Publications by authors named "Catia Moutinho"

40Publications

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer.

Cell Stem Cell 2020 06 11;26(6):845-861.e12. Epub 2020 May 11.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10, 08028 Barcelona, Spain; ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.04.012DOI Listing
June 2020

Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis.

Cell Rep 2019 07;28(2):352-367.e9

Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès 08193, Spain; Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès 08193, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635386PMC
July 2019

Germline variation in O-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer.

Cancer Lett 2019 04 21;447:86-92. Epub 2019 Jan 21.

Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Program in Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell), IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.01.019DOI Listing
April 2019

Tutorial: guidelines for the experimental design of single-cell RNA sequencing studies.

Nat Protoc 2018 12;13(12):2742-2757

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

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http://www.nature.com/articles/s41596-018-0073-y
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http://dx.doi.org/10.1038/s41596-018-0073-yDOI Listing
December 2018

MicroRNAs and Epigenetics.

Adv Cancer Res 2017 4;135:189-220. Epub 2017 Aug 4.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain; School of Medicine and Health Sciences, University of Barcelona (UB), Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2017.06.003DOI Listing
June 2018

Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer.

Oncotarget 2017 Aug 29;8(31):51621-51629. Epub 2017 May 29.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.18632/oncotarget.18255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584274PMC
August 2017

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.

Lancet Oncol 2016 Oct 27;17(10):1386-1395. Epub 2016 Aug 27.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain; School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30297-2DOI Listing
October 2016

Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer.

Gastroenterology 2016 11 10;151(5):961-972. Epub 2016 Aug 10.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.08.001DOI Listing
November 2016

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.

J Natl Cancer Inst 2016 11 5;108(11). Epub 2016 Jul 5.

Affiliations of authors: Division of Molecular Pathology and Cancer Genomics Centre Netherlands (PtB, PK, EvdB, UB, MdM, EL, LM, JdR, JW, JJ), Division of Molecular Carcinogenesis (IM), Department of Epidemiology and Biostatistics (KJ), and Family Cancer Clinic and Department of Pathology (FH), The Netherlands Cancer Institute, Amsterdam, the Netherlands; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain (CM, ME); The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK (HG, NT); Laboratory of Preclinical Investigation, Translational Research Department, Curie Institute, Paris, France (EM); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (WK, MvR, KD, EC); Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain (ME); Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain (ME).

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http://dx.doi.org/10.1093/jnci/djw148DOI Listing
November 2016

KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.

Cancer Res 2015 Sep 24;75(18):3936-45. Epub 2015 Jul 24.

Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3702DOI Listing
September 2015

Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance.

Mol Cancer Ther 2015 Aug 16;14(8):1767-76. Epub 2015 Jul 16.

Medical Oncology Service, Catalan Institute of Oncology (ICO), Hospital Germans Trias i Pujol, Badalona, Barcelona, Catalonia, Spain. Health Sciences Research Institute of the Germans Trias i Pujol Foundation (IGTP). Badalona, Catalonia, Spain. Oncology Unit, Hospital CIMA Sanitas, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0636DOI Listing
August 2015

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.

Nat Med 2015 Jul 1;21(7):741-50. Epub 2015 Jun 1.

1] Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain. [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. [3] Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1038/nm.3863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968631PMC
July 2015

Linkage of DNA methylation quantitative trait loci to human cancer risk.

Cell Rep 2014 Apr 3;7(2):331-338. Epub 2014 Apr 3.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.016DOI Listing
April 2014

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Nat Commun 2014 Apr 3;5:3608. Epub 2014 Apr 3.

1] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain [3] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010 Catalonia, Spain.

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http://dx.doi.org/10.1038/ncomms4608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988805PMC
April 2014

Epigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer.

J Natl Cancer Inst 2014 Jan 22;106(1):djt322. Epub 2013 Nov 22.

Affiliations of authors: Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain (CM, AM-C, FJC, ME); Medical Oncology Service, Catalan Institute of Oncology, Health Sciences Research Institute of the Germans Trias i Pujol Foundation, Barcelona, Spain (AM-C, EM-B, AA); Department of Medical Oncology (CS, RS) and Clinical Informatics Unit (VN-P), Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain; Department of Pathology, Germans Trias i Pujol Foundation, Barcelona, Spain (EM); Department of Hematology and Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy (AS-B, AC, SS); Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain (EE, JT); Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Barcelona, Spain (ME); Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain (ME).

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http://dx.doi.org/10.1093/jnci/djt322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906989PMC
January 2014

CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer.

RNA Biol 2012 Jun 23;9(6):881-90. Epub 2012 May 23.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.4161/rna.19353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495749PMC
June 2012

Epidermal growth factor receptor structural alterations in gastric cancer.

BMC Cancer 2008 Jan 16;8:10. Epub 2008 Jan 16.

Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), 4200-465 Porto, Portugal.

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http://dx.doi.org/10.1186/1471-2407-8-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2244615PMC
January 2008

A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation.

Virchows Arch 2007 Jun 9;450(6):619-26. Epub 2007 May 9.

Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal.

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http://link.springer.com/content/pdf/10.1007/s00428-007-0420
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http://link.springer.com/10.1007/s00428-007-0420-9
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http://dx.doi.org/10.1007/s00428-007-0420-9DOI Listing
June 2007

BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes.

Oncogene 2005 Jun;24(24):3995-8

Molecular Oncology and Aging Research, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona 08035, Spain.

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http://dx.doi.org/10.1038/sj.onc.1208569DOI Listing
June 2005

Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour.

Oncogene 2004 Mar;23(12):2236-40

Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal.

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http://dx.doi.org/10.1038/sj.onc.1207335DOI Listing
March 2004