Catherine M Greene

Catherine M Greene

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Catherine M Greene

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Transforming Growth Factor-β1 Selectively Recruits microRNAs to the RNA-Induced Silencing Complex and Degrades CFTR mRNA under Permissive Conditions in Human Bronchial Epithelial Cells.

Int J Mol Sci 2019 Oct 5;20(19). Epub 2019 Oct 5.

Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224 USA.

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http://dx.doi.org/10.3390/ijms20194933DOI Listing
October 2019

The Estrogen-Induced miR-19 Downregulates Secretory Leucoprotease Inhibitor Expression in Monocytes.

J Innate Immun 2019 Jul 2:1-13. Epub 2019 Jul 2.

Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland,

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http://dx.doi.org/10.1159/000500419DOI Listing
July 2019

Characterisation of the Major Extracellular Proteases of and Their Effects on Pulmonary Antiproteases.

Pathogens 2019 06 28;8(3). Epub 2019 Jun 28.

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, D02 YN77 Dublin, Ireland.

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http://dx.doi.org/10.3390/pathogens8030092DOI Listing
June 2019

Nebulised lipid-polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells.

ERJ Open Res 2019 Apr 8;5(2). Epub 2019 Apr 8.

Lung Biology Group, Dept of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1183/23120541.00161-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452044PMC
April 2019

From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science."

ERJ Open Res 2019 Apr 10;5(2). Epub 2019 May 10.

Early Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany.

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http://dx.doi.org/10.1183/23120541.00194-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513036PMC
April 2019

Unmasking the pathological and therapeutic potential of histone deacetylases for liver cancer.

Expert Rev Gastroenterol Hepatol 2019 Mar 29;13(3):247-256. Epub 2019 Jan 29.

a Experimental Medicine, UCD School of Medicine and Medical Science , Mater Misericordiae University Hospital , Dublin , Ireland.

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http://dx.doi.org/10.1080/17474124.2019.1568870DOI Listing
March 2019

Knockdown of Gene Expression in Macrophages by microRNA Mimic-Containing Poly (Lactic--glycolic Acid) Microparticles.

Medicines (Basel) 2018 Dec 15;5(4). Epub 2018 Dec 15.

Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://www.mdpi.com/2305-6320/5/4/133
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http://dx.doi.org/10.3390/medicines5040133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313440PMC
December 2018

Airway Epithelium Dysfunction in Cystic Fibrosis and COPD.

Mediators Inflamm 2018 8;2018:1309746. Epub 2018 Apr 8.

Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Dublin, Ireland.

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http://dx.doi.org/10.1155/2018/1309746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911336PMC
October 2018

Author Correction: α1-Antitrypsin deficiency.

Nat Rev Dis Primers 2018 Oct 29;4(1):40. Epub 2018 Oct 29.

Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1038/s41572-018-0043-2DOI Listing
October 2018

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95).

J Cyst Fibros 2018 09 2;17(5):616-623. Epub 2018 Mar 2.

Airway Innate Immunity Research Group, Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1016/j.jcf.2018.01.010DOI Listing
September 2018

Non-coding RNA in cystic fibrosis.

Biochem Soc Trans 2018 06 9;46(3):619-630. Epub 2018 May 9.

Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland

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http://dx.doi.org/10.1042/BST20170469DOI Listing
June 2018

CFTR dysfunction in cystic fibrosis and chronic obstructive pulmonary disease.

Expert Rev Respir Med 2018 06 23;12(6):483-492. Epub 2018 May 23.

a Lung Biology Group, Department of Clinical Microbiology , RCSI Education & Research Centre, Beaumont Hospital , Dublin 9 , Ireland.

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http://dx.doi.org/10.1080/17476348.2018.1475235DOI Listing
June 2018

Gender disparities in preterm neonatal outcomes.

Acta Paediatr 2018 May 11. Epub 2018 May 11.

Paediatrics, Academic Centre, Tallaght Hospital, Trinity College and Trinity Translational Medicine Institute, St James' Hospital, the University of Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1111/apa.14390DOI Listing
May 2018

The therapeutic properties of resminostat for hepatocellular carcinoma.

Oncoscience 2018 May 23;5(5-6):196-208. Epub 2018 Jun 23.

Experimental Medicine, UCD School of Medicine and Medical Science, Mater Misericordiae University Hospital, Dublin, Ireland.

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http://dx.doi.org/10.18632/oncoscience.420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049311PMC
May 2018

Challenges and future direction of molecular research in air pollution-related lung cancers.

Lung Cancer 2018 04 31;118:69-75. Epub 2018 Jan 31.

Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, 56000 Kuala Lumpur, Malaysia. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.01.016DOI Listing
April 2018

X Chromosome-encoded MicroRNAs Are Functionally Increased in Cystic Fibrosis Monocytes.

Am J Respir Crit Care Med 2018 03;197(5):668-670

1 Royal College of Surgeons in Ireland Dublin, Ireland.

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http://www.atsjournals.org/doi/10.1164/rccm.201707-1417LE
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http://dx.doi.org/10.1164/rccm.201707-1417LEDOI Listing
March 2018

miR-CATCH Identifies Biologically Active miRNA Regulators of the Pro-Survival Gene XIAP, in Chinese Hamster Ovary Cells.

Biotechnol J 2018 Mar 30;13(3):e1700299. Epub 2017 Oct 30.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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http://dx.doi.org/10.1002/biot.201700299DOI Listing
March 2018

Assembly 3: Basic and Translational Sciences.

Breathe (Sheff) 2018 Mar;14(1):67-68

Chair of Assembly 3, European Respiratory Society.

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http://dx.doi.org/10.1183/20734735.020017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831348PMC
March 2018

Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine.

J Innate Immun 2018 13;10(5-6):487-501. Epub 2018 Feb 13.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1159/000487057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089674PMC
February 2018

Identification of a novel functional miR-143-5p recognition element in the Cystic Fibrosis Transmembrane Conductance Regulator 3'UTR.

AIMS Genet 2018 23;5(1):53-62. Epub 2018 Feb 23.

Lung Biology Group, Department of Clinical Microbiology, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.3934/genet.2018.1.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690249PMC
February 2018

Biopolymer-Based Nanoparticles for Cystic Fibrosis Lung Gene Therapy Studies.

Materials (Basel) 2018 Jan 13;11(1). Epub 2018 Jan 13.

Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.3390/ma11010122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793620PMC
January 2018

Immune function? A missing link in the gender disparity in preterm neonatal outcomes.

Expert Rev Clin Immunol 2017 11;13(11):1061-1071

a Neonatology , National Maternity Hospital , Dublin , Ireland.

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http://dx.doi.org/10.1080/1744666X.2017.1386555DOI Listing
November 2017

Best of Milan 2017-ERS Lung Science Conference session "Lung tissue repair and remodeling in chronic lung diseases: mechanisms and therapeutic approaches".

J Thorac Dis 2017 Nov;9(Suppl 16):S1541-S1543

Department of Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.21037/jtd.2017.11.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717364PMC
November 2017

Toll-Like Receptors in Cystic Fibrosis: Impact of Dysfunctional microRNA on Innate Immune Responses in the Cystic Fibrosis Lung.

J Innate Immun 2016 5;8(6):541-549. Epub 2016 Apr 5.

Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1159/000444687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738783PMC
October 2017

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB.

Sci Rep 2017 10 23;7(1):13803. Epub 2017 Oct 23.

Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1038/s41598-017-14310-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653852PMC
October 2017

Expression of X-linked Toll-like receptor 4 signaling genes in female vs. male neonates.

Pediatr Res 2017 May 6;81(5):831-837. Epub 2017 Jan 6.

Clinical Microbiology, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1038/pr.2017.2DOI Listing
May 2017

High-throughput profiling for discovery of non-coding RNA biomarkers of lung disease.

Expert Rev Mol Diagn 2016 10;16(2):173-85. Epub 2015 Dec 10.

a Respiratory Research, Department of Medicine, The Royal College of Surgeons in Ireland, Education and Research Centre , Beaumont Hospital , Dublin , Ireland.

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http://dx.doi.org/10.1586/14737159.2016.1122526DOI Listing
November 2016

Ursodeoxycholic acid inhibits TNFα-induced IL-8 release from monocytes.

Am J Physiol Gastrointest Liver Physiol 2016 08 23;311(2):G334-41. Epub 2016 Jun 23.

Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education & Research Centre, Beaumont Hospital, Dublin, Ireland; and

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http://dx.doi.org/10.1152/ajpgi.00406.2015DOI Listing
August 2016

α1-Antitrypsin deficiency.

Nat Rev Dis Primers 2016 07 28;2:16051. Epub 2016 Jul 28.

Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1038/nrdp.2016.51DOI Listing
July 2016

MicroRNA Dysregulation in Cystic Fibrosis.

Mediators Inflamm 2015 22;2015:529642. Epub 2015 Jun 22.

Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1155/2015/529642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491587PMC
May 2016

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity.

J Immunol Res 2015 12;2015:507315. Epub 2015 Jul 12.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Health Sciences Building, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.

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http://dx.doi.org/10.1155/2015/507315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515294PMC
March 2016

The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis.

J Allergy Clin Immunol 2016 Feb 18;137(2):436-443.e9. Epub 2015 Sep 18.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.jaci.2015.07.045DOI Listing
February 2016

Sexual maturation protects against development of lung inflammation through estrogen.

Am J Physiol Lung Cell Mol Physiol 2016 Jan 25;310(2):L166-74. Epub 2015 Nov 25.

University of Groningen, Department of Pharmacokinetics, Toxicology, and Targeting, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands;

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http://dx.doi.org/10.1152/ajplung.00119.2015DOI Listing
January 2016

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6.

Mol Cell Pediatr 2015 Dec 7;2(1). Epub 2015 Jan 7.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, 9, Ireland.

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http://dx.doi.org/10.1186/s40348-014-0012-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407678PMC
December 2015

miR-17 overexpression in cystic fibrosis airway epithelial cells decreases interleukin-8 production.

Eur Respir J 2015 Nov 9;46(5):1350-60. Epub 2015 Jul 9.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

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http://erj.ersjournals.com/content/erj/early/2015/07/09/0903
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http://erj.ersjournals.com/lookup/doi/10.1183/09031936.00163
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http://dx.doi.org/10.1183/09031936.00163414DOI Listing
November 2015

Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease.

Biomolecules 2015 Jul 1;5(3):1386-98. Epub 2015 Jul 1.

Department of Medicine, Respiratory Research Division, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.3390/biom5031386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598756PMC
July 2015

miR-CATCH: microRNA capture affinity technology.

Methods Mol Biol 2015 ;1218:365-73

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.

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http://dx.doi.org/10.1007/978-1-4939-1538-5_23DOI Listing
June 2015

Non-coding RNA as lung disease biomarkers.

Thorax 2015 May 30;70(5):501-3. Epub 2014 Dec 30.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1136/thoraxjnl-2014-206193DOI Listing
May 2015

Developmental control of CFTR: from bioinformatics to novel therapeutic approaches.

Eur Respir J 2015 Jan;45(1):18-20

CF Research Group, Children's Hospital, Dept I, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1183/09031936.00138914DOI Listing
January 2015

Therapeutic aerosol bioengineering of siRNA for the treatment of inflammatory lung disease by TNFα gene silencing in macrophages.

Mol Pharm 2014 Nov 13;11(11):4270-9. Epub 2014 Oct 13.

School of Pharmacy and §Department of Physiology, Royal College of Surgeons in Ireland , Dublin 2, Ireland.

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http://pubs.acs.org/doi/10.1021/mp500473d
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http://dx.doi.org/10.1021/mp500473dDOI Listing
November 2014

Chemical structure and biological activity of a highly branched (1 → 3,1 → 6)-β-D-glucan from Isochrysis galbana.

Carbohydr Polym 2014 Oct 28;111:139-48. Epub 2014 Apr 28.

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii prosp. 47, Moscow, Russian Federation. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2014.04.077DOI Listing
October 2014

Long noncoding RNAs in liver cancer: what we know in 2014.

Expert Opin Ther Targets 2014 Oct 22;18(10):1207-18. Epub 2014 Aug 22.

Experimental Medicine, UCD School of Medicine and Medical Science, Mater Misericordiae University Hospital, Catherine McAuley Centre, Nelson Street , Dublin 7 , Ireland

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http://dx.doi.org/10.1517/14728222.2014.941285DOI Listing
October 2014

Protein quality control in lung disease: it's all about cloud networking.

Eur Respir J 2014 Oct;44(4):846-9

Dept of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1183/09031936.00105214DOI Listing
October 2014

Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis.

Antimicrob Agents Chemother 2014 25;58(2):978-85. Epub 2013 Nov 25.

Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1128/AAC.01167-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910818PMC
September 2014

Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium.

Int J Biochem Cell Biol 2014 Jul 12;52:184-91. Epub 2014 Mar 12.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.02.022DOI Listing
July 2014

Targeting miRNA-based medicines to cystic fibrosis airway epithelial cells using nanotechnology.

Int J Nanomedicine 2013 11;8:3907-15. Epub 2013 Oct 11.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.2147/IJN.S47551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798151PMC
April 2014

Aspergillus-associated airway disease, inflammation, and the innate immune response.

Biomed Res Int 2013 21;2013:723129. Epub 2013 Jul 21.

Department of Respiratory Medicine, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1155/2013/723129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736487PMC
February 2014

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.

Am J Respir Crit Care Med 2014 Feb;189(4):419-27

1 Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland; and.

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http://dx.doi.org/10.1164/rccm.201311-1984OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955067PMC
February 2014

MicroRNAs and liver cancer associated with iron overload: therapeutic targets unravelled.

World J Gastroenterol 2013 Aug;19(32):5212-26

Respiratory Research Division, Department of Medicine, Education and Research Centre, Royal College of Surgeons In Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.3748/wjg.v19.i32.5212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752555PMC
August 2013

Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique.

Nucleic Acids Res 2013 Apr 15;41(6):e71. Epub 2013 Jan 15.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Republic of Ireland.

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http://dx.doi.org/10.1093/nar/gks1466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616726PMC
April 2013

Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ΔF508 cystic fibrosis airway epithelium.

J Immunol 2013 Apr 22;190(7):3354-62. Epub 2013 Feb 22.

Respiratory Research Division, Department of Medicine, Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.4049/jimmunol.1202960DOI Listing
April 2013

Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?

Nutrients 2013 Mar 11;5(3):758-70. Epub 2013 Mar 11.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.3390/nu5030758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705318PMC
March 2013

MicroRNA Expression in Cystic Fibrosis Airway Epithelium.

Biomolecules 2013 Feb 11;3(1):157-67. Epub 2013 Feb 11.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.3390/biom3010157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030891PMC
February 2013

microRNAs in asthma: potential therapeutic targets.

Curr Opin Pulm Med 2013 Jan;19(1):66-72

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1097/MCP.0b013e32835a5bc8DOI Listing
January 2013

Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.

Br J Neurosurg 2012 Dec 3;26(6):792-7. Epub 2012 Feb 3.

Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.3109/02688697.2011.651514DOI Listing
December 2012

The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis.

Am J Respir Crit Care Med 2012 Nov 16;186(10):999-1007. Epub 2012 Aug 16.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1164/rccm.201203-0478OCDOI Listing
November 2012

Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis.

N Engl J Med 2012 May 20;366(21):1978-86. Epub 2012 May 20.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1056/NEJMoa1106126DOI Listing
May 2012

Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.

Expert Rev Anti Infect Ther 2012 Mar;10(3):359-68

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1586/eri.11.175DOI Listing
March 2012

SLPI and inflammatory lung disease in females.

Biochem Soc Trans 2011 Oct;39(5):1421-6

Department of Medicine, Respiratory Research Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://www.biochemsoctrans.org/content/ppbiost/39/5/1421.ful
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http://biochemsoctrans.org/lookup/doi/10.1042/BST0391421
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http://dx.doi.org/10.1042/BST0391421DOI Listing
October 2011

Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.

Pulm Med 2011 31;2011:826160. Epub 2011 Mar 31.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1155/2011/826160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109555PMC
July 2011

The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency.

Expert Rev Respir Med 2011 Jun;5(3):395-411

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://www.tandfonline.com/doi/full/10.1586/ers.11.20
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http://dx.doi.org/10.1586/ers.11.20DOI Listing
June 2011

Measurement of the unfolded protein response (UPR) in monocytes.

Methods Enzymol 2011 ;489:83-95

Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/B978-0-12-385116-1.00005-4DOI Listing
May 2011

Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway.

J Biol Chem 2011 Mar 30;286(9):7692-704. Epub 2010 Dec 30.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1074/jbc.M110.183863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045023PMC
March 2011

Protein misfolding and obstructive lung disease.

Proc Am Thorac Soc 2010 Nov;7(6):346-55

Respiratory Research Division, Dept. Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1513/pats.201002-019AWDOI Listing
November 2010

Candida species in cystic fibrosis: A road less travelled.

Med Mycol 2010 Nov;48 Suppl 1:S114-24

Department of Medicine, Royal College of Surgeons, Ireland.

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http://dx.doi.org/10.3109/13693786.2010.503320DOI Listing
November 2010

MicroRNAs in inflammatory lung disease--master regulators or target practice?

Respir Res 2010 Oct 28;11:148. Epub 2010 Oct 28.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1186/1465-9921-11-148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984500PMC
October 2010

Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response.

World J Gastrointest Pharmacol Ther 2010 Oct;1(5):94-101

Catherine M Greene, Noel G McElvaney, Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.4292/wjgpt.v1.i5.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091154PMC
October 2010

17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor.

Am J Respir Crit Care Med 2010 Jul 8;182(1):62-72. Epub 2010 Apr 8.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1164/rccm.201001-0053OCDOI Listing
July 2010

Alpha-1 antitrypsin deficiency.

Respir Med 2010 Jun 20;104(6):763-72. Epub 2010 Mar 20.

Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Education Research Building, Beaumont Road, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.rmed.2010.01.016DOI Listing
June 2010

Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor.

Mediators Inflamm 2010 31;2010:423241. Epub 2010 Mar 31.

Department of Medicine, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1155/2010/423241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850130PMC
June 2010

Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency.

J Immunol 2010 Apr 12;184(8):4538-46. Epub 2010 Mar 12.

Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.4049/jimmunol.0802864DOI Listing
April 2010

How can we target pulmonary inflammation in cystic fibrosis?

Open Respir Med J 2010 Mar 30;4:18-9. Epub 2010 Mar 30.

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http://dx.doi.org/10.2174/1874306401004020018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864425PMC
March 2010

Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency.

Biologics 2009 13;3:63-75. Epub 2009 Jul 13.

Respiratory Research Division, Dept. Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726058PMC
February 2010

miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression.

J Immunol 2010 Feb 18;184(4):1702-9. Epub 2010 Jan 18.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Ireland.

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http://dx.doi.org/10.4049/jimmunol.0902669DOI Listing
February 2010

Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease.

Am J Respir Crit Care Med 2010 Jan 17;181(1):31-5. Epub 2009 Sep 17.

Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1164/rccm.200904-0545OCDOI Listing
January 2010

Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery.

Br J Pharmacol 2009 Oct;158(4):1048-58

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1111/j.1476-5381.2009.00448.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785526PMC
October 2009

Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis.

J Med Microbiol 2009 Jul 5;58(Pt 7):855-62. Epub 2009 Jun 5.

Department of Clinical Microbiology, Royal College of Surgeons in Ireland Education & Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1099/jmm.0.009209-0DOI Listing
July 2009

LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline.

J Immunol 2009 Jul;183(1):543-51

Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.4049/jimmunol.0803959DOI Listing
July 2009

Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency.

J Biol Chem 2009 Jun 27;284(25):16891-7. Epub 2009 Apr 27.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1074/jbc.M109.006288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719325PMC
June 2009

Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2.

Cell Microbiol 2009 Mar 7;11(3):421-32. Epub 2008 Nov 7.

Department of Clinical Microbiology, Royal College of Surgeons in Ireland Education & Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1111/j.1462-5822.2008.01264.xDOI Listing
March 2009

Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia?

Respirology 2009 Mar;14(2):210-6

Division of Respiratory Research, Department of Medicine, RCSI Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1111/j.1440-1843.2008.01423.xDOI Listing
March 2009

Toll-like receptors as therapeutic targets in cystic fibrosis.

Expert Opin Ther Targets 2008 Dec;12(12):1481-95

Beaumont Hospital, Education and Research Centre, Respiratory Research Division, Royal College of Surgeons in Ireland, 9 Dublin, Ireland.

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http://dx.doi.org/10.1517/14728220802515293 DOI Listing
December 2008

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.

J Biol Chem 2008 Nov 4;283(46):31736-44. Epub 2008 Sep 4.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1074/jbc.M803732200DOI Listing
November 2008

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.

J Biol Chem 2008 Nov 17;283(47):32377-85. Epub 2008 Sep 17.

Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1074/jbc.M803707200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583315PMC
November 2008

Targeting neutrophil elastase in cystic fibrosis.

Expert Opin Ther Targets 2008 Feb;12(2):145-57

Beaumont Hospital, Department of Respiratory Research, RCSI Smurfit Building, Beaumont, Dublin 9, Ireland.

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http://dx.doi.org/10.1517/14728222.12.2.145 DOI Listing
February 2008

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.

J Biol Chem 2007 Nov 18;282(46):33389-95. Epub 2007 Sep 18.

Pulmonary Research Division, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland.

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http://dx.doi.org/10.1074/jbc.M706884200DOI Listing
November 2007

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke.

Respir Res 2007 Nov 22;8:84. Epub 2007 Nov 22.

Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1186/1465-9921-8-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194695PMC
November 2007

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.

Hepatology 2007 Aug;46(2):496-503

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1002/hep.21689DOI Listing
August 2007