Cees van Kooten

Cees van Kooten

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Cees van Kooten

Publications by authors named "Cees van Kooten"

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Proteinase-3-anti-neutrophil cytoplasmic antibodies (PR3-ANCAs) predict relapses in ANCA-associated vasculitis patients after rituximab.

Nephrol Dial Transplant 2020 Jun 30. Epub 2020 Jun 30.

Centre of Expertise for Lupus-, Vasculitis-, and Complement-Mediated Systemic Autoimmune Diseases Leiden, The Netherlands, Department of Internal Medicine, Section of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfaa066DOI Listing
June 2020

Culture medium used during small interfering RNA (siRNA) transfection determines the maturation status of dendritic cells.

J Immunol Methods 2020 Apr 17;479:112748. Epub 2020 Jan 17.

Div. of Nephrology and Transplant Medicine, Dept. of Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2020.112748DOI Listing
April 2020

Diabetic nephropathy alters circulating long noncoding RNA levels that normalize following simultaneous pancreas-kidney transplantation.

Am J Transplant 2020 Apr 30. Epub 2020 Apr 30.

Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/ajt.15961DOI Listing
April 2020

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population.

Front Immunol 2018 20;9:2664. Epub 2018 Nov 20.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.02664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255829PMC
October 2019

Measuring plasma C4D to monitor immune complexes in lupus nephritis.

Lupus Sci Med 2019 3;6(1):e000326. Epub 2019 Jun 3.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/lupus-2019-000326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560920PMC
June 2019

Role of properdin in complement-mediated kidney diseases.

Nephrol Dial Transplant 2019 05;34(5):742-750

Division of Nephrology and Transplant Medicine, Department Of Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfy233DOI Listing
May 2019

Clinical Implications of Excessive Neutrophil Extracellular Trap Formation in Renal Autoimmune Diseases.

Kidney Int Rep 2019 Feb 19;4(2):196-211. Epub 2018 Nov 19.

Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ekir.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365354PMC
February 2019

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation.

J Vis Exp 2019 01 29(143). Epub 2019 Jan 29.

Department of Nephrology, Leiden University Medical Center;

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http://dx.doi.org/10.3791/59150DOI Listing
January 2019

Properdin binds independent of complement activation in an in vivo model of anti-glomerular basement membrane disease.

Kidney Int 2018 12 12;94(6):1141-1150. Epub 2018 Oct 12.

Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.06.030DOI Listing
December 2018

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA.

Kidney Int 2018 07 30;94(1):139-149. Epub 2018 Mar 30.

Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands; Clinic for Lupus, Vasculitis and Complement-mediated Systemic Diseases, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.01.013DOI Listing
July 2018

Elevated intragraft expression of innate immunity and cell death-related markers is a risk factor for adverse graft outcome.

Transpl Immunol 2018 06 20;48:39-46. Epub 2018 Feb 20.

Dept. of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.trim.2018.02.009DOI Listing
June 2018

The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment.

Sci Rep 2018 05 16;8(1):7716. Epub 2018 May 16.

Department of Cell Biology Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-25700-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956003PMC
May 2018

Complement Activation in Patients With Diabetic Nephropathy.

Kidney Int Rep 2018 Mar 16;3(2):302-313. Epub 2017 Oct 16.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ekir.2017.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932121PMC
March 2018

Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells.

Kidney Int 2018 02 20;93(2):355-364. Epub 2017 Oct 20.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.08.006DOI Listing
February 2018

Mesenchymal Stromal Cell Therapy for Solid Organ Transplantation.

Transplantation 2018 01;102(1):35-43

Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000001879DOI Listing
January 2018

C1-Inhibitor Treatment Decreases Renal Injury in an Established Brain-Dead Rat Model.

Transplantation 2018 01;102(1):79-87

Department of Pathology, Academic Medical Centre Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000001895DOI Listing
January 2018

The human kidney capsule contains a functionally distinct mesenchymal stromal cell population.

PLoS One 2017 5;12(12):e0187118. Epub 2017 Dec 5.

Department of Internal Medicine, division of Nephrology, Einthoven laboratory of Vascular and Regenerative Medicine; Leiden University Medical Centre, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187118PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716605PMC
December 2017

Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.

Am J Pathol 2017 Nov 22;187(11):2430-2440. Epub 2017 Aug 22.

Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.07.020DOI Listing
November 2017

Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms.

Immunogenetics 2017 08 17;69(8-9):631-641. Epub 2017 Jul 17.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00251-017-0989-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537314PMC
August 2017

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury.

FASEB J 2017 07 10;31(7):3193-3204. Epub 2017 Apr 10.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands;

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http://dx.doi.org/10.1096/fj.201601218RDOI Listing
July 2017

Counteracting dysfunction of regulatory T cells in organ transplantation.

Authors:
Cees van Kooten

Proc Natl Acad Sci U S A 2017 07 22;114(27):6883-6884. Epub 2017 Jun 22.

Department of Internal Medicine-Nephrology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

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http://dx.doi.org/10.1073/pnas.1708493114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502658PMC
July 2017

Uptake of HLA Alloantigens via CD89 and CD206 Does Not Enhance Antigen Presentation by Indirect Allorecognition.

J Immunol Res 2016 20;2016:4215684. Epub 2016 Jun 20.

Department of Nephrology, Leiden University Medical Center (LUMC), 2333 ZA Leiden, Netherlands.

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http://dx.doi.org/10.1155/2016/4215684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931073PMC
March 2017

Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney.

EBioMedicine 2017 Feb 24;16:302-311. Epub 2017 Jan 24.

Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474509PMC
February 2017

Mesenchymal stromal cells in clinical kidney transplantation: how tolerant can it be?

Curr Opin Organ Transplant 2016 Dec;21(6):550-558

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MOT.0000000000000364DOI Listing
December 2016

Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components.

Mol Immunol 2016 08 20;76:13-21. Epub 2016 Jun 20.

Leiden University Medical Center (LUMC), Department of Nephrology, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2016.06.004DOI Listing
August 2016

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes.

Autoimmun Rev 2016 Jun 27;15(6):577-84. Epub 2016 Feb 27.

Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2016.02.018DOI Listing
June 2016

Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin.

Am J Physiol Renal Physiol 2016 06 16;310(11):F1308-16. Epub 2016 Mar 16.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands; and.

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http://dx.doi.org/10.1152/ajprenal.00645.2014DOI Listing
June 2016

Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction.

PLoS One 2015 14;10(9):e0137795. Epub 2015 Sep 14.

Department of Surgery, division of Transplant Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137795PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569339PMC
May 2016

Role of complement in IgA nephropathy.

J Nephrol 2016 Feb 13;29(1):1-4. Epub 2015 Nov 13.

Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s40620-015-0245-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733139PMC
February 2016

Introducing this special issue.

Mol Immunol 2015 Nov;68(1)

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http://dx.doi.org/10.1016/j.molimm.2015.09.009DOI Listing
November 2015

Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia.

Hypertension 2015 Jul 4;66(1):117-25. Epub 2015 May 4.

From the Department of Pathology (M.P., J.S.C., M.Z., A.B., J.A.B., H.B.), Department of Nephrology (C.v.K.), and Department of Obstetrics (K.B.), Leiden University Medical Center, Leiden, the Netherlands; Department of Obstetrics & Gynecology, Isala Zwolle, Zwolle, the Netherlands (J.S.); and Howard Hughes Medical Institute and Department of Medicine, Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (E.V.K., S.A.K.).

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.115.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465860PMC
July 2015

Emerging biomarkers in renal damage.

Biomed Res Int 2014 3;2014:893068. Epub 2014 Sep 3.

Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy.

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http://dx.doi.org/10.1155/2014/893068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168029PMC
June 2015

Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members.

Eur J Immunol 2015 Jun;45(6):1736-47

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/eji.201445217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617619PMC
June 2015

Myeloperoxidase directs properdin-mediated complement activation.

J Innate Immun 2014 20;6(4):417-25. Epub 2013 Dec 20.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1159/000356980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741500PMC
May 2015

Half a century of Dutch transplant immunology.

Immunol Lett 2014 Dec 18;162(2 Pt B):145-9. Epub 2014 Oct 18.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2014.10.017DOI Listing
December 2014

Immunogenetics and immunology of transplantation in Leiden.

Transpl Immunol 2014 Oct 22;31(4):195-9. Epub 2014 Sep 22.

Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; Leiden University Medical Center, Department of Nephrology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.trim.2014.09.009DOI Listing
October 2014

Human renal fibroblasts generate dendritic cells with a unique regulatory profile.

Immunol Cell Biol 2014 Sep 10;92(8):688-98. Epub 2014 Jun 10.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/icb.2014.41DOI Listing
September 2014

Redefining Strategies to Introduce Tolerance-Inducing Cellular Therapy in Human beings to Combat Autoimmunity and Transplantation Reactions.

Front Immunol 2014 15;5:392. Epub 2014 Aug 15.

Laboratory for Translational Immunology, Center for Molecular and Cellular Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht , Utrecht , Netherlands.

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http://dx.doi.org/10.3389/fimmu.2014.00392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133652PMC
September 2014

Phagocytosis of apoptotic or necrotic cells differentially regulates the transcriptional expression of IL-12 family members in dendritic cells.

J Leukoc Biol 2014 Aug 29;96(2):313-24. Epub 2014 Apr 29.

Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands

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http://dx.doi.org/10.1189/jlb.3A1013-538RRDOI Listing
August 2014

Purification and functional analysis of human properdin.

Methods Mol Biol 2014 ;1100:161-7

Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/978-1-62703-724-2_13DOI Listing
June 2014

HLA monomers as a tool to monitor indirect allorecognition.

Transplantation 2014 Jun;97(11):1119-27

1 Department of Nephrology, Leiden University Medical Center (LUMC), Leiden, the Netherlands. 2 Department of Immunohematology and Blood Transfusion, LUMC, Leiden, the Netherlands. 3 Department of Hematology, LUMC, Leiden, The Netherlands. 4 Address correspondence to: Cees van Kooten, MD, PhD, Albinusdreef 2, C07-35 2333ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000000113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032218PMC
June 2014

Subsets of human type 2 macrophages show differential capacity to produce reactive oxygen species.

Cell Immunol 2013 Jul-Aug;284(1-2):1-8. Epub 2013 Jul 18.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.cellimm.2013.07.006DOI Listing
March 2014

The NOX2-mediated ROS producing capacity of recipient cells is associated with reduced T cell infiltrate in an experimental model of chronic renal allograft inflammation.

Transpl Immunol 2014 Mar 21;30(2-3):65-70. Epub 2013 Dec 21.

Dept. of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.trim.2013.12.001DOI Listing
March 2014

Identification of a novel CD40 ligand for targeted imaging of inflammatory plaques by phage display.

FASEB J 2013 Oct 29;27(10):4136-46. Epub 2013 Jul 29.

2Department of Pathology, University Hospital Maastricht, Debeijelaan 25, 6229 HX Maastricht, The Netherlands.

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http://dx.doi.org/10.1096/fj.12-224667DOI Listing
October 2013

Deposition of IgA in primary IgA nephropathy: it takes at least four to tango.

Nephrol Dial Transplant 2013 Apr 12;28(4):794-7. Epub 2012 Dec 12.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfs445DOI Listing
April 2013

Reversible differentiation of pro- and anti-inflammatory macrophages.

Mol Immunol 2013 Mar 1;53(3):179-86. Epub 2012 Sep 1.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2012.07.005DOI Listing
March 2013

Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.

J Biol Chem 2012 Sep 19;287(37):31471-81. Epub 2012 Jul 19.

Department of Nephrology, University Medical Center, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M112.380386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438980PMC
September 2012

Pitfalls in urinary complement measurements.

Transpl Immunol 2012 Aug 16;27(1):55-8. Epub 2012 Jun 16.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.trim.2012.06.001DOI Listing
August 2012

No prominent role for terminal complement activation in the early myocardial reperfusion phase following cardiac surgery.

Eur J Cardiothorac Surg 2012 May 9;41(5):e117-25. Epub 2012 Mar 9.

Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands.

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https://academic.oup.com/ejcts/article-lookup/doi/10.1093/ej
Publisher Site
http://dx.doi.org/10.1093/ejcts/ezs088DOI Listing
May 2012

Dexamethasone increases ROS production and T cell suppressive capacity by anti-inflammatory macrophages.

Mol Immunol 2011 Dec 1;49(3):549-57. Epub 2011 Nov 1.

Leiden University Medical Center, Department of Nephrology, 2300 RC Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S01615890110076
Publisher Site
http://dx.doi.org/10.1016/j.molimm.2011.10.002DOI Listing
December 2011

Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation.

Mol Immunol 2011 Oct 19;49(1-2):75-83. Epub 2011 Aug 19.

Department of Nephrology, Leiden University Medical Centre, Albinusdreef 2, 2300 ZA, Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2011.07.020DOI Listing
October 2011