Publications by authors named "Chandra Mohan Sharma"

10 Publications

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Juvenile Onset Niemann-Pick Type C Disease with Refractory Seizures.

Ann Indian Acad Neurol 2019 Oct-Dec;22(4):539-540. Epub 2019 Oct 25.

Department of Neurology, S.M.S. Medical College, Jaipur, Rajasthan, India.

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http://dx.doi.org/10.4103/aian.AIAN_292_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839306PMC
October 2019

Central nervous system blast crisis of chronic myeloid leukaemia misdiagnosed as tubercular meningitis.

BMJ Case Rep 2018 Jun 12;2018. Epub 2018 Jun 12.

Department of Neurology, Sawai Mansingh Medical College and Hospital, Jaipur, Rajasthan, India.

Chronic Myeloid Leukaemia (CML) presenting with isolated Central Nervous System (CNS) blast crisis is an uncommon entity. A 22-year-old man, diagnosed with chronic phase CML in 2011 and was in haematological and cytogenetic remission until July 2016, had acute onset headache and vomiting with meningeal signs and was admitted elsewhere, investigated by brain imaging and cerebrospinal fluid (CSF) analysis and suspected to have tubercular meningitis, for which steroids and antitubercular medications were started. The patient's sensorium further deteriorated, and Ventriculoperitoneal shunt surgery was done for hydrocephalus by a neurosurgeon. After 2 months of the illness, he was admitted to our hospital with a persistent headache, vomiting and altered sensorium. CSF for cytospin confirmed myeloid blasts. He was still in haematological remission. So, a diagnosis of isolated CNS blast crisis was made. The patient was started on triple intrathecal chemotherapy and cranial radiotherapy. He had improvement with treatment and is still in remission.
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http://dx.doi.org/10.1136/bcr-2017-223923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011440PMC
June 2018

Late-onset myoclonic epilepsy in Down syndrome (LOMEDS): A spectrum of progressive myoclonic epilepsy - Case report.

Ann Indian Acad Neurol 2016 Apr-Jun;19(2):267-8

Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.

Cognitive decline and epilepsy are well recognized complication of Down syndrome (DS). Here, we intend to present a case of 28 year old male who presented with progressive mental regression, gait ataxia and myoclonic jerking especially on awakening in morning. His EEG was normal and karyotyping revealed trisomy of chromosome 21. Very few cases had been described in literature of late-onset myoclonic epilepsy in DS. This is first case report from India and our aim is to propose the inclusion of this entity in the spectrum of progressive myoclonic epilepsies but still more cases are yet to be found.
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http://dx.doi.org/10.4103/0972-2327.173411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888697PMC
June 2016

A unique combination of autoimmune limbic encephalitis, type 1 diabetes, and Stiff person syndrome associated with GAD-65 antibody.

Ann Indian Acad Neurol 2016 Jan-Mar;19(1):146-9

Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.

Antibodies to GAD-65 have been implicated in the pathogenesis of type 1 diabetes, limbic encephalitis and Stiff person syndrome, however these diseases rarely occur concurrently. We intend to present a rare case of 35 year old female who was recently diagnosed as having type 1 diabetes presented with 1½ month history of recurrent seizures, subacute onset gait ataxia, dysathria, psychiatric disturbance and cognitive decline. No tumor was found on imaging and the classic paraneoplastic panel was negative. Cerebrospinal fluid and blood was positive for GAD-65 antibodies. Patient showed significant improvement with immunomodulatory therapy. Association of GAD-65 antibodies has been found with various disorders including type 1 diabetes, limbic encephalitis, Stiff person syndrome, cerebellar ataxia and palatal myoclonus. This case presents with unique combination of type 1 diabetes, Stiff person syndrome and limbic encephalitis associated with GAD-65 antibodies that is responsive to immunotherapy. It also highlights the emerging concept of autoimmunity in the causation of various disorders and there associations.
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http://dx.doi.org/10.4103/0972-2327.165462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782537PMC
March 2016

Alien hand and leg as the presenting feature of probable sporadic Creutzfeldt-Jakob disease: A rare presentation of a rare disease.

Ann Indian Acad Neurol 2015 Jan-Mar;18(1):99-102

Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.

Sporadic Creutzfeldt-Jakob disease (sCJD) can have varied clinical presentation depending upon the genotype at codon 129. The common presenting clinical features of sCJD are rapid onset cognitive impairment, ataxia, psychosis and visual signs (field defects, distortion, cortical blindness). Alien limb sign was first described in patients with corpus callosal tumors and later with other neurodegenerative conditions like corticobasal degeneration. Alien hand complaints as the presenting feature of sCJD has been described in literature, but simultaneous alien hand and leg has been rarely described as presenting feature of sCJD. We describe here a case of a 55-year-old man who presented with progressive left alien hand and leg as the sole clinical manifestation of probable sCJD.
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http://dx.doi.org/10.4103/0972-2327.144278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350228PMC
March 2015

Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME): Probable first family from India.

Ann Indian Acad Neurol 2014 Oct;17(4):433-6

Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.

Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME) is an extremely rare syndrome characterized by familial occurrence of postural and action-induced tremors of the hands but showing electrophysiologic findings of cortical reflex myoclonus. Patients also have cognitive decline and tonic-clonic seizures, often precipitated by sleep deprivation or photic stimulation. We describe probably the first family from India of this ill-defined syndrome.
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http://dx.doi.org/10.4103/0972-2327.144025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251019PMC
October 2014

Rare presentation of botulism with generalized fasciculations.

Int J Appl Basic Med Res 2014 Jan;4(1):56-8

Department of Neurology, Sawai ManSingh Medical College and Hospital, Jaipur, Rajasthan, India.

Botulism is a dreadful, life-threatening, neuroparalytic disease caused by gram positive bacteria Clostridium botulinum. Food borne botulism has been described following ingestion of preformed toxins in canned food or food products that have not been preserved properly. Botulinum toxin acts on neuromuscular junction and manifests as ophthalmoplegia, bulbar and limb weakness, and autonomic features along with respiratory compromise. The literature and case reports regarding neuroparalytic botulism in India are sparse. Generalized fasciculations have been rarely reported in literature as manifestation of food borne botulism. We present a 35-year-male presenting with usual features described, but with prominent generalized fasciculations which are rare, and which rapidly responded to treatment.
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http://dx.doi.org/10.4103/2229-516X.125698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931218PMC
January 2014

Reproductive ecology of male and female Strobili and mating system in two different populations of Pinus roxburghii.

ScientificWorldJournal 2012 30;2012:271389. Epub 2012 Apr 30.

Department of Botany, HNB, Garhwal University, Srinagar Garhwal 246 174, India.

We studied several flowering traits, namely, male-female cone phenology, male-female cone production per tree, mating system, sex ratio, air-borne pollen grains and pollen migration, over four successive years in two different natural populations of P. roxburghii from Garhwal Himalaya, India. Assessment of each trait mentioned except pollen dispersion was done by selecting five representative trees randomly in each population. The pollen migration was studied on naturally isolated source trees. The pollen trapping was done in all directions up to 2.5 km. The average reproductive period in P. roxburghii was 36 days with 3-5 days protandry. There were significant year and population effects for male and female cone output and pollen grains production per tree. In mass production year (1999), an average production of pollen cone per tree was estimated as 42.44 ± 8.32 × 10(3) at lower altitude and 28.1 ± 0.89 × 10(3) at higher altitude. The controlled pollination results in high level of outcrossing with 90% seed setting. We conclude that the high male-female ratio and tremendous pollen production capacity in P. roxburghii indicate high male competition among trees within populations. The isolation strip of 600 m is considered minimal for the management of seed orchard.
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http://dx.doi.org/10.1100/2012/271389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361147PMC
September 2012

Guillain-Barre syndrome occurring during dengue fever.

J Indian Med Assoc 2011 Sep;109(9):675, 682

Department of Neurology, BMRC, SMS Medical College, Jaipur 302004.

Various types of neurological manifestations are described in dengue fever, of which peripheral neuropathy is rarely reported. We are reporting such a case that presented with three days' history of fever and weakness of all the four limbs of two days' duration. On investigations it turned out to be acute motor sensory axonal neuropathy (AMSAN) type of Guillain-Barre syndrome with decrease platelet counts and positive serology for dengue. All other causes of acute polyneuropathy were ruled out by history and relevant investigations. Patient improved with intravenous immunoglobulin and other supportive therapy.
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September 2011

Cyclic pollen production in Cedrus deodara.

Sex Plant Reprod 2009 Jun 1;22(2):53-61. Epub 2009 Jan 1.

Department of Forestry, Mizoram University, Aizawl, Mizoram, India.

Based on a seven-year study of pollen production and release in two different natural populations of Cedrus deodara from Garhwal Himalaya, India, we determined that pollen output follows a two-year cycle. Pollen productivity determinations considered various sources of variability, including the number of pollen strobili per branch, strobili per tree, microsporophylls per tree and pollen grains per tree. Each of these parameters revealed significant year-to-year and population effects. Microsporangium dehiscence took from 2.5 to 3.5 days. Maximum dehiscence was observed between 12:00 and 14:00 h, which coincides with diurnal highest temperature and lowest relative humidity. Annual production of pollen per tree varied from averages of 4.7 x 10(9), 7.2 x 10(9) and 5.1 x 10(9) in years of low production, with alternate high years, producing 12.6 x 10(9), 14.1 x 10(9), 13.3 x 10(9) and 14.0 x 10(9) pollen grains per tree. Annual pollen production in individual trees of C. deodara ranged from 1.4 x 10(9) to 22.3 x 10(9).
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http://dx.doi.org/10.1007/s00497-008-0091-yDOI Listing
June 2009
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