Catharien M Hilkens

Catharien M Hilkens

UNVERIFIED PROFILE

Are you Catharien M Hilkens?   Register this Author

Register author
Catharien M Hilkens

Catharien M Hilkens

Publications by authors named "Catharien M Hilkens"

Are you Catharien M Hilkens?   Register this Author

42Publications

997Reads

33Profile Views

Matured Tolerogenic Dendritic Cells Effectively Inhibit Autoantigen Specific CD4 T Cells in a Murine Arthritis Model.

Front Immunol 2019 28;10:2068. Epub 2019 Aug 28.

Division of Immunology, Department of Infectious Diseases and Immunology, Faculty Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.02068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724516PMC
August 2019

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.

Front Immunol 2018 9;9:755. Epub 2018 May 9.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.00755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968398PMC
June 2019

Targeting of tolerogenic dendritic cells towards heat-shock proteins: a novel therapeutic strategy for autoimmune diseases?

Immunology 2018 01 18;153(1):51-59. Epub 2017 Sep 18.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imm.12811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721256PMC
January 2018

The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy.

J Allergy Clin Immunol 2018 01 5;141(1):445-448.e4. Epub 2017 Oct 5.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research, Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals, NHS Foundation Trust, and Newcastle University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751729PMC
January 2018

β Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function.

Front Immunol 2017 20;8:1866. Epub 2017 Dec 20.

Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
Publisher Site
http://dx.doi.org/10.3389/fimmu.2017.01866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742326PMC
December 2017

A document-centric approach for developing the tolAPC ontology.

J Biomed Semantics 2017 Nov 28;8(1):54. Epub 2017 Nov 28.

School of Computing Science, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13326-017-0159-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704585PMC
November 2017

Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions.

Chembiochem 2017 09 19;18(17):1688-1691. Epub 2017 Jul 19.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201700214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708275PMC
September 2017

T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans.

Eur J Appl Physiol 2017 Aug 23;117(8):1727-1737. Epub 2017 Jun 23.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00421-017-3667-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506211PMC
August 2017

Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort.

Mediators Inflamm 2015 24;2015:471719. Epub 2015 Dec 24.

Immunology Division, Germans Trias i Pujol University Hospital, Department of Cellular Biology, Physiology, and Immunology, Universitat Autònoma Barcelona, Campus Can Ruti, 08916 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2015/471719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706930PMC
September 2016

Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4 T Cells.

Front Immunol 2016 19;7:359. Epub 2016 Sep 19.

Programa Disciplinario de Inmunología, Immune Regulation and Tolerance Research Group, Facultad de Medicina, Instituto de Ciencias Biomédicas (ICBM), Universidad de Chile, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy (MIII), Santiago, Chile.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2016.00359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027201PMC
September 2016

AIRE is not essential for the induction of human tolerogenic dendritic cells.

Autoimmunity 2016 06 25;49(4):211-8. Epub 2016 Feb 25.

a Primary Immune Deficiency Group, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/08916934.2016.1148692DOI Listing
June 2016

Emerging immunotherapies for rheumatoid arthritis.

Hum Vaccin Immunother 2014 17;10(4):822-37. Epub 2014 Feb 17.

Institute of Cellular Medicine; Musculoskeletal Research Group; Newcastle University; Newcastle upon Tyne, Tyne & Wear UK.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896612PMC
http://dx.doi.org/10.4161/hv.27910DOI Listing
April 2016

Dendritic cell maturation and survival are differentially regulated by TNFR1 and TNFR2.

J Immunol 2014 Nov 6;193(10):4914-4923. Epub 2014 Oct 6.

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1302929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896387PMC
November 2014

A negative feedback loop mediated by STAT3 limits human Th17 responses.

J Immunol 2014 Aug 27;193(3):1142-50. Epub 2014 Jun 27.

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom

View Article

Download full-text PDF

Source
http://www.jimmunol.org/content/early/2014/06/27/jimmunol.13
Web Search
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1302467
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1302467DOI Listing
August 2014

Immunity 12 years after alemtuzumab in RA: CD5⁺ B-cell depletion, thymus-dependent T-cell reconstitution and normal vaccine responses.

Rheumatology (Oxford) 2012 Aug 24;51(8):1397-406. Epub 2012 Mar 24.

Institute of Cellular Medicine, Musculoskeletal Research Group, 4th Floor Catherine Cookson Building, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kes038DOI Listing
August 2012

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.

Mech Ageing Dev 2012 Jun 1;133(6):456-66. Epub 2012 Jun 1.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2012.05.005DOI Listing
June 2012

Developing tolerogenic dendritic cell therapy for rheumatoid arthritis: what can we learn from mouse models?

Ann Rheum Dis 2011 Sep;70(9):1526-33

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ard.2011.151654DOI Listing
September 2011

Low-strength T-cell activation promotes Th17 responses.

Blood 2010 Dec 16;116(23):4829-37. Epub 2010 Aug 16.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-03-272153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223073PMC
December 2010

Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis.

Ann Rheum Dis 2010 Nov 15;69(11):2042-50. Epub 2010 Jun 15.

Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ard.2009.126383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002758PMC
November 2010

Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis.

Ann Rheum Dis 2010 Jun 22;69(6):1200-7. Epub 2009 Sep 22.

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle-upon-Tyne, UK.

View Article

Download full-text PDF

Source
http://ard.bmj.com/content/early/2010/04/07/ard.2009.110502.
Web Search
http://ard.bmj.com/cgi/doi/10.1136/ard.2009.110502
Publisher Site
http://dx.doi.org/10.1136/ard.2009.110502DOI Listing
June 2010

Development of dendritic cell-based immunotherapy for autoimmunity.

Int Rev Immunol 2010 Apr;29(2):156-83

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/08830180903281193DOI Listing
April 2010

A novel paradigm for dendritic cells as effectors of cartilage destruction.

Rheumatology (Oxford) 2009 May 5;48(5):502-7. Epub 2009 Mar 5.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kep040DOI Listing
May 2009

LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells.

J Leukoc Biol 2009 Feb 6;85(2):243-50. Epub 2008 Nov 6.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1189/jlb.0608374
Publisher Site
http://dx.doi.org/10.1189/jlb.0608374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700018PMC
February 2009

Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells.

J Leukoc Biol 2008 Jul 22;84(1):124-33. Epub 2008 Apr 22.

Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.1107744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504714PMC
July 2008

Impact of psoralen/UVA-treatment on survival, activation, and immunostimulatory capacity of monocyte-derived dendritic cells.

Transplantation 2008 Mar;85(5):757-66

Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00007890-200803150-000
Publisher Site
http://dx.doi.org/10.1097/TP.0b013e31816650f6DOI Listing
March 2008

Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells.

J Immunol 2007 Aug;179(3):1595-604

Hematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.179.3.1595DOI Listing
August 2007

Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice.

Arthritis Res Ther 2006 ;8(4):R93

Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/ar1964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779380PMC
February 2007

Sustained IL-12 signaling is required for Th1 development.

J Immunol 2004 Jan;172(1):61-9

Lymphocyte Activation Laboratory and Biochemical Regulatory Mechanisms Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.172.1.61DOI Listing
January 2004

Differential responses to IFN-alpha subtypes in human T cells and dendritic cells.

J Immunol 2003 Nov;171(10):5255-63

Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.171.10.5255DOI Listing
November 2003

Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays.

J Biol Chem 2002 Dec 16;277(51):49428-37. Epub 2002 Oct 16.

Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M205571200DOI Listing
December 2002