Catherine L Worth

Catherine L Worth

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Catherine L Worth

Catherine L Worth

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The Translational Landscape of the Human Heart.

Authors:
Sebastiaan van Heesch Franziska Witte Valentin Schneider-Lunitz Jana F Schulz Eleonora Adami Allison B Faber Marieluise Kirchner Henrike Maatz Susanne Blachut Clara-Louisa Sandmann Masatoshi Kanda Catherine L Worth Sebastian Schafer Lorenzo Calviello Rhys Merriott Giannino Patone Oliver Hummel Emanuel Wyler Benedikt Obermayer Michael B Mücke Eric L Lindberg Franziska Trnka Sebastian Memczak Marcel Schilling Leanne E Felkin Paul J R Barton Nicholas M Quaife Konstantinos Vanezis Sebastian Diecke Masaya Mukai Nancy Mah Su-Jun Oh Andreas Kurtz Christoph Schramm Dorothee Schwinge Marcial Sebode Magdalena Harakalova Folkert W Asselbergs Aryan Vink Roel A de Weger Sivakumar Viswanathan Anissa A Widjaja Anna Gärtner-Rommel Hendrik Milting Cris Dos Remedios Christoph Knosalla Philipp Mertins Markus Landthaler Martin Vingron Wolfgang A Linke Jonathan G Seidman Christine E Seidman Nikolaus Rajewsky Uwe Ohler Stuart A Cook Norbert Hubner

Cell 2019 Jun 30;178(1):242-260.e29. Epub 2019 May 30.

Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.010DOI Listing
June 2019

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level.

Authors:
Jana Fischer Gunnar Kleinau Claudia Rutz Denise Zwanziger Noushafarin Khajavi Anne Müller Maren Rehders Klaudia Brix Catherine L Worth Dagmar Führer Heiko Krude Burkhard Wiesner Ralf Schülein Heike Biebermann

Cell Mol Life Sci 2018 06 30;75(12):2227-2239. Epub 2017 Dec 30.

Institut für Experimentelle Pädiatrische Endokrinologie, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.

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http://dx.doi.org/10.1007/s00018-017-2728-1DOI Listing
June 2018

Structural changes of TasA in biofilm formation of .

Authors:
Anne Diehl Yvette Roske Linda Ball Anup Chowdhury Matthias Hiller Noel Molière Regina Kramer Daniel Stöppler Catherine L Worth Brigitte Schlegel Martina Leidert Nils Cremer Natalja Erdmann Daniel Lopez Heike Stephanowitz Eberhard Krause Barth-Jan van Rossum Peter Schmieder Udo Heinemann Kürşad Turgay Ümit Akbey Hartmut Oschkinat

Proc Natl Acad Sci U S A 2018 03 12;115(13):3237-3242. Epub 2018 Mar 12.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany;

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http://dx.doi.org/10.1073/pnas.1718102115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879678PMC
March 2018

GPCR-SSFE 2.0-a fragment-based molecular modeling web tool for Class A G-protein coupled receptors.

Authors:
Catherine L Worth Franziska Kreuchwig Johanna K S Tiemann Annika Kreuchwig Michele Ritschel Gunnar Kleinau Peter W Hildebrand Gerd Krause

Nucleic Acids Res 2017 07;45(W1):W408-W415

Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), D-13125 Berlin, Germany.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkx399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570183PMC
July 2017

Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.

Authors:
Gunnar Kleinau Catherine L Worth Annika Kreuchwig Heike Biebermann Patrick Marcinkowski Patrick Scheerer Gerd Krause

Front Endocrinol (Lausanne) 2017 24;8:86. Epub 2017 Apr 24.

Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany.

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http://dx.doi.org/10.3389/fendo.2017.00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401882PMC
April 2017

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Authors:
Moritz Schütte Thomas Risch Nilofar Abdavi-Azar Karsten Boehnke Dirk Schumacher Marlen Keil Reha Yildiriman Christine Jandrasits Tatiana Borodina Vyacheslav Amstislavskiy Catherine L Worth Caroline Schweiger Sandra Liebs Martin Lange Hans-Jörg Warnatz Lee M Butcher James E Barrett Marc Sultan Christoph Wierling Nicole Golob-Schwarzl Sigurd Lax Stefan Uranitsch Michael Becker Yvonne Welte Joseph Lewis Regan Maxine Silvestrov Inge Kehler Alberto Fusi Thomas Kessler Ralf Herwig Ulf Landegren Dirk Wienke Mats Nilsson Juan A Velasco Pilar Garin-Chesa Christoph Reinhard Stephan Beck Reinhold Schäfer Christian R A Regenbrecht David Henderson Bodo Lange Johannes Haybaeck Ulrich Keilholz Jens Hoffmann Hans Lehrach Marie-Laure Yaspo

Nat Commun 2017 02 10;8:14262. Epub 2017 Feb 10.

Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany.

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http://dx.doi.org/10.1038/ncomms14262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309787PMC
February 2017

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.

Authors:
Ute Fischer Michael Forster Anna Rinaldi Thomas Risch Stéphanie Sungalee Hans-Jörg Warnatz Beat Bornhauser Michael Gombert Christina Kratsch Adrian M Stütz Marc Sultan Joelle Tchinda Catherine L Worth Vyacheslav Amstislavskiy Nandini Badarinarayan André Baruchel Thies Bartram Giuseppe Basso Cengiz Canpolat Gunnar Cario Hélène Cavé Dardane Dakaj Mauro Delorenzi Maria Pamela Dobay Cornelia Eckert Eva Ellinghaus Sabrina Eugster Viktoras Frismantas Sebastian Ginzel Oskar A Haas Olaf Heidenreich Georg Hemmrich-Stanisak Kebria Hezaveh Jessica I Höll Sabine Hornhardt Peter Husemann Priyadarshini Kachroo Christian P Kratz Geertruy Te Kronnie Blerim Marovca Felix Niggli Alice C McHardy Anthony V Moorman Renate Panzer-Grümayer Britt S Petersen Benjamin Raeder Meryem Ralser Philip Rosenstiel Daniel Schäfer Martin Schrappe Stefan Schreiber Moritz Schütte Björn Stade Ralf Thiele Nicolas von der Weid Ajay Vora Marketa Zaliova Langhui Zhang Thomas Zichner Martin Zimmermann Hans Lehrach Arndt Borkhardt Jean-Pierre Bourquin Andre Franke Jan O Korbel Martin Stanulla Marie-Laure Yaspo

Nat Genet 2015 Sep 27;47(9):1020-1029. Epub 2015 Jul 27.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1038/ng.3362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603357PMC
September 2015

Residues of a proposed gate region in type I ATP-binding cassette import systems are crucial for function as revealed by mutational analysis.

Authors:
Daniela Weidlich Nicole Wiesemann Johanna Heuveling Kristina Wardelmann Heidi Landmesser Katayoun Behnam Sani Catherine L Worth Robert Preissner Erwin Schneider

Biochim Biophys Acta 2013 Sep 6;1828(9):2164-72. Epub 2013 Jun 6.

Institut für Biologie/Bakterienphysiologie, Humboldt Universität zu Berlin, Chausseestr. 117, D-10115 Berlin, Germany.

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http://dx.doi.org/10.1016/j.bbamem.2013.05.032DOI Listing
September 2013

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Authors:
David T W Jones Barbara Hutter Natalie Jäger Andrey Korshunov Marcel Kool Hans-Jörg Warnatz Thomas Zichner Sally R Lambert Marina Ryzhova Dong Anh Khuong Quang Adam M Fontebasso Adrian M Stütz Sonja Hutter Marc Zuckermann Dominik Sturm Jan Gronych Bärbel Lasitschka Sabine Schmidt Huriye Seker-Cin Hendrik Witt Marc Sultan Meryem Ralser Paul A Northcott Volker Hovestadt Sebastian Bender Elke Pfaff Sebastian Stark Damien Faury Jeremy Schwartzentruber Jacek Majewski Ursula D Weber Marc Zapatka Benjamin Raeder Matthias Schlesner Catherine L Worth Cynthia C Bartholomae Christof von Kalle Charles D Imbusch Sylwester Radomski Chris Lawerenz Peter van Sluis Jan Koster Richard Volckmann Rogier Versteeg Hans Lehrach Camelia Monoranu Beate Winkler Andreas Unterberg Christel Herold-Mende Till Milde Andreas E Kulozik Martin Ebinger Martin U Schuhmann Yoon-Jae Cho Scott L Pomeroy Andreas von Deimling Olaf Witt Michael D Taylor Stephan Wolf Matthias A Karajannis Charles G Eberhart Wolfram Scheurlen Martin Hasselblatt Keith L Ligon Mark W Kieran Jan O Korbel Marie-Laure Yaspo Benedikt Brors Jörg Felsberg Guido Reifenberger V Peter Collins Nada Jabado Roland Eils Peter Lichter Stefan M Pfister

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:1982973/compon
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http://www.nature.com/doifinder/10.1038/ng.2682
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http://dx.doi.org/10.1038/ng.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951336PMC
August 2013

Binding sites in membrane proteins--diversity, druggability and prospects.

Authors:
Robert Adams Catherine L Worth Stefan Guenther Mathias Dunkel Robert Lehmann Robert Preissner

Eur J Cell Biol 2012 Apr 27;91(4):326-39. Epub 2011 Aug 27.

Charité-Universitätsklinikum Berlin, Structural Bioinformatics Group, Lindenberger Weg 80, 13125 Berlin, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S017193351100109
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http://dx.doi.org/10.1016/j.ejcb.2011.06.003DOI Listing
April 2012

Development of immune-specific interaction potentials and their application in the multi-agent-system VaccImm.

Authors:
Anna Lena Woelke Joachim von Eichborn Manuela S Murgueitio Catherine L Worth Filippo Castiglione Robert Preissner

PLoS One 2011 17;6(8):e23257. Epub 2011 Aug 17.

Institute for Physiology, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023257PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157361PMC
February 2012

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).

Authors:
Gunnar Kleinau Inna Hoyer Annika Kreuchwig Ann-Karin Haas Claudia Rutz Jens Furkert Catherine L Worth Gerd Krause Ralf Schülein

J Biol Chem 2011 Jul 17;286(29):25859-71. Epub 2011 May 17.

Leibniz-Institut für Molekulare Pharmakologie, 13125 Berlin, Germany.

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http://dx.doi.org/10.1074/jbc.M110.196980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138303PMC
July 2011

SDM--a server for predicting effects of mutations on protein stability and malfunction.

Authors:
Catherine L Worth Robert Preissner Tom L Blundell

Nucleic Acids Res 2011 Jul 18;39(Web Server issue):W215-22. Epub 2011 May 18.

Biochemistry Department, University of Cambridge, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1093/nar/gkr363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125769PMC
July 2011

Meet me halfway: when genomics meets structural bioinformatics.

Authors:
Sungsam Gong Catherine L Worth Tammy M K Cheng Tom L Blundell

J Cardiovasc Transl Res 2011 Jun 25;4(3):281-303. Epub 2011 Feb 25.

Biocomputing Group, Department of Biochemistry, University of Cambridge, UK.

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http://dx.doi.org/10.1007/s12265-011-9259-1DOI Listing
June 2011

GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models.

Authors:
Catherine L Worth Annika Kreuchwig Gunnar Kleinau Gerd Krause

BMC Bioinformatics 2011 May 23;12:185. Epub 2011 May 23.

Leibniz-Institut für Molekulare Pharmakologie, 13125 Berlin, Germany.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-12-185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113946PMC
May 2011

Research resource: Update and extension of a glycoprotein hormone receptors web application.

Authors:
Annika Kreuchwig Gunnar Kleinau Franziska Kreuchwig Catherine L Worth Gerd Krause

Mol Endocrinol 2011 Apr 3;25(4):707-12. Epub 2011 Feb 3.

Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1210/me.2010-0510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417262PMC
April 2011

SuperSweet--a resource on natural and artificial sweetening agents.

Authors:
Jessica Ahmed Saskia Preissner Mathias Dunkel Catherine L Worth Andreas Eckert Robert Preissner

Nucleic Acids Res 2011 Jan 14;39(Database issue):D377-82. Epub 2010 Oct 14.

Charité - Universitätsmedizin Berlin, Institute of Physiology, Structural Bioinformatics Group, Lindenberger Weg 80, 13125 Berlin, Germany.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkq917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013782PMC
January 2011

FragmentStore--a comprehensive database of fragments linking metabolites, toxic molecules and drugs.

Authors:
Jessica Ahmed Catherine L Worth Paul Thaben Christian Matzig Corinna Blasse Mathias Dunkel Robert Preissner

Nucleic Acids Res 2011 Jan 21;39(Database issue):D1049-54. Epub 2010 Oct 21.

Charité-University Medicine Berlin, Institute of Physiology, Structural Bioinformatics Group, Lindenberger Weg 80, 13125 Berlin, Germany.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkq969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013803PMC
January 2011

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.

Authors:
Gunnar Kleinau Ann-Karin Haas Susanne Neumann Catherine L Worth Inna Hoyer Jens Furkert Claudia Rutz Marvin C Gershengorn Ralf Schülein Gerd Krause

FASEB J 2010 Jul 23;24(7):2347-54. Epub 2010 Feb 23.

Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, D-13125 Berlin, Germany.

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http://www.fasebj.org/doi/10.1096/fj.09-149146
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http://dx.doi.org/10.1096/fj.09-149146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230523PMC
July 2010

An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors.

Authors:
Gunnar Kleinau Annika Kreuchwig Catherine L Worth Gerd Krause

Hum Mutat 2010 Jun;31(6):E1519-25

Leibniz-Institut für Molekulare Pharmakologie (FMP), D-13125 Berlin, Germany.

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http://doi.wiley.com/10.1002/humu.21265
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http://dx.doi.org/10.1002/humu.21265DOI Listing
June 2010

On the evolutionary conservation of hydrogen bonds made by buried polar amino acids: the hidden joists, braces and trusses of protein architecture.

Authors:
Catherine L Worth Tom L Blundell

BMC Evol Biol 2010 May 31;10:161. Epub 2010 May 31.

Biocomputing Group, Biochemistry Department, University of Cambridge, Cambridge, CB2 1GA, UK.

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http://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2148-10-161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892493PMC
May 2010

Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.

Authors:
Gunnar Kleinau Holger Jaeschke Catherine L Worth Sandra Mueller Jorge Gonzalez Ralf Paschke Gerd Krause

PLoS One 2010 Mar 18;5(3):e9745. Epub 2010 Mar 18.

Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009745PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841179PMC
March 2010

Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis.

Authors:
Julia R Forman Catherine L Worth G Richard J Bickerton Tim G Eisen Tom L Blundell

Proteins 2009 Oct;77(1):84-96

Biocomputing Group, Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1002/prot.22419DOI Listing
October 2009

Structural and functional constraints in the evolution of protein families.

Authors:
Catherine L Worth Sungsam Gong Tom L Blundell

Nat Rev Mol Cell Biol 2009 Oct 16;10(10):709-20. Epub 2009 Sep 16.

Biochemistry Department, University of Cambridge, UK.

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http://dx.doi.org/10.1038/nrm2762DOI Listing
October 2009

Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.

Authors:
Catherine L Worth Gunnar Kleinau Gerd Krause

PLoS One 2009 Sep 16;4(9):e7011. Epub 2009 Sep 16.

Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007011PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738427PMC
September 2009

Structural and functional restraints in the evolution of protein families and superfamilies.

Authors:
Sungsam Gong Catherine L Worth G Richard J Bickerton Semin Lee Duangrudee Tanramluk Tom L Blundell

Biochem Soc Trans 2009 Aug;37(Pt 4):727-33

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST0370727
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http://dx.doi.org/10.1042/BST0370727DOI Listing
August 2009

Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains.

Authors:
Catherine L Worth Tom L Blundell

Proteins 2009 May;75(2):413-29

Biochemistry Department, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/prot.22248DOI Listing
May 2009

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

Authors:
Brian J Ferguson Clare Alexander Simona W Rossi Ingrid Liiv Ana Rebane Catherine L Worth Joyce Wong Martti Laan Pärt Peterson Eric J Jenkinson Graham Anderson Hamish S Scott Anne Cooke Tina Rich

J Biol Chem 2008 Jan 1;283(3):1723-31. Epub 2007 Nov 1.

Department of Pathology, Divisions of Immunology and Cellular Pathology, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M707211200DOI Listing
January 2008

A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease.

Authors:
Catherine L Worth G Richard J Bickerton Adrian Schreyer Julia R Forman Tammy M K Cheng Semin Lee Sungsam Gong David F Burke Tom L Blundell

J Bioinform Comput Biol 2007 Dec;5(6):1297-318

Biocomputing Group, Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1142/s0219720007003120DOI Listing
December 2007

Genome bioinformatic analysis of nonsynonymous SNPs.

Authors:
David F Burke Catherine L Worth Eva-Maria Priego Tammy Cheng Luc J Smink John A Todd Tom L Blundell

BMC Bioinformatics 2007 Aug 20;8:301. Epub 2007 Aug 20.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.

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http://dx.doi.org/10.1186/1471-2105-8-301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978506PMC
August 2007

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

Authors:
Tom L Blundell Bancinyane L Sibanda Rinaldo Wander Montalvão Suzanne Brewerton Vijayalakshmi Chelliah Catherine L Worth Nicholas J Harmer Owen Davies David Burke

Philos Trans R Soc Lond B Biol Sci 2006 Mar;361(1467):413-23

Department of Biochemistry, University of Cambridge 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1098/rstb.2005.1800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609333PMC
March 2006

PDBLIG: classification of small molecular protein binding in the Protein Data Bank.

Authors:
Andrew J Chalk Catherine L Worth John P Overington A W Edith Chan

J Med Chem 2004 Jul;47(15):3807-16

Department of Molecular Design, Inpharmatica, 60 Charlotte Street, London W1T 2NU, U.K.

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http://dx.doi.org/10.1021/jm040804fDOI Listing
July 2004