Catherijne A J Knibbe

Catherijne A J Knibbe

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Catherijne A J Knibbe

Publications by authors named "Catherijne A J Knibbe"

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Rapidly maturing fentanyl clearance in preterm neonates.

Arch Dis Child Fetal Neonatal Ed 2019 Nov 1;104(6):F598-F603. Epub 2019 Feb 1.

Division of Pharmacology, Division Systems Pharmacology and Biomedicine, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2018-315920DOI Listing
November 2019

Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model.

J Clin Pharmacol 2019 Oct 15;59(10):1300-1308. Epub 2019 May 15.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/jcph.1429DOI Listing
October 2019

Pharmacokinetics and Pharmacodynamics of Drugs in Obese Pediatric Patients: How to Map Uncharted Clinical Territories.

Handb Exp Pharmacol 2019 Oct 10. Epub 2019 Oct 10.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/164_2019_250DOI Listing
October 2019

Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing.

Crit Care Med 2019 Oct 14. Epub 2019 Oct 14.

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000004032DOI Listing
October 2019

Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms.

CPT Pharmacometrics Syst Pharmacol 2019 Oct 15. Epub 2019 Oct 15.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12469DOI Listing
October 2019

Fixed Dosing of Liposomal Amphotericin B in Morbidly Obese Individuals.

Clin Infect Dis 2019 Sep 7. Epub 2019 Sep 7.

Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1093/cid/ciz885DOI Listing
September 2019

Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus.

Clin Pharmacokinet 2019 Aug 21. Epub 2019 Aug 21.

Pediatric Intensive Care Unit, Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-019-00811-yDOI Listing
August 2019

Big Data Analyses for Continuous Evaluation of Pharmacotherapy: A Proof of Principle with Doxapram in Preterm Infants.

Curr Pharm Des 2017 ;23(38):5919-5927

Department of Pediatrics, Division of Neonatology, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, Netherlands.

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http://dx.doi.org/10.2174/1381612823666170918121556DOI Listing
June 2019

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.

AAPS J 2019 Jun 27;21(5):81. Epub 2019 Jun 27.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-019-0351-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597607PMC
June 2019

Asthma medication in children who are overweight/obese: justified treatment?

BMC Pediatr 2019 May 11;19(1):148. Epub 2019 May 11.

Department of Pediatrics, St Antonius Hospital, P.O. Box 2500 3430, EM, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1186/s12887-019-1526-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511208PMC
May 2019

Pharmacokinetics and probability of target attainment for micafungin in normal-weight and morbidly obese adults.

J Antimicrob Chemother 2019 Apr;74(4):978-985

Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/jac/dky554DOI Listing
April 2019

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method.

AAPS J 2019 Mar 8;21(3):38. Epub 2019 Mar 8.

Division Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-019-0295-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505506PMC
March 2019

Increased Arterial Stiffness in Adolescents With Obesity.

Glob Pediatr Health 2019 25;6:2333794X19831297. Epub 2019 Feb 25.

St. Antonius Hospital, Nieuwegein, Netherlands.

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http://dx.doi.org/10.1177/2333794X19831297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390226PMC
February 2019

Predictors of Insulin Resistance in Children versus Adolescents with Obesity.

J Obes 2017 10;2017:3793868. Epub 2017 Dec 10.

Department of Pediatrics, St. Antonius Hospital, Nieuwegein/Utrecht, Postbus 2500, 3430 EM Nieuwegein, Netherlands.

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http://dx.doi.org/10.1155/2017/3793868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742469PMC
January 2019

The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models.

Clin Pharmacokinet 2019 01;58(1):131-138

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s40262-018-0652-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325985PMC
January 2019

Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial.

Eur J Anaesthesiol 2019 01;36(1):32-39

From the Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein (SdH, CAJK), Intensive Care and Department of Paediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam (AJV, DT, CAJK), Department of Anaesthesiology and Intensive Care (EPAvD), Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein (EJD), Department of Biostatistics, Erasmus MC, Rotterdam (JvR), Department of Anaesthesiology, Leiden University Medical Centre (AD) and Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (CAJK).

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http://dx.doi.org/10.1097/EJA.0000000000000887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286874PMC
January 2019

Skin autofluorescence in children with and without obesity.

J Pediatr Endocrinol Metab 2019 Jan;32(1):41-47

Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1515/jpem-2018-0237DOI Listing
January 2019

Children Are Not Small Adults, but Can We Treat Them As Such?

CPT Pharmacometrics Syst Pharmacol 2019 Jan 28;8(1):34-38. Epub 2019 Jan 28.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Center of Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363065PMC
January 2019

Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

Eur J Clin Pharmacol 2018 Dec 28;74(12):1585-1591. Epub 2018 Jul 28.

Department of Pediatrics, Division of Neonatology, Erasmus University Medical Center - Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00228-018-2529-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244763PMC
December 2018

Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools.

AAPS J 2018 12 18;21(1):11. Epub 2018 Dec 18.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Room number 0.2.11, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-018-0278-6DOI Listing
December 2018

Psychostimulants: Influence on Body Mass Index and Height in a Pediatric Population with Attention-Deficit/Hyperactivity Disorder?

J Child Adolesc Psychopharmacol 2018 10 16;28(8):530-536. Epub 2018 May 16.

1 Department of Pediatrics, St. Antonius Hospital , Nieuwegein, The Netherlands .

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http://dx.doi.org/10.1089/cap.2017.0163DOI Listing
October 2018

Author's Reply to Reith: "Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults".

Clin Pharmacokinet 2018 10;57(10):1357-1358

Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1007/s40262-018-0692-zDOI Listing
October 2018

Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory.

Pharm Res 2018 Sep 14;35(11):209. Epub 2018 Sep 14.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Gorlaeus Laboratories, Leiden University, Einstein weg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11095-018-2487-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156772PMC
September 2018

Author's Reply to Reith: "Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen".

Clin Pharmacokinet 2018 07;57(7):897-899

Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1007/s40262-018-0665-2DOI Listing
July 2018

First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

CPT Pharmacometrics Syst Pharmacol 2018 06 10;7(6):374-383. Epub 2018 May 10.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/psp4.12295
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http://dx.doi.org/10.1002/psp4.12295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027733PMC
June 2018

Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients.

Expert Opin Drug Metab Toxicol 2018 Apr 11;14(4):417-428. Epub 2018 Apr 11.

a Intensive Care and Department of Pediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/17425255.2018.1
Publisher Site
http://dx.doi.org/10.1080/17425255.2018.1461836DOI Listing
April 2018

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.

CPT Pharmacometrics Syst Pharmacol 2018 03 5;7(3):175-185. Epub 2018 Feb 5.

Division Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869561PMC
March 2018

Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters.

Expert Opin Drug Metab Toxicol 2018 Mar 15;14(3):275-285. Epub 2018 Feb 15.

a Department of Clinical Pharmacy , St. Antonius Hospital , Nieuwegein , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/17425255.2018.1
Publisher Site
http://dx.doi.org/10.1080/17425255.2018.1440287DOI Listing
March 2018

Amikacin Pharmacokinetics To Optimize Dosing in Neonates with Perinatal Asphyxia Treated with Hypothermia.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Intensive Care, Department of Pediatric Surgery, and Department of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands

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http://dx.doi.org/10.1128/AAC.01282-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700363PMC
December 2017

Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies.

Pediatr Clin North Am 2017 12;64(6):1417-1438

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229-3039, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pcl.2017.08.011DOI Listing
December 2017

Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine.

Eur J Pharm Sci 2017 Nov 11;109S:S15-S21. Epub 2017 May 11.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.018DOI Listing
November 2017

Evidence-based drug treatment for special patient populations through model-based approaches.

Eur J Pharm Sci 2017 Nov 11;109S:S22-S26. Epub 2017 May 11.

Leiden Academic Center for Drug Research, Systems Pharmacology Cluster, Division of Pharmacology, Leiden University, Leiden, The Netherlands; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1016/j.ejps.2017.05.022DOI Listing
November 2017

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

Eur J Pharm Sci 2017 Nov 12;109S:S32-S38. Epub 2017 May 12.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.027DOI Listing
November 2017

Model-based clinical dose optimization for phenobarbital in neonates: An illustration of the importance of data sharing and external validation.

Eur J Pharm Sci 2017 Nov 12;109S:S90-S97. Epub 2017 May 12.

Division of Pharmacology, Leiden Academic Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC Leiden, The Netherlands; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1016/j.ejps.2017.05.026DOI Listing
November 2017

Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models.

AAPS J 2017 11 27;20(1). Epub 2017 Nov 27.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-017-0162-9DOI Listing
November 2017

Infants Operated on for Necrotizing Enterocolitis: Towards Evidence-Based Pain Guidelines.

Neonatology 2016 20;110(3):190-7. Epub 2016 May 20.

Division of Neonatology, Department of Pediatrics, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1159/000445284DOI Listing
October 2017

Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants.

Pediatr Res 2017 Oct 21;82(4):678-684. Epub 2017 Jun 21.

Department of Pediatrics, Division of Neonatology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/pr.2017.129DOI Listing
October 2017

Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics.

Br J Clin Pharmacol 2017 Sep 14;83(9):1966-1975. Epub 2017 May 14.

Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/bcp.13311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555864PMC
September 2017

Augmented Renal Clearance in Critically Ill Pediatric Patients: Does It Impact the Outcome of Pharmacotherapy?

Pediatr Crit Care Med 2017 09;18(9):901-902

Division of Clinical Pharmacology, Children's National Health System, Washington, DC Paediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, the Netherlands Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1097/PCC.0000000000001264DOI Listing
September 2017

Dose evaluation of lamivudine in human immunodeficiency virus-infected children aged 5 months to 18 years based on a population pharmacokinetic analysis.

Br J Clin Pharmacol 2017 06 14;83(6):1287-1297. Epub 2017 Feb 14.

Department of Pharmacy & Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1111/bcp.13227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427247PMC
June 2017

Pharmacological sedation management in the paediatric intensive care unit.

J Pharm Pharmacol 2017 May 21;69(5):498-513. Epub 2016 Aug 21.

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/jphp.12630DOI Listing
May 2017

Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a multicentre, retrospective, pharmacodynamic cohort analysis.

Lancet Haematol 2017 Apr 16;4(4):e183-e191. Epub 2017 Mar 16.

Paediatric Blood and Marrow Transplant Program, University Medical Centre Utrecht, Utrecht, Netherlands; Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(17)30029-7DOI Listing
April 2017

Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

Clin Pharmacokinet 2017 03;56(3):273-285

Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Gorlaeus Laboratories, Einsteinweg, 552333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s40262-016-0436-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315734PMC
March 2017

Paracetamol and morphine for infant and neonatal pain; still a long way to go?

Expert Rev Clin Pharmacol 2017 Jan 9;10(1):111-126. Epub 2016 Nov 9.

a Intensive Care and department of Pediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , the Netherlands.

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http://dx.doi.org/10.1080/17512433.2017.1254040DOI Listing
January 2017

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Metabolomics 2017 19;13(1). Epub 2016 Dec 19.

Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-016-1143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165030PMC
December 2016

Pharmacodynamics and Pharmacokinetics of Morphine After Cardiac Surgery in Children With and Without Down Syndrome.

Pediatr Crit Care Med 2016 10;17(10):930-938

1Intensive Care and Department of Pediatric Surgery, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.2Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.3Department of Anesthesia and Critical Care Medicine, Our Lady's Children's Hospital, Dublin, Ireland.4Department of Pharmacy, Academic Medical Center, Amsterdam, The Netherlands.5Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.

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http://pdfs.journals.lww.com/pccmjournal/2016/10000/Pharmaco
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http://dx.doi.org/10.1097/PCC.0000000000000904DOI Listing
October 2016

Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling.

Expert Rev Clin Pharmacol 2016 Sep 27;9(9):1235-44. Epub 2016 Jun 27.

a Division of Pharmacology, Leiden Academic Centre for Drug Research , Leiden University , Leiden , The Netherlands.

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http://dx.doi.org/10.1080/17512433.2016.1198256DOI Listing
September 2016

Is Intraoperative Remifentanil Associated With Acute or Chronic Postoperative Pain After Prolonged Surgery? An Update of the Literature.

Clin J Pain 2016 08;32(8):726-35

Departments of *Clinical Pharmacy †Anesthesiology and Intensive Care, St Antonius Hospital, Nieuwegein ‡Department of Anesthesiology, Leiden University Medical Center ∥Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden §Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/AJP.0000000000000317DOI Listing
August 2016

Pain and distress caused by endotracheal suctioning in neonates is better quantified by behavioural than physiological items: a comparison based on item response theory modelling.

Pain 2016 08;157(8):1611-7

aDivision of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands bIntensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands cDepartment of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands dTrillium Health Partners, Mississauga, ON, Canada eDepartment of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, the Netherlands.

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http://dx.doi.org/10.1097/j.pain.0000000000000485DOI Listing
August 2016

Pediatric pharmacology: current efforts and future goals to improve clinical practice.

Expert Opin Drug Metab Toxicol 2015 13;11(11):1679-82. Epub 2015 Jul 13.

a 1 Leiden University, Leiden Academic Center for Drug Research, Division of Pharmacology , Leiden, The Netherlands.

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http://dx.doi.org/10.1517/17425255.2015.1065815DOI Listing
June 2016

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics.

Clin Pharmacokinet 2016 May;55(5):507-24

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Room Sp-3458, Wytemaweg 80, PO-box 2060, 3000 CB, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-015-0328-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823323PMC
May 2016

Increasing trends in the incidence and prevalence rates of type 1 diabetes among children and adolescents in the Netherlands.

Pediatr Diabetes 2016 Feb 7;17(1):44-52. Epub 2014 Nov 7.

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, Netherlands.

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http://dx.doi.org/10.1111/pedi.12232DOI Listing
February 2016

A randomized controlled trial of daily sedation interruption in critically ill children.

Intensive Care Med 2016 Feb 24;42(2):233-44. Epub 2015 Nov 24.

Intensive Care, Erasmus MC - Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00134-015-4136-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726735PMC
February 2016

Towards Rational Dosing Algorithms for Vancomycin in Neonates and Infants Based on Population Pharmacokinetic Modeling.

Antimicrob Agents Chemother 2016 Feb 7;60(2):1013-21. Epub 2015 Dec 7.

Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, the Netherlands

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http://dx.doi.org/10.1128/AAC.01968-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750654PMC
February 2016

Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.

Br J Clin Pharmacol 2015 Nov 10;80(5):1185-96. Epub 2015 Sep 10.

Division of Clinical Pharmacology, Children's National Medical Center, Washington DC, USA.

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http://dx.doi.org/10.1111/bcp.12693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631191PMC
November 2015

Morphine Glucuronidation and Elimination in Intensive Care Patients: A Comparison with Healthy Volunteers.

Anesth Analg 2015 Nov;121(5):1261-73

From the *Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands; †Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden, The Netherlands; ‡Department of Anaesthesiology, Intensive Care and Pain Management, Nieuwegein, The Netherlands; §Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands; and ∥Intensive Care and Department of Pediatric Surgery, Erasmus Medical Centre, Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1213/ANE.0000000000000936DOI Listing
November 2015

Paracetamol pharmacokinetics and metabolism in young women.

BMC Anesthesiol 2015 Nov 13;15:163. Epub 2015 Nov 13.

Department of Clinical Pharmacy, St Antonius hospital, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1186/s12871-015-0144-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644344PMC
November 2015

Drug disposition in obesity: toward evidence-based dosing.

Annu Rev Pharmacol Toxicol 2015 17;55:149-67. Epub 2014 Oct 17.

Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden, The Netherlands; email:

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http://www.annualreviews.org/doi/10.1146/annurev-pharmtox-01
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http://dx.doi.org/10.1146/annurev-pharmtox-010814-124354DOI Listing
September 2015

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants.

Eur J Clin Pharmacol 2015 Sep 3;71(9):1075-82. Epub 2015 Jul 3.

Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00228-015-1887-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532713PMC
September 2015

Chronic comorbidities in children with type 1 diabetes: a population-based cohort study.

Arch Dis Child 2015 Aug 15;100(8):763-8. Epub 2015 Apr 15.

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2014-307654DOI Listing
August 2015

Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates.

J Antimicrob Chemother 2015 Jul 12;70(7):2074-7. Epub 2015 Mar 12.

Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands

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http://dx.doi.org/10.1093/jac/dkv052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472325PMC
July 2015

Why do children decide not to participate in clinical research: a quantitative and qualitative study.

Pediatr Res 2015 Jul 9;78(1):103-8. Epub 2015 Apr 9.

Department of Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/pr.2015.74DOI Listing
July 2015

Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis.

Lancet Haematol 2015 May 21;2(5):e194-203. Epub 2015 Apr 21.

Paediatric Blood and Marrow Transplant Program, University Medical Center Utrecht, Utrecht, Netherlands; U-DANCE, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(15)00045-9DOI Listing
May 2015

Population pharmacodynamic model for low molecular weight heparin nadroparin in morbidly obese and non-obese patients using anti-Xa levels as endpoint.

Eur J Clin Pharmacol 2015 Jan 12;71(1):25-34. Epub 2014 Oct 12.

Department of Clinical Pharmacy, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1007/s00228-014-1760-4DOI Listing
January 2015

Vancomycin pharmacokinetic models: informing the clinical management of drug-resistant bacterial infections.

Expert Rev Anti Infect Ther 2014 Nov;12(11):1371-88

Department of Pediatrics, Division of Clinical Pharmacology, University of Utah School of Medicine, 295 Chipeta Way, Salt Lake City, Utah 84108, USA.

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http://dx.doi.org/10.1586/14787210.2014.966081DOI Listing
November 2014

Population-based cohort study of anti-infective medication use before and after the onset of type 1 diabetes in children and adolescents.

Antimicrob Agents Chemother 2014 Aug 2;58(8):4666-74. Epub 2014 Jun 2.

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands

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http://dx.doi.org/10.1128/AAC.03080-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136045PMC
August 2014

Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates.

Ther Drug Monit 2014 Jun;36(3):278-87

*Division of Pharmacology, LACDR, Leiden University, Leiden, the Netherlands; †Neonatal Intensive Care Unit; ‡Centre for Clinical Pharmacology, University Hospitals Leuven, Leuven, Belgium; and §Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, the Netherlands.

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http://dx.doi.org/10.1097/FTD.0000000000000003DOI Listing
June 2014

Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults.

J Clin Pharmacol 2014 Jun 23;54(6):619-29. Epub 2014 Jan 23.

Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands; Erasmus MC Sophia Children's Hospital, Intensive Care and Department of Paediatric Intensive Care, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/jcph.259
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June 2014

Evidence-based morphine dosing for postoperative neonates and infants.

Clin Pharmacokinet 2014 Jun;53(6):553-63

Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://link.springer.com/content/pdf/10.1007/s40262-014-0135
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June 2014

How to screen obese children at risk for type 2 diabetes mellitus?

Clin Pediatr (Phila) 2014 Apr 14;53(4):337-42. Epub 2013 Nov 14.

1St. Antonius Hospital, Nieuwegein, Netherlands.

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http://dx.doi.org/10.1177/0009922813509480DOI Listing
April 2014

Towards evidence-based dosing regimens in children on the basis of population pharmacokinetic pharmacodynamic modelling.

Arch Dis Child 2014 Mar 19;99(3):267-72. Epub 2013 Dec 19.

Department of Paediatric Immunology, University Medical Centre Utrecht, , Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2013-303721DOI Listing
March 2014

Daily interruption of sedation in critically ill children: study protocol for a randomized controlled trial.

Trials 2014 Feb 13;15:55. Epub 2014 Feb 13.

Intensive Care, Erasmus MC - Sophia Children's Hospital, Dr, Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/1745-6215-15-55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928607PMC
February 2014