Celia M T Greenwood

Celia M T Greenwood

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Celia M T Greenwood

Publications by authors named "Celia M T Greenwood"

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Constrained instruments and their application to Mendelian randomization with pleiotropy.

Genet Epidemiol 2019 06 12;43(4):373-401. Epub 2019 Jan 12.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/gepi.22184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537099PMC
June 2019

General psychopathology, internalising and externalising in children and functional outcomes in late adolescence.

J Child Psychol Psychiatry 2019 May 2. Epub 2019 May 2.

Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/jcpp.13067DOI Listing
May 2019

A hidden markov model for identifying differentially methylated sites in bisulfite sequencing data.

Biometrics 2019 03 9;75(1):210-221. Epub 2018 Oct 9.

Department of Decision Sciences, HEC Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1111/biom.12965
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http://dx.doi.org/10.1111/biom.12965DOI Listing
March 2019

CpG-set association assessment of lipid concentration changes and DNA methylation.

BMC Proc 2018 17;12(Suppl 9):30. Epub 2018 Sep 17.

3Department of Mathematics, Université du Québec à Montréal, 201, Ave. President Kennedy, Montreal, Montreal, H2X 3Y7 Canada.

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https://bmcproc.biomedcentral.com/articles/10.1186/s12919-01
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http://dx.doi.org/10.1186/s12919-018-0127-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157033PMC
September 2018

Investigating potential causal relationships between SNPs, DNA methylation and HDL.

BMC Proc 2018 17;12(Suppl 9):20. Epub 2018 Sep 17.

1Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Quebec, Montreal H3A 1A2 Canada.

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http://dx.doi.org/10.1186/s12919-018-0117-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157157PMC
September 2018

Model-Free Linkage Analysis of a Binary Trait.

Methods Mol Biol 2017 ;1666:343-373

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60 Murray St., Box 18, Toronto, ON, Canada, M5T 3L9.

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http://dx.doi.org/10.1007/978-1-4939-7274-6_17DOI Listing
May 2018

An analytic approach for interpretable predictive models in high-dimensional data in the presence of interactions with exposures.

Genet Epidemiol 2018 04 8;42(3):233-249. Epub 2018 Feb 8.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, QC, Canada.

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http://dx.doi.org/10.1002/gepi.22112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175336PMC
April 2018

Distinct homologous recombination gene expression profiles after neoadjuvant chemotherapy associated with clinical outcome in patients with ovarian cancer.

Gynecol Oncol 2018 03 1;148(3):553-558. Epub 2018 Feb 1.

Division of Gynecologic Oncology, Segal Cancer Center, Lady Davis Institute of Research, Jewish General Hospital, McGill University, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.01.017DOI Listing
March 2018

Genetic architecture: the shape of the genetic contribution to human traits and disease.

Nat Rev Genet 2018 02 11;19(2):110-124. Epub 2017 Dec 11.

Departments of Human Genetics and Epidemiology, Biostatistics and Occupational Health, McGill University, 3755 Cote Ste Catherine, Montréal, Québec H3T 1E2, Canada.

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http://dx.doi.org/10.1038/nrg.2017.101DOI Listing
February 2018

Heritable contributions versus genetic architecture.

Nat Rev Genet 2018 02;19(3):185

Departments of Human Genetics and Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/nrg.2018.7DOI Listing
February 2018

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.

Am J Hum Genet 2017 Aug 27;101(2):227-238. Epub 2017 Jul 27.

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada; Department of Twin Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK; Department of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544392PMC
August 2017

Gene networks show associations with seed region connectivity.

Hum Brain Mapp 2017 06 21;38(6):3126-3140. Epub 2017 Mar 21.

Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/hbm.23579DOI Listing
June 2017

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

Authors:
Ioanna Tachmazidou Dániel Süveges Josine L Min Graham R S Ritchie Julia Steinberg Klaudia Walter Valentina Iotchkova Jeremy Schwartzentruber Jie Huang Yasin Memari Shane McCarthy Andrew A Crawford Cristina Bombieri Massimiliano Cocca Aliki-Eleni Farmaki Tom R Gaunt Pekka Jousilahti Marjolein N Kooijman Benjamin Lehne Giovanni Malerba Satu Männistö Angela Matchan Carolina Medina-Gomez Sarah J Metrustry Abhishek Nag Ioanna Ntalla Lavinia Paternoster Nigel W Rayner Cinzia Sala William R Scott Hashem A Shihab Lorraine Southam Beate St Pourcain Michela Traglia Katerina Trajanoska Gialuigi Zaza Weihua Zhang María S Artigas Narinder Bansal Marianne Benn Zhongsheng Chen Petr Danecek Wei-Yu Lin Adam Locke Jian'an Luan Alisa K Manning Antonella Mulas Carlo Sidore Anne Tybjaerg-Hansen Anette Varbo Magdalena Zoledziewska Chris Finan Konstantinos Hatzikotoulas Audrey E Hendricks John P Kemp Alireza Moayyeri Kalliope Panoutsopoulou Michal Szpak Scott G Wilson Michael Boehnke Francesco Cucca Emanuele Di Angelantonio Claudia Langenberg Cecilia Lindgren Mark I McCarthy Andrew P Morris Børge G Nordestgaard Robert A Scott Martin D Tobin Nicholas J Wareham Paul Burton John C Chambers George Davey Smith George Dedoussis Janine F Felix Oscar H Franco Giovanni Gambaro Paolo Gasparini Christopher J Hammond Albert Hofman Vincent W V Jaddoe Marcus Kleber Jaspal S Kooner Markus Perola Caroline Relton Susan M Ring Fernando Rivadeneira Veikko Salomaa Timothy D Spector Oliver Stegle Daniela Toniolo André G Uitterlinden Inês Barroso Celia M T Greenwood John R B Perry Brian R Walker Adam S Butterworth Yali Xue Richard Durbin Kerrin S Small Nicole Soranzo Nicholas J Timpson Eleftheria Zeggini

Am J Hum Genet 2017 Jun 25;100(6):865-884. Epub 2017 May 25.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473732PMC
June 2017

A Set-Based Mixed Effect Model for Gene-Environment Interaction and Its Application to Neuroimaging Phenotypes.

Front Neurosci 2017 6;11:191. Epub 2017 Apr 6.

Department of Biomedical Engineering, National University of SingaporeSingapore, Singapore.

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http://dx.doi.org/10.3389/fnins.2017.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382297PMC
April 2017

Response to: Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies.

Genome Biol 2017 01 30;18(1):25. Epub 2017 Jan 30.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.

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http://dx.doi.org/10.1186/s13059-017-1149-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282700PMC
January 2017

Assessing transmission ratio distortion in extended families: a comparison of analysis methods.

BMC Proc 2016 18;10(Suppl 7):197-202. Epub 2016 Oct 18.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, QC H3A 1A2 Canada ; Department of Psychiatry, McGill University, Montreal, QC Canada.

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http://dx.doi.org/10.1186/s12919-016-0030-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133486PMC
October 2016

Joint analysis of multiple blood pressure phenotypes in GAW19 data by using a multivariate rare-variant association test.

BMC Proc 2016 18;10(Suppl 7):309-313. Epub 2016 Oct 18.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC H3A 1A2 Canada ; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2 Canada ; Department of Oncology, McGill University, Montreal, QC H2W 1S6 Canada ; Department of Human Genetics, McGill University, Montreal, QC H3A 1B1 Canada.

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http://dx.doi.org/10.1186/s12919-016-0048-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133485PMC
October 2016

Gene Coexpression Analyses Differentiate Networks Associated with Diverse Cancers Harboring TP53 Missense or Null Mutations.

Front Genet 2016 3;7:137. Epub 2016 Aug 3.

Lady Davis Research Institute, Jewish General HospitalMontreal, QC, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill UniversityMontreal, QC, Canada; Departments of Oncology and Human Genetics, McGill UniversityMontreal, QC, Canada.

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http://dx.doi.org/10.3389/fgene.2016.00137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971393PMC
August 2016

An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies.

Genome Biol 2016 May 3;17:84. Epub 2016 May 3.

Lady Davis Research Institute, Jewish General Hospital, 3755 Chemin de la Côte Sainte Catherine, Montréal, H3T 1E2, QC, Canada.

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http://dx.doi.org/10.1186/s13059-016-0935-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855979PMC
May 2016

A rare variant association test in family-based designs and non-normal quantitative traits.

Stat Med 2016 Mar 29;35(6):905-21. Epub 2015 Sep 29.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada.

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http://doi.wiley.com/10.1002/sim.6750
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http://dx.doi.org/10.1002/sim.6750DOI Listing
March 2016

funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types.

Bioinformatics 2016 Feb 24;32(4):593-5. Epub 2015 Oct 24.

Lady Davis Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada, Department of Biochemistry, Université de Sherbrooke, QC J1K 2R1, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC H3A 1A2, Canada, Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada and.

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http://dx.doi.org/10.1093/bioinformatics/btv615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743629PMC
February 2016

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Authors:
Hou-Feng Zheng Vincenzo Forgetta Yi-Hsiang Hsu Karol Estrada Alberto Rosello-Diez Paul J Leo Chitra L Dahia Kyung Hyun Park-Min Jonathan H Tobias Charles Kooperberg Aaron Kleinman Unnur Styrkarsdottir Ching-Ti Liu Charlotta Uggla Daniel S Evans Carrie M Nielson Klaudia Walter Ulrika Pettersson-Kymmer Shane McCarthy Joel Eriksson Tony Kwan Mila Jhamai Katerina Trajanoska Yasin Memari Josine Min Jie Huang Petr Danecek Beth Wilmot Rui Li Wen-Chi Chou Lauren E Mokry Alireza Moayyeri Melina Claussnitzer Chia-Ho Cheng Warren Cheung Carolina Medina-Gómez Bing Ge Shu-Huang Chen Kwangbom Choi Ling Oei James Fraser Robert Kraaij Matthew A Hibbs Celia L Gregson Denis Paquette Albert Hofman Carl Wibom Gregory J Tranah Mhairi Marshall Brooke B Gardiner Katie Cremin Paul Auer Li Hsu Sue Ring Joyce Y Tung Gudmar Thorleifsson Anke W Enneman Natasja M van Schoor Lisette C P G M de Groot Nathalie van der Velde Beatrice Melin John P Kemp Claus Christiansen Adrian Sayers Yanhua Zhou Sophie Calderari Jeroen van Rooij Chris Carlson Ulrike Peters Soizik Berlivet Josée Dostie Andre G Uitterlinden Stephen R Williams Charles Farber Daniel Grinberg Andrea Z LaCroix Jeff Haessler Daniel I Chasman Franco Giulianini Lynda M Rose Paul M Ridker John A Eisman Tuan V Nguyen Jacqueline R Center Xavier Nogues Natalia Garcia-Giralt Lenore L Launer Vilmunder Gudnason Dan Mellström Liesbeth Vandenput Najaf Amin Cornelia M van Duijn Magnus K Karlsson Östen Ljunggren Olle Svensson Göran Hallmans François Rousseau Sylvie Giroux Johanne Bussière Pascal P Arp Fjorda Koromani Richard L Prince Joshua R Lewis Bente L Langdahl A Pernille Hermann Jens-Erik B Jensen Stephen Kaptoge Kay-Tee Khaw Jonathan Reeve Melissa M Formosa Angela Xuereb-Anastasi Kristina Åkesson Fiona E McGuigan Gaurav Garg Jose M Olmos Maria T Zarrabeitia Jose A Riancho Stuart H Ralston Nerea Alonso Xi Jiang David Goltzman Tomi Pastinen Elin Grundberg Dominique Gauguier Eric S Orwoll David Karasik George Davey-Smith Albert V Smith Kristin Siggeirsdottir Tamara B Harris M Carola Zillikens Joyce B J van Meurs Unnur Thorsteinsdottir Matthew T Maurano Nicholas J Timpson Nicole Soranzo Richard Durbin Scott G Wilson Evangelia E Ntzani Matthew A Brown Kari Stefansson David A Hinds Tim Spector L Adrienne Cupples Claes Ohlsson Celia M T Greenwood Rebecca D Jackson David W Rowe Cynthia A Loomis David M Evans Cheryl L Ackert-Bicknell Alexandra L Joyner Emma L Duncan Douglas P Kiel Fernando Rivadeneira J Brent Richards

Nature 2015 Oct 14;526(7571):112-7. Epub 2015 Sep 14.

Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.

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http://dx.doi.org/10.1038/nature14878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755714PMC
October 2015

Using gene genealogies to detect rare variants associated with complex traits.

Hum Hered 2014 15;78(3-4):117-30. Epub 2014 Aug 15.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Que., Canada.

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http://dx.doi.org/10.1159/000363443DOI Listing
September 2015

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study.

PLoS Med 2015 Aug 25;12(8):e1001866. Epub 2015 Aug 25.

Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549308PMC
August 2015

A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.

Nat Commun 2015 May 28;6:7060. Epub 2015 May 28.

1] Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec H3A 0G4, Canada [2] Department of Medicine, McGill University, Montreal, Quebec H3A 0G4, Canada [3] Department of Human Genetics, McGill University, Montréal, Québec H3A 0G4, Canada [4] Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.

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http://dx.doi.org/10.1038/ncomms8060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458864PMC
May 2015

Chromosome-breakage genomic instability and chromothripsis in breast cancer.

BMC Genomics 2014 Jul 9;15:579. Epub 2014 Jul 9.

Department of Oncology, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste-Catherine Road, Montreal, Quebec H3T-1E2, Canada.

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http://dx.doi.org/10.1186/1471-2164-15-579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227294PMC
July 2014

Estimating genome-wide significance for whole-genome sequencing studies.

Genet Epidemiol 2014 May 14;38(4):281-90. Epub 2014 Feb 14.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.

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http://dx.doi.org/10.1002/gepi.21797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489336PMC
May 2014

Exploring the potential benefits of stratified false discovery rates for region-based testing of association with rare genetic variation.

Front Genet 2014 29;5:11. Epub 2014 Jan 29.

Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, QC, Canada ; Department of Epidemiology, Biostatistics and Occupational Health, McGill University Montreal, QC, Canada ; Departments of Oncology and Human Genetics, McGill University Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fgene.2014.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905218PMC
February 2014

Somatic point mutations occurring early in development: a monozygotic twin study.

J Med Genet 2014 Jan 11;51(1):28-34. Epub 2013 Oct 11.

Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1136/jmedgenet-2013-101712DOI Listing
January 2014

Gene genealogies for genetic association mapping, with application to Crohn's disease.

Front Genet 2013 2;4:260. Epub 2013 Dec 2.

Department of Statistics and Actuarial Science, Simon Fraser University Burnaby, BC, Canada.

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http://dx.doi.org/10.3389/fgene.2013.00260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845011PMC
December 2013

Empirical power of very rare variants for common traits and disease: results from sanger sequencing 1998 individuals.

Eur J Hum Genet 2013 Sep 16;21(9):1027-30. Epub 2013 Jan 16.

Research Center of Montreal Heart Institute, Montreal, Quebec, Canada.

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http://www.nature.com/articles/ejhg2012284
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http://dx.doi.org/10.1038/ejhg.2012.284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746260PMC
September 2013

Biopsies: next-generation biospecimens for tailoring therapy.

Nat Rev Clin Oncol 2013 Aug 25;10(8):437-50. Epub 2013 Jun 25.

Department of Surgery, Jewish General Hospital, McGill University, 3755 Côte Sainte Catherine Road, Montreal, QC H3T 1E2, Canada.

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http://dx.doi.org/10.1038/nrclinonc.2013.101DOI Listing
August 2013

Adjusted sequence kernel association test for rare variants controlling for cryptic and family relatedness.

Genet Epidemiol 2013 May 25;37(4):366-76. Epub 2013 Mar 25.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.

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http://dx.doi.org/10.1002/gepi.21725DOI Listing
May 2013

Analysis of genomic abnormalities in tumors: a review of available methods for Illumina two-color SNP genotyping and evaluation of performance.

Cancer Genet 2013 Apr 25;206(4):103-15. Epub 2013 Apr 25.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.cancergen.2013.03.001DOI Listing
April 2013

Effect of genome-wide genotyping and reference panels on rare variants imputation.

J Genet Genomics 2012 Oct 24;39(10):545-50. Epub 2012 Jul 24.

Department of Medicine, Human Genetics, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1016/j.jgg.2012.07.002DOI Listing
October 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Authors:
Zari Dastani Marie-France Hivert Nicholas Timpson John R B Perry Xin Yuan Robert A Scott Peter Henneman Iris M Heid Jorge R Kizer Leo-Pekka Lyytikäinen Christian Fuchsberger Toshiko Tanaka Andrew P Morris Kerrin Small Aaron Isaacs Marian Beekman Stefan Coassin Kurt Lohman Lu Qi Stavroula Kanoni James S Pankow Hae-Won Uh Ying Wu Aurelian Bidulescu Laura J Rasmussen-Torvik Celia M T Greenwood Martin Ladouceur Jonna Grimsby Alisa K Manning Ching-Ti Liu Jaspal Kooner Vincent E Mooser Peter Vollenweider Karen A Kapur John Chambers Nicholas J Wareham Claudia Langenberg Rune Frants Ko Willems-Vandijk Ben A Oostra Sara M Willems Claudia Lamina Thomas W Winkler Bruce M Psaty Russell P Tracy Jennifer Brody Ida Chen Jorma Viikari Mika Kähönen Peter P Pramstaller David M Evans Beate St Pourcain Naveed Sattar Andrew R Wood Stefania Bandinelli Olga D Carlson Josephine M Egan Stefan Böhringer Diana van Heemst Lyudmyla Kedenko Kati Kristiansson Marja-Liisa Nuotio Britt-Marie Loo Tamara Harris Melissa Garcia Alka Kanaya Margot Haun Norman Klopp H-Erich Wichmann Panos Deloukas Efi Katsareli David J Couper Bruce B Duncan Margreet Kloppenburg Linda S Adair Judith B Borja James G Wilson Solomon Musani Xiuqing Guo Toby Johnson Robert Semple Tanya M Teslovich Matthew A Allison Susan Redline Sarah G Buxbaum Karen L Mohlke Ingrid Meulenbelt Christie M Ballantyne George V Dedoussis Frank B Hu Yongmei Liu Bernhard Paulweber Timothy D Spector P Eline Slagboom Luigi Ferrucci Antti Jula Markus Perola Olli Raitakari Jose C Florez Veikko Salomaa Johan G Eriksson Timothy M Frayling Andrew A Hicks Terho Lehtimäki George Davey Smith David S Siscovick Florian Kronenberg Cornelia van Duijn Ruth J F Loos Dawn M Waterworth James B Meigs Josee Dupuis J Brent Richards Benjamin F Voight Laura J Scott Valgerdur Steinthorsdottir Christian Dina Ryan P Welch Eleftheria Zeggini Cornelia Huth Yurii S Aulchenko Gudmar Thorleifsson Laura J McCulloch Teresa Ferreira Harald Grallert Najaf Amin Guanming Wu Cristen J Willer Soumya Raychaudhuri Steve A McCarroll Oliver M Hofmann Ayellet V Segrè Mandy van Hoek Pau Navarro Kristin Ardlie Beverley Balkau Rafn Benediktsson Amanda J Bennett Roza Blagieva Eric Boerwinkle Lori L Bonnycastle Kristina Bengtsson Boström Bert Bravenboer Suzannah Bumpstead Noël P Burtt Guillaume Charpentier Peter S Chines Marilyn Cornelis Gabe Crawford Alex S F Doney Katherine S Elliott Amanda L Elliott Michael R Erdos Caroline S Fox Christopher S Franklin Martha Ganser Christian Gieger Niels Grarup Todd Green Simon Griffin Christopher J Groves Candace Guiducci Samy Hadjadj Neelam Hassanali Christian Herder Bo Isomaa Anne U Jackson Paul R V Johnson Torben Jørgensen Wen H L Kao Augustine Kong Peter Kraft Johanna Kuusisto Torsten Lauritzen Man Li Aloysius Lieverse Cecilia M Lindgren Valeriya Lyssenko Michel Marre Thomas Meitinger Kristian Midthjell Mario A Morken Narisu Narisu Peter Nilsson Katharine R Owen Felicity Payne Ann-Kristin Petersen Carl Platou Christine Proença Inga Prokopenko Wolfgang Rathmann N William Rayner Neil R Robertson Ghislain Rocheleau Michael Roden Michael J Sampson Richa Saxena Beverley M Shields Peter Shrader Gunnar Sigurdsson Thomas Sparsø Klaus Strassburger Heather M Stringham Qi Sun Amy J Swift Barbara Thorand Jean Tichet Tiinamaija Tuomi Rob M van Dam Timon W van Haeften Thijs van Herpt Jana V van Vliet-Ostaptchouk G Bragi Walters Michael N Weedon Cisca Wijmenga Jacqueline Witteman Richard N Bergman Stephane Cauchi Francis S Collins Anna L Gloyn Ulf Gyllensten Torben Hansen Winston A Hide Graham A Hitman Albert Hofman David J Hunter Kristian Hveem Markku Laakso Andrew D Morris Colin N A Palmer Igor Rudan Eric Sijbrands Lincoln D Stein Jaakko Tuomilehto Andre Uitterlinden Mark Walker Richard M Watanabe Goncalo R Abecasis Bernhard O Boehm Harry Campbell Mark J Daly Andrew T Hattersley Oluf Pedersen Inês Barroso Leif Groop Rob Sladek Unnur Thorsteinsdottir James F Wilson Thomas Illig Philippe Froguel Cornelia M van Duijn Kari Stefansson David Altshuler Michael Boehnke Mark I McCarthy Nicole Soranzo Eleanor Wheeler Nicole L Glazer Nabila Bouatia-Naji Reedik Mägi Joshua Randall Paul Elliott Denis Rybin Abbas Dehghan Jouke Jan Hottenga Kijoung Song Anuj Goel Taina Lajunen Alex Doney Christine Cavalcanti-Proença Meena Kumari Nicholas J Timpson Carina Zabena Erik Ingelsson Ping An Jeffrey O'Connell Jian'an Luan Amanda Elliott Steven A McCarroll Rosa Maria Roccasecca François Pattou Praveen Sethupathy Yavuz Ariyurek Philip Barter John P Beilby Yoav Ben-Shlomo Sven Bergmann Murielle Bochud Amélie Bonnefond Knut Borch-Johnsen Yvonne Böttcher Eric Brunner Suzannah J Bumpstead Yii-Der Ida Chen Peter Chines Robert Clarke Lachlan J M Coin Matthew N Cooper Laura Crisponi Ian N M Day Eco J C de Geus Jerome Delplanque Annette C Fedson Antje Fischer-Rosinsky Nita G Forouhi Maria Grazia Franzosi Pilar Galan Mark O Goodarzi Jürgen Graessler Scott Grundy Rhian Gwilliam Göran Hallmans Naomi Hammond Xijing Han Anna-Liisa 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Andrew Singleton Nicholas L Smith Ulla Sovio Amy Swift Holly Syddall Ann-Christine Syvänen Anke Tönjes André G Uitterlinden Ko Willems van Dijk Dhiraj Varma Sophie Visvikis-Siest Veronique Vitart Nicole Vogelzangs Gérard Waeber Peter J Wagner Andrew Walley Kim L Ward Hugh Watkins Sarah H Wild Gonneke Willemsen Jaqueline C M Witteman John W G Yarnell Diana Zelenika Björn Zethelius Guangju Zhai Jing Hua Zhao M Carola Zillikens Ingrid B Borecki Pierre Meneton Patrik K E Magnusson David M Nathan Gordon H Williams Kaisa Silander Stefan R Bornstein Peter Schwarz Joachim Spranger Fredrik Karpe Alan R Shuldiner Cyrus Cooper Manuel Serrano-Ríos Lars Lind Lyle J Palmer Frank B Hu Paul W Franks Shah Ebrahim Michael Marmot W H Linda Kao Peter Paul Pramstaller Alan F Wright Michael Stumvoll Anders Hamsten Thomas A Buchanan Timo T Valle Jerome I Rotter Brenda W J H Penninx Dorret I Boomsma Antonio Cao Angelo Scuteri David Schlessinger Manuela Uda Aimo Ruokonen Marjo-Riitta Jarvelin Leena Peltonen Vincent Mooser Robert Sladek Kiran Musunuru Albert V Smith Andrew C Edmondson Ioannis M Stylianou Masahiro Koseki James P Pirruccello Daniel I Chasman Christopher T Johansen Sigrid W Fouchier Gina M Peloso Maja Barbalic Sally L Ricketts Joshua C Bis Mary F Feitosa Marju Orho-Melander Olle Melander Xiaohui Li Mingyao Li Yoon Shin Cho Min Jin Go Young Jin Kim Jong-Young Lee Taesung Park Kyunga Kim Xueling Sim Rick Twee-Hee Ong Damien C Croteau-Chonka Leslie A Lange Joshua D Smith Andreas Ziegler Weihua Zhang Robert Y L Zee John B Whitfield John R Thompson Ida Surakka Tim D Spector Johannes H Smit Juha Sinisalo James Scott Juha Saharinen Chiara Sabatti Lynda M Rose Robert Roberts Mark Rieder Alex N Parker Guillaume Pare Christopher J O'Donnell Markku S Nieminen Deborah A Nickerson Grant W Montgomery Wendy McArdle David Masson Nicholas G Martin Fabio Marroni Gavin Lucas Robert Luben Marja-Liisa Lokki Guillaume Lettre Lenore J Launer Edward G Lakatta Reijo Laaksonen Kirsten O Kyvik Inke R König Kay-Tee Khaw Lee M Kaplan Åsa Johansson A Cecile J W Janssens Wilmar Igl G Kees Hovingh Christian Hengstenberg Aki S Havulinna Nicholas D Hastie Tamara B Harris Talin Haritunians Alistair S Hall Leif C Groop Elena Gonzalez Nelson B Freimer Jeanette Erdmann Kenechi G Ejebe Angela Döring Anna F Dominiczak Serkalem Demissie Panagiotis Deloukas Ulf de Faire Gabriel Crawford Yii-der I Chen Mark J Caulfield S Matthijs Boekholdt Themistocles L Assimes Thomas Quertermous Mark Seielstad Tien Y Wong E-Shyong Tai Alan B Feranil Christopher W Kuzawa Herman A Taylor Stacey B Gabriel Hilma Holm Vilmundur Gudnason Ronald M Krauss Jose M Ordovas Patricia B Munroe Jaspal S Kooner Alan R Tall Robert A Hegele John J P Kastelein Eric E Schadt David P Strachan Muredach P Reilly Nilesh J Samani Heribert Schunkert L Adrienne Cupples Manjinder S Sandhu Paul M Ridker Daniel J Rader Sekar Kathiresan

PLoS Genet 2012 29;8(3):e1002607. Epub 2012 Mar 29.

Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada.

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September 2012

Model-free linkage analysis of a binary trait.

Methods Mol Biol 2012 ;850:317-45

Department of Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada.

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May 2012

Breast and ovarian cancer: the forgotten paternal contribution.

J Genet Couns 2011 Oct 19;20(5):442-9. Epub 2011 Apr 19.

Division of Gynecologic Oncology, Princess Margaret Hospital - University Health Network, Toronto, Canada.

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October 2011

High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis.

Ann Rheum Dis 2011 Apr 17;70(4):690-4. Epub 2011 Jan 17.

Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada.

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http://dx.doi.org/10.1136/ard.2010.133561DOI Listing
April 2011

How old is this mutation? - a study of three Ashkenazi Jewish founder mutations.

BMC Genet 2010 May 14;11:39. Epub 2010 May 14.

Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/1471-2156-11-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889843PMC
May 2010

Evidence of linkage to chromosome 1 for early age of onset of rheumatoid arthritis and HLA marker DRB1 genotype in NARAC data.

BMC Proc 2007 18;1 Suppl 1:S78. Epub 2007 Dec 18.

Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, 610 University Avenue, Room 15-507, Toronto, Ontario, Canada M5G 2M9.

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http://dx.doi.org/10.1186/1753-6561-1-s1-s78DOI Listing
December 2009

Using the ratio of means as the effect size measure in combining results of microarray experiments.

BMC Syst Biol 2009 Nov 5;3:106. Epub 2009 Nov 5.

The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784452PMC
November 2009

IL-23R polymorphisms in patients with ankylosing spondylitis in Korea.

J Rheumatol 2009 May 15;36(5):1003-5. Epub 2009 Apr 15.

Hanyang University College of Medicine, and the Hospital for Rheumatic Diseases, Seoul, Korea.

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http://dx.doi.org/10.3899/jrheum.081121DOI Listing
May 2009

Data integration in genetics and genomics: methods and challenges.

Hum Genomics Proteomics 2009 Jan 12;2009. Epub 2009 Jan 12.

Biostatistics Methodology Unit, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, ON, Canada M5G 1X8.

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http://dx.doi.org/10.4061/2009/869093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950414PMC
January 2009

Efficient p-value estimation in massively parallel testing problems.

Biostatistics 2008 Oct 27;9(4):601-12. Epub 2008 Feb 27.

Department of Public Health Sciences, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/biostatistics/kxm053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536722PMC
October 2008

Interleukin 1 polymorphisms in patients with ankylosing spondylitis in Korea.

J Rheumatol 2008 Aug 15;35(8):1603-8. Epub 2008 May 15.

Chonnam National University Medical School and Hospital, Gwangju, Seoul, Korea.

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August 2008

Haplotype inference using a Bayesian Hidden Markov model.

Genet Epidemiol 2007 Dec;31(8):937-48

Mathematical Biosciences Institute, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1002/gepi.20253DOI Listing
December 2007

A hierarchical clustering method for estimating copy number variation.

Biostatistics 2007 Jul 23;8(3):632-53. Epub 2006 Oct 23.

Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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July 2007

Optimal selection of markers for validation or replication from genome-wide association studies.

Genet Epidemiol 2007 Jul;31(5):396-407

Genetics and Genome Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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July 2007

Integrative analysis of gene expression data including an assessment of pathway enrichment for predicting prostate cancer.

Cancer Inform 2007 Feb 21;2:289-300. Epub 2007 Feb 21.

Program in Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, 15-706 TMDT, 101 College Street, Toronto, ON, M5G 1L7, Canada.

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February 2007

Heritability of schizophrenia and major affective disorder as a function of age, in the presence of strong cohort effects.

Eur Arch Psychiatry Clin Neurosci 2006 Jun 5;256(4):222-9. Epub 2005 Dec 5.

Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130033PMC
June 2006

Tests for differential gene expression using weights in oligonucleotide microarray experiments.

BMC Genomics 2006 Feb 22;7:33. Epub 2006 Feb 22.

Program in Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, 15-706 TMDT, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1186/1471-2164-7-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420292PMC
February 2006

A genome scan for parent-of-origin linkage effects in alcoholism.

BMC Genet 2005 Dec 30;6 Suppl 1:S160. Epub 2005 Dec 30.

Program in Genetics and Genomic Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866773PMC
December 2005

Recursive partitioning models for linkage in COGA data.

BMC Genet 2005 Dec 30;6 Suppl 1:S38. Epub 2005 Dec 30.

Genetics and Genomic Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866747PMC
December 2005

Linkage and association analysis in pedigrees from different populations.

BMC Genet 2005 Dec 30;6 Suppl 1:S59. Epub 2005 Dec 30.

Program in Population Health Sciences, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866724PMC
December 2005

Integrative analysis of multiple gene expression profiles with quality-adjusted effect size models.

BMC Bioinformatics 2005 May 27;6:128. Epub 2005 May 27.

The Hospital for Sick Children Research Institute, 555 University Ave,, Toronto, ON, M5G 1X8, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1173085PMC
May 2005

Regression models for allele sharing: analysis of accumulating data in affected sib pair studies.

Stat Med 2002 Feb;21(3):431-44

Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Department of Public Health Sciences, University of Toronto Suite 850, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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February 2002

Inheritance patterns of maternal alleles in imprinted regions of the mouse genome at different stages of development.

Mamm Genome 2002 Jan;13(1):24-9

Department of Obstetrics and Gynecology, Royal Victoria Hospital, Women's Pavilion, F3.36, 687 Pine Ave. West, Montreal, QC, Canada, H3A 1A1.

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January 2002