Chandan Kumar-Sinha

Chandan Kumar-Sinha

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Chandan Kumar-Sinha

Chandan Kumar-Sinha

Publications by authors named "Chandan Kumar-Sinha"

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48Publications

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Development of the CNS TAP tool for the selection of precision medicine therapies in neuro-oncology.

J Neurooncol 2018 Mar 12;137(1):155-169. Epub 2017 Dec 12.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan Medical School, 3520 D MSRB 1, 1150 W Medical Center Dr., Ann Arbor, MI, 48109, USA.

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March 2018

Precision oncology in the age of integrative genomics.

Nat Biotechnol 2018 Jan;36(1):46-60

Michigan Center for Translational Pathology, Ann Arbor, Michigan, USA.

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January 2018

ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer.

Cancer Cell 2017 06;31(6):790-803.e8

Drug Discovery Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA; Department of Oncological Sciences, University of South Florida, Tampa, FL 33612, USA. Electronic address:

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June 2017

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.

Nat Commun 2017 Apr 10;8:14929. Epub 2017 Apr 10.

National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 333 Haike Road, Shanghai 201210, China.

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April 2017

Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling.

Adv Sci (Weinh) 2016 Sep 18;3(9):1600063. Epub 2016 Apr 18.

Department of Chemical Engineering3074 H.H. Dow Building2300 Hayward St.Ann ArborMI48109-2136USA; Biointerfaces InstituteNorth Campus Research Complex2800 Plymouth Road, Bldg. 90Ann ArborMI48109-2800USA.

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September 2016

KRAS Engages AGO2 to Enhance Cellular Transformation.

Cell Rep 2016 Feb 4;14(6):1448-1461. Epub 2016 Feb 4.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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February 2016

ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.

Cancer Res 2015 Dec 15;75(23):5155-66. Epub 2015 Oct 15.

Translational Oncology Program, University of Michigan Medical Center, Ann Arbor, Michigan. Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan. Department of Molecular and Integrative Physiology, University of Michigan Medical Center, Ann Arbor, Michigan.

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December 2015

Landscape of gene fusions in epithelial cancers: seq and ye shall find.

Genome Med 2015 Dec 18;7:129. Epub 2015 Dec 18.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

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December 2015

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling.

Sci Signal 2015 Jan 6;8(358):ra1. Epub 2015 Jan 6.

Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.

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January 2015

RNA-Seq accurately identifies cancer biomarker signatures to distinguish tissue of origin.

Neoplasia 2014 Nov 20;16(11):918-27. Epub 2014 Nov 20.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA 48109 ; University of Michigan Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA 48109 ; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA 48109 ; University of Michigan Department of Urology, University of Michigan Medical School, Ann Arbor, MI, USA 48109 ; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI, USA 48109.

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November 2014

Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease.

Cancer Med 2013 Dec 31;2(6):836-48. Epub 2013 Oct 31.

Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, India.

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December 2013

Outlier kinase expression by RNA sequencing as targets for precision therapy.

Cancer Discov 2013 Mar 5;3(3):280-93. Epub 2013 Feb 5.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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March 2013

Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response.

Proc Natl Acad Sci U S A 2013 Feb 23;110(6):2240-5. Epub 2013 Jan 23.

Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center and Translational Oncology Program, University of Michigan, Ann Arbor, MI 48109, USA.

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February 2013

Emerging frontiers in pancreatic cancer research: elaboration of key genes, cells and the extracellular milieu.

Curr Opin Gastroenterol 2012 Sep;28(5):516-22

Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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September 2012

SLC45A3-ELK4 chimera in prostate cancer: spotlight on cis-splicing.

Cancer Discov 2012 Jul;2(7):582-5

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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July 2012

Characterization of bone metastases from rapid autopsies of prostate cancer patients.

Clin Cancer Res 2011 Jun 9;17(12):3924-32. Epub 2011 May 9.

Department of Internal Medicine and Urology, University of Michigan Medical School, 7303 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.

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June 2011

A comparison of single molecule and amplification based sequencing of cancer transcriptomes.

PLoS One 2011 Mar 1;6(3):e17305. Epub 2011 Mar 1.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, United States of America.

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March 2011

Recurrent gene fusions in prostate cancer.

Nat Rev Cancer 2008 Jul 19;8(7):497-511. Epub 2008 Jun 19.

Michigan Center for Translational Pathology, University of Michigan Medical School, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, Michigan 48109-0602, USA.

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July 2008

Human papillomavirus genotyping by multiplex pyrosequencing in cervical cancer patients from India.

J Biosci 2008 Mar;33(1):73-80

Advanced Center for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India.

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March 2008

Integrative analysis of genomic aberrations associated with prostate cancer progression.

Cancer Res 2007 Sep;67(17):8229-39

Michigan Center for Translational Pathology, Department of Pathology, Department of Urology, Program of Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-0940, USA.

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September 2007

Evidence of recurrent gene fusions in common epithelial tumors.

Trends Mol Med 2006 Nov 29;12(11):529-36. Epub 2006 Sep 29.

Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai 410208, India.

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November 2006

A SLAMS dunk for cancer regulators.

Nat Biotechnol 2006 May;24(5):524-6

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May 2006

Elevated alpha-methylacyl-CoA racemase enzymatic activity in prostate cancer.

Am J Pathol 2004 Mar;164(3):787-93

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0602, USA.

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March 2004

C5a-induced gene expression in human umbilical vein endothelial cells.

Am J Pathol 2004 Mar;164(3):849-59

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0602, USA.

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March 2004

RhoC induces differential expression of genes involved in invasion and metastasis in MCF10A breast cells.

Breast Cancer Res Treat 2004 Mar;84(1):3-12

Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109-0948, USA.

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March 2004

Molecular markers to identify patients at risk for recurrence after primary treatment for prostate cancer.

Urology 2003 Dec;62 Suppl 1:19-35

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0602, USA.

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December 2003

Prostate cancer biomarkers: a current perspective.

Expert Rev Mol Diagn 2003 Jul;3(4):459-70

Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA.

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July 2003

Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.

Cancer Res 2003 Jan;63(1):132-9

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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January 2003

Molecular cross-talk between the TRAIL and interferon signaling pathways.

J Biol Chem 2002 Jan 24;277(1):575-85. Epub 2001 Oct 24.

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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January 2002