Chand Khanna

Chand Khanna

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Chand Khanna

Chand Khanna

Publications by authors named "Chand Khanna"

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Towards the Delivery of Precision Veterinary Cancer Medicine.

Vet Clin North Am Small Anim Pract 2019 Sep 28;49(5):809-818. Epub 2019 Jun 28.

EthosVeterinaryHealth LLC, 20 Cabot Road, Woburn, MA 01801, USA; EthosDiscovery(501c3), Washington, DC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cvsm.2019.04.011DOI Listing
September 2019

Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.

PLoS One 2017 19;12(9):e0185089. Epub 2017 Sep 19.

Tumor Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185089PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605117PMC
October 2017

Leveraging Comparative Oncology in the Hopes of Improving Therapies for Breast Cancer.

Authors:
Chand Khanna

Semin Oncol 2017 08 23;44(4):301. Epub 2017 Nov 23.

Ethos Veterinary Health, Woburn, MA; Ethos Discovery, Washington, DC.

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http://dx.doi.org/10.1053/j.seminoncol.2017.11.003DOI Listing
August 2017

Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis.

Oncotarget 2017 Jun;8(24):38541-38553

Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.15872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503552PMC
June 2017

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.

Neoplasia 2016 Oct 28;18(11):699-710. Epub 2016 Oct 28.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Ethos Discovery in Washington DC and Ethos Veterinary Health, Wolburn MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094383PMC
October 2016

Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies.

Crit Rev Oncog 2015 ;20(3-4):173-97

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894524PMC
http://dx.doi.org/10.1615/critrevoncog.2015013713DOI Listing
June 2016

Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer.

PLoS One 2015 9;10(9):e0136688. Epub 2015 Sep 9.

Department of Veterinary Clinical Sciences, Purdue University College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States of America; Purdue Oncological Sciences Center, Purdue University, West Lafayette, Indiana, United States of America; Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136688PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564191PMC
May 2016

Letter to the Editor.

J Vet Intern Med 2016 Jan-Feb;30(1). Epub 2015 Nov 30.

Veterinary Cancer Group of Orange County, Tustin, CA.

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http://dx.doi.org/10.1111/jvim.13790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913650PMC
May 2016

Defining the Value of a Comparative Approach to Cancer Drug Development.

Clin Cancer Res 2016 05 28;22(9):2133-8. Epub 2015 Dec 28.

Comparative Oncology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111620PMC
May 2016

A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells.

PLoS Genet 2016 Feb 29;12(2):e1005884. Epub 2016 Feb 29.

Cancer and Stem Cell Epigenetics Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771715PMC
February 2016

CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ.

Cancer Res 2015 Dec 19;75(24):5283-98. Epub 2015 Oct 19.

Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2282-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120555PMC
December 2015

Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.

Oncotarget 2015 Oct;6(30):29469-81

Molecular Oncology Section - Metastasis Biology Group, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.5177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745740PMC
October 2015

Comparative Aspects of Osteosarcoma Pathogenesis in Humans and Dogs.

Vet Sci 2015 Aug 17;2(3):210-230. Epub 2015 Aug 17.

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Clinical Research, The National Cancer Institute, Washington, DC 20004, USA.

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http://dx.doi.org/10.3390/vetsci2030210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644632PMC
August 2015

Germline TP53 variants and susceptibility to osteosarcoma.

J Natl Cancer Inst 2015 Jul 20;107(7). Epub 2015 Apr 20.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (LM, PLM, SJC, SAS); Cancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD (MY, XZ, AV, KJ, JFB); Nationwide Children's Hospital and The Ohio State University Department of Pathology and Pediatrics, Columbus, OH (JMGF); Albert Einstein College of Medicine, The Children's Hospital at Montefiore, Bronx, NY (RG); Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (CK); Department Of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain (APG, LS, FL); University of Toronto, Litwin Centre for Cancer Genetics, Lunenfeld Tanenbaum Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada (ILA, JSW, NG); Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA (DAB).

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http://jnci.oxfordjournals.org/content/107/7/djv101.full.pdf
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http://dx.doi.org/10.1093/jnci/djv101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651039PMC
July 2015

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Nat Genet 2015 Jun 11;47(6):615-24. Epub 2015 May 11.

1] Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA. [2] Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA. [3] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [4] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1038/ng.3293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767150PMC
June 2015

Type III Collagen Directs Stromal Organization and Limits Metastasis in a Murine Model of Breast Cancer.

Am J Pathol 2015 May 17;185(5):1471-86. Epub 2015 Mar 17.

Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440150012
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http://dx.doi.org/10.1016/j.ajpath.2015.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419211PMC
May 2015

A summary of the osteosarcoma banking efforts: a report from the Children's Oncology Group and the QuadW Foundation.

Pediatr Blood Cancer 2015 Mar 8;62(3):450-5. Epub 2014 Dec 8.

Children's Cancer and Blood Disorders Program, Randall Children's Hospital, Portland, Oregon.

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http://dx.doi.org/10.1002/pbc.25346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304398PMC
March 2015

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

Authors:
Zhaoming Wang Bin Zhu Mingfeng Zhang Hemang Parikh Jinping Jia Charles C Chung Joshua N Sampson Jason W Hoskins Amy Hutchinson Laurie Burdette Abdisamad Ibrahim Christopher Hautman Preethi S Raj Christian C Abnet Andrew A Adjei Anders Ahlbom Demetrius Albanes Naomi E Allen Christine B Ambrosone Melinda Aldrich Pilar Amiano Christopher Amos Ulrika Andersson Gerald Andriole Irene L Andrulis Cecilia Arici Alan A Arslan Melissa A Austin Dalsu Baris Donald A Barkauskas Bryan A Bassig Laura E Beane Freeman Christine D Berg Sonja I Berndt Pier Alberto Bertazzi Richard B Biritwum Amanda Black William Blot Heiner Boeing Paolo Boffetta Kelly Bolton Marie-Christine Boutron-Ruault Paige M Bracci Paul Brennan Louise A Brinton Michelle Brotzman H Bas Bueno-de-Mesquita Julie E Buring Mary Ann Butler Qiuyin Cai Geraldine Cancel-Tassin Federico Canzian Guangwen Cao Neil E Caporaso Alfredo Carrato Tania Carreon Angela Carta Gee-Chen Chang I-Shou Chang Jenny Chang-Claude Xu Che Chien-Jen Chen Chih-Yi Chen Chung-Hsing Chen Constance Chen Kuan-Yu Chen Yuh-Min Chen Anand P Chokkalingam Lisa W Chu Francoise Clavel-Chapelon Graham A Colditz Joanne S Colt David Conti Michael B Cook Victoria K Cortessis E David Crawford Olivier Cussenot Faith G Davis Immaculata De Vivo Xiang Deng Ti Ding Colin P Dinney Anna Luisa Di Stefano W Ryan Diver Eric J Duell Joanne W Elena Jin-Hu Fan Heather Spencer Feigelson Maria Feychting Jonine D Figueroa Adrienne M Flanagan Joseph F Fraumeni Neal D Freedman Brooke L Fridley Charles S Fuchs Manuela Gago-Dominguez Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Reina Garcia-Closas Julie M Gastier-Foster J Michael Gaziano Daniela S Gerhard Carol A Giffen Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Michael Goggins Nalan Gokgoz Alisa M Goldstein Carlos Gonzalez Richard Gorlick Mark H Greene Myron Gross H Barton Grossman Robert Grubb Jian Gu Peng Guan Christopher A Haiman Goran Hallmans Susan E Hankinson Curtis C Harris Patricia Hartge Claudia Hattinger Richard B Hayes Qincheng He Lee Helman Brian E Henderson Roger Henriksson Judith Hoffman-Bolton Chancellor Hohensee Elizabeth A Holly Yun-Chul Hong Robert N Hoover H Dean Hosgood Chin-Fu Hsiao Ann W Hsing Chao Agnes Hsiung Nan Hu Wei Hu Zhibin Hu Ming-Shyan Huang David J Hunter Peter D Inskip Hidemi Ito Eric J Jacobs Kevin B Jacobs Mazda Jenab Bu-Tian Ji Christoffer Johansen Mattias Johansson Alison Johnson Rudolf Kaaks Ashish M Kamat Aruna Kamineni Margaret Karagas Chand Khanna Kay-Tee Khaw Christopher Kim In-Sam Kim Jin Hee Kim Yeul Hong Kim Young-Chul Kim Young Tae Kim Chang Hyun Kang Yoo Jin Jung Cari M Kitahara Alison P Klein Robert Klein Manolis Kogevinas Woon-Puay Koh Takashi Kohno Laurence N Kolonel Charles Kooperberg Christian P Kratz Vittorio Krogh Hideo Kunitoh Robert C Kurtz Nilgun Kurucu Qing Lan Mark Lathrop Ching C Lau Fernando Lecanda Kyoung-Mu Lee Maxwell P Lee Loic Le Marchand Seth P Lerner Donghui Li Linda M Liao Wei-Yen Lim Dongxin Lin Jie Lin Sara Lindstrom Martha S Linet Jolanta Lissowska Jianjun Liu Börje Ljungberg Josep Lloreta Daru Lu Jing Ma Nuria Malats Satu Mannisto Neyssa Marina Giuseppe Mastrangelo Keitaro Matsuo Katherine A McGlynn Roberta McKean-Cowdin Lorna H McNeill Robert R McWilliams Beatrice S Melin Paul S Meltzer James E Mensah Xiaoping Miao Dominique S Michaud Alison M Mondul Lee E Moore Kenneth Muir Shelley Niwa Sara H Olson Nick Orr Salvatore Panico Jae Yong Park Alpa V Patel Ana Patino-Garcia Sofia Pavanello Petra H M Peeters Beata Peplonska Ulrike Peters Gloria M Petersen Piero Picci Malcolm C Pike Stefano Porru Jennifer Prescott Xia Pu Mark P Purdue You-Lin Qiao Preetha Rajaraman Elio Riboli Harvey A Risch Rebecca J Rodabough Nathaniel Rothman Avima M Ruder Jeong-Seon Ryu Marc Sanson Alan Schned Fredrick R Schumacher Ann G Schwartz Kendra L Schwartz Molly Schwenn Katia Scotlandi Adeline Seow Consol Serra Massimo Serra Howard D Sesso Gianluca Severi Hongbing Shen Min Shen Sanjay Shete Kouya Shiraishi Xiao-Ou Shu Afshan Siddiq Luis Sierrasesumaga Sabina Sierri Alan Dart Loon Sihoe Debra T Silverman Matthias Simon Melissa C Southey Logan Spector Margaret Spitz Meir Stampfer Par Stattin Mariana C Stern Victoria L Stevens Rachael Z Stolzenberg-Solomon Daniel O Stram Sara S Strom Wu-Chou Su Malin Sund Sook Whan Sung Anthony Swerdlow Wen Tan Hideo Tanaka Wei Tang Ze-Zhang Tang Adonina Tardon Evelyn Tay Philip R Taylor Yao Tettey David M Thomas Roberto Tirabosco Anne Tjonneland Geoffrey S Tobias Jorge R Toro Ruth C Travis Dimitrios Trichopoulos Rebecca Troisi Ann Truelove Ying-Huang Tsai Margaret A Tucker Rosario Tumino David Van Den Berg Stephen K Van Den Eeden Roel Vermeulen Paolo Vineis Kala Visvanathan Ulla Vogel Chaoyu Wang Chengfeng Wang Junwen Wang Sophia S Wang Elisabete Weiderpass Stephanie J Weinstein Nicolas Wentzensen William Wheeler Emily White John K Wiencke Alicja Wolk Brian M Wolpin Maria Pik Wong Margaret Wrensch Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S Wunder Yong-Bing Xiang Jun Xu Hannah P Yang Pan-Chyr Yang Yasushi Yatabe Yuanqing Ye Edward D Yeboah Zhihua Yin Chen Ying Chong-Jen Yu Kai Yu Jian-Min Yuan Krista A Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Lisa Mirabello Sharon A Savage Peter Kraft Stephen J Chanock Meredith Yeager Maria Terese Landi Jianxin Shi Nilanjan Chatterjee Laufey T Amundadottir

Hum Mol Genet 2014 Dec 15;23(24):6616-33. Epub 2014 Jul 15.

Division of Cancer Epidemiology and Genetics,

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http://kooperberg.fhcrc.org/papers/2014wang.pdf
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http://hmg.oxfordjournals.org/content/23/24/6616.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu363
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http://dx.doi.org/10.1093/hmg/ddu363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240198PMC
December 2014

Role of ezrin in osteosarcoma metastasis.

Adv Exp Med Biol 2014 ;804:181-201

Molecular Oncology Section - Metastasis Biology Group, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Rm 2144, Bethesda, MD, 20892, USA,

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http://dx.doi.org/10.1007/978-3-319-04843-7_10DOI Listing
September 2014

The role of clinical trials in veterinary oncology.

Vet Clin North Am Small Anim Pract 2014 Sep;44(5):977-87

Comparative Oncology Program, Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Building 37, Suite 2144, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cvsm.2014.05.006DOI Listing
September 2014

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression.

Proc Natl Acad Sci U S A 2014 Apr 14;111(17):6323-8. Epub 2014 Apr 14.

Radiation Biology Branch, Tumor and Metastasis Biology Section, Pediatric Oncology Branch, and Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1401799111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035989PMC
April 2014

A novel noninvasive method for evaluating experimental lung metastasis in mice.

J Am Assoc Lab Anim Sci 2013 Sep;52(5):584-9

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784665PMC
September 2013

The ezrin metastatic phenotype is associated with the initiation of protein translation.

Neoplasia 2012 Apr;14(4):297-310

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349256PMC
http://dx.doi.org/10.1593/neo.11518DOI Listing
April 2012

Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells.

Neoplasia 2012 Mar;14(3):249-58

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323902PMC
http://dx.doi.org/10.1593/neo.111498DOI Listing
March 2012

Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma.

Cancer Res 2012 Feb 6;72(4):1001-12. Epub 2011 Dec 6.

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-11-0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867810PMC
February 2012

A compendium of canine normal tissue gene expression.

PLoS One 2011 31;6(5):e17107. Epub 2011 May 31.

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://home.ccr.cancer.gov/oncology/oncogenomics/Papers/2011
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http://dx.plos.org/10.1371/journal.pone.0017107
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017107PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104984PMC
October 2011

Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray.

J Pediatr Hematol Oncol 2011 Oct;33(7):524-8

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/MPH.0b013e318223d0c1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179611PMC
October 2011

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

J Natl Cancer Inst 2011 Jun 8;103(12):962-78. Epub 2011 Jun 8.

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr-MSC 1104, 10 CRC 1W-3816, Bethesda, MD 20892-1104, USA.

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http://dx.doi.org/10.1093/jnci/djr156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119649PMC
June 2011

Modeling opportunities in comparative oncology for drug development.

ILAR J 2010 ;51(3):214-20

NCI Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/ilar.51.3.214DOI Listing
March 2011

Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.

Neoplasia 2011 Feb;13(2):145-53

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033593PMC
http://dx.doi.org/10.1593/neo.101202DOI Listing
February 2011

Bridging the gap between experimental animals and humans in osteosarcoma.

Cancer Treat Res 2009 ;152:439-46

College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Ft Collins, CO 80523, USA.

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http://link.springer.com/10.1007/978-1-4419-0284-9_24
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http://dx.doi.org/10.1007/978-1-4419-0284-9_24DOI Listing
October 2010

Modeling metastasis biology and therapy in real time in the mouse lung.

J Clin Invest 2010 Aug 19;120(8):2979-88. Epub 2010 Jul 19.

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1172/JCI40252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912183PMC
August 2010

Osteosarcoma.

J Bone Miner Res 2010 Apr;25(4):683-91

Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine, Yeshiva University, Department of Pediatrics, Children's Hospital at Montefiore, Bronx, NY 10467, USA.

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http://dx.doi.org/10.1002/jbmr.77DOI Listing
April 2010

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.

BMC Genomics 2009 Dec 23;10:625. Epub 2009 Dec 23.

Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1471-2164-10-625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803201PMC
December 2009

Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma.

Cancer 2009 Nov;115(22):5243-50

Department of Orthopaedic Surgery, Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1002/cncr.24562DOI Listing
November 2009

The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway.

PLoS Med 2009 Oct 13;6(10):e1000161. Epub 2009 Oct 13.

Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753665PMC
October 2009

Guiding the optimal translation of new cancer treatments from canine to human cancer patients.

Clin Cancer Res 2009 Sep 8;15(18):5671-7. Epub 2009 Sep 8.

School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748812PMC
September 2009

Revisiting the seed and soil in cancer metastasis.

Int J Biochem Cell Biol 2009 Jul 3;41(7):1452-62. Epub 2009 Feb 3.

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S135727250900038
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http://dx.doi.org/10.1016/j.biocel.2009.01.015DOI Listing
July 2009

Catching cancer by the tail: new perspectives on the use of kinase inhibitors.

Clin Cancer Res 2009 Jun 26;15(11):3645-7. Epub 2009 May 26.

Center for Cancer Research, Comparative Oncology Program, and Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0132DOI Listing
June 2009

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Int J Cancer 2009 May;124(9):2042-9

Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/ijc.24169DOI Listing
May 2009

Inhibition of tumor cell motility by the interferon-inducible GTPase MxA.

J Biol Chem 2009 May 18;284(22):15206-14. Epub 2009 Mar 18.

Laboratory of Cancer Biology and Genetics, Medical Oncology Branch, Pediatric Oncology Branch, and Urologic Oncology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M806324200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685701PMC
May 2009

Use of single-agent carboplatin as adjuvant or neoadjuvant therapy in conjunction with amputation for appendicular osteosarcoma in dogs.

J Am Anim Hosp Assoc 2009 Jan-Feb;45(1):33-8

Veterinary Specialty Hospital of San Diego, 1733 Nautilus Street, La Jolla, California 92037, USA.

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http://jaaha.org/doi/abs/10.5326/0450033
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http://dx.doi.org/10.5326/0450033DOI Listing
March 2009

Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.

Am J Pathol 2009 Jan 12;174(1):265-75. Epub 2008 Dec 12.

Cell and Cancer Biology Department, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.2353/ajpath.2009.071006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631339PMC
January 2009

Novel targets with potential therapeutic applications in osteosarcoma.

Authors:
Chand Khanna

Curr Oncol Rep 2008 Jul;10(4):350-8

National Institutes of Health, National Cancer Institute, Pediatric Oncology Branch, Tumor Metastasis Biology Section, 37 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s11912-008-0054-3DOI Listing
July 2008

Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma.

Cancer Chemother Pharmacol 2008 Jun 1;62(1):19-31. Epub 2007 Sep 1.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Albert-Ludwigs-University, Mathildenstr. 1, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00280-007-0566-9DOI Listing
June 2008

Translation of new cancer treatments from pet dogs to humans.

Nat Rev Cancer 2008 Feb;8(2):147-56

Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 2144, Bethesda, Maryland 20892, USA.

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http://www.nature.com/articles/nrc2273
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http://dx.doi.org/10.1038/nrc2273DOI Listing
February 2008

Alterations in Gemin5 expression contribute to alternative mRNA splicing patterns and tumor cell motility.

Cancer Res 2008 Feb;68(3):639-44

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678556PMC
February 2008

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.

Nat Med 2007 Dec 25;13(12):1504-9. Epub 2007 Nov 25.

Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://www.nature.com/articles/nm1686
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http://dx.doi.org/10.1038/nm1686DOI Listing
December 2007

Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.

Cancer Res 2007 Dec;67(24):11751-9

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-3175DOI Listing
December 2007

Comparative oncology today.

Vet Clin North Am Small Anim Pract 2007 Nov;37(6):1023-32; v

Comparative Oncology Program, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2144, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cvsm.2007.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174910PMC
November 2007

Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin.

J Cell Biol 2007 Nov;179(4):733-46

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1083/jcb.200707199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080902PMC
November 2007

Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma.

Mol Cancer Res 2007 Oct;5(10):991-9

Division of Pediatrics Research, Unit 853, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0007DOI Listing
October 2007

Immune reconstitution prevents metastatic recurrence of murine osteosarcoma.

Cancer Immunol Immunother 2007 Jul 6;56(7):1037-46. Epub 2006 Dec 6.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00262-006-0257-0DOI Listing
July 2007

Expression of the cytoskeleton linker protein ezrin in human cancers.

Clin Exp Metastasis 2007 17;24(2):69-78. Epub 2007 Mar 17.

Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s10585-006-9050-xDOI Listing
June 2007

Fishing for the origins of cancer.

Genes Dev 2007 Jun;21(11):1275-9

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1101/gad.1563707DOI Listing
June 2007

Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway.

Clin Exp Metastasis 2006 22;23(3-4):227-36. Epub 2006 Sep 22.

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1-3816, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10585-006-9033-yDOI Listing
February 2007

Molecular approaches in pediatric oncology.

Annu Rev Med 2006 ;57:83-97

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Rockville and Bethesda, Maryland, USA.

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http://dx.doi.org/10.1146/annurev.med.57.121304.131247DOI Listing
May 2006

CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling.

Neoplasia 2006 May;8(5):394-401

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://dx.doi.org/10.1593/neo.05820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592447PMC
May 2006

The molecular biology of pulmonary metastasis.

Thorac Surg Clin 2006 May;16(2):115-24

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1-3816, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.thorsurg.2005.12.003DOI Listing
May 2006

CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta.

Cancer Res 2006 Apr;66(7):3869-75

Vaccine Branch and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bldg. 10/Rm. 6B12, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3421DOI Listing
April 2006

Results of a phase II clinical trial on the use of ifosfamide for treatment of cats with vaccine-associated sarcomas.

Am J Vet Res 2006 Mar;67(3):517-23

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.2460/ajvr.67.3.517DOI Listing
March 2006

The biology of metastases in pediatric sarcomas.

Cancer J 2005 Jul-Aug;11(4):306-13

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/00130404-200507000-00006DOI Listing
December 2005