Changjiang Xu

Changjiang Xu

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Changjiang Xu

Publications by authors named "Changjiang Xu"

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EPIC: software toolkit for elution profile-based inference of protein complexes.

Nat Methods 2019 Aug 15;16(8):737-742. Epub 2019 Jul 15.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41592-019-0461-4DOI Listing
August 2019

Restricted access magnetic core-mesoporous shell microspheres with C8-modified interior pore walls for the identification of 20(S)-protopanaxadiol metabolites in rat plasma using UPLC-Q-TOF-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Jun 3;1054:73-79. Epub 2017 Apr 3.

Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2017.04.004DOI Listing
June 2017

Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents.

Chem Pharm Bull (Tokyo) 2017 ;65(4):381-388

Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy.

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http://dx.doi.org/10.1248/cpb.c16-00839DOI Listing
April 2017

A highly sensitive HPLC-MS/MS method for quantification of 20(S)-protopanaxadiol in human plasma and its application in phase IIa clinical trial of a novel antidepressant agent.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Sep 27;1031:214-220. Epub 2016 Jul 27.

Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, No.826 Zhangheng Road, Shanghai, 201203, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2016.07.044DOI Listing
September 2016

The complete chloroplast genome sequence of Fagopyrum cymosum.

Mitochondrial DNA A DNA Mapp Seq Anal 2016 07 29;27(4):2410-1. Epub 2015 Jun 29.

a Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing , China .

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http://www.tandfonline.com/doi/full/10.3109/19401736.2015.10
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http://dx.doi.org/10.3109/19401736.2015.1030619DOI Listing
July 2016

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.

Cancer Cell 2016 06;29(6):859-873

Arthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children (SickKids), Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, SickKids, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(16)30207-0.pd
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http://dx.doi.org/10.1016/j.ccell.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968455PMC
June 2016

A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II.

Oncotarget 2016 May;7(22):32054-64

State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China.

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http://dx.doi.org/10.18632/oncotarget.8410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077996PMC
May 2016

HOX gene complement and expression in the planarian Schmidtea mediterranea.

Evodevo 2016 30;7. Epub 2016 Mar 30.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G10A4 Canada ; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G10A4 Canada ; Ontario Institute for Cancer Research, Toronto, ON M5G10A4 Canada.

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http://dx.doi.org/10.1186/s13227-016-0044-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815179PMC
April 2016

A mex3 homolog is required for differentiation during planarian stem cell lineage development.

Elife 2015 Jun 26;4. Epub 2015 Jun 26.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.7554/eLife.07025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507787PMC
June 2015

Estimating genome-wide significance for whole-genome sequencing studies.

Genet Epidemiol 2014 May 14;38(4):281-90. Epub 2014 Feb 14.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.

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http://dx.doi.org/10.1002/gepi.21797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489336PMC
May 2014

Exploring the potential benefits of stratified false discovery rates for region-based testing of association with rare genetic variation.

Front Genet 2014 29;5:11. Epub 2014 Jan 29.

Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, QC, Canada ; Department of Epidemiology, Biostatistics and Occupational Health, McGill University Montreal, QC, Canada ; Departments of Oncology and Human Genetics, McGill University Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fgene.2014.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905218PMC
February 2014

20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests.

Prog Neuropsychopharmacol Biol Psychiatry 2010 Dec 18;34(8):1402-11. Epub 2010 Jul 18.

Shanghai Innovative Research Centre of Traditional Chinese Medicine, Shanghai, China.

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http://dx.doi.org/10.1016/j.pnpbp.2010.07.010DOI Listing
December 2010

Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis.

Biochem Pharmacol 2008 Dec 23;76(11):1485-9. Epub 2008 Jul 23.

Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/j.bcp.2008.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610259PMC
December 2008

Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells.

Pharm Res 2008 Feb 27;25(2):387-99. Epub 2007 Jul 27.

Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1007/s11095-007-9364-7DOI Listing
February 2008

Complexity and scoring function of MS/MS peptide de novo sequencing.

Comput Syst Bioinformatics Conf 2006 :361-9

Department of Computer Science, University of Western Ontario, London, ON N6A 5B7, Canada.

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June 2007

Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.

Toxicol Lett 2007 Jan 10;168(1):21-39. Epub 2006 Nov 10.

Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/j.toxlet.2006.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847389PMC
January 2007

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.

Biopharm Drug Dispos 2006 Dec;27(9):407-20

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1002/bdd.522DOI Listing
December 2006

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

Cancer Lett 2006 Nov 3;243(2):170-92. Epub 2006 Mar 3.

Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/j.canlet.2005.11.050DOI Listing
November 2006

Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells.

Mol Carcinog 2006 Nov;45(11):841-50

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1002/mc.20234DOI Listing
November 2006

Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.

Pharm Res 2006 Nov 13;23(11):2621-37. Epub 2006 Sep 13.

Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.

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http://link.springer.com/10.1007/s11095-006-9099-x
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http://dx.doi.org/10.1007/s11095-006-9099-xDOI Listing
November 2006

Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes.

Pharm Res 2006 Nov 18;23(11):2586-94. Epub 2006 Oct 18.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854, USA.

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http://link.springer.com/10.1007/s11095-006-9094-2
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http://dx.doi.org/10.1007/s11095-006-9094-2DOI Listing
November 2006

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.

Carcinogenesis 2006 Oct 4;27(10):2038-46. Epub 2006 May 4.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1093/carcin/bgl049DOI Listing
October 2006

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.

Life Sci 2006 Oct 20;79(20):1944-55. Epub 2006 Jun 20.

Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/j.lfs.2006.06.019DOI Listing
October 2006

In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice.

Arch Pharm Res 2006 Oct;29(10):911-20

Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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October 2006

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

Cancer Res 2006 Aug;66(16):8293-6

Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-06-0300DOI Listing
August 2006

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.

Mol Cancer Ther 2006 Aug;5(8):1918-26

Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, 08854, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0497DOI Listing
August 2006

Software for computational peptide identification from MS-MS data.

Drug Discov Today 2006 Jul;11(13-14):595-600

Department of Computer Science, University of Western Ontario, London, Ontario N6A 5B7, Canada.

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http://dx.doi.org/10.1016/j.drudis.2006.05.011DOI Listing
July 2006

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

Carcinogenesis 2006 Mar 4;27(3):437-45. Epub 2005 Nov 4.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1093/carcin/bgi251DOI Listing
March 2006

Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.

Carcinogenesis 2006 Mar 19;27(3):475-82. Epub 2005 Nov 19.

Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1093/carcin/bgi272DOI Listing
March 2006

p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.

Cancer Chemother Pharmacol 2006 Feb 17;57(3):317-27. Epub 2005 Sep 17.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA.

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http://dx.doi.org/10.1007/s00280-005-0050-3DOI Listing
February 2006

Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.

Cancer Res 2006 Jan;66(2):613-21

Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, 160 Freilinghuysen Road, Piscataway, NJ 08854, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-2708DOI Listing
January 2006

Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin.

Mol Cancer Ther 2006 Jan;5(1):39-51

Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, 08854, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0293DOI Listing
January 2006

Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

Pharm Res 2005 Nov 16;22(11):1805-20. Epub 2005 Aug 16.

Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1007/s11095-005-7546-8DOI Listing
November 2005

Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

Oncogene 2005 Jun;24(28):4486-95

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1038/sj.onc.1208656DOI Listing
June 2005

Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Arch Pharm Res 2005 Mar;28(3):249-68

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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March 2005

Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein.

J Biol Chem 2004 May 13;279(22):23052-60. Epub 2004 Mar 13.

Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M401368200DOI Listing
May 2004