Dr. César Rivera, DDS, MSc - Universidad de Talca - Cirujano Dentista

Dr. César Rivera

DDS, MSc

Universidad de Talca

Cirujano Dentista

Talca, Región del Maule | Chile

Main Specialties: Oral Medicine

Additional Specialties: Patología y Medicina Oral

Dr. César Rivera, DDS, MSc - Universidad de Talca - Cirujano Dentista

Dr. César Rivera

DDS, MSc

Introduction

Primary Affiliation: Universidad de Talca - Talca, Región del Maule , Chile

Specialties:

Additional Specialties:

Publications

26Publications

139Reads

2Profile Views

93PubMed Central Citations

Essentials of oral cancer.

Authors:
César Rivera

Int J Clin Exp Pathol 2015 1;8(9):11884-94. Epub 2015 Sep 1.

Department of Basic Biomedical Sciences, University of Talca (UTALCA) Talca Maule Region, Chile ; Department of Oral Diagnosis, School of Dentistry, State University of Campinas (UNICAMP) Piracicaba São Paulo, Brazil ; Mass Spectrometry Laboratory, Brazilian Biosciences National Laboratory (LNBio), National Center for Research in Energy and Materials (CNPEM) Campinas São Paulo, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637760PMC
September 2016
10 Reads
27 Citations
1.783 Impact Factor

Gentian Violet Used as an Epithelial Cell Monolayer Stain in the Scratch Wound Healing Assay.

Authors:
César Rivera

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):137-8

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April 2016
7 Reads
1 Citation

A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva.

Proteomics 2016 Jan 15;16(1):159-73. Epub 2015 Dec 15.

Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/pmic.201500224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703492PMC
January 2016
17 Reads
9 Citations
3.810 Impact Factor

Oral pemphigus vulgaris after Chilean earthquake.

Pan Afr Med J 2014 16;18:219. Epub 2014 Jul 16.

Unit of Oral Pathology, Department of Stomatology, Faculty of Health Sciences, University of Talca, Talca, Chile.

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http://dx.doi.org/10.11604/pamj.2014.18.219.4273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239450PMC
July 2015
4 Reads

Clinicopathological and immunohistochemical evaluation of oral and oropharyngeal squamous cell carcinoma in Chilean population.

Int J Clin Exp Pathol 2014 15;7(9):5968-77. Epub 2014 Aug 15.

Unit of Oral Pathology, Department of Stomatology, University of Talca Talca, Maule Region, Chile ; Carlos Van Buren Hospital Valparaíso, Valparaíso Region, Chile.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203212PMC
July 2015
23 Reads
2 Citations
1.783 Impact Factor

Opportunities for biomarkers with potential clinical use in oral cancer.

Authors:
César Rivera

Medwave 2015 Jul 20;15(6):e6186. Epub 2015 Jul 20.

Facultad de Ciencias de la Salud, Departamento de Ciencias Básicas Biomédicas, Universidad de Talca (UTALCA), Talca, Chile; Centro Nacional de Investigación en Energía y Materiales (CNPEM), Laboratorio Nacional de Biociencias (LNBio), Campinas, São Paulo, Brasil. Address: Universidad de Talca Campus Norte, Laboratorio de Morfología, Avenida Lircay S/N Talca 3460000 Región del Maule Chile. Email:

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http://dx.doi.org/10.5867/medwave.2015.06.6186DOI Listing
July 2015
8 Reads
2 Citations

The challenge of the state of susceptibility to oral cancer

Authors:
César Rivera

J Oral Res. 2015 February; 4(1):8-9

J Oral Res

Over the last few decades, the efforts of biomedical research in genomics and proteomics have focused on understanding the mechanisms which trigger cancer, including oral cancer. Despite the knowledge acquired so far, only 50% of our patients survive after 5 years. What happened with the clinical utility of molecular evidence?

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February 2015
7 Reads

Histological and molecular aspects of oral squamous cell carcinoma (Review).

Oncol Lett 2014 Jul 29;8(1):7-11. Epub 2014 Apr 29.

Unit of Oral Pathology, Department of Dentistry, Faculty of Health Sciences, University of Talca, Talca 3460000, Chile.

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http://dx.doi.org/10.3892/ol.2014.2103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063640PMC
July 2014
16 Reads
15 Citations
0.990 Impact Factor

Narrative review: environmental and genetic basis of orofacial clefts

J Oral Res. 2013 March; 2(1):35-41

J Oral Res

Complex genetic process guides the embryonic head development. Alterations in these processes result instructural abnormalities. An example of these are the cleft lip and palate. The major pathways involved in the fissures are families: the Fibroblast Growth Factor (FGF) family, the Hedgehog (HH) family, the Wingless (WNT) family and the Transforming Growth Factor beta (TGF-ß) family, which includes the Bone Morphogenetic Proteins (BMPs) and Activins. In this review, we discuss some of the celular/molecular processes and environmental factors involved in the development of the orofacial complex, ending with therapeutic possibilities and potential clinical relevance to the accumulated evidence.

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March 2014
5 Reads

Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone.

Exp Ther Med 2013 Dec 7;6(6):1543-1549. Epub 2013 Oct 7.

Unit of Histology and Embryology, Faculty of Health Sciences, University of Talca, Talca 3460000, Chile ; Biomedical Sciences Master Program, Oral Pathology, University of Talca, Talca 3460000, Chile.

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http://dx.doi.org/10.3892/etm.2013.1327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829710PMC
December 2013
4 Reads
3 Citations
0.941 Impact Factor

Workshop on Literature Searching and References Managing for Freshmen of Morphology Class

Authors:
César Rivera

Int J Morphol. 2013 December; 31(4):1505-1510

Int J Morphol

This paper presents the design and implementation of a workshop based on the integration of Internet-based technologies, for literature research and preparation of citations for freshmen in the career of dentistry (n = 30) enrolled from the morphology class. Most students achieved the proposed competencies; the presentation of a search strategy and a uniform format delivers in better references and best evaluated activities (averaging 4.5 points, up to 5). This research provides new evidence on practices that can be incorporated, give and deliver literacy information, according to training dental curriculum.

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December 2013
8 Reads

Prevalence of actinic cheilitis in Chilean workers exposed to ultraviolet radiation

Rev Clin Periodoncia Implantol Rehabil Oral. 2013 December; 6(3):217-129

Rev Clin Periodoncia Implantol Rehabil Oral

The objective of this research is to determine the prevalence of actinic cheilitis (AC) and associated factors in workers exposed to solar UV radiation in the city of Talca (Chile). A total of 151 workers, of which 16.6% exhibited AC, were examined. All lesions appeared on the lower lip. The 40% of cases aged between 50–59 years and 96% of patients diagnosed worked up to 6 hours daily exposed to the sun. 56% of the diagnoses of AC had a history of 20 or more years of exposure to UV radiation for work. 56% of cases of AC had a history of smoking. Major signs present in the AC cases were the dryness (100%), blurred demarcation between the lip vermilion border and the skin (88%) and labial edema (84%). Most lesions were asymptomatic (60%).

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December 2013
8 Reads

Exfoliative cytology of oral epithelial cells from patients with type 2 diabetes: cytomorphometric analysis.

Int J Clin Exp Med 2013 1;6(8):667-76. Epub 2013 Sep 1.

Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca Talca, Chile ; Biomedical Sciences Master Program, Oral Pathology mention, University of Talca Talca, Chile.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762622PMC
September 2013
4 Reads
1 Citation
1.422 Impact Factor

Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser.

Int J Clin Exp Med 2013 26;6(6):444-51. Epub 2013 Jun 26.

Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca Talca, Chile.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703115PMC
July 2013
3 Reads
4 Citations
1.422 Impact Factor

Stress increases periodontal inflammation.

Exp Ther Med 2012 Nov 20;4(5):883-888. Epub 2012 Aug 20.

Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of Health Sciences; ; Master Program in Biomedical Sciences, Oral Pathology mention, University of Talca, Talca;

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http://dx.doi.org/10.3892/etm.2012.675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493748PMC
November 2012
10 Reads
2 Citations
0.941 Impact Factor

Nucleolar organizer regions in a chronic stress and oral cancer model.

Oncol Lett 2012 Mar 6;3(3):541-544. Epub 2011 Dec 6.

Department of Stomatology, Faculty of Health Sciences, University of Talca.

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http://dx.doi.org/10.3892/ol.2011.514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362340PMC
March 2012
4 Reads
0.990 Impact Factor

Age estimation by aspartic acid racemization in human dentin

Med Leg Costa Rica. 2012 March; 29(1):35-41

Med Leg Costa Rica

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March 2012
7 Reads

4NQO Carcinogenesis: A Model of Oral Squamous Cell Carcinoma

Authors:
César Rivera

Int J Morphol. 2012 March; 30(1):309-314

Int J Morphol

The experimental oral carcinogenesis induced by the chemical 4-nitroquinoline 1-oxide (4NQO) is one of the most frequent in the study of squamous cell carcinoma of the oral cavity (CCEC). The clear advantage is that the model is very similar to the physiological process of malignancy. The model has clear benefits by and is suitable for applications in therapeutic research.

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March 2012
6 Reads

Chronic restraint stress in oral squamous cell carcinoma.

J Dent Res 2011 Jun 10;90(6):799-803. Epub 2011 Mar 10.

J. Dent. Res.

Pathogenic processes have been identified that could associate chronic stress and cancer, but these findings have not been observed in oral cancer. This study examined the role of chronic restraint stress on the incidence and severity of OSCC induced with 4-nitroquinoline-1-oxide (4-NQO) in the tongues of CF-1 mice. One hundred twenty CF-1 male mice were divided into 4 groups: (A) received two treatments - restraint stress and induction of chemical carcinogenesis (n = 50); (B) induction of chemical carcinogenesis, without restraint stress (n = 50); (C) restraint stress (n = 10); and (D) control (n = 10). After 30 weeks, tongues were dissected and analyzed by conventional histopathology. The severity of OSSC was analyzed according to the International Histological Classification of Tumors and Bryne's Multifactorial Grading System for the Invasive Tumor Front (ITF). Chronic stress induction was confirmed by plasma corticosterone levels. Results showed that chronic stress was induced with movement restriction (p ≤ 0.05, Mann-Whitney U-test). However, chronic stress did not increase the incidence (p > 0.05, Chi-square) or severity (p > 0.05, Mann-Whitney U-test) of the 4-NQO-induced OSSC in the tongues of CF-1 mice. These results suggest that there is no relationship between chronic stress (induced in mice by restraint) and the incidence and severity of OSSC.

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June 2011
11 Reads

Pre-school child oral health in a rural Chilean community

Authors:
César Rivera

Int J Odontostomatol. 2011 April; 5(1):83-86

Int J Odontostomatol

Caries and gingivitis are the most prevalent diseases in Chile. The aim of this study is to determine the damage of oral health in children ages 4 and 5 years, in Peralillo, Chile, prior to the start of oral health program promoted by JUNAEB (Junta Nacional de Auxilio Escolar y Becas) in the commune. The sample consisted of 130 children, admitted to the student dental clinic between November 2010 and February 2011. Oral exam seeks to know presence of dental caries and number of teeth affected, using dmft index (decayed, missing and filled primary teeth), simplified oral hygiene index (OHI-S) and presence or absence of gingivitis. 49.2 percent of children had caries, with an dmft index 2.4 (S.D. +/- 3.5). The OHI-S of the entire sample was 1.4 (S.D. +/- 0.4). Gingivitis was reported in 9.2 percent of cases. The results of this investigation shows that following dental intervention, the goals set by FDI (FDI World Dental Federation) and WHO (World Health Organization) were obtained. Efforts are required in promotion and education in oral health, as well an increase in resources to attend these patients to decrease impact of oral diseases in the future.

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April 2011
7 Reads

Lip biting following dental local anesthesia

Rev Méd Maule. 2012; 28(2):79-80

Rev Méd Maule

Niña de 6 años de edad, acude a la consulta odontológica24 horas después de una atención previa, mostrando una lesión en el labio inferior, blanco-amarillenta, con áreas de ulceración cubiertas por fibrina. La paciente relata prurito y sensación urente con hiperestesia en el área. No hay compromiso del estado general. Descartada una reacción alérgica y angioedema, el diagnóstico fue una úlcera traumática, como resultado de una mordida posterior a la anestesia del nervio alveolar inferior. El tratamiento consistió en ibuprofeno (suspensión oral, 200 mg / 5 ml, en dosis de 10mg / kg cada 8 horas por 5 días) y control clínico cada dos días. La resolución definitiva ocurrió 10 días después de la primera atención. Con el fin de prevenir lesiones de los tejidos blandos, el odontólogo debe indicara los padres y cuidadores la importancia del monitoreo del niño por varias horas, luego de la atención odontológica que implique procedimientos con anestesia local por bloqueo troncular (nervio alveolar inferior), recordando que es más seguro para el paciente comer luego de que el efecto del anestésico desaparece.

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47 Reads

Determination of Cellular Debris in Endodontically Treated Teeth: a Pilot Study

Int J Odontostomat. 2012; 6(3):291-295

Int J Odontostomat

Previous studies indicate that dental tissues are a source of mitochondrial DNA that could be useful for human identification. The main cell in the pulpo-dentin complex is the odontoblast, whose cellular body is located on the border between the pulp and dentin and continues through cell processes. In endodontically treated teeth, pulp tissue is removed, assuming the complete elimination of cellular content and the inner third of dentin. Facing the possibility of finding teeth that were treated endodontically as the only source available for a forensic analysis, is that the objective of this study is to determine the presence of cellular debris in the dentin of teeth with root canal treatment. Twenty teeth roots obtained from 8 single and multi-rooted teeth were treated endodontically, with conventional manual technique. The samples were processed by conventional histological analysis (H&E). In root canals endodontic cement remnants and cylinder-cubic structures resembled odontoblastic bodies were observed, but without certainty to establish its presence. This research concludes that it is not possible to determine presence of cellular debris in endodontically treated teeth using the described technique.

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6 Reads

Progressive Extracellular Matrix Disorganization in Chemically Induced Murine Oral Squamous Cell Carcinoma

ISRN pathology. 2012; 2012:Article ID 359421

ISRN pathology

Introduction. Oral squamous cell carcinoma (OSCC) is one of the ten most common cancers affecting the human population. Tumor pathogenesis implies a multistep process in which cells acquire features that enable them to become tumorigenic and ultimately malignant. The process of OSCC carcinogenesis can be reproduced in animal models, the OSCC induction with 4-nitroquinoline-1-oxide (4NQO) in mice is a widely used tool for studying tumor pathogenesis. Objective. The aim of the present study was to determine the progressive changes in basal lamina and connective tissue remodeling during 4NQO-induced OSCC carcinogenesis. Material and Methods. Samples were classified according to “International Histological Classification of tumors” in mild, moderate, and severe dysplasia and invasive carcinoma. Five samples of each pathologic entity and control healthy tongues were used. Immunohistochemical analysis of collagen IV as well as histochemical analysis of glycosylated molecules (PAS) and collagen I (Picro Sirius red) were performed. Results. During experimental-induced carcinogenesis by 4NQO a progressive basal lamina destruction and collagen I disorganization in adjacent connective tissue can be observed. Conclusion. Our results confirm previous studies that show alterations in extracellular matrix (ECM) in malignant lesions, validating the experimental carcinogenesis induced by 4NQO.

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5 Reads

Top co-authors

Francisco Monsalve
Francisco Monsalve

University of Talca

3
Bernardo Venegas
Bernardo Venegas

University of Talca

3
Ivan Suazo
Ivan Suazo

Director de Postgrado e investigación

2
Ricardo D Coletta
Ricardo D Coletta

State University of Campinas

2
Rebeca Kawahara
Rebeca Kawahara

Laboratório de Espectrometria de Massas

2
Juan Salas
Juan Salas

University of Granada

1
Andrea Moran
Andrea Moran

Stowers Institute for Medical Research

1