Chandanamali Punchihewa

Chandanamali Punchihewa

UNVERIFIED PROFILE

Are you Chandanamali Punchihewa?   Register this Author

Register author
Chandanamali Punchihewa

Chandanamali Punchihewa

Publications by authors named "Chandanamali Punchihewa"

Are you Chandanamali Punchihewa?   Register this Author

21Publications

878Reads

20Profile Views

Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.

Bioorg Med Chem 2013 Apr 22;21(7):1972-7. Epub 2013 Jan 22.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2013.01.022DOI Listing
April 2013

A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription.

Biopolymers 2011 Jan;95(1):24-30

Medicinal Chemistry Center, Departments of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.21544DOI Listing
January 2011

Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.

Bioorg Med Chem 2010 Jul 7;18(13):4801-11. Epub 2010 May 7.

Departments of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2010.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952073PMC
July 2010

Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

J Med Chem 2009 Jul;52(13):3829-45

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm801420yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743241PMC
July 2009

DNA sequence selectivity of human topoisomerase I-mediated DNA cleavage induced by camptothecin.

Protein Sci 2009 Jun;18(6):1326-31

College of Pharmacy, The University of Arizona, 1703 E. Mabel Street, Tucson, AZ 85721, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pro.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774443PMC
June 2009

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

Protein Sci 2009 May;18(5):994-1002

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-36781, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pro.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771301PMC
May 2009

Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription.

Mol Cancer Ther 2008 Jun;7(6):1633-8

Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-08-0155DOI Listing
June 2008

Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.

Bioorg Med Chem Lett 2008 Feb 23;18(3):946-9. Epub 2007 Dec 23.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.12.039DOI Listing
February 2008

Human topoisomerase I C-terminal domain fragment containing the active site tyrosine is a molten globule: implication for the formation of competent productive complex.

J Struct Biol 2007 Jul 12;159(1):111-21. Epub 2007 Mar 12.

College of Pharmacy, The University of Arizona, 1703 E. Mabel Street, Tucson, AZ 85721, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsb.2007.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993844PMC
July 2007

XR5944: A potent inhibitor of estrogen receptors.

Mol Cancer Ther 2007 Jan 11;6(1):213-9. Epub 2007 Jan 11.

College of Pharmacy, University of Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-06-0392DOI Listing
January 2007