Celeste M Karch

Celeste M Karch

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Celeste M Karch

Celeste M Karch

Publications by authors named "Celeste M Karch"

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58Publications

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Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.

Neuron 2019 Nov 18;104(3):458-470.e5. Epub 2019 Sep 18.

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.08.008DOI Listing
November 2019

Immunological signatures in frontotemporal lobar degeneration.

Curr Opin Neurol 2019 04;32(2):272-278

Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1097/WCO.0000000000000665DOI Listing
April 2019

RAB10: an Alzheimer's disease resilience locus and potential drug target.

Clin Interv Aging 2019 28;14:73-79. Epub 2018 Dec 28.

Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA,

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http://dx.doi.org/10.2147/CIA.S159148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312396PMC
March 2019

The BDNF SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.

Mol Psychiatry 2019 Mar 21. Epub 2019 Mar 21.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.

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http://dx.doi.org/10.1038/s41380-019-0404-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754794PMC
March 2019

Recent advances in the genetics of frontotemporal dementia.

Curr Genet Med Rep 2019 Mar 30;7(1):41-52. Epub 2019 Jan 30.

Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1007/s40142-019-0160-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827567PMC
March 2019

Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.

Neurol Genet 2018 Oct 1;4(5):e266. Epub 2018 Oct 1.

Department of Neurology (L.W.B., N.Z.R.S., E.G.G., Z.A.M., B.L.M., W.W.S., J.S.Y.), Memory and Aging Center, University of California, San Francisco; Department of Psychiatry (C.M.K., N.W., A.O.-K.), Washington University, St. Louis, MO; School of Pharmacy (C.M., P.L.), University of Reading, Reading, UK; Laboratory of Neurogenetics (P.M.), Texas Tech University Health Science Center, Lubbock; Department of Molecular Neuroscience (C.M., J.H., P.L., R.F.), UCL Institute of Neurology, London, UK; Department of Radiology and Biomedical Imaging, Neuroradiology Section (C.P.H., R.S.D.), University of California, San Francisco; and Department of Neurology (S.E.B.), University of California, San Francisco.

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http://ng.neurology.org/lookup/doi/10.1212/NXG.0000000000000
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http://dx.doi.org/10.1212/NXG.0000000000000266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167176PMC
October 2018

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network.

Alzheimers Res Ther 2018 07 25;10(1):69. Epub 2018 Jul 25.

Department of Neuroscience and Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.

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http://dx.doi.org/10.1186/s13195-018-0400-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060509PMC
July 2018

Tau Kinetics in Neurons and the Human Central Nervous System.

Neuron 2018 03;97(6):1284-1298.e7

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273183013
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http://dx.doi.org/10.1016/j.neuron.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137722PMC
March 2018

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.

Stem Cell Reports 2017 10 28;9(4):1221-1233. Epub 2017 Sep 28.

Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639430PMC
October 2017

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells.

Stem Cell Reports 2017 08 27;9(2):600-614. Epub 2017 Jul 27.

Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550034PMC
August 2017

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.

Elife 2016 12 20;5. Epub 2016 Dec 20.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, United States.

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https://elifesciences.org/articles/20391
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http://dx.doi.org/10.7554/eLife.20391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173322PMC
December 2016

Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.

PLoS One 2016 26;11(2):e0148717. Epub 2016 Feb 26.

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148717PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769299PMC
July 2016

BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells.

Proc Natl Acad Sci U S A 2016 Apr 4;113(16):E2335-44. Epub 2016 Apr 4.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1073/pnas.1516863113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843459PMC
April 2016

Alzheimer's disease risk genes and mechanisms of disease pathogenesis.

Biol Psychiatry 2015 Jan 17;77(1):43-51. Epub 2014 May 17.

Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234692PMC
January 2015

Coding variants in TREM2 increase risk for Alzheimer's disease.

Hum Mol Genet 2014 Nov 4;23(21):5838-46. Epub 2014 Jun 4.

Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO 63110, USA, Hope Center Program on Protein Aggregation and Neurodegeneration and

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http://dx.doi.org/10.1093/hmg/ddu277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189899PMC
November 2014

Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.

PLoS Genet 2014 Oct 23;10(10):e1004758. Epub 2014 Oct 23.

Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, United States of America; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri, United States of America; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America; Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207667PMC
October 2014

Alzheimer's disease genetics: from the bench to the clinic.

Neuron 2014 Jul;83(1):11-26

Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120741PMC
July 2014

Novel progranulin variants do not disrupt progranulin secretion and cleavage.

Neurobiol Aging 2013 Nov 4;34(11):2538-40. Epub 2013 Jun 4.

Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745590PMC
November 2013

Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains.

PLoS One 2012 30;7(11):e50976. Epub 2012 Nov 30.

Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050976PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511432PMC
May 2013

Calcium phosphatase calcineurin influences tau metabolism.

Neurobiol Aging 2013 Feb 6;34(2):374-86. Epub 2012 Jun 6.

Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879081PMC
February 2013

Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies.

J Biol Chem 2012 Dec 26;287(51):42751-62. Epub 2012 Oct 26.

Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M112.380642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522274PMC
December 2012

Aggregation modulating elements in mutant human superoxide dismutase 1.

Arch Biochem Biophys 2010 Nov 2;503(2):175-82. Epub 2010 Aug 2.

Department of Neuroscience, University of Florida, McKnight Brain Institute, Gainesville, 32610, USA.

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http://dx.doi.org/10.1016/j.abb.2010.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997613PMC
November 2010

An examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis.

J Neurochem 2010 Jun 7;113(5):1092-100. Epub 2010 Jan 7.

Department of Neuroscience, McKnight Brain Institute, SantaFe HealthCare Alzheimer's Disease Research Center, University of Florida, Gainesville, Florida 32611, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06572.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971727PMC
June 2010

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS.

Proc Natl Acad Sci U S A 2009 May 30;106(19):7774-9. Epub 2009 Apr 30.

Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610-0235, USA.

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http://dx.doi.org/10.1073/pnas.0902505106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675570PMC
May 2009

A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis.

J Biol Chem 2008 May 3;283(20):13528-37. Epub 2008 Mar 3.

Department of Neuroscience, McKnight Brain Institute, SantaFe HealthCare Alzheimer's Disease Research Center, University of Florida, Gainesville, Florida 32611, USA.

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http://dx.doi.org/10.1074/jbc.M800564200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376231PMC
May 2008