Publications by authors named "Chandan Kumar-Sinha"

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Development of the CNS TAP tool for the selection of precision medicine therapies in neuro-oncology.
J Neurooncol 2018 Mar 12;137(1):155-169. Epub 2017 Dec 12.
Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan Medical School, 3520 D MSRB 1, 1150 W Medical Center Dr., Ann Arbor, MI, 48109, USA.


Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun 2017 Apr 10;8:14929. Epub 2017 Apr 10.
National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 333 Haike Road, Shanghai 201210, China.

Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling.
Adv Sci (Weinh) 2016 Sep 18;3(9):1600063. Epub 2016 Apr 18.
Department of Chemical Engineering3074 H.H. Dow Building2300 Hayward St.Ann ArborMI48109-2136USA; Biointerfaces InstituteNorth Campus Research Complex2800 Plymouth Road, Bldg. 90Ann ArborMI48109-2800USA.

KRAS Engages AGO2 to Enhance Cellular Transformation.
Cell Rep 2016 Feb 4;14(6):1448-1461. Epub 2016 Feb 4.
Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.
Cancer Res 2015 Dec 15;75(23):5155-66. Epub 2015 Oct 15.
Translational Oncology Program, University of Michigan Medical Center, Ann Arbor, Michigan. Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan. Department of Molecular and Integrative Physiology, University of Michigan Medical Center, Ann Arbor, Michigan.

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling.
Sci Signal 2015 Jan 6;8(358):ra1. Epub 2015 Jan 6.
Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.

RNA-Seq accurately identifies cancer biomarker signatures to distinguish tissue of origin.
Neoplasia 2014 Nov 20;16(11):918-27. Epub 2014 Nov 20.
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA 48109 ; University of Michigan Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA 48109 ; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA 48109 ; University of Michigan Department of Urology, University of Michigan Medical School, Ann Arbor, MI, USA 48109 ; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI, USA 48109.


Outlier kinase expression by RNA sequencing as targets for precision therapy.
Cancer Discov 2013 Mar 5;3(3):280-93. Epub 2013 Feb 5.
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response.
Proc Natl Acad Sci U S A 2013 Feb 23;110(6):2240-5. Epub 2013 Jan 23.
Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center and Translational Oncology Program, University of Michigan, Ann Arbor, MI 48109, USA.




Characterization of bone metastases from rapid autopsies of prostate cancer patients.
Clin Cancer Res 2011 Jun 9;17(12):3924-32. Epub 2011 May 9.
Department of Internal Medicine and Urology, University of Michigan Medical School, 7303 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.





Integrative analysis of genomic aberrations associated with prostate cancer progression.
Cancer Res 2007 Sep;67(17):8229-39
Michigan Center for Translational Pathology, Department of Pathology, Department of Urology, Program of Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-0940, USA.


ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer.
Cancer Cell 2017 06;31(6):790-803.e8
Drug Discovery Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA; Department of Oncological Sciences, University of South Florida, Tampa, FL 33612, USA. Electronic address:



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