Chad J Creighton

Chad J Creighton

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Chad J Creighton

Publications by authors named "Chad J Creighton"

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Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness.

Oncogene 2019 Aug 9. Epub 2019 Aug 9.

Department of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1038/s41388-019-0917-0DOI Listing
August 2019

Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.

Cell Stem Cell 2019 May 11;24(5):753-768.e6. Epub 2019 Apr 11.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Urology, University of Washington, Seattle, WA 98109, USA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548441PMC
May 2019

Reply to Liu et al.: ALK5-mediated tumor suppressor signaling through SMAD2 and SMAD3 in the uterus.

Proc Natl Acad Sci U S A 2019 May;116(19):9166-9167

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1904354116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511039PMC
May 2019

JNK represses Lkb-deficiency-induced lung squamous cell carcinoma progression.

Nat Commun 2019 05 14;10(1):2148. Epub 2019 May 14.

Reproductive & Developmental Biology Laboratory, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park (RTP), 27709, NC, USA.

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http://dx.doi.org/10.1038/s41467-019-09843-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517592PMC
May 2019

Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq.

iScience 2019 Mar 2;13:328-338. Epub 2019 Mar 2.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA; Department of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423355PMC
March 2019

MicroRNAs as prognostic markers in prostate cancer.

Prostate 2019 Feb 21;79(3):265-271. Epub 2018 Oct 21.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/pros.23731DOI Listing
February 2019

Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas.

Mol Cancer Res 2019 02 6;17(2):476-487. Epub 2018 Nov 6.

Division of Biostatistics, Dan L. Duncan Comprehensive Cancer Center Baylor College of Medicine, Houston, Texas.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-18-0601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359982PMC
February 2019

Uterine double-conditional inactivation of and in mice causes endometrial dysregulation, infertility, and uterine cancer.

Proc Natl Acad Sci U S A 2019 02 16;116(9):3873-3882. Epub 2019 Jan 16.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1806862116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397514PMC
February 2019

miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution.

Stem Cells 2018 Dec 31;36(12):1875-1889. Epub 2018 Oct 31.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/stem.2914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379077PMC
December 2018

The clinical applications of The Cancer Genome Atlas project for bladder cancer.

Authors:
Chad J Creighton

Expert Rev Anticancer Ther 2018 10 13;18(10):973-980. Epub 2018 Aug 13.

a Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics , Baylor College of Medicine , Houston , TX , USA.

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https://www.tandfonline.com/doi/full/10.1080/14737140.2018.1
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http://dx.doi.org/10.1080/14737140.2018.1508999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295312PMC
October 2018

Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny.

Cell Rep 2018 Oct;25(3):811-821.e5

Department of Medical Oncology, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Sorbonnes-Universités, University Pierre and Marie Curie, Paris, France; Department of Hematology and Medical Oncology, CHRU Strasbourg, Hôpital Hautepierre, Strasbourg, France; Institut Génomique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch-Graffenstaden, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183149
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http://dx.doi.org/10.1016/j.celrep.2018.09.047DOI Listing
October 2018

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.

Cell Rep 2018 Oct;25(5):1304-1317.e5

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183156
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http://dx.doi.org/10.1016/j.celrep.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326181PMC
October 2018

Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer.

Breast Cancer Res Treat 2018 Sep 1;171(2):283-293. Epub 2018 Jun 1.

Departments of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/s10549-018-4835-6DOI Listing
September 2018

A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases.

Cell Rep 2018 07;24(2):515-527

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092947PMC
July 2018

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

Nat Commun 2018 07 16;9(1):2731. Epub 2018 Jul 16.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41467-018-05013-x
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http://dx.doi.org/10.1038/s41467-018-05013-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048095PMC
July 2018

Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases.

Clin Cancer Res 2018 05 9;24(9):2182-2193. Epub 2018 Feb 9.

Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932236PMC
May 2018

Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan-omics precision.

J Pathol 2018 04 14;244(5):525-537. Epub 2018 Feb 14.

Human Genome Sequencing Center, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1002/path.5022DOI Listing
April 2018

Pan-cancer survey of epithelial-mesenchymal transition markers across the Cancer Genome Atlas.

Dev Dyn 2018 03 4;247(3):555-564. Epub 2017 May 4.

Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas.

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http://doi.wiley.com/10.1002/dvdy.24485
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http://dx.doi.org/10.1002/dvdy.24485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503821PMC
March 2018

A Landscape of Metabolic Variation across Tumor Types.

Cell Syst 2018 Mar 27;6(3):301-313.e3. Epub 2018 Jan 27.

cBio Center, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876114PMC
March 2018

Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN.

Oncotarget 2018 Mar 12;9(18):14456-14471. Epub 2018 Feb 12.

Deptartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.18632/oncotarget.24470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865682PMC
March 2018

Influence of the neural microenvironment on prostate cancer.

Prostate 2018 Feb 13;78(2):128-139. Epub 2017 Nov 13.

Department of Pathology and Laboratory Medicine, University of Texas Health Sciences Center Medical School, Houston, Texas.

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http://dx.doi.org/10.1002/pros.23454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836952PMC
February 2018

Making Use of Cancer Genomic Databases.

Authors:
Chad J Creighton

Curr Protoc Mol Biol 2018 01 16;121:19.14.1-19.14.13. Epub 2018 Jan 16.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/cpmb.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774229PMC
January 2018

WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis.

Dev Cell 2017 11 2;43(4):436-448.e6. Epub 2017 Nov 2.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698144PMC
November 2017

miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer.

Oncotarget 2017 Sep 24;8(36):60243-60256. Epub 2017 Jul 24.

Department of Pathology and Immunology and Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.19521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601135PMC
September 2017

RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression.

Cancer Res 2017 08 13;77(16):4247-4257. Epub 2017 Jun 13.

Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559317PMC
August 2017

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses.

Neoplasia 2017 Aug 18;19(8):649-658. Epub 2017 Jul 18.

Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516091PMC
August 2017

Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nat Commun 2017 08 4;8(1):199. Epub 2017 Aug 4.

Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-017-00289-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543131PMC
August 2017

Macrophages promote the progression of premalignant mammary lesions to invasive cancer.

Oncotarget 2017 Aug 31;8(31):50731-50746. Epub 2017 Jan 31.

Department of Biochemistry and Molecular Biology, Tulane School of Medicine, New Orleans, LA, USA.

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http://dx.doi.org/10.18632/oncotarget.14913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584199PMC
August 2017

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Cancer Cell 2017 06 18;31(6):820-832.e3. Epub 2017 May 18.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502825PMC
June 2017

A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.

Neoplasia 2017 May 20;19(5):421-428. Epub 2017 Apr 20.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402631PMC
May 2017

Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).

J Clin Oncol 2017 Apr 3;35(10):1061-1069. Epub 2017 Jan 3.

Matthew J. Ellis and Chad J. Creighton, Baylor College of Medicine; Gildy Babiera and Kelly Hunt, MD Anderson Cancer Center, Houston; Gary Unzeitig, Doctor's Hospital of Laredo, Laredo; Marilyn Leitch, University of Texas Southwestern Campus, Dallas, TX; Vera J. Suman, Mayo Clinic, Rochester MN; Jeremy Hoog, Rodrigo Goncalves, Souzan Sanati, Katherine DeSchryver, Erika Crouch, Amy Brink, Mark Watson, Jingqin Luo, Yu Tao, Cynthia X. Ma, and D. Craig Allred, Washington University School of Medicine, St Louis; Timothy Pluard, St Lukes Hospital, Kansas City, MO; Michael Barnes, Roche Diagnostics, Mountain View; Laura Esserman, University of California San Francisco, San Francisco, CA; Mitchell Dowsett, Royal Marsden Hospital, London, UK; G. Thomas Budd, Cleveland Clinic; Paula Silverman, Case Western Reserve University, Cleveland OH; Eric Winer, Dana-Farber Cancer Institute, Boston MA; Lisa Carey, University of North Carolina, Chapel Hill; David Ota, Duke University, Durham, NC; Pat Whitworth, Nashville Breast Center, Nashville, TN; J. Michael Guenther, St Elizabeth Medical Center, Edgewood, KY; Zoneddy Dayao, University of New Mexico, Albuquerque, NM; and John A. Olson Jr, University of Maryland School of Medicine and Greenebaum Cancer Center, Baltimore, MD.

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http://dx.doi.org/10.1200/JCO.2016.69.4406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455353PMC
April 2017

Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway.

Oncotarget 2017 Feb;8(6):10145-10160

Department of Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.14358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354648PMC
February 2017

Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment.

Biol Reprod 2017 02;96(2):313-326

Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA.

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http://dx.doi.org/10.1095/biolreprod.116.144410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225975PMC
February 2017

MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer.

Cancer Res 2016 11 30;76(21):6290-6298. Epub 2016 Aug 30.

Department of Pathology and Immunology and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093064PMC
November 2016

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.

Proc Natl Acad Sci U S A 2016 10 6;113(43):E6600-E6609. Epub 2016 Oct 6.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; Department of Medicine, Baylor College of Medicine, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1612835113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087040PMC
October 2016

Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor.

Mol Cell 2016 09 1;63(6):976-89. Epub 2016 Sep 1.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026614PMC
September 2016

Unique Transcriptomic Profile of Collecting Duct Carcinomas Relative to Upper Tract Urothelial Carcinomas and other Kidney Carcinomas.

Sci Rep 2016 08 3;6:30988. Epub 2016 Aug 3.

Department of Medical Oncology, Groupe Hospitalier Pitié-Salpêtrière, University Pierre and Marie Curie (Paris VI), GRC5, ONCOTYPE-Uro, Institut Universitaire de Cancérologie, Assistance-Publique Hôpitaux de Paris, 75013, France.

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http://dx.doi.org/10.1038/srep30988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971524PMC
August 2016

A genetic cell context-dependent role for ZEB1 in lung cancer.

Nat Commun 2016 07 26;7:12231. Epub 2016 Jul 26.

Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Cancer Center and College of Medicine, Mayo Clinic, 200 First Street SW, Stabile Building Room st8-08 Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/ncomms12231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963474PMC
July 2016

Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.

Mol Cancer Res 2016 05 10;14(5):470-81. Epub 2016 Mar 10.

Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas. Department of Medicine, Baylor College of Medicine, Houston, Texas. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867274PMC
May 2016

Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.

Mol Endocrinol 2016 May 28;30(5):518-32. Epub 2016 Mar 28.

Department of Molecular and Cellular Biology (Y.M.V., S.Y.T., M.-J.T., J.P.L., F.J.D.), Baylor College of Medicine, Houston, Texas 77030; Department of Obstetrics and Gynecology (M.L.A., S.M.H.), Baylor College of Medicine, Houston, Texas 77030; Dan L. Duncan Cancer Center (M.L.A., C.J.C.), Division of Biostatistics, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030; and Pregnancy and Female Reproduction Group (S.-P.W., M.R., M.J.D.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

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http://dx.doi.org/10.1210/me.2015-1215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853565PMC
May 2016

Reverse phase protein arrays in signaling pathways: a data integration perspective.

Drug Des Devel Ther 2015 7;9:3519-27. Epub 2015 Jul 7.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA ; Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.2147/DDDT.S38375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500628PMC
April 2016

Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study.

Cell Oncol (Dordr) 2016 Apr 9;39(2):187-93. Epub 2015 Dec 9.

Department of Medical Genetics, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s13402-015-0259-zDOI Listing
April 2016

Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer.

Nat Commun 2016 04 25;7:11418. Epub 2016 Apr 25.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncomms11418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848536PMC
April 2016

SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma.

Clin Cancer Res 2016 Mar 16;22(5):1150-60. Epub 2015 Oct 16.

The Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Surgical Oncology, Comprehensive Cancer Center, The Ohio State University (OSU), Columbus, Ohio. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775372PMC
March 2016

The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells.

Tumour Biol 2016 Mar 22;37(3):4183-92. Epub 2015 Oct 22.

Department of Medical Genetics, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s13277-015-4219-zDOI Listing
March 2016

Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.

Mol Cancer Res 2016 Mar 2;14(3):287-95. Epub 2015 Dec 2.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794404PMC
March 2016

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.

Cell Rep 2016 Mar 3;14(10):2476-89. Epub 2016 Mar 3.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794376PMC
March 2016

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

Authors:
W Marston Linehan Paul T Spellman Christopher J Ricketts Chad J Creighton Suzanne S Fei Caleb Davis David A Wheeler Bradley A Murray Laura Schmidt Cathy D Vocke Myron Peto Abu Amar M Al Mamun Eve Shinbrot Anurag Sethi Samira Brooks W Kimryn Rathmell Angela N Brooks Katherine A Hoadley A Gordon Robertson Denise Brooks Reanne Bowlby Sara Sadeghi Hui Shen Daniel J Weisenberger Moiz Bootwalla Stephen B Baylin Peter W Laird Andrew D Cherniack Gordon Saksena Scott Haake Jun Li Han Liang Yiling Lu Gordon B Mills Rehan Akbani Mark D M Leiserson Benjamin J Raphael Pavana Anur Donald Bottaro Laurence Albiges Nandita Barnabas Toni K Choueiri Bogdan Czerniak Andrew K Godwin A Ari Hakimi Thai H Ho James Hsieh Michael Ittmann William Y Kim Bhavani Krishnan Maria J Merino Kenna R Mills Shaw Victor E Reuter Ed Reznik Carl S Shelley Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Satish Tickoo Kenneth Burnett Daniel Crain Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph D Paulauskis Robert J Penny Candace Shelton W Troy Shelton Mark Sherman Eric Thompson Peggy Yena Melissa T Avedon Jay Bowen Julie M Gastier-Foster Mark Gerken Kristen M Leraas Tara M Lichtenberg Nilsa C Ramirez Tracie Santos Lisa Wise Erik Zmuda John A Demchok Ina Felau Carolyn M Hutter Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C Zenklusen Jiashan Zhang Brenda Ayala Julien Baboud Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Adrian Ally Miruna Balasundaram Saianand Balu Rameen Beroukhim Tom Bodenheimer Christian Buhay Yaron S N Butterfield Rebecca Carlsen Scott L Carter Hsu Chao Eric Chuah Amanda Clarke Kyle R Covington Mahmoud Dahdouli Ninad Dewal Noreen Dhalla Harsha V Doddapaneni Jennifer A Drummond Stacey B Gabriel Richard A Gibbs Ranabir Guin Walker Hale Alicia Hawes D Neil Hayes Robert A Holt Alan P Hoyle Stuart R Jefferys Steven J M Jones Corbin D Jones Divya Kalra Christie Kovar Lora Lewis Jie Li Yussanne Ma Marco A Marra Michael Mayo Shaowu Meng Matthew Meyerson Piotr A Mieczkowski Richard A Moore Donna Morton Lisle E Mose Andrew J Mungall Donna Muzny Joel S Parker Charles M Perou Jeffrey Roach Jacqueline E Schein Steven E Schumacher Yan Shi Janae V Simons Payal Sipahimalani Tara Skelly Matthew G Soloway Carrie Sougnez Angela Tam Donghui Tan Nina Thiessen Umadevi Veluvolu Min Wang Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Jane Zhou Jason Bedford Fengju Chen Yao Fu Mark Gerstein David Haussler Katayoon Kasaian Phillip Lai Shiyun Ling Amie Radenbaugh David Van Den Berg John N Weinstein Jingchun Zhu Monique Albert Iakovina Alexopoulou Jeremiah J Andersen J Todd Auman John Bartlett Sheldon Bastacky Julie Bergsten Michael L Blute Lori Boice Roni J Bollag Jeff Boyd Erik Castle Ying-Bei Chen John C Cheville Erin Curley Benjamin Davies April DeVolk Rajiv Dhir Laura Dike John Eckman Jay Engel Jodi Harr Ronald Hrebinko Mei Huang Lori Huelsenbeck-Dill Mary Iacocca Bruce Jacobs Michael Lobis Jodi K Maranchie Scott McMeekin Jerome Myers Joel Nelson Jeremy Parfitt Anil Parwani Nicholas Petrelli Brenda Rabeno Somak Roy Andrew L Salner Joel Slaton Melissa Stanton R Houston Thompson Leigh Thorne Kelinda Tucker Paul M Weinberger Cynthia Winemiller Leigh Anne Zach Rosemary Zuna

Uterine ALK3 is essential during the window of implantation.

Proc Natl Acad Sci U S A 2016 Jan 31;113(3):E387-95. Epub 2015 Dec 31.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030; Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030; Center for Drug Discovery, Baylor College of Medicine, Houston, TX 77030

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http://dx.doi.org/10.1073/pnas.1523758113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725477PMC
January 2016

The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL.

Sci Rep 2016 Jan 5;6:18652. Epub 2016 Jan 5.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/srep18652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700473PMC
January 2016

Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.

Cancer Res 2015 Dec 1;75(24):5341-54. Epub 2015 Dec 1.

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas. Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681596PMC
December 2015

Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors.

Cancer 2015 Nov 8;121(22):4088-96. Epub 2015 Sep 8.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncr.29564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635059PMC
November 2015

Novel POC1A mutation in primordial dwarfism reveals new insights for centriole biogenesis.

Hum Mol Genet 2015 Oct 10;24(19):5378-87. Epub 2015 Jul 10.

Department of Medical Genetics, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey, Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA and Department of Molecular Biology and Genetics, Biruni University, Topkapi, Istanbul, Turkey

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http://dx.doi.org/10.1093/hmg/ddv261DOI Listing
October 2015

Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling.

Mol Endocrinol 2015 Oct 18;29(10):1440-53. Epub 2015 Aug 18.

Departments of Molecular and Human Genetics (P.T.F., M.M.M.), Pathology and Immunology (P.T.F., M.M.M.), Molecular and Cellular Biology (M.M.M.), Pharmacology (M.M.M.), and Medicine (C.J.C.); the Center for Drug Discovery (P.T.F., M.M.M.); and the Dan L. Duncan Cancer Center (P.T.F., C.J.C., M.M.M.), Baylor College of Medicine, Houston, Texas 77030.

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http://dx.doi.org/10.1210/me.2015-1102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588735PMC
October 2015

Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise.

Clin Cancer Res 2015 Oct;21(20):4514-24

The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts. Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610178PMC
October 2015

Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.

Cell Rep 2015 Jul 9;12(3):511-24. Epub 2015 Jul 9.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512851PMC
July 2015