Publications by authors named "Celia L Gregson"

37Publications

Mendelian randomization provides evidence for a causal effect of higher serum IGF-1 concentration on risk of hip and knee osteoarthritis.

Rheumatology (Oxford) 2020 Oct 7. Epub 2020 Oct 7.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/rheumatology/keaa597DOI Listing
October 2020

Hip fractures in South Africa: mortality outcomes over 12 months post-fracture.

Arch Osteoporos 2020 05 19;15(1):76. Epub 2020 May 19.

Department of Geriatrics, Division of Internal Medicine, School of Clinical Medicine, College of Health Science, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1007/s11657-020-00741-4DOI Listing
May 2020

Age at puberty and accelerometer-measured physical activity: Findings from two independent UK cohorts.

Ann Hum Biol 2020 Jun 7;47(4):391-399. Epub 2020 May 7.

Population Health Sciences, Bristol Medical School, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1080/03014460.2019.1707284DOI Listing
June 2020

Chronic comorbidities in children and adolescents with perinatally acquired HIV infection in sub-Saharan Africa in the era of antiretroviral therapy.

Lancet Child Adolesc Health 2020 09 30;4(9):688-698. Epub 2020 Apr 30.

Biomedical Research and Training Institute, Harare, Zimbabwe; Clinical Research Department, London School of Hygiene & Tropical Medicine, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(20)30037-7DOI Listing
September 2020

Metabolomics analysis in adults with high bone mass identifies a relationship between bone resorption and circulating citrate which replicates in the general population.

Clin Endocrinol (Oxf) 2020 01 20;92(1):29-37. Epub 2019 Nov 20.

Musculoskeletal Research Unit, Translation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/cen.14119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017780PMC
January 2020

A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis.

J Bone Miner Res 2020 01 14;35(1):92-105. Epub 2019 Nov 14.

Faculty of Health, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia.

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http://dx.doi.org/10.1002/jbmr.3875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004081PMC
January 2020

Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe.

Bone 2019 08 10;125:96-102. Epub 2019 May 10.

Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe; Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), London, UK.

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http://dx.doi.org/10.1016/j.bone.2019.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599174PMC
August 2019

Management of fracture risk in Parkinson's: A revised algorithm and focused review of treatments.

Parkinsonism Relat Disord 2019 07 8;64:181-187. Epub 2019 Apr 8.

Older People's Unit, Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, UK; Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.021DOI Listing
July 2019

Fragility fractures in sub-Saharan Africa: time to break the myth.

Lancet Glob Health 2019 01;7(1):e26-e27

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Medical Research Council Elsie Widdowson Laboratory, Cambridge, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X183041
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http://dx.doi.org/10.1016/S2214-109X(18)30412-1DOI Listing
January 2019

The impact of vitamin D supplementation on musculoskeletal health outcomes in children, adolescents, and young adults living with HIV: A systematic review.

PLoS One 2018 15;13(11):e0207022. Epub 2018 Nov 15.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207022PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237309PMC
April 2019

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes.

Bone 2018 09 5;114:62-71. Epub 2018 Jun 5.

Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD, Australia; Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183022
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http://dx.doi.org/10.1016/j.bone.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086337PMC
September 2018

Sarcopenia Is Negatively Related to High Gravitational Impacts Achieved From Day-to-day Physical Activity.

J Gerontol A Biol Sci Med Sci 2018 04;73(5):652-659

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, UK.

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http://dx.doi.org/10.1093/gerona/glx223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905580PMC
April 2018

Letter regarding 'Does a bit of alcohol turn off inflammation and improve health?'

Age Ageing 2017 01;46(1):158-159

Senior Research Fellow, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ageing/afw236DOI Listing
January 2017

Genetic Studies of Endophenotypes From Spine CT Scans Provide Novel Insights Into the Contribution of Mechanosensory Pathways to Vertebral Fractures and Spinal Curvature.

J Bone Miner Res 2016 12 21;31(12):2073-2076. Epub 2016 Nov 21.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.3032DOI Listing
December 2016

Bone Mineral Density Is Positively Related to Carotid Intima-Media Thickness: Findings From a Population-Based Study in Adolescents and Premenopausal Women.

J Bone Miner Res 2016 12 1;31(12):2139-2148. Epub 2016 Sep 1.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.2903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244498PMC
December 2016

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Authors:
Hou-Feng Zheng Vincenzo Forgetta Yi-Hsiang Hsu Karol Estrada Alberto Rosello-Diez Paul J Leo Chitra L Dahia Kyung Hyun Park-Min Jonathan H Tobias Charles Kooperberg Aaron Kleinman Unnur Styrkarsdottir Ching-Ti Liu Charlotta Uggla Daniel S Evans Carrie M Nielson Klaudia Walter Ulrika Pettersson-Kymmer Shane McCarthy Joel Eriksson Tony Kwan Mila Jhamai Katerina Trajanoska Yasin Memari Josine Min Jie Huang Petr Danecek Beth Wilmot Rui Li Wen-Chi Chou Lauren E Mokry Alireza Moayyeri Melina Claussnitzer Chia-Ho Cheng Warren Cheung Carolina Medina-Gómez Bing Ge Shu-Huang Chen Kwangbom Choi Ling Oei James Fraser Robert Kraaij Matthew A Hibbs Celia L Gregson Denis Paquette Albert Hofman Carl Wibom Gregory J Tranah Mhairi Marshall Brooke B Gardiner Katie Cremin Paul Auer Li Hsu Sue Ring Joyce Y Tung Gudmar Thorleifsson Anke W Enneman Natasja M van Schoor Lisette C P G M de Groot Nathalie van der Velde Beatrice Melin John P Kemp Claus Christiansen Adrian Sayers Yanhua Zhou Sophie Calderari Jeroen van Rooij Chris Carlson Ulrike Peters Soizik Berlivet Josée Dostie Andre G Uitterlinden Stephen R Williams Charles Farber Daniel Grinberg Andrea Z LaCroix Jeff Haessler Daniel I Chasman Franco Giulianini Lynda M Rose Paul M Ridker John A Eisman Tuan V Nguyen Jacqueline R Center Xavier Nogues Natalia Garcia-Giralt Lenore L Launer Vilmunder Gudnason Dan Mellström Liesbeth Vandenput Najaf Amin Cornelia M van Duijn Magnus K Karlsson Östen Ljunggren Olle Svensson Göran Hallmans François Rousseau Sylvie Giroux Johanne Bussière Pascal P Arp Fjorda Koromani Richard L Prince Joshua R Lewis Bente L Langdahl A Pernille Hermann Jens-Erik B Jensen Stephen Kaptoge Kay-Tee Khaw Jonathan Reeve Melissa M Formosa Angela Xuereb-Anastasi Kristina Åkesson Fiona E McGuigan Gaurav Garg Jose M Olmos Maria T Zarrabeitia Jose A Riancho Stuart H Ralston Nerea Alonso Xi Jiang David Goltzman Tomi Pastinen Elin Grundberg Dominique Gauguier Eric S Orwoll David Karasik George Davey-Smith Albert V Smith Kristin Siggeirsdottir Tamara B Harris M Carola Zillikens Joyce B J van Meurs Unnur Thorsteinsdottir Matthew T Maurano Nicholas J Timpson Nicole Soranzo Richard Durbin Scott G Wilson Evangelia E Ntzani Matthew A Brown Kari Stefansson David A Hinds Tim Spector L Adrienne Cupples Claes Ohlsson Celia M T Greenwood Rebecca D Jackson David W Rowe Cynthia A Loomis David M Evans Cheryl L Ackert-Bicknell Alexandra L Joyner Emma L Duncan Douglas P Kiel Fernando Rivadeneira J Brent Richards

Nature 2015 Oct 14;526(7571):112-7. Epub 2015 Sep 14.

Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.

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http://dx.doi.org/10.1038/nature14878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755714PMC
October 2015

Longitudinal changes in lean mass predict pQCT measures of tibial geometry and mineralisation at 6-7 years.

Bone 2015 Jun 20;75:105-10. Epub 2015 Feb 20.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2015.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556067PMC
June 2015

Osteoarthritis and bone mineral density: are strong bones bad for joints?

Bonekey Rep 2015 21;4:624. Epub 2015 Jan 21.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol , Bristol, UK.

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http://dx.doi.org/10.1038/bonekey.2014.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303262PMC
January 2015

Atypical femoral fracture in osteoporosis pseudoglioma syndrome associated with two novel compound heterozygous mutations in LRP5.

J Bone Miner Res 2015 Apr;30(4):615-20

Rheumatic Diseases Unit, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1002/jbmr.2403DOI Listing
April 2015

Variation in access to community rehabilitation services and length of stay in hospital following a hip fracture: a cross-sectional study.

BMJ Open 2014 Sep 10;4(9):e005469. Epub 2014 Sep 10.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK Older Person's Unit, Royal United Hospital Bath NHS Trust, Bath, UK.

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http://bmjopen.bmj.com/cgi/doi/10.1136/bmjopen-2014-005469
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http://dx.doi.org/10.1136/bmjopen-2014-005469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160836PMC
September 2014

Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.

J Clin Endocrinol Metab 2014 Aug 25;99(8):2897-907. Epub 2014 Feb 25.

Musculoskeletal Research Unit (C.L.G., J.H.T.), School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, United Kingdom; Medical Research Council (MRC) Lifecourse Epidemiology Unit (C.L.G.), University of Southampton, Southampton, SO16 6YD United Kingdom; Department of Medicine (K.E.S.P.), University of Cambridge, Cambridge, CB2 0SP United Kingdom; Metabolic Bone Centre (E.V.M.), Sheffield University, Sheffield, S3 7HF United Kingdom; Human Genetics Group (E.L.D.), University of Queensland Diamantina Institute, Brisbane, Australia; Department of Endocrinology (E.L.D), Royal Brisbane and Women's Hospital, Brisbane, Australia; Institute of Aerospace Medicine (J.R.), German Aerospace Center (Deutschen Zentrums fuür Luft- und Raumfahrt), Cologne, Germany; Institute for Biomedical Research into Human Movement and Health Research Institute (J.R.), Manchester Metropolitan University, Manchester, M1 5GD United Kingdom; Department of Medicine (W.D.F.), Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ United Kingdom; and MRC Integrative Epidemiology Unit (G.D.S.), School of Social and Community Based Medicine, University of Bristol, Bristol, BS8 2BN United Kingdom.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2013-3958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207929PMC
August 2014

Jump power and force have distinct associations with cortical bone parameters: findings from a population enriched by individuals with high bone mass.

J Clin Endocrinol Metab 2014 Jan 20;99(1):266-75. Epub 2013 Dec 20.

Musculoskeletal Research Unit (S.A.H., C.L.G., J.H.T.), School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, United Kingdom; Institute of Aerospace Medicine (J.R.), German Aerospace Center, D-51147 Cologne, Germany; Institute for Biomedical Research into Human Movement and Health Research Institute (J.R.), Manchester Metropolitan University, Manchester M1 5GD, United Kingdom; Birmingham Children's Hospital (N.C.), Birmingham B4 6NH, United Kingdom; and Nutrition and Bone Health, Medical Research Council Human Nutrition Research, Cambridge CB1 9NL, United Kingdom.

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http://dx.doi.org/10.1210/jc.2013-2837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952022PMC
January 2014

Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study.

J Bone Miner Res 2013 Nov;28(11):2295-304

MRC Lifecourse Epidemiology Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.

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http://dx.doi.org/10.1002/jbmr.1972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805465PMC
November 2013

Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management.

Rheumatology (Oxford) 2013 Jun 27;52(6):968-85. Epub 2013 Feb 27.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/rheumatology/ket007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651616PMC
June 2013

High bone mass is associated with an increased prevalence of joint replacement: a case-control study.

Rheumatology (Oxford) 2013 Jun 28;52(6):1042-51. Epub 2013 Jan 28.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/rheumatology/kes411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651613PMC
June 2013

Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men.

J Clin Endocrinol Metab 2013 Feb 21;98(2):818-28. Epub 2013 Jan 21.

Musculoskeletal Research Unit, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-3342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589712PMC
February 2013

The association between graded physical activity in postmenopausal British women, and the prevalence and incidence of hip and wrist fractures.

Age Ageing 2010 Sep 17;39(5):565-74. Epub 2010 Jun 17.

Department of Social Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ageing/afq068DOI Listing
September 2010