Chad A Cowan

Chad A Cowan

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Chad A Cowan

Publications by authors named "Chad A Cowan"

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Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics.

Trends Endocrinol Metab 2019 Jun 6;30(6):396-406. Epub 2019 May 6.

Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2019.03.002DOI Listing
June 2019

Generation of hypoimmunogenic human pluripotent stem cells.

Proc Natl Acad Sci U S A 2019 May 30;116(21):10441-10446. Epub 2019 Apr 30.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1902566116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535035PMC
May 2019

Humanity in a Dish: Population Genetics with iPSCs.

Trends Cell Biol 2018 01 23;28(1):46-57. Epub 2017 Nov 23.

Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.09.006DOI Listing
January 2018

FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism.

Biochem Biophys Res Commun 2018 01 3;495(1):254-260. Epub 2017 Nov 3.

Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.11.008DOI Listing
January 2018

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

Utility of CRISPR/Cas9 systems in hematology research.

Exp Hematol 2017 10 28;54:1-3. Epub 2017 Jun 28.

Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.06.006DOI Listing
October 2017

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Cell Stem Cell 2017 09 10;21(3):305-318.e8. Epub 2017 Aug 10.

Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909173028
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http://dx.doi.org/10.1016/j.stem.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591074PMC
September 2017

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.

Stem Cell Reports 2017 05 13;8(5):1164-1173. Epub 2017 Apr 13.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425619PMC
May 2017

The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics.

Cell Stem Cell 2017 04;20(4):431-433

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.03.021DOI Listing
April 2017

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Cell Stem Cell 2017 04;20(4):547-557.e7

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.01.010DOI Listing
April 2017

Microenvironmental Control of Adipocyte Fate and Function.

Trends Cell Biol 2016 10 4;26(10):745-755. Epub 2016 Jun 4.

Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.05.005DOI Listing
October 2016

Adipocyte insulin receptor activity maintains adipose tissue mass and lifespan.

Biochem Biophys Res Commun 2016 08 28;476(4):487-492. Epub 2016 May 28.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.05.151DOI Listing
August 2016

Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease.

Mol Endocrinol 2016 Jun 13;30(6):575-86. Epub 2016 Apr 13.

Department of Stem Cell and Regenerative Biology (H.Y., C.A.C.), Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138; and Center for Regenerative Medicine (C.A.C.), Massachusetts General Hospital, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1210/me.2015-1290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884342PMC
June 2016

Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells.

Development 2016 05;143(9):1475-81

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

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http://dx.doi.org/10.1242/dev.132209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909860PMC
May 2016

Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report.

Arterioscler Thromb Vasc Biol 2016 Jan 5;36(1):15-8. Epub 2015 Nov 5.

From the Department of Stem Cell and Regenerative Biology, Harvard University, and Harvard Stem Cell Institute, Cambridge, MA (R.M.G., T.B.M., C.A.C., K.M.); and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (R.M.G., K.M.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690765PMC
January 2016

Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions.

Cell Stem Cell 2016 Jan;18(1):53-65

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709030PMC
January 2016

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.

Nat Cell Biol 2015 Aug 27;17(8):994-1003. Epub 2015 Jul 27.

1] Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Massachusetts 02138, USA [2] Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA [3] Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb3205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566857PMC
August 2015

TALEN- and CRISPR/Cas9-Mediated Gene Editing in Human Pluripotent Stem Cells Using Lipid-Based Transfection.

Curr Protoc Stem Cell Biol 2015 Aug 3;34:5B.3.1-25. Epub 2015 Aug 3.

Harvard University, Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/9780470151808.sc05b03s34DOI Listing
August 2015

Type 1 Diabetes and MicroRNA: It's Complicated.

Cell Metab 2015 Aug;22(2):202-3

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.018DOI Listing
August 2015

Genome editing for human gene therapy.

Methods Enzymol 2014 ;546:273-95

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA; Harvard Stem Cell Institute, Sherman Fairchild Biochemistry, Cambridge, Massachusetts, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801185-0.00013-1DOI Listing
July 2015

A comparison of non-integrating reprogramming methods.

Nat Biotechnol 2015 Jan 1;33(1):58-63. Epub 2014 Dec 1.

1] Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [3] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329913PMC
January 2015

White-to-brown metabolic conversion of human adipocytes by JAK inhibition.

Nat Cell Biol 2015 Jan 8;17(1):57-67. Epub 2014 Dec 8.

1] Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Massachusetts 02138, USA [2] Center for Regenerative Medicine, Massachusetts General Hospital, Boston Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncb3075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276482PMC
January 2015

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Cell Stem Cell 2014 Nov 6;15(5):643-52. Epub 2014 Nov 6.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269831PMC
November 2014

Differentiation of white and brown adipocytes from human pluripotent stem cells.

Methods Enzymol 2014 ;538:35-47

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-800280-3.00003-7DOI Listing
October 2014

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing.

Circ Res 2014 Aug 10;115(5):488-92. Epub 2014 Jun 10.

From the Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA (Q.D., S.-L.N., B.S.G., S.N.R., C.A.C., K.M.); Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity and Metabolism, and Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (A.S., K.M.P., D.J.R.); Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (K.M.); and Broad Institute, Cambridge, MA (C.A.C., K.M.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.115.30435
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http://dx.doi.org/10.1161/CIRCRESAHA.115.304351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134749PMC
August 2014

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

Cell Stem Cell 2014 Jul;15(1):27-30

Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082799PMC
July 2014

β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

Cell Metab 2014 Jan;19(1):96-108

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017355PMC
January 2014

Liver in a dish.

Cell Res 2013 Nov 27;23(11):1242-3. Epub 2013 Aug 27.

Department of Stem Cell and Regenerative Biology, Harvard University, Sherman Fairchild Biochemistry Bldg 153, 7 Divinity Ave, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1038/cr.2013.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817545PMC
November 2013

White to brite adipocyte transition and back again.

Nat Cell Biol 2013 Jun;15(6):568-9

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http://dx.doi.org/10.1038/ncb2776DOI Listing
June 2013

Expression analysis of macrodactyly identifies pleiotrophin upregulation.

PLoS One 2012 27;7(7):e40423. Epub 2012 Jul 27.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040423PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407187PMC
April 2013

Efficient culturing and genetic manipulation of human pluripotent stem cells.

PLoS One 2011 15;6(12):e27495. Epub 2011 Dec 15.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027495PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240614PMC
August 2012

Cbx proteins help ESCs walk the line between self-renewal and differentiation.

Cell Stem Cell 2012 Jan;10(1):4-6

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.stem.2011.12.011DOI Listing
January 2012

Rapid cellular turnover in adipose tissue.

PLoS One 2011 Mar 2;6(3):e17637. Epub 2011 Mar 2.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017637PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047582PMC
March 2011

Genome modification in human embryonic stem cells.

J Cell Physiol 2010 Feb;222(2):278-81

Stowers Medical Institute, Harvard Stem Cell Institute, Center for Regenerative Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1002/jcp.21948DOI Listing
February 2010

Induced pluripotent stem (iPS) cells: an up-to-the-minute review.

F1000 Biol Rep 2009 Nov 16;1:84. Epub 2009 Nov 16.

Stowers Medical Institute and Harvard Stem Cell Institute, Harvard University, Department of Stem Cell and Regenerative Biology, 185 Cambridge Street CPZN 4234, Boston, MA 02114, USA.

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http://dx.doi.org/10.3410/B1-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948253PMC
November 2009

Human embryonic stem cells: emerging technologies and practical applications.

Curr Opin Genet Dev 2008 Aug 30;18(4):324-9. Epub 2008 Jul 30.

Stowers Medical Institute, Harvard Stem Cell Institute, Center for Regenerative Medicine, Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, CPZN-4234, Boston, MA 02114, United States.

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http://dx.doi.org/10.1016/j.gde.2008.06.004DOI Listing
August 2008

Marked differences in differentiation propensity among human embryonic stem cell lines.

Nat Biotechnol 2008 Mar 17;26(3):313-5. Epub 2008 Feb 17.

Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nbt1383DOI Listing
March 2008

New tools for genome modification in human embryonic stem cells.

Cell Stem Cell 2007 Dec;1(6):600-2

Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.stem.2007.11.004DOI Listing
December 2007

Human embryonic stem cells.

Methods Enzymol 2006 ;418:78-92

Harvard University, Howard Huges Medical Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)18005-2DOI Listing
January 2007

Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.

Science 2005 Aug;309(5739):1369-73

Howard Hughes Medical Institute, Harvard Stem Cell Institute, Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1116447DOI Listing
August 2005

Gene expression in the preimplantation embryo: in-vitro developmental changes.

Reprod Biomed Online 2005 May;10(5):607-16

Boston IVF, 40 Second Avenue, Suite 200, Waltham, MA 02451, USA.

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May 2005

The Src family of tyrosine kinases is important for embryonic stem cell self-renewal.

J Biol Chem 2004 Jul 17;279(30):31590-8. Epub 2004 May 17.

Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1074/jbc.M403547200DOI Listing
July 2004

Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development.

Dev Biol 2004 Jul;271(2):263-71

Center for Developmental Biology and Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390-9133, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060400238
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http://dx.doi.org/10.1016/j.ydbio.2004.03.026DOI Listing
July 2004

Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development.

Dev Biol 2004 Jul;271(2):272-90

Center for Developmental Biology and Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390-9133, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060400239
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http://dx.doi.org/10.1016/j.ydbio.2004.03.027DOI Listing
July 2004

Derivation of embryonic stem-cell lines from human blastocysts.

N Engl J Med 2004 Mar 3;350(13):1353-6. Epub 2004 Mar 3.

Howard Hughes Medical Institute, Cambridge, Mass, USA.

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http://dx.doi.org/10.1056/NEJMsr040330DOI Listing
March 2004

Ephrins in reverse, park and drive.

Trends Cell Biol 2002 Jul;12(7):339-46

Center for Developmental Biology, Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390-9133, USA.

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July 2002