Publications by authors named "Celina G Kleer"

100Publications

Subcellular localization of EZH2 phosphorylated at T367 stratifies metaplastic breast carcinoma subtypes.

Breast Cancer 2020 Nov 27. Epub 2020 Nov 27.

Department of Pathology, University of Michigan Medical School, 4217 Rogel Cancer Center, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109, USA.

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November 2020

Cancer Cell Invasion of Mammary Organoids with Basal-In Phenotype.

Adv Healthc Mater 2020 Jun 25:e2000810. Epub 2020 Jun 25.

Wallace H. Coulter Department of Biomedical Engineering and The Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332, USA.

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June 2020

Metaplastic Breast Carcinoma: Update on Histopathology and Molecular Alterations.

Arch Pathol Lab Med 2019 12;143(12):1492-1496

From the Department of Pathology (Drs McMullen, Zoumberos, and Kleer) and Rogel Cancer Center (Dr Kleer), University of Michigan Medical School, Ann Arbor.

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December 2019

Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer.

Cell Rep 2019 06;27(13):3916-3926.e5

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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June 2019

A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer.

J Cell Commun Signal 2019 Mar 4;13(1):129-143. Epub 2018 Dec 4.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

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March 2019

Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations.

J Glob Oncol 2018 10;4:1-8

Evelyn Jiagge, Carlos Murga-Zamalloa, Celina G. Kleer, Mark Hoenerhoff, Kathy Toy, Sofia Merajver, Barbara Salem, and Max Wicha, University of Michigan, Ann Arbor; George Divine, Jessica Bensenhaver, Henry Ford Health System, Detroit, MI; Evelyn Jiagge, Baffour Awuah, Joseph Oppong, and Ernest Adjei, Komfo Anokye Teaching Hospital, Kumasi, Ghana; and Aisha Souleiman Jibril, St. Paul's Hospital, Millenium Medical Center, Addis Ababa, Ethiopia; Lisa Newman, Melissa Davis, and Kofi Gyan, Weill Cornell Medicine, New York, NY.

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October 2018

Atypical Ductal Lesions of the Breast: Criteria, Significance, and Laboratory Updates.

Arch Pathol Lab Med 2018 10;142(10):1182-1185

From the Department of Pathology, Michigan Medicine, University of Michigan Rogel Cancer Center, Ann Arbor.

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October 2018

CCN6 regulates IGF2BP2 and HMGA2 signaling in metaplastic carcinomas of the breast.

Breast Cancer Res Treat 2018 Dec 15;172(3):577-586. Epub 2018 Sep 15.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

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December 2018

Matricellular CCN6 (WISP3) protein: a tumor suppressor for mammary metaplastic carcinomas.

J Cell Commun Signal 2018 Mar 22;12(1):13-19. Epub 2018 Jan 22.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

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March 2018

Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth.

Cell Rep 2017 01;18(5):1215-1228

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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January 2017

Atypical Apocrine Adenosis: Diagnostic Challenges and Pitfalls.

Arch Pathol Lab Med 2016 Oct;140(10):1045-51

From the Departments of Pathology and Laboratory Medicine (Drs Asirvatham and Kleer) and the Comprehensive Cancer Center (Dr Kleer), University of Michigan Hospital and Health Systems, Ann Arbor; and Department of Pathology, CEMIC University Hospital, Buenos Aires, Argentina (Dr Falcone).

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October 2016

ESR1 and PGR polymorphisms are associated with estrogen and progesterone receptor expression in breast tumors.

Physiol Genomics 2016 09 19;48(9):688-98. Epub 2016 Aug 19.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.

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September 2016

Dual roles of CCN proteins in breast cancer progression.

Authors:
Celina G Kleer

J Cell Commun Signal 2016 Sep 12;10(3):217-222. Epub 2016 Aug 12.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.

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September 2016

Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.

Arch Pathol Lab Med 2016 Jul;140(7):665-71

From the Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento (Dr Zhang); and the Department of Pathology, University of Michigan, Ann Arbor (Dr Kleer).

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July 2016

Stromal cells in phyllodes tumors of the breast are enriched for EZH2 and stem cell marker expression.

Breast Cancer Res Treat 2016 07 11;158(1):21-28. Epub 2016 Jun 11.

Department of Pathology, University of Michigan, 4217 Comprehensive Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.

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July 2016

The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells.

Oncotarget 2016 May;7(18):25180-93

Department of Pathology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.

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May 2016

Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers.

Am J Transl Res 2015 15;7(6):1009-20. Epub 2015 Jun 15.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston, Texas 77030 ; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston Houston, Texas 77030 ; Center for Molecular Medicine, and Graduate Institute of Cancer Biology, China Medical University Taichung 404, Taiwan ; Department of Biotechnology, Asia University Taichung 413, Taiwan.

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August 2015

Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer.

Breast Cancer Res Treat 2015 Feb 10;150(1):9-18. Epub 2015 Feb 10.

Department of Pathology and Comprehensive Cancer Center, University of Michigan, 4217 Comprehensive Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.

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February 2015

Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors.

Mol Cancer Res 2015 Apr 15;13(4):613-9. Epub 2015 Jan 15.

Department of Pathology, Michigan Center for Translational Pathology, Ann Arbor, Michigan. Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan. Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.

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April 2015

A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies.

Proc Natl Acad Sci U S A 2014 Oct 29;111(41):14882-7. Epub 2014 Sep 29.

Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, and

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October 2014

Characterization of type III TGF-β receptor expression in invasive breast carcinomas: a potential new marker and target for triple negative breast cancer.

J Cell Commun Signal 2014 Sep 19;8(3):211-8. Epub 2014 Aug 19.

Department of Pathology, University of Michigan Medical School, 4217 Comprehensive Cancer Center, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.

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September 2014

Three dimensional cultures: a tool to study normal acinar architecture vs. malignant transformation of breast cells.

J Vis Exp 2014 Apr 25(86). Epub 2014 Apr 25.

Department of Pathology, University of Michigan Comprehensive Cancer Center;

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April 2014

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

Proc Natl Acad Sci U S A 2014 Feb 10;111(8):3098-103. Epub 2014 Feb 10.

Department of Pathology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109.

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February 2014

Tissue-based identification of stem cells and epithelial-to-mesenchymal transition in breast cancer.

Hum Pathol 2013 Aug 8;44(8):1457-64. Epub 2013 Apr 8.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.

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August 2013

EZH2 inhibition decreases p38 signaling and suppresses breast cancer motility and metastasis.

Breast Cancer Res Treat 2013 Apr 29;138(3):741-52. Epub 2013 Mar 29.

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

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April 2013

Invasive ductal carcinoma with lobular features: a comparison study to invasive ductal and invasive lobular carcinomas of the breast.

Breast Cancer Res Treat 2013 Apr 28;138(3):719-26. Epub 2013 Mar 28.

Department of Pathology, University of Michigan Health System, 1500 E. Medical Center Dr., 2G340, Ann Arbor, MI 48109, USA.

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April 2013

CCN6 knockdown disrupts acinar organization of breast cells in three-dimensional cultures through up-regulation of type III TGF-β receptor.

Neoplasia 2012 Nov;14(11):1067-74

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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November 2012

Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression.

Proc Natl Acad Sci U S A 2012 Oct 24;109(41):16654-9. Epub 2012 Sep 24.

Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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October 2012

RhoC impacts the metastatic potential and abundance of breast cancer stem cells.

PLoS One 2012 23;7(7):e40979. Epub 2012 Jul 23.

Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.

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April 2013

Metaplastic carcinomas of the breast: diagnostic challenges and new translational insights.

Arch Pathol Lab Med 2012 Aug;136(8):896-900

Department of Pathology and the Comprehensive Cancer Center, University of Michigan Hospital and Health Systems, Ann Arbor, MI 48109, USA.

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August 2012

CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer.

Cancer Res 2012 Sep 17;72(18):4818-28. Epub 2012 Jul 17.

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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September 2012

Invasive breast carcinomas in Ghana: high frequency of high grade, basal-like histology and high EZH2 expression.

Breast Cancer Res Treat 2012 Aug 13;135(1):59-66. Epub 2012 Apr 13.

Department of Pathology, University of Michigan Medical School, 4217 Comprehensive Cancer Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, USA.

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August 2012

Discoidin domain receptor tyrosine kinases: new players in cancer progression.

Cancer Metastasis Rev 2012 Jun;31(1-2):295-321

Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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June 2012

Metaplastic breast carcinomas are enriched in markers of tumor-initiating cells and epithelial to mesenchymal transition.

Mod Pathol 2012 Feb 11;25(2):178-84. Epub 2011 Nov 11.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

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February 2012

On how CCN6 suppresses breast cancer growth and invasion.

J Cell Commun Signal 2012 Mar 13;6(1):5-10. Epub 2011 Aug 13.

Department of Pathology and 4217 Comprehensive Cancer Center, University of Michigan Medical School, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.

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March 2012

Increased risk for distant metastasis in patients with familial early-stage breast cancer and high EZH2 expression.

Breast Cancer Res Treat 2012 Apr 26;132(2):429-37. Epub 2011 May 26.

Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.

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April 2012

CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer.

J Cell Sci 2011 May 26;124(Pt 10):1752-8. Epub 2011 Apr 26.

CIBICI-CONICET, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina.

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May 2011

Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.

Cancer Res 2011 Mar;71(6):2360-70

Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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March 2011

EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development.

Mod Pathol 2011 Jun 11;24(6):786-93. Epub 2011 Mar 11.

Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

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June 2011

Membrane localization of insulin receptor substrate-2 (IRS-2) is associated with decreased overall survival in breast cancer.

Breast Cancer Res Treat 2011 Dec 22;130(3):759-72. Epub 2011 Jan 22.

Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation St., Worcester, MA 01605, USA.

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December 2011

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma.

Hum Pathol 2010 Sep 22;41(9):1205-9. Epub 2010 Jun 22.

Department of Pathology, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA.

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September 2010

Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells.

Cancer Res 2010 Apr;70(8):3340-50

Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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April 2010

Antiangiogenic tetrathiomolybdate protects against Her2/neu-induced breast carcinoma by hypoplastic remodeling of the mammary gland.

Clin Cancer Res 2009 Dec 24;15(23):7441-6. Epub 2009 Nov 24.

Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA. Quintin.Pan

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December 2009

Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions.

Authors:
Celina G Kleer

Arch Pathol Lab Med 2009 Nov;133(11):1822-5

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

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November 2009

The emerging role of CCN6 in breast cancer invasion.

Cellscience 2009 Oct;6(2):146-157

Dept. of Pathology & Comprehensive Cancer Center, University of Michigan Medical School, USA.

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October 2009

Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia.

Am J Pathol 2009 Sep 6;175(3):1246-54. Epub 2009 Aug 6.

Department of Pathology, University of Michigan Medical School, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.

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September 2009

AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist.

Proc Natl Acad Sci U S A 2009 Jun 1;106(25):10284-9. Epub 2009 Jun 1.

Michigan Center for Translational Pathology, Howard Hughes Medical Institute, and Departments of Urology, and Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-5602.

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June 2009

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers.

Am J Pathol 2009 Jun 1;174(6):2023-34. Epub 2009 May 1.

Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA.

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June 2009

Residual disease after re-excision lumpectomy for close margins.

J Surg Oncol 2009 Feb;99(2):99-103

Division of Surgical Oncology, Department of Surgery, Biostatistics Core of the University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.

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February 2009

Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesions.

Pathol Int 2008 Oct;58(10):620-5

Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.

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October 2008

Axillary staging prior to neoadjuvant chemotherapy for breast cancer: predictors of recurrence.

Ann Surg Oncol 2008 Nov 11;15(11):3252-8. Epub 2008 Sep 11.

Department of Surgical Oncology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.

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November 2008

Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast.

Clin Cancer Res 2008 Jul;14(13):4038-44

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical Center, Ann Arbor, Michigan, USA.

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July 2008

Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.

Am J Pathol 2008 Apr 5;172(4):893-904. Epub 2008 Mar 5.

Department of Pathology, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0605, USA.

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April 2008

BRCA1 regulates human mammary stem/progenitor cell fate.

Proc Natl Acad Sci U S A 2008 Feb 29;105(5):1680-5. Epub 2008 Jan 29.

Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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February 2008

Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients.

Breast Cancer Res Treat 2008 Nov 4;112(1):141-7. Epub 2007 Dec 4.

Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, USA.

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November 2008

Expression of polycomb group protein EZH2 in nevi and melanoma.

J Cutan Pathol 2007 Aug;34(8):597-600

Department of Pathology, University of Michigan, 1301 Catherine Road, Ann Arbor, MI 48109, USA.

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August 2007

Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression.

Cancer Res 2007 Jul 27;67(13):6064-74. Epub 2007 Jun 27.

Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0638, USA.

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July 2007

CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancer.

Cells Tissues Organs 2007 ;185(1-3):95-9

Department of Pathology, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, Mich. 48109, USA.

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July 2007

Significance of flat epithelial atypia on mammotome core needle biopsy: Should it be excised?

Hum Pathol 2007 Jan 13;38(1):35-41. Epub 2006 Nov 13.

Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48331, USA.

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January 2007

Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast.

Cancer Res 2006 Oct;66(19):9352-5

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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October 2006

The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer.

J Mol Histol 2006 Sep 20;37(5-7):219-23. Epub 2006 Jul 20.

Department of Pathology and Comprehensive Cancer Center, University of Michigan, 3510C MSRB1, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.

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September 2006

ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease.

Neoplasia 2006 Apr;8(4):319-29

Department of Urology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-0944, USA.

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April 2006

Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells.

Breast Cancer Res 2005 8;7(6):R1080-9. Epub 2005 Nov 8.

Department of Pathology, University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.

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February 2006

Is lobular carcinoma in situ as a component of breast carcinoma a risk factor for local failure after breast-conserving therapy? Results of a matched pair analysis.

Cancer 2006 Jan;106(1):28-34

Department of Radiation Oncology, Cancer and Geriatrics Center, University of Michigan Medical School, Ann Arbor, Michigan 48109-0010, USA.

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January 2006

RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast.

Breast Cancer Res Treat 2005 Sep;93(2):101-10

Department of Pathology and Internal Medicine, University of Michigan, Ann Arbour, MI 48109-0054, USA.

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September 2005

Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy.

Cancer Res 2005 Sep;65(18):8366-71

Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA.

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September 2005