Catharine West

Catharine West

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Catharine West

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Dynamics of circulating vascular endothelial growth factor-A predict benefit from antiangiogenic cediranib in metastatic or recurrent cervical cancer patients.

Br J Clin Pharmacol 2019 Aug 13;85(8):1781-1789. Epub 2019 Apr 13.

Division of Cancer Sciences, University of Manchester, Christie Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1111/bcp.13965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624436PMC
August 2019

The implications of genetic testing on radiotherapy decisions: a guide for radiation oncologists.

Int J Radiat Oncol Biol Phys 2019 Aug 2. Epub 2019 Aug 2.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 1202, Houston, TX, 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2019.07.026DOI Listing
August 2019

Guidelines for using sigQC for systematic evaluation of gene signatures.

Nat Protoc 2019 05 10;14(5):1377-1400. Epub 2019 Apr 10.

Computational Biology and Integrative Genomics Lab, MRC/CRUK Oxford Institute and Department of Oncology, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/s41596-019-0136-8
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http://dx.doi.org/10.1038/s41596-019-0136-8DOI Listing
May 2019

Correction: Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts.

Oncotarget 2019 03 8;10(20):2007. Epub 2019 Mar 8.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, UK.

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http://www.oncotarget.com/fulltext/26783
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http://dx.doi.org/10.18632/oncotarget.26783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443018PMC
March 2019

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2019 02;51(2):363

Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0330-6
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http://dx.doi.org/10.1038/s41588-018-0330-6DOI Listing
February 2019

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.

Cancer Epidemiol Biomarkers Prev 2019 Jan 23;28(1):208-216. Epub 2018 Oct 23.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0079DOI Listing
January 2019

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Nat Commun 2019 01 17;10(1):382. Epub 2019 Jan 17.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA.

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http://dx.doi.org/10.1038/s41467-019-08293-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336778PMC
January 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Radiation biology and oncology in the genomic era.

Br J Radiol 2018 Nov 14;91(1091):20170949. Epub 2018 Jun 14.

6 Departments of Radiation Oncology, Genetics and Genomic Sciences, and Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY , USA.

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http://dx.doi.org/10.1259/bjr.20170949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475928PMC
November 2018

Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Nat Commun 2018 11 5;9(1):4616. Epub 2018 Nov 5.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA.

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http://www.nature.com/articles/s41467-018-06863-1
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http://dx.doi.org/10.1038/s41467-018-06863-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218483PMC
November 2018

Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology.

Radiology 2018 09 5;288(3):739-747. Epub 2018 Jun 5.

From the Centre for Imaging Sciences (R.A.L., J.H.N., Y.W., S.C., K.F.H., H.L., D.J.M., G.J.M.P., J.C.W.) and Division of Cancer Sciences (J.I., C.M.L.W., N.W.C., J.P.B.O.), University of Manchester, Manchester, England; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, England (Y.J., J.K.R.B., S.P.R.); Department of Pathology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, England (G.N.B.); Department of Histology, CRUK Manchester Institute, Manchester, England (G.A.); Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, England (A.R.R.); Department of Urology, Salford Royal Hospitals NHS Foundation Trust, Salford, England (S.M., N.W.C.); Bioxydyn Ltd, Manchester, England (G.J.M.P., J.C.W.); and Department of Radiology, The Christie NHS Foundation Trust, Manchester, England (J.P.B.O.).

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http://dx.doi.org/10.1148/radiol.2018171531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122194PMC
September 2018

Radiogenomic Predictors of Adverse Effects following Charged Particle Therapy.

Int J Part Ther 2018 21;5(1):103-113. Epub 2018 Sep 21.

Department of Radiation Oncology and Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.14338/IJPT-18-00009.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261418PMC
September 2018

Prospective evaluation of relationships between radiotherapy dose to masticatory apparatus and trismus.

Acta Oncol 2018 Aug 9;57(8):1038-1042. Epub 2018 Apr 9.

a Department of Head and Neck Clinical Oncology , The Christie NHS Foundation Trust , Manchester , UK.

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http://dx.doi.org/10.1080/0284186X.2018.1459047DOI Listing
August 2018

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2018 07 11;50(7):928-936. Epub 2018 Jun 11.

Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0142-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568012PMC
July 2018

Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study.

Int J Radiat Oncol Biol Phys 2018 07 11;101(4):957-963. Epub 2018 Apr 11.

The University of Manchester and Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2018.04.009DOI Listing
July 2018

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Authors:
Tokhir Dadaev Edward J Saunders Paul J Newcombe Ezequiel Anokian Daniel A Leongamornlert Mark N Brook Clara Cieza-Borrella Martina Mijuskovic Sarah Wakerell Ali Amin Al Olama Fredrick R Schumacher Sonja I Berndt Sara Benlloch Mahbubl Ahmed Chee Goh Xin Sheng Zhuo Zhang Kenneth Muir Koveela Govindasami Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Hakansson Catharine West Alison M Dunning Neil Burnet Lorelei Mucci Edward Giovannucci Gerald Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry Rosenstein Sarah Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Laura Fachal Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weisher Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Chavdar Slavov Vanio Mitev Matthew Parliament Sandeep Singhal Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Andrzej Kierzek Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Peter Kraft Matthew Freedman Fredrik Wiklund Stephen Chanock Brian E Henderson Douglas F Easton Christopher A Haiman Rosalind A Eeles David V Conti Zsofia Kote-Jarai

Nat Commun 2018 06 11;9(1):2256. Epub 2018 Jun 11.

The Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1038/s41467-018-04109-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995836PMC
June 2018

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

EBioMedicine 2018 May 23;31:182-189. Epub 2018 Apr 23.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester M20 4BX, UK; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014579PMC
May 2018

The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma.

Br J Cancer 2018 03 12;118(5):698-704. Epub 2017 Dec 12.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1038/bjc.2017.430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846059PMC
March 2018

Hypoxia gene expression signatures as predictive biomarkers for personalising radiotherapy.

Br J Radiol 2018 Mar 20:20180036. Epub 2018 Mar 20.

1 Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Foundation Trust , Manchester , UK.

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http://dx.doi.org/10.1259/bjr.20180036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435086PMC
March 2018

Taxane, platinum and 5-FU prior to chemoradiotherapy benefits patients with stage IV neck node-positive head and neck cancer and a good performance status.

J Cancer Res Clin Oncol 2018 Feb 8;144(2):389-401. Epub 2017 Dec 8.

Translational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, The Christie NHS Foundation Trust, University of Manchester, Wilmslow Road, Manchester, England, M20 4BX, UK.

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http://dx.doi.org/10.1007/s00432-017-2553-9DOI Listing
February 2018

Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome.

J Natl Cancer Inst 2018 01;110(1)

Division of Cancer Sciences and Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK; Department of Radiation Oncology (MAASTRO Lab), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands.

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http://dx.doi.org/10.1093/jnci/djx160DOI Listing
January 2018

Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts.

Oncotarget 2018 Jan 12;9(3):3946-3955. Epub 2017 Dec 12.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, UK.

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http://dx.doi.org/10.18632/oncotarget.23280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790513PMC
January 2018

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients.

Clin Cancer Res 2017 Aug 11;23(16):4761-4768. Epub 2017 Apr 11.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0038DOI Listing
August 2017

Radiogenomics and radiotherapy response modeling.

Phys Med Biol 2017 Aug 1;62(16):R179-R206. Epub 2017 Aug 1.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States of America.

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http://dx.doi.org/10.1088/1361-6560/aa7c55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557376PMC
August 2017

Ionizing radiation biomarkers in epidemiological studies - An update.

Mutat Res 2017 Jan - Mar;771:59-84. Epub 2017 Jan 16.

Barcelona Institute of Global Health (ISGlobal), Centre for Research in Environmental Epidemiology, Radiation Programme, Barcelona Biomedical Research Park, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF) (MTD formerly), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2017.01.001DOI Listing
May 2017

The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant K in cervical cancer is explained by plasma flow rather than vessel permeability.

Br J Cancer 2017 May 27;116(11):1436-1443. Epub 2017 Apr 27.

Division of Molecular and Clinical Cancer Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1038/bjc.2017.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520098PMC
May 2017

Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic.

Oncotarget 2017 Feb;8(9):14416-14427

Translational Radiobiology Group, Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Trust, Manchester, UK.

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http://dx.doi.org/10.18632/oncotarget.14796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362415PMC
February 2017

Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?

Cancer Lett 2016 11 2;382(1):95-109. Epub 2016 Mar 2.

Institute of Cancer Sciences, University of Manchester, Christie Hospital, Manchester, UK.

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http://dx.doi.org/10.1016/j.canlet.2016.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016239PMC
November 2016

Improved accuracy and precision of tracer kinetic parameters by joint fitting to variable flip angle and dynamic contrast enhanced MRI data.

Magn Reson Med 2016 10 19;76(4):1270-81. Epub 2015 Oct 19.

Centre for Imaging Sciences, Institute of Population Health, Centre for Imaging Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/mrm.26013DOI Listing
October 2016

Patients with a High Polygenic Risk of Breast Cancer do not have An Increased Risk of Radiotherapy Toxicity.

Clin Cancer Res 2016 Mar 28;22(6):1413-20. Epub 2015 Oct 28.

Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751620PMC
March 2016

Tumor plasma flow determined by dynamic contrast-enhanced MRI predicts response to induction chemotherapy in head and neck cancer.

Oral Oncol 2015 May 18;51(5):508-13. Epub 2015 Feb 18.

Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.oraloncology.2015.01.013DOI Listing
May 2015

Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.

Laryngoscope 2015 Jan 17;125(1):E8-15. Epub 2014 Sep 17.

University Department of Otolaryngology-Head & Neck Surgery, Manchester Royal Infirmary and Manchester Academic Health Science Centre; Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester.

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http://dx.doi.org/10.1002/lary.24933DOI Listing
January 2015

Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: potential to guide treatment? A systematic review.

Oral Oncol 2014 Oct 10;50(10):963-70. Epub 2014 Aug 10.

Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Wilmslow Road, Withington, Manchester M20 4BX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2014.07.011DOI Listing
October 2014

A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1.

Nat Genet 2014 Aug 29;46(8):891-4. Epub 2014 Jun 29.

1] Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Spain. [2] Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.

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http://dx.doi.org/10.1038/ng.3020DOI Listing
August 2014

FGFR2, HER2 and cMet in gastric adenocarcinoma: detection, prognostic significance and assessment of downstream pathway activation.

Virchows Arch 2014 Feb 4;464(2):145-56. Epub 2013 Dec 4.

Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK,

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http://dx.doi.org/10.1007/s00428-013-1517-yDOI Listing
February 2014

Phase II Trial of Cetuximab and Conformal Radiotherapy Only in Locally Advanced Pancreatic Cancer with Concurrent Tissue Sampling Feasibility Study.

Transl Oncol 2014 Feb 1;7(1):55-64. Epub 2014 Feb 1.

Academic Department of Radiation Oncology, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom ; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998695PMC
http://dx.doi.org/10.1593/tlo.13724DOI Listing
February 2014

Molecular and cellular processes underlying the hallmarks of head and neck cancer.

Eur Arch Otorhinolaryngol 2013 Sep 23;270(10):2585-93. Epub 2012 Dec 23.

University Department of Otolaryngology-Head and Neck Surgery, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK.

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http://dx.doi.org/10.1007/s00405-012-2323-xDOI Listing
September 2013

Necrosis predicts benefit from hypoxia-modifying therapy in patients with high risk bladder cancer enrolled in a phase III randomised trial.

Radiother Oncol 2013 Jul 14;108(1):40-7. Epub 2013 Jun 14.

Translational Radiobiology Group, Institute of Cancer Sciences, The University of Manchester, Manchester Academic Health Centre, Christie Hospital, Manchester, UK.

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http://dx.doi.org/10.1016/j.radonc.2013.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885794PMC
July 2013

The case for including bowel urgency in toxicity reporting after pelvic cancer treatment.

J Natl Compr Canc Netw 2013 Jul;11(7):827-33

Department of aRadiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, United Kingdom.

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July 2013

An in vivo hypoxia metagene identifies the novel hypoxia inducible factor target gene SLCO1B3.

Eur J Cancer 2013 May 23;49(7):1741-51. Epub 2013 Jan 23.

Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1016/j.ejca.2012.12.003DOI Listing
May 2013

Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity.

Int J Radiat Oncol Biol Phys 2013 Apr 17;85(5):e223-9. Epub 2013 Jan 17.

Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2012.11.030DOI Listing
April 2013

Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.

Eur J Cancer 2013 Jan 27;49(1):156-65. Epub 2012 Aug 27.

Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, Wilmslow Road, Manchester M20 4BX, United Kingdom.

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http://dx.doi.org/10.1016/j.ejca.2012.07.028DOI Listing
January 2013

FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder.

J Biophotonics 2013 Jan 2;6(1):73-87. Epub 2012 Nov 2.

Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/jbio.201200126DOI Listing
January 2013

Lysyl oxidase: from basic science to future cancer treatment.

Cell Struct Funct 2012 ;37(1):75-80

Department of Biomedical Sciences and Engineering, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

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June 2012

Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.

J Proteome Res 2012 Apr 12;11(4):2103-13. Epub 2012 Mar 12.

Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom.

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http://pubs.acs.org/doi/10.1021/pr200636x
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http://dx.doi.org/10.1021/pr200636xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320746PMC
April 2012

Genome-wide association studies and prediction of normal tissue toxicity.

Semin Radiat Oncol 2012 Apr;22(2):91-9

The University of Manchester, The Christie Foundation Trust, Withington, Manchester, UK.

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http://dx.doi.org/10.1016/j.semradonc.2011.12.007DOI Listing
April 2012

Osteoradionecrosis in head-and-neck cancer has a distinct genotype-dependent cause.

Int J Radiat Oncol Biol Phys 2012 Mar 25;82(4):1479-84. Epub 2011 Jun 25.

Head and Neck Unit, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/j.ijrobp.2011.05.016DOI Listing
March 2012

Genetics and genomics of radiotherapy toxicity: towards prediction.

Genome Med 2011 Aug 23;3(8):52. Epub 2011 Aug 23.

School of Cancer and Enabling Sciences, The University of Manchester, Manchester Academic Health Science Centre, The Christie, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1186/gm268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238178PMC
August 2011

Use of multiple biological markers in radiotherapy-treated head and neck cancer.

J Laryngol Otol 2010 Jun 14;124(6):650-8. Epub 2010 Apr 14.

School of Cancer & Enabling Sciences, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1017/S0022215110000228DOI Listing
June 2010

hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer.

Cancer 2010 May;116(9):2148-58

Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/cncr.25009DOI Listing
May 2010

Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning.

World J Gastrointest Oncol 2010 Apr;2(4):197-204

Karim Sillah, Ian M Welch, Department of Gastrointestinal Surgery, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, United Kingdom.

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http://dx.doi.org/10.4251/wjgo.v2.i4.197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999183PMC
April 2010

Establishment of a radiogenomics consortium.

Radiother Oncol 2010 Jan 13;94(1):117-8. Epub 2010 Jan 13.

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http://dx.doi.org/10.1016/j.radonc.2009.12.007DOI Listing
January 2010

Point: why choose pulsed-dose-rate brachytherapy for treating gynecologic cancers?

Brachytherapy 2009 Jul-Sep;8(3):269-72

Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.brachy.2009.06.004DOI Listing
November 2009

Exon array analysis of head and neck cancers identifies a hypoxia related splice variant of LAMA3 associated with a poor prognosis.

PLoS Comput Biol 2009 Nov 20;5(11):e1000571. Epub 2009 Nov 20.

Applied Computational Biology and Bioinformatics Group, Cancer Research UK Paterson Institute for Cancer Research, The University of Manchester, Christie Hospital, Manchester, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1000571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773424PMC
November 2009

The degree of circumferential tumour involvement as a prognostic factor in oesophageal cancer.

Eur J Cardiothorac Surg 2009 Aug 21;36(2):368-73. Epub 2009 Mar 21.

Department of Gastrointestinal Surgery, University Hospital of South Manchester NHS Foundation Trust, South Moor Road, Wythenshawe, Manchester M23 9LT, United Kingdom.

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http://dx.doi.org/10.1016/j.ejcts.2008.12.052DOI Listing
August 2009

Comparison of predicted and clinical response to radiotherapy: a radiobiology modelling study.

Acta Oncol 2009 ;48(4):584-90

Department of Oncology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://www.tandfonline.com/doi/full/10.1080/0284186080263775
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http://dx.doi.org/10.1080/02841860802637757DOI Listing
May 2009

Measurement tools for gastrointestinal symptoms in radiation oncology.

Curr Opin Support Palliat Care 2009 Mar;3(1):36-40

Academic Department of Radiation Oncology, The University of Manchester, UK.

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http://dx.doi.org/10.1097/SPC.0b013e328325d18dDOI Listing
March 2009

Blood flow and Vd (water): both biomarkers required for interpreting the effects of vascular targeting agents on tumor and normal tissue.

Mol Cancer Ther 2009 Feb 10;8(2):303-9. Epub 2009 Feb 10.

Academic Department of Radiation Oncology, The University of Manchester, Manchester, UK.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-08
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http://dx.doi.org/10.1158/1535-7163.MCT-08-1016DOI Listing
February 2009

Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer.

Int J Radiat Oncol Biol Phys 2008 Dec;72(5):1551-9

Academic Radiation Oncology, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2008.07.051DOI Listing
December 2008