Publications by authors named "Chang Chan"

57Publications

Early lung cancer diagnostic biomarker discovery by machine learning methods.

Transl Oncol 2020 Nov 17;14(1):100907. Epub 2020 Nov 17.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China; Respiratory Medicine department of Taihe Hospital, Hubei University of Medicine, Hubei, China. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2020.100907DOI Listing
November 2020

Evodiamine suppresses non-small cell lung cancer by elevating CD8 T cells and downregulating the MUC1-C/PD-L1 axis.

J Exp Clin Cancer Res 2020 Nov 19;39(1):249. Epub 2020 Nov 19.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Macao, Taipa Macau (SAR), China.

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http://dx.doi.org/10.1186/s13046-020-01741-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677782PMC
November 2020

Triptolide induces apoptosis through the calcium/calmodulin‑dependent protein kinase kinaseβ/AMP‑activated protein kinase signaling pathway in non‑small cell lung cancer cells.

Oncol Rep 2020 Nov 11;44(5):2288-2296. Epub 2020 Sep 11.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

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http://dx.doi.org/10.3892/or.2020.7763DOI Listing
November 2020

Socioeconomic Inequalities in Colorectal Cancer Survival in Southern Spain: A Multilevel Population-Based Cohort Study.

Clin Epidemiol 2020 21;12:797-806. Epub 2020 Jul 21.

Instituto de Investigación Biosanitaria de Granada, Non-Communicable Disease and Cancer Epidemiology Group, ibs.GRANADA, University of Granada, Granada, Spain.

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http://dx.doi.org/10.2147/CLEP.S261355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383045PMC
July 2020

Loss of Setd4 delays radiation-induced thymic lymphoma in mice.

DNA Repair (Amst) 2020 02 25;86:102754. Epub 2019 Nov 25.

Rutgers Cancer Institute of New Jersey, Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960333PMC
February 2020

Approaches of anatomy teaching for seriously resource-deprived countries: A literature review.

Educ Health (Abingdon) 2019 May-Aug;32(2):62-74

Department of Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.4103/efh.EfH_272_17DOI Listing
June 2020

Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids.

Cancer Res 2019 09 12;79(17):4339-4347. Epub 2019 Jul 12.

Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733269PMC
September 2019

Patient, tumor, and healthcare factors associated with regional variability in lung cancer survival: a Spanish high-resolution population-based study.

Clin Transl Oncol 2019 May 19;21(5):621-629. Epub 2018 Oct 19.

Andalusian School of Public Health, Granada Cancer Registry, Campus Universitario de Cartuja, C/Cuesta del Observatorio 4, 18080, Granada, Spain.

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http://dx.doi.org/10.1007/s12094-018-1962-9DOI Listing
May 2019

Why are there hotspot mutations in the TP53 gene in human cancers?

Cell Death Differ 2018 01 3;25(1):154-160. Epub 2017 Nov 3.

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1038/cdd.2017.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729536PMC
January 2018

Expression of Nischarin negatively correlates with estrogen receptor and alters apoptosis, migration and invasion in human breast cancer.

Biochem Biophys Res Commun 2017 03 26;484(3):536-542. Epub 2017 Jan 26.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.01.109DOI Listing
March 2017

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.

Genes Dev 2016 08 11;30(15):1704-17. Epub 2016 Aug 11.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1101/gad.283416.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002976PMC
August 2016

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.

Cold Spring Harb Perspect Med 2016 Sep 1;6(9). Epub 2016 Sep 1.

Grenoble Institute for Research on Cancer, Grenoble, France.

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http://dx.doi.org/10.1101/cshperspect.a026153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008064PMC
September 2016

microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis.

Oncotarget 2016 Feb;7(8):8783-96

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.18632/oncotarget.7088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891004PMC
February 2016

The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.

Cell Rep 2015 Dec 19;13(9):1895-908. Epub 2015 Nov 19.

Rutgers Cancer Institute of New Jersey (CINJ), 195 Little Albany Street, New Brunswick, NJ 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779191PMC
December 2015

The Evolution of Tumors in Mice and Humans with Germline p53 Mutations.

Cold Spring Harb Symp Quant Biol 2015 7;80:139-45. Epub 2015 Dec 7.

Grenoble Institute for Research on Cancer, Grenoble 38706, France.

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http://dx.doi.org/10.1101/sqb.2015.80.027631DOI Listing
January 2018

Autophagy, Metabolism, and Cancer.

Clin Cancer Res 2015 Nov;21(22):5037-46

Rutgers Cancer Institute of New Jersey (CINJ), New Brunswick, New Jersey. Department of Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, New Jersey.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646728PMC
November 2015

Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway.

Oncotarget 2015 Dec;6(38):40907-19

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.18632/oncotarget.5723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747377PMC
December 2015

The evolution of thymic lymphomas in p53 knockout mice.

Genes Dev 2014 Dec;28(23):2613-20

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08901, USA; Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, New Jersey 08540, USA

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http://dx.doi.org/10.1101/gad.252148.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248292PMC
December 2014

Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome.

Proc Natl Acad Sci U S A 2014 Oct 13;111(43):15497-501. Epub 2014 Oct 13.

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903

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http://dx.doi.org/10.1073/pnas.1417322111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217424PMC
October 2014

MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling.

Oncotarget 2014 Oct;5(19):9106-17

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253422PMC
http://dx.doi.org/10.18632/oncotarget.2379DOI Listing
October 2014

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD.

Oncotarget 2014 Jul;5(14):5535-46

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, USA.

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http://www.oncotarget.com/fulltext/2137
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170611PMC
http://dx.doi.org/10.18632/oncotarget.2137DOI Listing
July 2014

Autophagy is required for glucose homeostasis and lung tumor maintenance.

Cancer Discov 2014 Aug 29;4(8):914-27. Epub 2014 May 29.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey. Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125614PMC
August 2014

Mutational landscape of the essential autophagy gene BECN1 in human cancers.

Mol Cancer Res 2014 Apr 29;12(4):485-90. Epub 2014 Jan 29.

Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903-2681.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989371PMC
April 2014

RNA interference-mediated simultaneous silencing of four genes using cross-shaped RNA.

Mol Cells 2013 Apr 4;35(4):320-6. Epub 2013 Apr 4.

Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.

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http://dx.doi.org/10.1007/s10059-013-2316-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887895PMC
April 2013

STK31 maintains the undifferentiated state of colon cancer cells.

Carcinogenesis 2012 Nov 24;33(11):2044-53. Epub 2012 Jul 24.

Epithelial Cell Biology Research Centre The Chinese University of Hong Kong Hong Kong SAR.

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http://dx.doi.org/10.1093/carcin/bgs246DOI Listing
November 2012

Enhanced intracellular delivery and multi-target gene silencing triggered by tripodal RNA structures.

J Gene Med 2012 Feb;14(2):138-46

Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon, Korea.

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http://dx.doi.org/10.1002/jgm.1653DOI Listing
February 2012

Branched, tripartite-interfering RNAs silence multiple target genes with long guide strands.

Nucleic Acid Ther 2012 Feb 5;22(1):30-9. Epub 2012 Jan 5.

Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon, Korea.

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http://www.liebertpub.com/doi/10.1089/nat.2011.0315
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http://dx.doi.org/10.1089/nat.2011.0315DOI Listing
February 2012

Smile esthetics from patients' perspectives for faces of varying attractiveness.

Am J Orthod Dentofacial Orthop 2011 Oct;140(4):e171-80

Division of Orthodontics, College of Dentistry, Ohio State University, Columbus, OH 43210-1267, USA.

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http://dx.doi.org/10.1016/j.ajodo.2011.03.022DOI Listing
October 2011

Long double-stranded RNA-mediated RNA interference and immunostimulation: long interfering double-stranded RNA as a potent anticancer therapeutics.

Nucleic Acid Ther 2011 Jun;21(3):149-55

Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon, Korea.

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http://dx.doi.org/10.1089/nat.2011.0296DOI Listing
June 2011

Structural diversity repertoire of gene silencing small interfering RNAs.

Nucleic Acid Ther 2011 Jun;21(3):125-31

Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon, Korea.

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http://dx.doi.org/10.1089/nat.2011.0286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198623PMC
June 2011

Silencing of the PP2A catalytic subunit causes HER-2/neu positive breast cancer cells to undergo apoptosis.

Exp Cell Res 2010 Dec 15;316(20):3387-96. Epub 2010 Jun 15.

Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/j.yexcr.2010.06.007DOI Listing
December 2010

Interaction between endometrial epithelial cells and blood leucocytes promotes cytokine release and epithelial barrier function in response to Chlamydia trachomatis lipopolysaccharide stimulation.

Cell Biol Int 2010 Sep;34(9):951-8

Epithelial Cell Biology Research Center, Key Laboratory for Regenerative Medicine of Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://doi.wiley.com/10.1042/CBI20100303
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http://dx.doi.org/10.1042/CBI20100303DOI Listing
September 2010

Negative regulation of tumor suppressor p53 by microRNA miR-504.

Mol Cell 2010 Jun;38(5):689-99

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900922PMC
June 2010

Dual-target gene silencing by using long, synthetic siRNA duplexes without triggering antiviral responses.

Mol Cells 2009 Jun 12;27(6):689-95. Epub 2009 Jun 12.

Global Research Laboratory for RNAi Medicine, Department of Chemistry and Brain Korea 21 School of Chemical Materials Science, Sungkyunkwan University, Suwon 440-746, Korea.

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http://link.springer.com/10.1007/s10059-009-0093-0
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http://dx.doi.org/10.1007/s10059-009-0093-0DOI Listing
June 2009

Tyrosine phosphorylation of PP2A is regulated by HER-2 signalling and correlates with breast cancer progression.

Int J Oncol 2009 May;34(5):1291-301

Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074.

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May 2009

Brief report--human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes.

Stem Cells 2009 Feb;27(2):451-6

Regenerative Medicine Research Group, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan.

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http://dx.doi.org/10.1634/stemcells.2008-0390DOI Listing
February 2009

CCCTC-binding factor confines the distal action of estrogen receptor.

Cancer Res 2008 Nov;68(21):9041-9

The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey 08540, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2632DOI Listing
November 2008

A structure-activity relationship study of siRNAs with structural variations.

Biochem Biophys Res Commun 2007 Aug 11;359(4):997-1003. Epub 2007 Jun 11.

Department of Chemistry and BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2007.06.004DOI Listing
August 2007

Revealing posttranscriptional regulatory elements through network-level conservation.

PLoS Comput Biol 2005 Dec 9;1(7):e69. Epub 2005 Dec 9.

Department of Molecular Biology and The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1371/journal.pcbi.0010069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1309705PMC
December 2005

Altered CD38 expression in thioacetamide-induced rat model of liver cirrhosis.

Liver Int 2005 Dec;25(6):1233-42

Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8, Medical Drive, Singapore 117597, Singapore.

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http://doi.wiley.com/10.1111/j.1478-3231.2005.01173.x
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http://dx.doi.org/10.1111/j.1478-3231.2005.01173.xDOI Listing
December 2005

Expression and purification of the recombinant His-tagged GST-CD38 fusion protein using the baculovirus/insect cell expression system.

Protein Expr Purif 2005 Apr;40(2):396-403

Department of Rheumatology, Allergy, and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.

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http://dx.doi.org/10.1016/j.pep.2004.11.010DOI Listing
April 2005

Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C.

Lancet 2003 Dec;362(9401):2059-65

Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, SAR, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1016/s0140-6736(03)15100-8DOI Listing
December 2003

CD157 undergoes ligand-independent dimerization and colocalizes with caveolin in CHO and MCA102 fibroblasts.

Cell Signal 2002 Nov;14(11):933-9

Department of Biochemistry, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/s0898-6568(02)00040-2DOI Listing
November 2002

Activation of caspase-3 alone is insufficient for apoptotic morphological changes in human neuroblastoma cells.

J Neurochem 2002 Mar;80(6):1039-48

Department of Cardiovascular Research, Eli Lilly and Company, Indianapolis, USA.

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http://dx.doi.org/10.1046/j.0022-3042.2002.00787.xDOI Listing
March 2002

NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis.

Biochem Biophys Res Commun 2002 Feb;291(1):101-10

Laboratory of Reproduction Medicine, Nanjing Medical University, Nanjing, 210029, People's Republic of China.

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http://dx.doi.org/10.1006/bbrc.2002.6396DOI Listing
February 2002

Identification and characterization of nuclear CD38 in the rat spleen.

Int J Biochem Cell Biol 2002 Jan;34(1):43-54

Clinical Research Unit, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, S308433, Singapore, Singapore.

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http://dx.doi.org/10.1016/s1357-2725(01)00101-7DOI Listing
January 2002