Publications by authors named "Chai K Lim"

37Publications

Picolinic acid, a catabolite of tryptophan, has an anabolic effect on bone in vivo.

J Bone Miner Res 2020 Jul 6. Epub 2020 Jul 6.

Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/jbmr.4125DOI Listing
July 2020

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.

J Neuroinflammation 2020 Jun 6;17(1):176. Epub 2020 Jun 6.

Peter Duncan Neurosciences Research Unit, St Vincent's Centre for Applied Medical Research, Sydney, NSW, 2010, Australia.

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http://dx.doi.org/10.1186/s12974-020-01844-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276083PMC
June 2020

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.

J Neuroinflammation 2020 Jun 6;17(1):176. Epub 2020 Jun 6.

Peter Duncan Neurosciences Research Unit, St Vincent's Centre for Applied Medical Research, Sydney, NSW, 2010, Australia.

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http://dx.doi.org/10.1186/s12974-020-01844-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276083PMC
June 2020

Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau.

Neurobiol Aging 2019 08 1;80:11-20. Epub 2019 Apr 1.

Department of Biomedical Sciences, Neuroinflammation Group, Centre for Motor Neuron Disease Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.03.015DOI Listing
August 2019

Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.

Neurotox Res 2019 Apr 21;35(3):530-541. Epub 2019 Jan 21.

Neuroinflammation Group, Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences (FMHS), Macquarie University, 2, Technology Place, North Ryde, NSW, 2109, Australia.

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http://dx.doi.org/10.1007/s12640-019-9997-4DOI Listing
April 2019

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.

Inflamm Bowel Dis 2018 06;24(7):1471-1480

Department of Medicine, Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago Medicine, Chicago, IL, United States.

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http://dx.doi.org/10.1093/ibd/izy103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196764PMC
June 2018

Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes.

Free Radic Biol Med 2018 02 2;115:371-382. Epub 2017 Dec 2.

Laboratório de Bioenergética e Estresse Oxidativo - LABOX, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Campus Universitário, Córrego Grande, Florianópolis, SC 88040-900, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.11.022DOI Listing
February 2018

Neurotoxicity of the Cyanotoxin BMAA Through Axonal Degeneration and Intercellular Spreading.

Neurotox Res 2018 Jan 25;33(1):62-75. Epub 2017 Aug 25.

Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neuroscience Paris Seine, Adaptation Biologique et vieillissement, F-75005, Paris, France.

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http://dx.doi.org/10.1007/s12640-017-9790-1DOI Listing
January 2018

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

N Engl J Med 2017 08;377(6):544-552

From the Divisions of Developmental and Stem Cell Biology (H.S., A.E., M.R., E.M.M.A.M., R.W., J.M., J.O.S., E.I., K.S., J.H., K.K., G.C., D.B.S., S.L.D.), Vascular Biology (G.J.M., R.S.), and Molecular, Structural, and Computational Biology (D.T.H., J.W.K.H., E.G.), Victor Chang Cardiac Research Institute, the Faculties of Medicine and Science, University of New South Wales (H.S., A.E., J.O.S., E.I., D.T.H., G.J.M., J.W.K.H., K.K., R.S., E.G., G.C., D.B.S., S.L.D.), Liverpool Hospital, Department of Clinical Genetics (A.E., A.C.), the Department of Clinical Genetics (A.E., J.S., F.C., D.O.S.) and the Heart Centre for Children (D.S.W.), Children's Hospital at Westmead, the Discipline of Genetic Medicine (A.E., J.S., F.C., D.O.S.) and the Medical School (D.S.W.), University of Sydney, and the Faculty of Medicine and Health Sciences, Macquarie University (C.K.L., G.J.G.) - all in Sydney, the School of Biological Sciences, University of Adelaide, Adelaide, SA (J.N.H., P.Q.T.), and the Institute of Health and Biomedical Innovation, Queensland University of Technology (A.M.M.-L., P.J.L., M.A.B., E.L.D.), the Translational Research Institute (A.M.M.-L., P.J.L., M.A.B., E.L.D.), the Department of Endocrinology, Royal Brisbane and Women's Hospital (E.L.D.), and the University of Queensland School of Medicine (E.L.D.), Brisbane - all in Australia; and Spectrum Health Medical Group, Medical Genetics, Grand Rapids, MI (P.R.M.).

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http://dx.doi.org/10.1056/NEJMoa1616361DOI Listing
August 2017

Human regulatory macrophages are potent in suppression of the xenoimmune response via indoleamine-2,3-dioxygenase-involved mechanism(s).

Xenotransplantation 2017 09 2;24(5). Epub 2017 Aug 2.

Centre for Transplant & Renal Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia.

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http://dx.doi.org/10.1111/xen.12326DOI Listing
September 2017

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression.

Sci Rep 2017 02 3;7:41473. Epub 2017 Feb 3.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, NSW 2109, Australia.

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http://dx.doi.org/10.1038/srep41473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290739PMC
February 2017

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis.

Front Immunol 2016 4;7:246. Epub 2016 Aug 4.

Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia; Faculty of Medicine, St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia; Department of Neurology, St Vincent's Hospital, Sydney, NSW, Australia.

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http://dx.doi.org/10.3389/fimmu.2016.00246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972824PMC
August 2016

Characterization of the Kynurenine Pathway in CD8 Human Primary Monocyte-Derived Dendritic Cells.

Neurotox Res 2016 11 10;30(4):620-632. Epub 2016 Aug 10.

Neuropharmacology Group, MND and Neurodegenerative Diseases Research Centre, Macquarie University, Sydney, NSW, 2109, Australia.

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http://dx.doi.org/10.1007/s12640-016-9657-xDOI Listing
November 2016

Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease.

Prog Neurobiol 2017 Aug 9;155:76-95. Epub 2016 Apr 9.

Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia; Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St Vincent's Centre for Applied Medical Research, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2015.12.009DOI Listing
August 2017

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases.

Neuropharmacology 2017 Jan 16;112(Pt B):373-388. Epub 2016 Mar 16.

Peter Duncan Neurosciences Research Unit, St Vincent's Centre for Applied Medical Research, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, University of NSW, Sydney, Australia; Department of Neurology, St Vincent's Hospital, Level 4 Xavier Building, Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.03.024DOI Listing
January 2017

Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66.

J Cell Sci 2016 Mar 29;129(6):1198-209. Epub 2016 Jan 29.

Inflammation and Infection Research Centre, School of Medical Sciences, Department of Pathology, UNSW, Sydney, New South Wales 2052, Australia

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http://dx.doi.org/10.1242/jcs.182006DOI Listing
March 2016

Understanding the role of the kynurenine pathway in human breast cancer immunobiology.

Oncotarget 2016 Feb;7(6):6506-20

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

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http://dx.doi.org/10.18632/oncotarget.6467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872729PMC
February 2016

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease.

PLoS One 2015 26;10(6):e0131389. Epub 2015 Jun 26.

Peter Duncan Neurosciences Research Unit, St Vincent's Centre for Applied Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney, Australia; Department of Neurology, St Vincent's Hospital, Sydney, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131389PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482723PMC
April 2016

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.

J Neuroinflammation 2015 May 30;12:110. Epub 2015 May 30.

Australian New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1186/s12974-015-0328-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457980PMC
May 2015

Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies.

J Neuroinflammation 2014 Dec 13;11:204. Epub 2014 Dec 13.

Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St Vincent's Centre for Applied Medical Research, Sydney, Australia.

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http://dx.doi.org/10.1186/s12974-014-0204-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302518PMC
December 2014

Involvement of the kynurenine pathway in human glioma pathophysiology.

PLoS One 2014 21;9(11):e112945. Epub 2014 Nov 21.

MND and Neurodegenerative Diseases Research Centre, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia; St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia; Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112945PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240539PMC
July 2015

Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton.

Neurol Neuroimmunol Neuroinflamm 2014 Jun 22;1(1):e12. Epub 2014 May 22.

Neuroimmunology Group (R.C.D., E.M.T., V.M., R.-Y.A.K., N.S., K. Pathmanandavel, S.R., F.B.), Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Westmead, Australia; Institute for Immunology and Allergy Research (D.R.B.), Westmead Millenium Institute for Medical Research, University of Sydney, Westmead, Australia; Clinical Immunology (L.A.W.), Royal Prince Alfred Hospital, Sydney Medical School Immunology & Infectious Diseases, University of Sydney, Camperdown, Australia; Department of Radiology (K. Prelog), the Children's Hospital at Westmead, Australia; Department of Paediatric Neurology (D.R.C.), Women's and Children's Hospital, North Adelaide, Australia; Neuroinflammation Group (G.J.G., C.K.L.), MND and Neurodegenerative Diseases Research Centre, Macquarie University, Australian School of Advanced Medicine, North Ryde, Australia; and Neuroinflammation Group (E.K.M.), Brain and Mind Research Institute, University of Sydney, Camperdown, Australia.

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http://dx.doi.org/10.1212/NXI.0000000000000012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202678PMC
June 2014

Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.

Brain Behav Immun 2014 Oct 27;41:173-81. Epub 2014 May 27.

School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; Neuroscience Research Australia, Randwick, NSW 2031, Australia; Schizophrenia Research Institute, Liverpool St, Darlinghurst, NSW 2011, Australia.

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http://dx.doi.org/10.1016/j.bbi.2014.05.011DOI Listing
October 2014

Serum nicotinamide adenine dinucleotide levels through disease course in multiple sclerosis.

Brain Res 2013 Nov 21;1537:267-72. Epub 2013 Aug 21.

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1016/j.brainres.2013.08.025DOI Listing
November 2013

Role of NAD(+), Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders.

Int J Tryptophan Res 2013 21;6(Suppl 1):15-28. Epub 2013 Jul 21.

Dept of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, Oman. ; School of Medical Sciences, Department of Pharmacology, Faculty of Medicine, University of NSW, Sydney, Australia.

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http://dx.doi.org/10.4137/IJTR.S11355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729335PMC
August 2013

Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages.

Int J Tryptophan Res 2013 15;6:7-19. Epub 2013 May 15.

Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia. ; MND and Neurodegenerative disease Research Group, Australian School of Advance Medicine, Macquarie University, Australia.

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http://www.jneurosci.org/content/27/47/12884.full.pdf
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http://www.la-press.com/characterization-of-the-kynurenine-p
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http://dx.doi.org/10.4137/IJTR.S11789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662399PMC
June 2013

Understanding the roles of the kynurenine pathway in multiple sclerosis progression.

Int J Tryptophan Res 2010 25;3:157-67. Epub 2010 Aug 25.

Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195238PMC
http://dx.doi.org/10.4137/ijtr.s4294DOI Listing
November 2011

Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells.

Neuroreport 2006 Jun;17(9):891-6

Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia.

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http://dx.doi.org/10.1097/01.wnr.0000221833.41340.cdDOI Listing
June 2006