Publications by authors named "Chang-Yue Wang"

4 Publications

  • Page 1 of 1

Regulating the balance of Th17/Treg cells in gut-lung axis contributed to the therapeutic effect of Houttuynia cordata polysaccharides on H1N1-induced acute lung injury.

Int J Biol Macromol 2020 Apr 28;158:52-66. Epub 2020 Apr 28.

Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, China. Electronic address:

Our previous study had demonstrated that oral administration of Houttuynia cordata polysaccharides (HCP) without in vitro antiviral activity ameliorated gut and lung injuries induced by influenza A virus (IAV) in mice. However, as macromolecules, HCP was hard to be absorbed in gastrointestinal tract and had no effect on lung injury when administrated intravenously. The action mechanism of HCP was thus proposed as regulating the gut mucosal-associated lymphoid tissue (GALT). Actually, HCP treatment restored the balance of Th17/Treg cells firstly in GALT and finally in the lung. HCP reduced the expression of chemokine CCL20 in the lung and regulated the balance of Th17/Treg carrying CCR6 (the CCL20 receptor), which was associated with specific migration of Th17/Treg cells from GALT to lung. In vitro, HCP inhibited Th17 cell differentiation through the downregulation of phospho-STAT3, whereas it promoted Treg cell differentiation by upregulating phospho-STAT5. Furthermore, its therapeutic effect was abolished in RORγt or Foxp3 mice. These findings indicated that oral administration of macromolecular polysaccharides like HCP might ameliorate lung injury in IAV infected mice via directly regulating the balance of Th17/Treg cells in gut-lung axis. Our results provided a potential mechanism underlying the therapeutic effect of polysaccharides on pulmonary infection.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.04.211DOI Listing
April 2020

Sextuple ratiometric thermometry based on 980-nm-upconverted green fluorescence of Er ions in submicron crystals.

Mater Sci Eng C Mater Biol Appl 2020 Mar 30;108:110512. Epub 2019 Nov 30.

Department of Opto-electronics and Information Engineering, School of Precision Instruments and Opto-electronics Engineering, and Key Laboratory of Optoelectronic Information Technology (Ministry of Education),Tianjin University, Tianjin 300072, China. Electronic address:

980-nm-upconverted 530 and 550 nm Er green fluorescence spectra of Er/Yb-codoped NaGd(WO) submicron crystals were measured in the temperature range of 298-383 K. A sextuple ratiometric thermometry is proposed. It is established on the basis of six schemes of fluorescence intensity ratio (FIR) that considers three component peaks of the 530 nm emission band and two component peaks of the 550 nm emission band, which involve electronic transitions between two Stark sublevels of Er. The study shows that the phosphor shows strong green fluorescence, which is verified by measured quantum yield, and thermally stable spectral structure desired for the sextuple ratiometric thermometry. All of the six FIR schemes display highly efficient sensing performances with slightly different thermal sensitivities. Each scheme gives a temperature value and the six schemes give an averaged result. In parallel, we have also carried out an ex vivo experimental study on the temperature characteristics of the green fluorescence of the phosphor. Almost same results have been obtained, verifying biological applicability of the phosphor. The ex vivo experimental results also show that the sextuple thermometry increases considerably the accuracy and reliability of temperature measurement in comparison with the conventional intensity integration method.
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http://dx.doi.org/10.1016/j.msec.2019.110512DOI Listing
March 2020

A new abietane diterpene and anti-complementary constituents from .

Nat Prod Res 2020 Jan 5:1-8. Epub 2020 Jan 5.

School of Pharmacy, Institutes of Integrative Medicine, Fudan University, Shanghai, China.

Anti-complementary activity-guided fractionation led to the isolation of a new abietane diterpene () and twenty-five known compounds () from the twigs and leaves of . All the compounds were isolated from for the first time. The structure of was assigned by spectroscopic data and X-ray crystallography analysis. Five lignans (, , , and ), two flavones ( and ), and one coumarin () exhibited anti-complementary activity with CH values ranging from 0.3 to 3.69 mM.
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http://dx.doi.org/10.1080/14786419.2019.1709191DOI Listing
January 2020

[Biomass Compositional Analysis Using Sparse Partial Least Squares Regression and Near Infrared Spectrum Technique].

Guang Pu Xue Yu Guang Pu Fen Xi 2015 Jul;35(7):1864-9

Forest bio-fuel, a new type renewable energy, has attracted increasing attention as a promising alternative. In this study, a new method called Sparse Partial Least Squares Regression (SPLS) is used to construct the proximate analysis model to analyze the fuel characteristics of sawdust combining Near Infrared Spectrum Technique. Moisture, Ash, Volatile and Fixed Carbon percentage of 80 samples have been measured by traditional proximate analysis. Spectroscopic data were collected by Nicolet NIR spectrometer. After being filtered by wavelet transform, all of the samples are divided into training set and validation set according to sample category and producing area. SPLS, Principle Component Regression (PCR), Partial Least Squares Regression (PLS) and Least Absolute Shrinkage and Selection Operator (LASSO) are presented to construct prediction model. The result advocated that SPLS can select grouped wavelengths and improve the prediction performance. The absorption peaks of the Moisture is covered in the selected wavelengths, well other compositions have not been confirmed yet. In a word, SPLS can reduce the dimensionality of complex data sets and interpret the relationship between spectroscopic data and composition concentration, which will play an increasingly important role in the field of NIR application.
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July 2015