccines, National Institutes for Food and Drug Control, No. 2 Tiantanxili, Beijing, 100050, China.

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http://dx.doi.org/10.1038/s41598-018-26822-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981435PMC
May 2018

The ongoing role of serum uric acid in blood pressure.

Clin Exp Hypertens 2017 5;39(7):601-605. Epub 2017 Jul 5.

a Shandong Gout Clinical Medical Center, The Affiliated Hospital of Qingdao University , Qingdao , China.

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http://dx.doi.org/10.1080/10641963.2017.1299750DOI Listing
April 2018

Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.

Kidney Int 2018 01 18;93(1):69-80. Epub 2017 Jul 18.

Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China; Institute of Metabolic Diseases, Qingdao University, Qingdao, China; Department of Endocrinology and Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00852538173033
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http://dx.doi.org/10.1016/j.kint.2017.04.031DOI Listing
January 2018

Universal type/subtype-specific antibodies for quantitative analyses of neuraminidase in trivalent influenza vaccines.

Sci Rep 2018 01 18;8(1):1067. Epub 2018 Jan 18.

The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, P.R. China.

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http://dx.doi.org/10.1038/s41598-017-18663-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773574PMC
January 2018

Fast and highly selective determination of hemagglutinin content in quadrivalent influenza vaccine by reversed-phase high-performance liquid chromatography method.

J Chromatogr A 2017 Dec 18;1528:18-24. Epub 2017 Oct 18.

Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, 251 Sir Frederick Banting, Tunney's Pasture, Ottawa, Ontario, K1A 0K9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2017.10.041DOI Listing
December 2017

Alprostadil protects type 2 diabetes mellitus patients treated with metformin from contrast-induced nephropathy.

Int Urol Nephrol 2017 Nov 27;49(11):2019-2026. Epub 2017 Jun 27.

Biotherapy Center, The Affiliated Central Hospital of Qingdao University, Qingdao, 266042, China.

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http://dx.doi.org/10.1007/s11255-017-1639-2DOI Listing
November 2017

Association between non-alcoholic fatty liver disease and peripheral artery disease in patients with type 2 diabetes.

Intern Med J 2017 Oct;47(10):1147-1153

Gout Laboratory, Shandong Provincial Key Laboratory of Metabolic Diseases, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

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http://dx.doi.org/10.1111/imj.13549DOI Listing
October 2017

Potential contribution of the neurodegenerative disorders risk loci to cognitive performance in an elderly male gout population.

Medicine (Baltimore) 2017 Sep;96(39):e8195

aDepartment of Endocrinology Qilu Hospital of Shandong University, Jinan bGout Laboratory, The Affiliated Hospital of Qingdao University, Qingdao cState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1097/MD.0000000000008195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626325PMC
September 2017

Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population.

Sci Rep 2017 06 22;7(1):4094. Epub 2017 Jun 22.

The Biomedical Sciences Institute of Qingdao University, Qingdao Branch of SJTU Bio-X Institutes & the Affiliated Hospital of Qingdao University, Qingdao, 266003, P.R. China.

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http://dx.doi.org/10.1038/s41598-017-04127-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481433PMC
June 2017

Immune Serum From Sabin Inactivated Poliovirus Vaccine Immunization Neutralizes Multiple Individual Wild and Vaccine-Derived Polioviruses.

Clin Infect Dis 2017 May;64(10):1317-1325

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan.

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http://dx.doi.org/10.1093/cid/cix110DOI Listing
May 2017

Immunopathogenesis associated with formaldehyde-inactivated RSV vaccine in preclinical and clinical studies.

Expert Rev Vaccines 2017 04 21;16(4):351-360. Epub 2016 Nov 21.

a Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate , Health Canada and WHO Collaborating Center for Standardization and Evaluation of Biologics , Ottawa , ON , Canada.

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https://www.tandfonline.com/doi/full/10.1080/14760584.2017.1
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http://dx.doi.org/10.1080/14760584.2017.1260452DOI Listing
April 2017

Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea.

Nat Commun 2017 04 27;8:14900. Epub 2017 Apr 27.

The Affiliated Hospital of Qingdao University &The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao 266003, China.

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http://dx.doi.org/10.1038/ncomms14900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414039PMC
April 2017

[Analysis of serum ferritin and high sensitive C reactive protein in patients with gout].

Wei Sheng Yan Jiu 2017 Mar;46(2):232-236

Department of Nutrition and Food Hygiene, College of Public Health, Qingdao University, Qingdao 266023, China.

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March 2017

Phase 3 Trial of a Sabin Strain-Based Inactivated Poliovirus Vaccine.

J Infect Dis 2016 Dec 22;214(11):1728-1734. Epub 2016 Sep 22.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming.

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http://dx.doi.org/10.1093/infdis/jiw433DOI Listing
December 2016

Association analysis between genetic variants in interleukin genes among different populations with hyperuricemia in Xinjiang Autonomous Region.

Int J Clin Exp Pathol 2015 1;8(10):13432-40. Epub 2015 Oct 1.

State Key Laboratory Incubation Base of Xinjiang Major Diseases Research (2010DS890294), First Affiliated Hospital of Xinjiang Medical University Urumqi, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680499PMC
October 2016

Epidermal growth factor gene is a newly identified candidate gene for gout.

Sci Rep 2016 08 10;6:31082. Epub 2016 Aug 10.

Shandong Gout Clinical Medical Center, Qingdao 266003, China.

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http://dx.doi.org/10.1038/srep31082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978989PMC
August 2016

Genetic Analysis of IL-17 Gene Polymorphisms in Gout in a Male Chinese Han Population.

PLoS One 2016 18;11(2):e0148082. Epub 2016 Feb 18.

Shandong Provincial Key Laboratory of Metabolic Disease, the Affiliated Hospital of Qingdao University, Qingdao, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148082PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758639PMC
July 2016

Evaluation of Commercial Diagnostic Assays for the Specific Detection of Avian Influenza A (H7N9) Virus RNA Using a Quality-Control Panel and Clinical Specimens in China.

PLoS One 2015 11;10(9):e0137862. Epub 2015 Sep 11.

Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, People's Republic of China; WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137862PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567293PMC
May 2016

Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke.

Mol Neurobiol 2016 Apr 7;53(3):1753-1759. Epub 2015 Mar 7.

Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.

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http://dx.doi.org/10.1007/s12035-015-9134-1DOI Listing
April 2016

Serum Uric Acid Levels and Diabetic Peripheral Neuropathy in Type 2 Diabetes: a Systematic Review and Meta-analysis.

Mol Neurobiol 2016 Mar 12;53(2):1045-51. Epub 2015 Jan 12.

Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.

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http://link.springer.com/10.1007/s12035-014-9075-0
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http://dx.doi.org/10.1007/s12035-014-9075-0DOI Listing
March 2016

A Recombinant G Protein Plus Cyclosporine A-Based Respiratory Syncytial Virus Vaccine Elicits Humoral and Regulatory T Cell Responses against Infection without Vaccine-Enhanced Disease.

J Immunol 2016 Feb 20;196(4):1721-31. Epub 2016 Jan 20.

Key Laboratory of Medical Molecular Virology of the Ministry of Health and the Ministry of Education, Shanghai Medical College, Fudan University, Shanghai 201508, China;

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http://dx.doi.org/10.4049/jimmunol.1502103DOI Listing
February 2016

The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia.

Stem Cells Int 2016 21;2016:1365257. Epub 2015 Dec 21.

Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China; Shandong Gout Clinical Medical Center, Qingdao 266003, China.

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http://dx.doi.org/10.1155/2016/1365257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691499PMC
January 2016

CARD8 rs2043211 polymorphism is associated with gout in a Chinese male population.

Cell Physiol Biochem 2015 12;35(4):1394-400. Epub 2015 Mar 12.

Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, China.

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http://dx.doi.org/10.1159/000373960DOI Listing
December 2015

Protection against multiple subtypes of influenza viruses by virus-like particle vaccines based on a hemagglutinin conserved epitope.

Biomed Res Int 2015 12;2015:901817. Epub 2015 Feb 12.

Shanghai Institute of Biological Products, Shanghai 200052, China ; College of Life Sciences, Hunan Normal University, Hunan, Changsha 410081, China.

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http://dx.doi.org/10.1155/2015/901817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341857PMC
November 2015

[Association of single nucleotide polymorphisms of susceptibility genes of type 2 diabetes mellitus with liability to gout among ethnic Han Chinese males from coastal region of Shandong].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2015 Oct;32(5):711-4

Shandong Provincial Gout Clinical Medical Center, Department of Metabolic Disease, Department of Pathology, Affiliated Hospital of Qingdao University. Email:

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2015.05.023DOI Listing
October 2015

Associations between interleukin and interleukin receptor gene polymorphisms and risk of gout.

Sci Rep 2015 Sep 24;5:13887. Epub 2015 Sep 24.

Shandong Provincial Key Laboratory of Metabolic Disease, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.

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http://dx.doi.org/10.1038/srep13887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585862PMC
September 2015

[Association of single nucleotide polymorphisms of cytochrome P450 gene with susceptibility to gout in ethnic Han males from coastal regions of Shandong province].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2015 Aug;32(4):538-42

Shandong Provincial Gout Clinical Medical Center, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P. R. China.

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2015.04.020DOI Listing
August 2015

Cyclic GMP-dependent protein kinase II is necessary for macrophage M1 polarization and phagocytosis via toll-like receptor 2.

J Mol Med (Berl) 2015 May 6;93(5):523-33. Epub 2014 Dec 6.

Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://link.springer.com/content/pdf/10.1007/s00109-014-1236
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http://link.springer.com/10.1007/s00109-014-1236-0
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http://dx.doi.org/10.1007/s00109-014-1236-0DOI Listing
May 2015

The rs7517847 polymorphism in the IL-23R gene is associated with gout in a Chinese Han male population.

Mod Rheumatol 2015 May 9;25(3):449-52. Epub 2015 Feb 9.

Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University , Qingdao , P. R. China.

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http://dx.doi.org/10.3109/14397595.2014.964823DOI Listing
May 2015

Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China.

Gene 2015 May 14;562(1):50-4. Epub 2015 Feb 14.

Department of Endocrinology and Metabolic Disease, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2015.02.033DOI Listing
May 2015

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.

Nat Commun 2015 May 13;6:7041. Epub 2015 May 13.

1] Shandong Gout Clinical Medical Center, Qingdao 266003, China [2] Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China [3] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China [4] Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.

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http://dx.doi.org/10.1038/ncomms8041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479022PMC
May 2015

The CC chemokine ligand 2 (CCL2) polymorphism -2518A/G is associated with gout in the Chinese Han male population.

Rheumatol Int 2015 Mar 14;35(3):479-84. Epub 2014 Aug 14.

Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.

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http://dx.doi.org/10.1007/s00296-014-3102-3DOI Listing
March 2015

Genetic heterogeneity of susceptibility gene in different ethnic populations: refining association study of PTPN22 for Graves' disease in a Chinese Han population.

PLoS One 2013 30;8(12):e84514. Epub 2013 Dec 30.

State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiaotong University (SJTU) School of Medicine, Shanghai, China ; Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084514PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875558PMC
February 2015

Development and applications of universal H7 subtype-specific antibodies for the analysis of influenza H7N9 vaccines.

Vaccine 2015 Feb 22;33(9):1129-34. Epub 2015 Jan 22.

Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.01.034DOI Listing
February 2015

Regulatory science accelerates the development of biotechnology drugs and vaccines by NIFDC.

Emerg Microbes Infect 2014 Sep 17;3(9):e67. Epub 2014 Sep 17.

National Institutes for Food and Drug Control, Beijing 100050, China.

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http://dx.doi.org/10.1038/emi.2014.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185363PMC
September 2014

CD40 ligand preferentially modulates immune response and enhances protection against influenza virus.

J Immunol 2014 Jul 13;193(2):722-34. Epub 2014 Jun 13.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada

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http://dx.doi.org/10.4049/jimmunol.1300093DOI Listing
July 2014

[Functional analysis of +11G > A single nucleotide polymorphisms in intron 3 of human urate transporter 1 gene].

Zhonghua Nei Ke Za Zhi 2014 Jul;53(7):550-4

Key Laboratory of Gout Disease, The Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, China. Email:

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July 2014

Hypothermia induced by adenosine 5'-monophosphate attenuates injury in an L-arginine-induced acute pancreatitis rat model.

J Gastroenterol Hepatol 2014 Apr;29(4):742-8

Gout Laboratory, Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao, China.

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http://dx.doi.org/10.1111/jgh.12448DOI Listing
April 2014

Universal anti-neuraminidase antibody inhibiting all influenza A subtypes.

Antiviral Res 2013 Nov 30;100(2):567-74. Epub 2013 Sep 30.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology and Emerging Pathogens Research Centre, University of Ottawa, Ottawa, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01663542130026
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http://dx.doi.org/10.1016/j.antiviral.2013.09.018DOI Listing
November 2013

A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains.

Biochem Biophys Res Commun 2013 Nov 16;441(1):226-9. Epub 2013 Oct 16.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

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http://dx.doi.org/10.1016/j.bbrc.2013.10.041DOI Listing
November 2013

Hypothermia induced by adenosine 5'-monophosphate attenuates early stage injury in an acute gouty arthritis rat model.

Rheumatol Int 2013 Aug 14;33(8):2085-92. Epub 2013 Feb 14.

Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s00296-013-2676-5DOI Listing
August 2013

The universal epitope of influenza A viral neuraminidase fundamentally contributes to enzyme activity and viral replication.

J Biol Chem 2013 Jun 3;288(25):18283-9. Epub 2013 May 3.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario K1A 0K9, Canada.

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http://dx.doi.org/10.1074/jbc.M113.468884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689970PMC
June 2013

Metabolic syndrome, diabetes, and hyperuricemia.

Curr Opin Rheumatol 2013 Mar;25(2):210-6

Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao Key Laboratory of Common Diseases Gout Laboratory, the Affiliated Hospital of Medical College, Qingdao University, China.

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http://dx.doi.org/10.1097/BOR.0b013e32835d951eDOI Listing
March 2013

Development of a Vero cell DNA reference standard for residual DNA measurement in China.

Hum Vaccin Immunother 2013 Feb 4;9(2):413-9. Epub 2013 Jan 4.

National Institutes for Food and Drug Control; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products; Beijing, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859766PMC
http://dx.doi.org/10.4161/hv.22699DOI Listing
February 2013

Modifying the thermostability of inactivated influenza vaccines.

Vaccine 2012 Aug 27;30(37):5506-11. Epub 2012 Jun 27.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Canada.

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http://dx.doi.org/10.1016/j.vaccine.2012.06.051DOI Listing
August 2012

Polymorphisms -1082 G/A and -819 C/T in the interleukin-10 gene are not associated with gout susceptibility in the Chinese Han male population.

Genet Test Mol Biomarkers 2012 Aug 12;16(8):879-83. Epub 2012 Jul 12.

Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.

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http://dx.doi.org/10.1089/gtmb.2011.0314DOI Listing
August 2012

Simultaneous quantification of the viral antigens hemagglutinin and neuraminidase in influenza vaccines by LC-MSE.

Vaccine 2012 Jul 27;30(32):4762-70. Epub 2012 May 27.

Centre for Vaccine Evaluation, Health Canada, 251 Sir Frederick Banting Driveway, Locator 2201E, Tunney's Pasture, Ottawa, ON K1A 0L2, Canada.

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http://dx.doi.org/10.1016/j.vaccine.2012.05.036DOI Listing
July 2012

Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population.

Rheumatol Int 2012 Jun 13;32(6):1805-7. Epub 2011 Apr 13.

Gout Laboratory, Medical School Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.

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http://dx.doi.org/10.1007/s00296-011-1936-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364418PMC
June 2012

Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: a phase II, randomized, positive-controlled trial.

J Infect Dis 2012 Jan 8;205(2):237-43. Epub 2011 Dec 8.

Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, China.

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http://dx.doi.org/10.1093/infdis/jir723DOI Listing
January 2012

Rapid and accurate determination of the potency of varicella vaccine by quantitative polymerase chain reaction.

Vaccine 2011 Nov 20;29(47):8490-5. Epub 2011 Sep 20.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Canada.

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http://dx.doi.org/10.1016/j.vaccine.2011.09.017DOI Listing
November 2011

Genetic association of polymorphism rs1333049 with gout.

Rheumatology (Oxford) 2011 Sep 9;50(9):1559-61. Epub 2011 May 9.

Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao Key Laboratory of Common Diseases Gout Laboratory, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, China.

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http://dx.doi.org/10.1093/rheumatology/ker135DOI Listing
September 2011

Association of catechol-O-methyl transferase (COMT) gene -287A/G polymorphism with susceptibility to obsessive-compulsive disorder in Chinese Han population.

Am J Med Genet B Neuropsychiatr Genet 2011 Jun 22;156B(4):393-400. Epub 2011 Feb 22.

Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, China.

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http://dx.doi.org/10.1002/ajmg.b.31173DOI Listing
June 2011

Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population.

J Rheumatol 2011 Apr 1;38(4):738-40. Epub 2011 Feb 1.

Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao Key Laboratory of Common Diseases Gout Laboratory, the Affiliated Hospital of the Medical College, Qingdao University, Qingdao, Shandong, China.

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http://www.jrheum.org/cgi/doi/10.3899/jrheum.101037
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http://dx.doi.org/10.3899/jrheum.101037DOI Listing
April 2011

Development and implementation of the quality control panel of RT-PCR and real-time RT-PCR for avian influenza A (H5N1) surveillance network in mainland China.

BMC Infect Dis 2011 Mar 16;11:67. Epub 2011 Mar 16.

Dept. of Influenza, Chinese National Influenza Center, State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese center for disease control and prevention (China CDC), Beijing 100052, PR China.

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http://dx.doi.org/10.1186/1471-2334-11-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066113PMC
March 2011

Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain.

Vaccine 2011 Feb 4;29(8):1529-33. Epub 2011 Jan 4.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Canada.

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http://dx.doi.org/10.1016/j.vaccine.2010.12.120DOI Listing
February 2011

Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus.

Biochem Biophys Res Commun 2010 Dec 13;403(2):247-51. Epub 2010 Nov 13.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada.

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http://www.kau.edu.sa/GetFile.aspx?id=223739&fn=2010-Hashem%
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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1002078
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http://dx.doi.org/10.1016/j.bbrc.2010.11.030DOI Listing
December 2010

Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population.

Hum Genet 2010 Feb 17;127(2):245-6. Epub 2009 Nov 17.

Graduate School, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1007/s00439-009-0760-4DOI Listing
February 2010

A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide.

Nat Protoc 2010 Jan;5(1):14-9

National Institute for the Control of Pharmaceutical and Biological Products, The State Food and Drug Administration, Beijing, P.R. China.

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http://dx.doi.org/10.1038/nprot.2009.200DOI Listing
January 2010

Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions.

Inflamm Res 2009 Oct 31;58(10):659-68. Epub 2009 Mar 31.

Department of Endocrinology, Medical School Hospital of Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China.

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http://link.springer.com/10.1007/s00011-009-0031-9
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http://dx.doi.org/10.1007/s00011-009-0031-9DOI Listing
October 2009

MicroRNA genes.

Ann N Y Acad Sci 2008 Dec;1150:72-5

Department of Pathology, Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, USA.

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http://dx.doi.org/10.1196/annals.1447.026DOI Listing
December 2008

Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins.

Vaccine 2008 Nov;26(48):6068-76

Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.vaccine.2008.09.015DOI Listing
November 2008

Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China.

J Rheumatol 2008 Sep 15;35(9):1859-64. Epub 2008 Jul 15.

Department of Endocrinology, Medical School Hospital of Qingdao University, Qingdao, China.

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September 2008

A Sabin 1 poliovirus-based vaccine vector transfects Vero cells with high efficiency.

Cytotechnology 2007 Jul 11;54(3):169-79. Epub 2007 Jul 11.

Biotechnology Center of the Forth Military Medical University, 17 Changle West Road, Xian, 710032, P. R. China.

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http://dx.doi.org/10.1007/s10616-007-9085-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267503PMC
July 2007

Real-time RT-PCR for H5N1 avian influenza A virus detection.

J Med Microbiol 2007 May;56(Pt 5):603-7

Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1099/jmm.0.47014-0DOI Listing
May 2007